TY - JOUR
T1 - Xenon-inhalation computed tomography for noninvasive quantitative measurement of tissue blood flow in pancreatic tumor
AU - Kubota, Masaru
AU - Murakami, Takamichi
AU - Nagano, Hiroaki
AU - Eguchi, Hidetoshi
AU - Marubashi, Shigeru
AU - Kobayashi, Shogo
AU - Wada, Hiroshi
AU - Tanemura, Masahiro
AU - Dono, Keizo
AU - Nakamori, Shoji
AU - Sakon, Masato
AU - Monden, Morito
AU - Mori, Masaki
AU - Doki, Yuichiro
PY - 2012/3
Y1 - 2012/3
N2 - Background and Aims The purpose of this prospective study was to demonstrate the ability to measure pancreatic tumor tissue blood flow (TBF) with a noninvasive method using xenon inhalation computed tomography (xenon-CT) and to correlate TBF with histological features, particularly microvascular density (MVD). Methods TBFs of pancreatic tumors in 14 consecutive patients were measured by means of xenon-CT at diagnosis and following therapy. Serial abdominal CT scans were obtained before and after inhalation of nonradioactive xenon gas. TBF was calculated using the Fick principle. Furthermore, intratumoral microvessels were stained with anti-CD34 monoclonal antibodies before being quantified by light microscopy (×200). We evaluated MVD based on CD34 expression and correlated it with TBF. Results The quantitative TBF of pancreatic tumors measured by xenon CT ranged from 22.3 to 111.4 ml/min/ 100 g (mean ± SD, 59.6 ± 43.9 ml/min/100 g). High correlation (r = 0.885, P<0.001) was observed between TBF and intratumoral MVD. Conclusion Xenon-CT is feasible in patients with pancreatic tumors and is able to accurately estimate MVD noninvasively.
AB - Background and Aims The purpose of this prospective study was to demonstrate the ability to measure pancreatic tumor tissue blood flow (TBF) with a noninvasive method using xenon inhalation computed tomography (xenon-CT) and to correlate TBF with histological features, particularly microvascular density (MVD). Methods TBFs of pancreatic tumors in 14 consecutive patients were measured by means of xenon-CT at diagnosis and following therapy. Serial abdominal CT scans were obtained before and after inhalation of nonradioactive xenon gas. TBF was calculated using the Fick principle. Furthermore, intratumoral microvessels were stained with anti-CD34 monoclonal antibodies before being quantified by light microscopy (×200). We evaluated MVD based on CD34 expression and correlated it with TBF. Results The quantitative TBF of pancreatic tumors measured by xenon CT ranged from 22.3 to 111.4 ml/min/ 100 g (mean ± SD, 59.6 ± 43.9 ml/min/100 g). High correlation (r = 0.885, P<0.001) was observed between TBF and intratumoral MVD. Conclusion Xenon-CT is feasible in patients with pancreatic tumors and is able to accurately estimate MVD noninvasively.
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U2 - 10.1007/s10620-011-1915-4
DO - 10.1007/s10620-011-1915-4
M3 - Article
C2 - 21953140
AN - SCOPUS:84859516183
SN - 0163-2116
VL - 57
SP - 801
EP - 805
JO - Digestive Diseases and Sciences
JF - Digestive Diseases and Sciences
IS - 3
ER -