Y-box binding protein expression in thyroid neoplasms: Its linkage with anaplastic transformation

Yasuhiro Ito, Hiroshi Yoshida, Kotaro Shibahara, Takashi Uruno, Keiichi Nakano, Yuuki Takamura, Akihiro Miya, Kaoru Kobayashi, Tamotsu Yokozawa, Fumio Matsuzuka, Takeshi Uchimi, Michihiko Kuwano, Eiji Miyoshi, Nariaki Matsuura, Kanji Kuma, Akira Miyauchi

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)

Abstract

Recent studies have demonstrated that Y-box binding protein (YB-1) regulates the transcription of genes linked to carcinoma progression. In this study, we investigated the expression of this protein in thyroid neoplasms to elucidate its significance. The expression of YB-1 was immunohistochemically investigated using the monoclonal antibody for various thyroid neoplasms. Normal follicles did not overexpress YB-1, and only moderate overexpression of YB-1 was observed in some follicular tumors and papillary carcinoma, especially those of a larger size. In contrast, 92.9% of anaplastic carcinoma strongly overexpressed YB-1. YB-1 immunoreactivity was seen in both cytoplasms and cell nuclei, but the former was more predominant. These findings suggest that YB-1 plays a role in regulating the transcription as well as translation of genes contributing to the anaplastic transformation of thyroid carcinoma.

Original languageEnglish
Pages (from-to)429-433
Number of pages5
JournalPathology International
Volume53
Issue number7
DOIs
Publication statusPublished - Jul 1 2003
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine

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