ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells

Takahiro Fujimoto, Keiko Doi, Midori Koyanagi, Toshiyuki Tsunoda, Yasuo Takashima, Yasuhiro Yoshida, Takehiko Sasazuki, Senji Shirasawa

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Abstract

ZFAT (also known as ZNF406), originally identified as a candidate gene for autoimmune thyroid disease, encodes a zinc-finger protein, however, its function has not been elucidated. Here, we report that human ZFAT protein is expressed in peripheral B and T lymphocytes and a human acute T lymphoblastic leukaemia cell line, MOLT-4 cells. Intriguing is that mouse ZFAT expression in CD4+ lymphocytes is increased during blast formation. Furthermore, ZFAT-knockdown in MOLT-4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells.

Original languageEnglish
Pages (from-to)568-572
Number of pages5
JournalFEBS Letters
Volume583
Issue number3
DOIs
Publication statusPublished - Feb 4 2009
Externally publishedYes

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All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

Cite this

Fujimoto, T., Doi, K., Koyanagi, M., Tsunoda, T., Takashima, Y., Yoshida, Y., ... Shirasawa, S. (2009). ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells. FEBS Letters, 583(3), 568-572. https://doi.org/10.1016/j.febslet.2008.12.063