Y-box binding protein-1 is a novel molecular target for tumor vessels

Mayu Takahashi, Shohei Shimajiri, Hiroto Izumi, Gen Hirano, Eiji Kashiwagi, Yoshihiro Yasuniwa, Ying Wu, Bin Han, Masaki Akiyama, Shigeru Nishizawa, Yasuyuki Sasaguri, Kimitoshi Kohno

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Y-box binding protein-1 (YB-1) is a member of the cold shock protein family and functions in transcription and translation. Many reports indicate that YB-1 is highly expressed in tumor cells and is a marker for tumor aggressiveness and clinical prognosis. Here, we show clear evidence that YB-1 is expressed in the angiogenic endothelial cells of various tumors, such as glioblastoma, esophageal cancer, gastric cancer, colon cancer, and lung cancer, as well as in tumor cells. YB-1 was highly expressed in glomeruloid microvascular endothelial cells of brain tumors and microvessels in the desmoplastic region around multiple solid tumors. On the other hand, no or low YB-1 expression was observed in normal angiogenic endothelial cells from fetal kidney, newborn lung, and placenta. The endothelial cells in inflammatory regions of granulomas were also weakly labeled. Knockdown of YB-1 expression by small-interfering RNA induced G1 cell cycle arrest and inhibited the growth of human umbilical vein endothelial cells stimulated by growth factors. Taken together, YB-1 plays an important role in the growth of not only tumor cells but also tumor-associated endothelial cells, suggesting that YB-1 is a promising target for cancer therapy. Cancer Sci 2010).

Original languageEnglish
Pages (from-to)1367-1373
Number of pages7
JournalCancer Science
Volume101
Issue number6
DOIs
Publication statusPublished - Jun 1 2010
Externally publishedYes

Fingerprint

Y-Box-Binding Protein 1
Endothelial Cells
Neoplasms
Colonic Neoplasms
Stomach Neoplasms
Lung Neoplasms
Cold Shock Proteins and Peptides
G1 Phase Cell Cycle Checkpoints
Human Umbilical Vein Endothelial Cells
Glioblastoma
Esophageal Neoplasms
Tumor Biomarkers
Growth
Microvessels
Granuloma
Brain Neoplasms
Placenta
Small Interfering RNA
Intercellular Signaling Peptides and Proteins
Biomarkers

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Takahashi, M., Shimajiri, S., Izumi, H., Hirano, G., Kashiwagi, E., Yasuniwa, Y., ... Kohno, K. (2010). Y-box binding protein-1 is a novel molecular target for tumor vessels. Cancer Science, 101(6), 1367-1373. https://doi.org/10.1111/j.1349-7006.2010.01534.x

Y-box binding protein-1 is a novel molecular target for tumor vessels. / Takahashi, Mayu; Shimajiri, Shohei; Izumi, Hiroto; Hirano, Gen; Kashiwagi, Eiji; Yasuniwa, Yoshihiro; Wu, Ying; Han, Bin; Akiyama, Masaki; Nishizawa, Shigeru; Sasaguri, Yasuyuki; Kohno, Kimitoshi.

In: Cancer Science, Vol. 101, No. 6, 01.06.2010, p. 1367-1373.

Research output: Contribution to journalArticle

Takahashi, M, Shimajiri, S, Izumi, H, Hirano, G, Kashiwagi, E, Yasuniwa, Y, Wu, Y, Han, B, Akiyama, M, Nishizawa, S, Sasaguri, Y & Kohno, K 2010, 'Y-box binding protein-1 is a novel molecular target for tumor vessels', Cancer Science, vol. 101, no. 6, pp. 1367-1373. https://doi.org/10.1111/j.1349-7006.2010.01534.x
Takahashi M, Shimajiri S, Izumi H, Hirano G, Kashiwagi E, Yasuniwa Y et al. Y-box binding protein-1 is a novel molecular target for tumor vessels. Cancer Science. 2010 Jun 1;101(6):1367-1373. https://doi.org/10.1111/j.1349-7006.2010.01534.x
Takahashi, Mayu ; Shimajiri, Shohei ; Izumi, Hiroto ; Hirano, Gen ; Kashiwagi, Eiji ; Yasuniwa, Yoshihiro ; Wu, Ying ; Han, Bin ; Akiyama, Masaki ; Nishizawa, Shigeru ; Sasaguri, Yasuyuki ; Kohno, Kimitoshi. / Y-box binding protein-1 is a novel molecular target for tumor vessels. In: Cancer Science. 2010 ; Vol. 101, No. 6. pp. 1367-1373.
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