Yokukansan enhances pentobarbital-induced sleep in socially isolated mice: Possible involvement of GABA A - Benzodiazepine receptor complex

Nobuaki Egashira, Ai Nogami, Katsunori Iwasaki, Ayumi Ishibashi, Naoki Uchida, Kotaro Takasaki, Kenichi Mishima, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwara

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep in group-housed mice. The prolongation of sleeping time by YKS was reversed by bicuculline (3 mg/kg, i.p.) and flumazenil (3 mg/kg, i.p.), but not WAY100635. These findings suggest that the GABA A - benzodiazepine receptor complex, but not 5-HT 1A receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation.

Original languageEnglish
Pages (from-to)316-320
Number of pages5
JournalJournal of Pharmacological Sciences
Volume116
Issue number3
DOIs
Publication statusPublished - Jul 21 2011

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Pentobarbital
GABA-A Receptors
Sleep
Kampo Medicine
Flumazenil
Social Isolation
Receptor, Serotonin, 5-HT1A
Bicuculline
Yi-Gan San

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

Cite this

Yokukansan enhances pentobarbital-induced sleep in socially isolated mice : Possible involvement of GABA A - Benzodiazepine receptor complex. / Egashira, Nobuaki; Nogami, Ai; Iwasaki, Katsunori; Ishibashi, Ayumi; Uchida, Naoki; Takasaki, Kotaro; Mishima, Kenichi; Nishimura, Ryoji; Oishi, Ryozo; Fujiwara, Michihiro.

In: Journal of Pharmacological Sciences, Vol. 116, No. 3, 21.07.2011, p. 316-320.

Research output: Contribution to journalArticle

Egashira, N, Nogami, A, Iwasaki, K, Ishibashi, A, Uchida, N, Takasaki, K, Mishima, K, Nishimura, R, Oishi, R & Fujiwara, M 2011, 'Yokukansan enhances pentobarbital-induced sleep in socially isolated mice: Possible involvement of GABA A - Benzodiazepine receptor complex', Journal of Pharmacological Sciences, vol. 116, no. 3, pp. 316-320. https://doi.org/10.1254/jphs.11079SC
Egashira, Nobuaki ; Nogami, Ai ; Iwasaki, Katsunori ; Ishibashi, Ayumi ; Uchida, Naoki ; Takasaki, Kotaro ; Mishima, Kenichi ; Nishimura, Ryoji ; Oishi, Ryozo ; Fujiwara, Michihiro. / Yokukansan enhances pentobarbital-induced sleep in socially isolated mice : Possible involvement of GABA A - Benzodiazepine receptor complex. In: Journal of Pharmacological Sciences. 2011 ; Vol. 116, No. 3. pp. 316-320.
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