TY - JOUR
T1 - Y-box binding protein expression in thyroid neoplasms
T2 - Its linkage with anaplastic transformation
AU - Ito, Yasuhiro
AU - Yoshida, Hiroshi
AU - Shibahara, Kotaro
AU - Uruno, Takashi
AU - Nakano, Keiichi
AU - Takamura, Yuuki
AU - Miya, Akihiro
AU - Kobayashi, Kaoru
AU - Yokozawa, Tamotsu
AU - Matsuzuka, Fumio
AU - Uchimi, Takeshi
AU - Kuwano, Michihiko
AU - Miyoshi, Eiji
AU - Matsuura, Nariaki
AU - Kuma, Kanji
AU - Miyauchi, Akira
PY - 2003/7/1
Y1 - 2003/7/1
N2 - Recent studies have demonstrated that Y-box binding protein (YB-1) regulates the transcription of genes linked to carcinoma progression. In this study, we investigated the expression of this protein in thyroid neoplasms to elucidate its significance. The expression of YB-1 was immunohistochemically investigated using the monoclonal antibody for various thyroid neoplasms. Normal follicles did not overexpress YB-1, and only moderate overexpression of YB-1 was observed in some follicular tumors and papillary carcinoma, especially those of a larger size. In contrast, 92.9% of anaplastic carcinoma strongly overexpressed YB-1. YB-1 immunoreactivity was seen in both cytoplasms and cell nuclei, but the former was more predominant. These findings suggest that YB-1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma.
AB - Recent studies have demonstrated that Y-box binding protein (YB-1) regulates the transcription of genes linked to carcinoma progression. In this study, we investigated the expression of this protein in thyroid neoplasms to elucidate its significance. The expression of YB-1 was immunohistochemically investigated using the monoclonal antibody for various thyroid neoplasms. Normal follicles did not overexpress YB-1, and only moderate overexpression of YB-1 was observed in some follicular tumors and papillary carcinoma, especially those of a larger size. In contrast, 92.9% of anaplastic carcinoma strongly overexpressed YB-1. YB-1 immunoreactivity was seen in both cytoplasms and cell nuclei, but the former was more predominant. These findings suggest that YB-1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma.
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U2 - 10.1046/j.1440-1827.2003.01494.x
DO - 10.1046/j.1440-1827.2003.01494.x
M3 - Article
C2 - 12828607
AN - SCOPUS:10744225284
SN - 1320-5463
VL - 53
SP - 429
EP - 433
JO - Acta Pathologica Japonica
JF - Acta Pathologica Japonica
IS - 7
ER -