Working memory dysfunction in obsessive-compulsive disorder: A neuropsychological and functional MRI study

Tomohiro Nakao, Akiko Nakagawa, Eriko Nakatani, Maiko Nabeyama, Hirokuni Sanematsu, Takashi Yoshiura, Osamu Togao, Mayumi Tomita, Yusuke Masuda, Kazuko Yoshioka, Toshihide Kuroki, Shigenobu Kanba

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, we applied neuropsychological batteries to demonstrate a working memory deficit in OCD by comparison with normal controls. In addition, working memory and brain activation were further examined with symptom-based analysis. Forty patients with OCD and 25 normal controls were examined using neuropsychological tests including the WAIS-R, WCST, WMS-R, and R-OCFT and functional MRI (fMRI) during the N-back task including 0- and 2-back task. On fMRI, the brain regions activated during the performance and the differences in the activation between patients and controls were identified. Additional analyses of severity and subtypes were conducted by using Y-BOCS severity score, symptom-checklist and Leckman's four-factor model, respectively. On the neuropsychological tests, the OCD patients had significantly lower scores on the delayed recall section of the WMS-R and the immediate recall section of the R-OCFT compared to the controls. On fMRI, the patients showed greater activation in the right dorsolateral prefrontal cortex (DLPFC), left superior temporal gyrus (STG), left insula, and cuneus during two-back task compared to the controls. Right orbitofrontal cortex activity showed a significant positive correlation with Y-BOCS scores in OCD. Furthermore, patients with obsessions/checking rituals (n = 10) showed severer memory deficits and decreased activity in the postcentral gyrus than patients with cleanliness/washing rituals (n = 14). In conclusion, we found neuropsychological dysfunction and brain abnormalities in OCD. Furthermore, our results suggested that symptom severity and symptom subtype such as obsessions/checking might affect neuropsychological dysfunction and related brain activities.

Original languageEnglish
Pages (from-to)784-791
Number of pages8
JournalJournal of Psychiatric Research
Volume43
Issue number8
DOIs
Publication statusPublished - May 1 2009

Fingerprint

Obsessive-Compulsive Disorder
Short-Term Memory
Magnetic Resonance Imaging
Ceremonial Behavior
Memory Disorders
Obsessive Behavior
Neuropsychological Tests
Brain
Prefrontal Cortex
Occipital Lobe
Functional Neuroimaging
Somatosensory Cortex
Frontal Lobe
Temporal Lobe
Checklist

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health
  • Biological Psychiatry

Cite this

Working memory dysfunction in obsessive-compulsive disorder : A neuropsychological and functional MRI study. / Nakao, Tomohiro; Nakagawa, Akiko; Nakatani, Eriko; Nabeyama, Maiko; Sanematsu, Hirokuni; Yoshiura, Takashi; Togao, Osamu; Tomita, Mayumi; Masuda, Yusuke; Yoshioka, Kazuko; Kuroki, Toshihide; Kanba, Shigenobu.

In: Journal of Psychiatric Research, Vol. 43, No. 8, 01.05.2009, p. 784-791.

Research output: Contribution to journalArticle

Nakao, T, Nakagawa, A, Nakatani, E, Nabeyama, M, Sanematsu, H, Yoshiura, T, Togao, O, Tomita, M, Masuda, Y, Yoshioka, K, Kuroki, T & Kanba, S 2009, 'Working memory dysfunction in obsessive-compulsive disorder: A neuropsychological and functional MRI study', Journal of Psychiatric Research, vol. 43, no. 8, pp. 784-791. https://doi.org/10.1016/j.jpsychires.2008.10.013
Nakao, Tomohiro ; Nakagawa, Akiko ; Nakatani, Eriko ; Nabeyama, Maiko ; Sanematsu, Hirokuni ; Yoshiura, Takashi ; Togao, Osamu ; Tomita, Mayumi ; Masuda, Yusuke ; Yoshioka, Kazuko ; Kuroki, Toshihide ; Kanba, Shigenobu. / Working memory dysfunction in obsessive-compulsive disorder : A neuropsychological and functional MRI study. In: Journal of Psychiatric Research. 2009 ; Vol. 43, No. 8. pp. 784-791.
@article{ad06c9a683ea46b68f192740fdec70a3,
title = "Working memory dysfunction in obsessive-compulsive disorder: A neuropsychological and functional MRI study",
abstract = "Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, we applied neuropsychological batteries to demonstrate a working memory deficit in OCD by comparison with normal controls. In addition, working memory and brain activation were further examined with symptom-based analysis. Forty patients with OCD and 25 normal controls were examined using neuropsychological tests including the WAIS-R, WCST, WMS-R, and R-OCFT and functional MRI (fMRI) during the N-back task including 0- and 2-back task. On fMRI, the brain regions activated during the performance and the differences in the activation between patients and controls were identified. Additional analyses of severity and subtypes were conducted by using Y-BOCS severity score, symptom-checklist and Leckman's four-factor model, respectively. On the neuropsychological tests, the OCD patients had significantly lower scores on the delayed recall section of the WMS-R and the immediate recall section of the R-OCFT compared to the controls. On fMRI, the patients showed greater activation in the right dorsolateral prefrontal cortex (DLPFC), left superior temporal gyrus (STG), left insula, and cuneus during two-back task compared to the controls. Right orbitofrontal cortex activity showed a significant positive correlation with Y-BOCS scores in OCD. Furthermore, patients with obsessions/checking rituals (n = 10) showed severer memory deficits and decreased activity in the postcentral gyrus than patients with cleanliness/washing rituals (n = 14). In conclusion, we found neuropsychological dysfunction and brain abnormalities in OCD. Furthermore, our results suggested that symptom severity and symptom subtype such as obsessions/checking might affect neuropsychological dysfunction and related brain activities.",
author = "Tomohiro Nakao and Akiko Nakagawa and Eriko Nakatani and Maiko Nabeyama and Hirokuni Sanematsu and Takashi Yoshiura and Osamu Togao and Mayumi Tomita and Yusuke Masuda and Kazuko Yoshioka and Toshihide Kuroki and Shigenobu Kanba",
year = "2009",
month = "5",
day = "1",
doi = "10.1016/j.jpsychires.2008.10.013",
language = "English",
volume = "43",
pages = "784--791",
journal = "Journal of Psychiatric Research",
issn = "0022-3956",
publisher = "Elsevier Limited",
number = "8",

}

TY - JOUR

T1 - Working memory dysfunction in obsessive-compulsive disorder

T2 - A neuropsychological and functional MRI study

AU - Nakao, Tomohiro

AU - Nakagawa, Akiko

AU - Nakatani, Eriko

AU - Nabeyama, Maiko

AU - Sanematsu, Hirokuni

AU - Yoshiura, Takashi

AU - Togao, Osamu

AU - Tomita, Mayumi

AU - Masuda, Yusuke

AU - Yoshioka, Kazuko

AU - Kuroki, Toshihide

AU - Kanba, Shigenobu

PY - 2009/5/1

Y1 - 2009/5/1

N2 - Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, we applied neuropsychological batteries to demonstrate a working memory deficit in OCD by comparison with normal controls. In addition, working memory and brain activation were further examined with symptom-based analysis. Forty patients with OCD and 25 normal controls were examined using neuropsychological tests including the WAIS-R, WCST, WMS-R, and R-OCFT and functional MRI (fMRI) during the N-back task including 0- and 2-back task. On fMRI, the brain regions activated during the performance and the differences in the activation between patients and controls were identified. Additional analyses of severity and subtypes were conducted by using Y-BOCS severity score, symptom-checklist and Leckman's four-factor model, respectively. On the neuropsychological tests, the OCD patients had significantly lower scores on the delayed recall section of the WMS-R and the immediate recall section of the R-OCFT compared to the controls. On fMRI, the patients showed greater activation in the right dorsolateral prefrontal cortex (DLPFC), left superior temporal gyrus (STG), left insula, and cuneus during two-back task compared to the controls. Right orbitofrontal cortex activity showed a significant positive correlation with Y-BOCS scores in OCD. Furthermore, patients with obsessions/checking rituals (n = 10) showed severer memory deficits and decreased activity in the postcentral gyrus than patients with cleanliness/washing rituals (n = 14). In conclusion, we found neuropsychological dysfunction and brain abnormalities in OCD. Furthermore, our results suggested that symptom severity and symptom subtype such as obsessions/checking might affect neuropsychological dysfunction and related brain activities.

AB - Previous neuropsychological studies indicate that OCD subtypes such as checking rituals might be associated with a working memory deficit. On the other hand, functional neuroimaging studies found functional abnormalities of the frontal cortex and subcortical structures in OCD. Combined with functional imaging method, we applied neuropsychological batteries to demonstrate a working memory deficit in OCD by comparison with normal controls. In addition, working memory and brain activation were further examined with symptom-based analysis. Forty patients with OCD and 25 normal controls were examined using neuropsychological tests including the WAIS-R, WCST, WMS-R, and R-OCFT and functional MRI (fMRI) during the N-back task including 0- and 2-back task. On fMRI, the brain regions activated during the performance and the differences in the activation between patients and controls were identified. Additional analyses of severity and subtypes were conducted by using Y-BOCS severity score, symptom-checklist and Leckman's four-factor model, respectively. On the neuropsychological tests, the OCD patients had significantly lower scores on the delayed recall section of the WMS-R and the immediate recall section of the R-OCFT compared to the controls. On fMRI, the patients showed greater activation in the right dorsolateral prefrontal cortex (DLPFC), left superior temporal gyrus (STG), left insula, and cuneus during two-back task compared to the controls. Right orbitofrontal cortex activity showed a significant positive correlation with Y-BOCS scores in OCD. Furthermore, patients with obsessions/checking rituals (n = 10) showed severer memory deficits and decreased activity in the postcentral gyrus than patients with cleanliness/washing rituals (n = 14). In conclusion, we found neuropsychological dysfunction and brain abnormalities in OCD. Furthermore, our results suggested that symptom severity and symptom subtype such as obsessions/checking might affect neuropsychological dysfunction and related brain activities.

UR - http://www.scopus.com/inward/record.url?scp=64249089140&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=64249089140&partnerID=8YFLogxK

U2 - 10.1016/j.jpsychires.2008.10.013

DO - 10.1016/j.jpsychires.2008.10.013

M3 - Article

C2 - 19081580

AN - SCOPUS:64249089140

VL - 43

SP - 784

EP - 791

JO - Journal of Psychiatric Research

JF - Journal of Psychiatric Research

SN - 0022-3956

IS - 8

ER -