Yokukansan enhances pentobarbital-induced sleep in socially isolated mice: Possible involvement of GABA A - Benzodiazepine receptor complex

Nobuaki Egashira, Ai Nogami, Katsunori Iwasaki, Ayumi Ishibashi, Naoki Uchida, Kotaro Takasaki, Kenichi Mishima, Ryoji Nishimura, Ryozo Oishi, Michihiro Fujiwara

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

In the present study, we investigated the effect of the Kampo medicine Yokukansan (YKS) on pentobarbital-induced sleep in group-housed and socially isolated mice. Socially isolated mice showed shorter sleeping time than the group-housed mice. YKS (300 mg/kg, p.o.) prolonged the pentobarbital-induced sleeping time in socially isolated mice without affecting pentobarbital sleep in group-housed mice. The prolongation of sleeping time by YKS was reversed by bicuculline (3 mg/kg, i.p.) and flumazenil (3 mg/kg, i.p.), but not WAY100635. These findings suggest that the GABA A - benzodiazepine receptor complex, but not 5-HT 1A receptors, is involved in the reversal effect of YKS on the decrease of pentobarbital sleep by social isolation.

Original languageEnglish
Pages (from-to)316-320
Number of pages5
JournalJournal of Pharmacological Sciences
Volume116
Issue number3
DOIs
Publication statusPublished - 2011

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology

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