Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer

Tomohiro Shibata, Eriko Tokunaga, Satoshi Hattori, Kosuke Watari, Yuichi Murakami, Nami Yamashita, Eiji Oki, Junji Itou, Masakazu Toi, Yoshihiko Maehara, Michihiko Kuwano, Mayumi Ono

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The enhanced expression of the Y-box binding protein YBX1 is consistently correlated with poor outcomes or reduced survival of breast cancer patients. However, the mechanism underlying the association between increased YBX1 expression and poor outcomes has yet to be revealed. We searched a database for the top 500 genes that are positively or negatively correlated with YBX1 and with ESR1 in breast cancer patients. We further examined the association between YBX1-correlated genes and breast cancer outcomes in patients at Kyushu University Hospital. More than 60% of genes that are positively correlated with YBX1 are also negatively correlated with ESR1. The enhanced expression levels of the top 20 positively correlated genes mostly predict negative outcomes, while the enhanced expression levels of the top 20 negatively correlated genes mostly predict positive outcomes. Furthermore, in breast cancer patients at Kyushu University Hospital, the expression levels of YBX1 and YBX1-positively correlated genes were significantly higher and the expression levels of genes negatively correlated with YBX1 were significantly lower in patients who relapsed after their primary surgery than in those who did not relapse. The expression of YBX1 together with the expression of its positively or negatively correlated genes may help to predict outcomes as well as resistance to endocrine therapies in breast cancer patients. Determining the expression of YBX1 and its closely correlated genes will contribute to the development of precision therapeutics for breast cancer.

Original languageEnglish
Pages (from-to)37216-37228
Number of pages13
JournalOncotarget
Volume9
Issue number98
Publication statusPublished - Dec 1 2018

Fingerprint

Carrier Proteins
Biomarkers
Breast Neoplasms
Genes
Databases
Gene Expression
Recurrence
Survival
Therapeutics

All Science Journal Classification (ASJC) codes

  • Oncology

Cite this

Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer. / Shibata, Tomohiro; Tokunaga, Eriko; Hattori, Satoshi; Watari, Kosuke; Murakami, Yuichi; Yamashita, Nami; Oki, Eiji; Itou, Junji; Toi, Masakazu; Maehara, Yoshihiko; Kuwano, Michihiko; Ono, Mayumi.

In: Oncotarget, Vol. 9, No. 98, 01.12.2018, p. 37216-37228.

Research output: Contribution to journalArticle

Shibata, T, Tokunaga, E, Hattori, S, Watari, K, Murakami, Y, Yamashita, N, Oki, E, Itou, J, Toi, M, Maehara, Y, Kuwano, M & Ono, M 2018, 'Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer', Oncotarget, vol. 9, no. 98, pp. 37216-37228.
Shibata, Tomohiro ; Tokunaga, Eriko ; Hattori, Satoshi ; Watari, Kosuke ; Murakami, Yuichi ; Yamashita, Nami ; Oki, Eiji ; Itou, Junji ; Toi, Masakazu ; Maehara, Yoshihiko ; Kuwano, Michihiko ; Ono, Mayumi. / Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer. In: Oncotarget. 2018 ; Vol. 9, No. 98. pp. 37216-37228.
@article{4c374877c8264c07873819472c9d2c9a,
title = "Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer",
abstract = "The enhanced expression of the Y-box binding protein YBX1 is consistently correlated with poor outcomes or reduced survival of breast cancer patients. However, the mechanism underlying the association between increased YBX1 expression and poor outcomes has yet to be revealed. We searched a database for the top 500 genes that are positively or negatively correlated with YBX1 and with ESR1 in breast cancer patients. We further examined the association between YBX1-correlated genes and breast cancer outcomes in patients at Kyushu University Hospital. More than 60{\%} of genes that are positively correlated with YBX1 are also negatively correlated with ESR1. The enhanced expression levels of the top 20 positively correlated genes mostly predict negative outcomes, while the enhanced expression levels of the top 20 negatively correlated genes mostly predict positive outcomes. Furthermore, in breast cancer patients at Kyushu University Hospital, the expression levels of YBX1 and YBX1-positively correlated genes were significantly higher and the expression levels of genes negatively correlated with YBX1 were significantly lower in patients who relapsed after their primary surgery than in those who did not relapse. The expression of YBX1 together with the expression of its positively or negatively correlated genes may help to predict outcomes as well as resistance to endocrine therapies in breast cancer patients. Determining the expression of YBX1 and its closely correlated genes will contribute to the development of precision therapeutics for breast cancer.",
author = "Tomohiro Shibata and Eriko Tokunaga and Satoshi Hattori and Kosuke Watari and Yuichi Murakami and Nami Yamashita and Eiji Oki and Junji Itou and Masakazu Toi and Yoshihiko Maehara and Michihiko Kuwano and Mayumi Ono",
year = "2018",
month = "12",
day = "1",
language = "English",
volume = "9",
pages = "37216--37228",
journal = "Oncotarget",
issn = "1949-2553",
publisher = "Impact Journals",
number = "98",

}

TY - JOUR

T1 - Y-box binding protein YBX1 and its correlated genes as biomarkers for poor outcomes in patients with breast cancer

AU - Shibata, Tomohiro

AU - Tokunaga, Eriko

AU - Hattori, Satoshi

AU - Watari, Kosuke

AU - Murakami, Yuichi

AU - Yamashita, Nami

AU - Oki, Eiji

AU - Itou, Junji

AU - Toi, Masakazu

AU - Maehara, Yoshihiko

AU - Kuwano, Michihiko

AU - Ono, Mayumi

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The enhanced expression of the Y-box binding protein YBX1 is consistently correlated with poor outcomes or reduced survival of breast cancer patients. However, the mechanism underlying the association between increased YBX1 expression and poor outcomes has yet to be revealed. We searched a database for the top 500 genes that are positively or negatively correlated with YBX1 and with ESR1 in breast cancer patients. We further examined the association between YBX1-correlated genes and breast cancer outcomes in patients at Kyushu University Hospital. More than 60% of genes that are positively correlated with YBX1 are also negatively correlated with ESR1. The enhanced expression levels of the top 20 positively correlated genes mostly predict negative outcomes, while the enhanced expression levels of the top 20 negatively correlated genes mostly predict positive outcomes. Furthermore, in breast cancer patients at Kyushu University Hospital, the expression levels of YBX1 and YBX1-positively correlated genes were significantly higher and the expression levels of genes negatively correlated with YBX1 were significantly lower in patients who relapsed after their primary surgery than in those who did not relapse. The expression of YBX1 together with the expression of its positively or negatively correlated genes may help to predict outcomes as well as resistance to endocrine therapies in breast cancer patients. Determining the expression of YBX1 and its closely correlated genes will contribute to the development of precision therapeutics for breast cancer.

AB - The enhanced expression of the Y-box binding protein YBX1 is consistently correlated with poor outcomes or reduced survival of breast cancer patients. However, the mechanism underlying the association between increased YBX1 expression and poor outcomes has yet to be revealed. We searched a database for the top 500 genes that are positively or negatively correlated with YBX1 and with ESR1 in breast cancer patients. We further examined the association between YBX1-correlated genes and breast cancer outcomes in patients at Kyushu University Hospital. More than 60% of genes that are positively correlated with YBX1 are also negatively correlated with ESR1. The enhanced expression levels of the top 20 positively correlated genes mostly predict negative outcomes, while the enhanced expression levels of the top 20 negatively correlated genes mostly predict positive outcomes. Furthermore, in breast cancer patients at Kyushu University Hospital, the expression levels of YBX1 and YBX1-positively correlated genes were significantly higher and the expression levels of genes negatively correlated with YBX1 were significantly lower in patients who relapsed after their primary surgery than in those who did not relapse. The expression of YBX1 together with the expression of its positively or negatively correlated genes may help to predict outcomes as well as resistance to endocrine therapies in breast cancer patients. Determining the expression of YBX1 and its closely correlated genes will contribute to the development of precision therapeutics for breast cancer.

UR - http://www.scopus.com/inward/record.url?scp=85058496526&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85058496526&partnerID=8YFLogxK

M3 - Article

VL - 9

SP - 37216

EP - 37228

JO - Oncotarget

JF - Oncotarget

SN - 1949-2553

IS - 98

ER -