Zebrafish as a model for the study of the phase II cytosolic sulfotransferases

Tzu An Liu, Shakhawat Bhuiyan, Ming Yih Liu, Takuya Sugahara, Yoichi Sakakibara, Masahito Suiko, Shin Yasuda, Yoshimitsu Kakuta, Makoto Kimura, Frederick E. Williams, Ming Cheh Liu

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

Cytosolic sulfotransferases (SULTs) are traditionally known as the Phase II drug-metabolizing or detoxifying enzymes that serve for the detoxification of drugs and other xenobiotics. These enzymes in general catalyze the transfer of a sulfonate group from the active sulfate, 3′-phophoadenosine 5′-phosphosulfate (PAPS), to low-molecular weight substrate compounds containing hydroxyl or amino group(s). Despite considerable efforts made in recent years, some fundamental aspects of the SULTs, particularly their ontogeny, cell type/tissue/organ-specific distribution, and physiological relevance, particularly their involvement in drug metabolism and detoxification, still remain poorly understood. To better understand these fundamental issues, we have embarked on developing the zebrafish as a model for studies concerning the SULTs. To date, fifteen zebrafish SULTs have been cloned, expressed, purified, and characterized. These zebrafish SULTs, which fall into four major SULT gene families, exhibited differential substrate specificities and distinct patterns of expression at different stages during embryogenesis, through larval development, and on to maturity. The information obtained, as summarized in this review, provides a foundation for further investigation into the physiological and pharmacological involvement of the SULTs using the zebrafish as a model.

Original languageEnglish
Pages (from-to)538-546
Number of pages9
JournalCurrent Drug Metabolism
Volume11
Issue number6
DOIs
Publication statusPublished - Jul 1 2010

Fingerprint

Sulfotransferases
Zebrafish
Detoxification
Pharmaceutical Preparations
Xenobiotics
Substrates
Enzymes
Substrate Specificity
Metabolism
Hydroxyl Radical
Sulfates
Embryonic Development
Genes
Molecular Weight
Molecular weight
Pharmacology
Tissue

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Clinical Biochemistry

Cite this

Liu, T. A., Bhuiyan, S., Liu, M. Y., Sugahara, T., Sakakibara, Y., Suiko, M., ... Liu, M. C. (2010). Zebrafish as a model for the study of the phase II cytosolic sulfotransferases. Current Drug Metabolism, 11(6), 538-546. https://doi.org/10.2174/138920010791636158

Zebrafish as a model for the study of the phase II cytosolic sulfotransferases. / Liu, Tzu An; Bhuiyan, Shakhawat; Liu, Ming Yih; Sugahara, Takuya; Sakakibara, Yoichi; Suiko, Masahito; Yasuda, Shin; Kakuta, Yoshimitsu; Kimura, Makoto; Williams, Frederick E.; Liu, Ming Cheh.

In: Current Drug Metabolism, Vol. 11, No. 6, 01.07.2010, p. 538-546.

Research output: Contribution to journalReview article

Liu, TA, Bhuiyan, S, Liu, MY, Sugahara, T, Sakakibara, Y, Suiko, M, Yasuda, S, Kakuta, Y, Kimura, M, Williams, FE & Liu, MC 2010, 'Zebrafish as a model for the study of the phase II cytosolic sulfotransferases', Current Drug Metabolism, vol. 11, no. 6, pp. 538-546. https://doi.org/10.2174/138920010791636158
Liu TA, Bhuiyan S, Liu MY, Sugahara T, Sakakibara Y, Suiko M et al. Zebrafish as a model for the study of the phase II cytosolic sulfotransferases. Current Drug Metabolism. 2010 Jul 1;11(6):538-546. https://doi.org/10.2174/138920010791636158
Liu, Tzu An ; Bhuiyan, Shakhawat ; Liu, Ming Yih ; Sugahara, Takuya ; Sakakibara, Yoichi ; Suiko, Masahito ; Yasuda, Shin ; Kakuta, Yoshimitsu ; Kimura, Makoto ; Williams, Frederick E. ; Liu, Ming Cheh. / Zebrafish as a model for the study of the phase II cytosolic sulfotransferases. In: Current Drug Metabolism. 2010 ; Vol. 11, No. 6. pp. 538-546.
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