X-ray crystallographic analysis of measles virus hemagglutinin.

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

X-ray crystallographic analyses, together with nuclear magnetic resonance, have revealed three-dimensional structures of many important viral proteins, thereby allowing us to better understand the interactions between viral and host cell molecules. In this review, we summarize the recently determined crystal structure of the measles virus (MV) attachment protein hemagglutinin. Based on this structural information, we also discuss how the MV hemagglutinin interacts with various cellular receptors and why MV vaccines have been effective for many years without inducing escape mutant viruses. Other topics discussed are a putative MV receptor present on polarized epithelial cells and the protein expression system using a cultured human cell line 293SGnTI(-), which is suitable for X-ray crystallographic analyses.

Original languageEnglish
Pages (from-to)1-10
Number of pages10
JournalUirusu. Journal of virology
Volume58
Issue number1
DOIs
Publication statusPublished - Jun 2008

Fingerprint

Measles virus
Hemagglutinins
X-Rays
Measles Vaccine
Virus Receptors
Virus Attachment
Viral Proteins
Cultured Cells
Proteins
Magnetic Resonance Spectroscopy
Epithelial Cells
Viruses
Cell Line

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

X-ray crystallographic analysis of measles virus hemagglutinin. / Hashiguchi, Takao; Maenaka, Katsumi; Yanagi, Yusuke.

In: Uirusu. Journal of virology, Vol. 58, No. 1, 06.2008, p. 1-10.

Research output: Contribution to journalReview article

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