ZFAT is an antiapoptotic molecule and critical for cell survival in MOLT-4 cells

Takahiro Fujimoto, Keiko Doi, Midori Koyanagi, Toshiyuki Tsunoda, Yasuo Takashima, Yasuhiro Yoshida, Takehiko Sasazuki, Senji Shirasawa

Research output: Contribution to journalArticlepeer-review

31 Citations (Scopus)

Abstract

ZFAT (also known as ZNF406), originally identified as a candidate gene for autoimmune thyroid disease, encodes a zinc-finger protein, however, its function has not been elucidated. Here, we report that human ZFAT protein is expressed in peripheral B and T lymphocytes and a human acute T lymphoblastic leukaemia cell line, MOLT-4 cells. Intriguing is that mouse ZFAT expression in CD4+ lymphocytes is increased during blast formation. Furthermore, ZFAT-knockdown in MOLT-4 induces apoptosis via activation of caspases. These results suggested that ZFAT protein is a critical regulator involved in apoptosis and cell survival for immune-related cells.

Original languageEnglish
Pages (from-to)568-572
Number of pages5
JournalFEBS Letters
Volume583
Issue number3
DOIs
Publication statusPublished - Feb 4 2009
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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