Zn(II) dipicolylamine-based artificial receptor as a new entry for surface recognition of α-helical peptides in aqueous solution

Yasuko Mito-oka; Shinya Tsukiji; Takashi Hiraoka; Noriyuki Kasagi; Seiji Shinkai; Itaru Hamachi

doi:10.1016/S0040-4039(01)01408-3

Zn(II) dipicolylamine-based artificial receptor as a new entry for surface recognition of α-helical peptides in aqueous solution

Yasuko Mito-oka, Shinya Tsukiji, Takashi Hiraoka, Noriyuki Kasagi, Seiji Shinkai, Itaru Hamachi

Institute for Advanced Study

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

It is clear by CD spectral titration that Zn(II)dipicolylamine-based dinuclear complexes selectively bind and stabilize the α-helix conformation of peptides having two histidine (His) residues at specific positions (H-i and i+4 or i+7 or i+11).

Original language	English
Pages (from-to)	7059-7062
Number of pages	4
Journal	Tetrahedron Letters
Volume	42
Issue number	40
DOIs	https://doi.org/10.1016/S0040-4039(01)01408-3
Publication status	Published - Oct 1 2001

All Science Journal Classification (ASJC) codes

Biochemistry
Drug Discovery
Organic Chemistry

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10.1016/S0040-4039(01)01408-3

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Zn(II) dipicolylamine-based artificial receptor as a new entry for surface recognition of α-helical peptides in aqueous solution. / Mito-oka, Yasuko; Tsukiji, Shinya; Hiraoka, Takashi; Kasagi, Noriyuki; Shinkai, Seiji; Hamachi, Itaru.

In: Tetrahedron Letters, Vol. 42, No. 40, 01.10.2001, p. 7059-7062.

Research output: Contribution to journal › Article › peer-review

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AU - Kasagi, Noriyuki

AU - Shinkai, Seiji

AU - Hamachi, Itaru

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AB - It is clear by CD spectral titration that Zn(II)dipicolylamine-based dinuclear complexes selectively bind and stabilize the α-helix conformation of peptides having two histidine (His) residues at specific positions (H-i and i+4 or i+7 or i+11).

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Zn(II) dipicolylamine-based artificial receptor as a new entry for surface recognition of α-helical peptides in aqueous solution

Abstract

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