研究成果 1983 2019

2019

Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones

Katoh-Fukui, Y., Baba, T., Sato, T., Otake, H., Nagakui-Noguchi, Y., Shindo, M., Suyama, M., Ohkawa, Y., Tsumura, H., Morohashi, K-I. & Fukami, M., 3 1 2019, : : Bone. 120, p. 219-231 13 p.

研究成果: ジャーナルへの寄稿記事

Mesenchymal Stromal Cells
Bone and Bones
Cell Lineage
Genes
Polycomb-Group Proteins
1 引用 (Scopus)

Three populations of adult Leydig cells in mouse testes revealed by a novel mouse HSD3B1-specific rat monoclonal antibody

Yokoyama, C., Chigi, Y., Baba, T., Ohshitanai, A., Harada, Y., Takahashi, F. & Morohashi, K-I., 4 16 2019, : : Biochemical and Biophysical Research Communications. 511, 4, p. 916-920 5 p.

研究成果: ジャーナルへの寄稿記事

Leydig Cells
Testis
Rats
3-Hydroxysteroid Dehydrogenases
Steroids
2018

Ad4BP/SF-1 regulates cholesterol synthesis to boost the production of steroids

Baba, T., Otake, H., Inoue, M., Sato, T., Ishihara, Y., Moon, J. Y., Tsuchiya, M., Miyabayashi, K., Ogawa, H., Shima, Y., Wang, L., Sato, R., Yamazaki, T., Suyama, M., Nomura, M., Choi, M. H., Ohkawa, Y. & Morohashi, K. I., 12 1 2018, : : Communications Biology. 1, 1, 18.

研究成果: ジャーナルへの寄稿記事

公開
steroids
Steroids
Cholesterol
cholesterol
Metabolic Networks and Pathways
1 引用 (Scopus)

Le développement du cortex surrénalien: leçons des modèles animaux

Dumontet, T., Sahut-Barnola, I., Septier, A., Montanier, N., Plotton, I., Roucher-Boulez, F., Ducros, V., Lefrançois-Martinez, A. M., Pointud, J. C., Zubair, M., Morohashi, K-I., Breault, D. T., Val, P. & Martinez, A., 6 1 2018, : : Annales d'Endocrinologie. 79, 3, p. 95-97 3 p.

研究成果: ジャーナルへの寄稿記事

Zona Reticularis
Cyclic AMP-Dependent Protein Kinases
Adrenarche
Zona Fasciculata
Cushing Syndrome
14 引用 (Scopus)

PKA signaling drives reticularis differentiation and sexually dimorphic adrenal cortex renewal

Dumontet, T., Sahut-Barnola, I., Septier, A., Montanier, N., Plotton, I., Roucher-Boulez, F., Ducros, V., Lefrançois-Martinez, A. M., Pointud, J. C., Zubair, M., Morohashi, K. I., Breault, D. T., Val, P. & Martinez, A., 1 25 2018, : : JCI Insight. 3, 2

研究成果: ジャーナルへの寄稿記事

公開
Adrenal Cortex
Androgens
Adrenarche
Zona Reticularis
Adrenocortical Hyperfunction
3 引用 (Scopus)

Recent progress in understanding the mechanisms of Leydig cell differentiation

Inoue, M., Baba, T. & Morohashi, K-I., 6 15 2018, : : Molecular and Cellular Endocrinology. 468, p. 39-46 8 p.

研究成果: ジャーナルへの寄稿評論記事

Leydig Cells
Androgens
Cell Differentiation
Genes
Testis

Regulation of metabolic pathways in steroidogenic cells by Ad4BP/SF-1

Morohashi, K-I., Inoue, M., Li, B. & Baba, T., 6 12 2018, Cell Biology of the Ovary: Stem Cells, Development, Cancer, and Clinical Aspects. Springer Singapore, p. 35-43 9 p.

研究成果: 著書/レポートタイプへの貢献

Metabolic Networks and Pathways
Genes
Gonads
NADP
High-Throughput Nucleotide Sequencing
Adrenal Glands
Steroids
2017
11 引用 (Scopus)

Alterations in Fetal Leydig Cell Gene Expression during Fetal and Adult Development

Miyabayashi, K., Shima, Y., Inoue, M., Sato, T., Baba, T., Ohkawa, Y., Suyama, M. & Morohashi, K. I., 5 1 2017, : : Sexual Development. 11, 2, p. 53-63 11 p.

研究成果: ジャーナルへの寄稿記事

Leydig Cells
Fetal Development
Gene Expression
Testis
Mitochondrial Genes
Manuscripts
Leydig Cells
Testis
Emotions
Stem Cells
1 引用 (Scopus)

Differential lactate and cholesterol synthetic activities in XY and XX Sertoli cells

Shishido, Y., Baba, T., Sato, T., Shima, Y., Miyabayashi, K., Inoue, M., Akiyama, H., Kimura, H., Kanai, Y., Ishihara, Y., Haraguchi, S., Miyazaki, A., Rozman, D., Yamazaki, T., Choi, M. H., Ohkawa, Y., Suyama, M. & Morohashi, K-I., 1 1 2017, : : Scientific reports. 7, 41912.

研究成果: ジャーナルへの寄稿記事

Sertoli Cells
Lactic Acid
Cholesterol
Germ Cells
Nursing
20 引用 (Scopus)

Identical NR5A1 Missense Mutations in Two Unrelated 46,XX Individuals with Testicular Tissues

Igarashi, M., Takasawa, K., Hakoda, A., Kanno, J., Takada, S., Miyado, M., Baba, T., Morohashi, K. I., Tajima, T., Hata, K., Nakabayashi, K., Matsubara, Y., Sekido, R., Ogata, T., Kashimada, K. & Fukami, M., 1 1 2017, : : Human mutation. 38, 1, p. 39-42 4 p.

研究成果: ジャーナルへの寄稿記事

Missense Mutation
Mutation
46, XX Testicular Disorders of Sex Development
46,XY Gonadal Dysgenesis
Ovotesticular Disorders of Sex Development
16 引用 (Scopus)

Leydig progenitor cells in fetal testis

Shima, Y. & Morohashi, K-I., 4 15 2017, : : Molecular and Cellular Endocrinology. 445, p. 55-64 10 p.

研究成果: ジャーナルへの寄稿記事

Leydig Cells
Androgens
Testis
Stem Cells
Cells
3 引用 (Scopus)

Lysosomal activity maintains glycolysis and cyclin E1 expression by mediating Ad4BP/SF-1 stability for proper steroidogenic cell growth

Syu, J. S., Baba, T., Huang, J. Y., Ogawa, H., Hsieh, C. H., Hu, J. X., Chen, T. Y., Lin, T. C., Tsuchiya, M., Morohashi, K-I., Huang, B. M., Lu, F. I. & Wang, C. Y., 1 1 2017, : : Scientific reports. 7, 1, 240.

研究成果: ジャーナルへの寄稿記事

Steroidogenic Factor 1
Cyclins
Glycolysis
Growth
Protein Stability

Mechanism for sex differentiation of the gonads

Morohashi, K-I., 1 1 2017, : : Japanese Journal of Clinical Urology. 71, 10, p. 746-751 6 p.

研究成果: ジャーナルへの寄稿記事

Sex Differentiation
Gonads
3 引用 (Scopus)

Role of Ad4-binding protein/steroidogenic factor 1 in regulating NADPH production in adrenocortical Y-1 cells

Li, B., Baba, T., Miyabayashi, K., Sato, T., Shima, Y., Ichinose, T., Miura, D., Ohkawa, Y., Suyama, M. & Morohashi, K. I., 1 1 2017, : : Endocrine Journal. 64, 3, p. 315-324 10 p.

研究成果: ジャーナルへの寄稿記事

Steroidogenic Factor 1
NADP
Genes
Pentose Phosphate Pathway
Chromatin Immunoprecipitation
2 引用 (Scopus)

The 5′ region of Xist RNA has the potential to associate with chromatin through the A-repeat

Chigi, Y., Sasaki, H. & Sado, T., 12 1 2017, : : RNA. 23, 12, p. 1894-1901 8 p.

研究成果: ジャーナルへの寄稿記事

Chromatin
RNA
Heterogeneous-Nuclear Ribonucleoprotein U
X Chromosome
Heterochromatin
3 引用 (Scopus)

Timing of adrenal regression controlled by synergistic interaction between Sf1 SUMOylation and Dax1

Xing, Y., Morohashi, K-I., Ingraham, H. A. & Hammer, G. D., 10 15 2017, : : Development (Cambridge). 144, 20, p. 3798-3807 10 p.

研究成果: ジャーナルへの寄稿記事

Sumoylation
Steroidogenic Factor 1
Adrenal Cortex
Cytoplasmic and Nuclear Receptors
Knockout Mice
2016
72 引用 (Scopus)

Drp1-dependent mitochondrial fission via MiD49/51 is essential for apoptotic cristae remodeling

Otera, H., Miyata, N., Kuge, O. & Mihara, K., 1 1 2016, : : Journal of Cell Biology. 212, 5, p. 531-544 14 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Dynamics
Cytochromes c
Apoptosis
Cytoplasm
Phenotype
22 引用 (Scopus)

Isolation and characterization of Fetal Leydig progenitor cells of male mice

Inoue, M., Shima, Y., Miyabayashi, K., Tokunaga, K., Sato, T., Baba, T., Ohkawa, Y., Akiyama, H., Suyama, M. & Morohashi, K. I., 3 2016, : : Endocrinology. 157, 3, p. 1222-1233 12 p.

研究成果: ジャーナルへの寄稿記事

Leydig Cells
Stem Cells
Testis
Growth Factor Receptors
Transcriptome

Mechanisms and Functions of Mitochondrial Dynamics

Mihara, K. & Otera, H., 1 1 2016, Organizational Cell Biology. Elsevier Inc., 巻 2. p. 279-292 14 p.

研究成果: 著書/レポートタイプへの貢献

Mitochondrial Dynamics
GTP Phosphohydrolases
Metabolic Diseases
Nervous System Diseases
Proteins
40 引用 (Scopus)

Mitochondrial division occurs concurrently with autophagosome formation but independently of Drp1 during mitophagy

Yamashita, S. I., Jin, X., Furukawa, K., Hamasaki, M., Nezu, A., Otera, H., Saigusa, T., Yoshimori, T., Sakai, Y., Mihara, K. & Kanki, T., 1 1 2016, : : Journal of Cell Biology. 215, 5, p. 649-665 17 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Degradation
Mitochondria
Membranes
Autophagosomes
Quality Control
6 引用 (Scopus)

Neuregulin 1 regulates proliferation of leydig cells to support spermatogenesis and sexual behavior in adult mice

Umehara, T., Kawashima, I., Kawai, T., Hoshino, Y., Morohashi, K. I., Shima, Y., Zeng, W., Richards, J. S. & Shimada, M., 12 2016, : : Endocrinology. 157, 12, p. 4899-4913 15 p.

研究成果: ジャーナルへの寄稿記事

Neuregulin-1
Leydig Cells
Spermatogenesis
Sexual Behavior
Testis
11 引用 (Scopus)

SF-1 deficiency causes lipid accumulation in Leydig cells via suppression of STAR and CYP11A1

Hatano, M., Migita, T., Ohishi, T., Shima, Y., Ogawa, Y., Morohashi, K-I., Hasegawa, Y. & Shibasaki, F., 11 1 2016, : : Endocrine. 54, 2, p. 484-496 13 p.

研究成果: ジャーナルへの寄稿記事

Steroidogenic Factor 1
Cholesterol Side-Chain Cleavage Enzyme
Leydig Cells
XY Disorders of Sex Development 46
Lipids
2015
28 引用 (Scopus)

Fetal leydig cells persist as an androgen-independent subpopulation in the postnatal testis

Shima, Y., Matsuzaki, S., Miyabayashi, K., Otake, H., Baba, T., Kato, S., Huhtaniemi, I. & Morohashi, K. I., 11 2015, : : Molecular Endocrinology. 29, 11, p. 1581-1593 13 p.

研究成果: ジャーナルへの寄稿記事

Leydig Cells
Androgens
Testis
Androgen Receptors
Knockout Mice
5 引用 (Scopus)

Heterogeneity of ovarian theca and interstitial gland cells in Mice

Miyabayashi, K., Tokunaga, K., Otake, H., Baba, T., Shima, Y. & Morohashi, K-I., 6 3 2015, : : PloS one. 10, 6, e0128352.

研究成果: ジャーナルへの寄稿記事

Genes
Gene expression
Reporter Genes
reporter genes
mice
3 引用 (Scopus)

Selective autophagic receptor p62 regulates the abundance of transcriptional coregulator ARIP4 during nutrient starvation

Tsuchiya, M., Isogai, S., Taniguchi, H., Tochio, H., Shirakawa, M., Morohashi, K. I., Hiraoka, Y., Haraguchi, T. & Ogawa, H., 9 28 2015, : : Scientific reports. 5, 14498.

研究成果: ジャーナルへの寄稿記事

Receptor-Interacting Protein Serine-Threonine Kinases
Androgen Receptors
Starvation
Food
Ubiquitin
8 引用 (Scopus)

Testicular dysgenesis/regression without campomelic dysplasia in patients carrying missense mutations and upstream deletion of sox9

Katoh-Fukui, Y., Igarashi, M., Nagasaki, K., Horikawa, R., Nagai, T., Tsuchiya, T., Suzuki, E., Miyado, M., Hata, K., Nakabayashi, K., Hayashi, K., Matsubara, Y., Baba, T., Morohashi, K. I., Igarashi, A., Ogata, T., Takada, S. & Fukami, M., 1 1 2015, : : Molecular Genetics and Genomic Medicine. 3, 6, p. 550-557 8 p.

研究成果: ジャーナルへの寄稿記事

公開
Campomelic Dysplasia
Missense Mutation
XY Disorders of Sex Development 46
Mutation
Exome
2014

[Regulation of metabolism by orphan receptor regulone]

Morohashi, K-I. & Baba, T., 12 1 2014, : : Seikagaku. The Journal of Japanese Biochemical Society. 86, 6, p. 719-725 7 p.

研究成果: ジャーナルへの寄稿評論記事

Regulon
Gene Expression Regulation
Gonadal Steroid Hormones
Cytoplasmic and Nuclear Receptors
Energy Metabolism
35 引用 (Scopus)

Glycolytic genes are targets of the nuclear receptor Ad4BP/SF-1

Baba, T., Otake, H., Sato, T., Miyabayashi, K., Shishido, Y., Wang, C. Y., Shima, Y., Kimura, H., Yagi, M., Ishihara, Y., Hino, S., Ogawa, H., Nakao, M., Yamazaki, T., Kang, D., Ohkawa, Y., Suyama, M., Chung, B. C. & Morohashi, K-I., 4 14 2014, : : Nature communications. 5, 3634.

研究成果: ジャーナルへの寄稿記事

Cytoplasmic and Nuclear Receptors
genes
Genes
Tissue
adrenal gland
18 引用 (Scopus)

Identification of myelin transcription factor 1 (MyT1) as a subunit of the neural cell type-specific lysine-specific demethylase 1 (LSD1) complex

Yokoyama, A., Igarashi, K., Sato, T., Takagi, K., Otsuka, M. I., Shishido, Y., Baba, T., Ito, R., Kanno, J., Ohkawa, Y., Morohashi, K-I. & Sugawara, A., 6 27 2014, : : Journal of Biological Chemistry. 289, 26, p. 18152-18162 11 p.

研究成果: ジャーナルへの寄稿記事

Myelin Sheath
Lysine
Transcription Factors
Genes
Histone Demethylases
70 引用 (Scopus)

Influenza a virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunity

Yoshizumi, T., Ichinohe, T., Sasaki, O., Otera, H., Kawabata, S-I., Mihara, K. & Koshiba, T., 8 20 2014, : : Nature communications. 5, 4713.

研究成果: ジャーナルへの寄稿記事

influenza
Mitochondria
mitochondria
immunity
viruses
2013
34 引用 (Scopus)

Aristaless Related Homeobox Gene, Arx, Is Implicated in Mouse Fetal Leydig Cell Differentiation Possibly through Expressing in the Progenitor Cells

Miyabayashi, K., Katoh-Fukui, Y., Ogawa, H., Baba, T., Shima, Y., Sugiyama, N., Kitamura, K. & Morohashi, K. I., 6 28 2013, : : PloS one. 8, 6, e68050.

研究成果: ジャーナルへの寄稿記事

homeotic genes
Leydig cells
Leydig Cells
Homeobox Genes
cell differentiation
89 引用 (Scopus)

Contribution of Leydig and Sertoli cells to testosterone production in mouse fetal testes

Shima, Y., Miyabayashi, K., Haraguchi, S., Arakawa, T., Otake, H., Baba, T., Matsuzaki, S., Shishido, Y., Akiyama, H., Tachibana, T., Tsutsui, K. & Morohashi, K-I., 1 7 2013, : : Molecular Endocrinology. 27, 1, p. 63-73 11 p.

研究成果: ジャーナルへの寄稿記事

Leydig Cells
Sertoli Cells
Testosterone
Testis
Androstenedione
52 引用 (Scopus)

Fis1 acts as a mitochondrial recruitment factor for TBC1D15 that is involved in regulation of mitochondrial morphology

Onoue, K., Jofuku, A., Ban-Ishihara, R., Ishihara, T., Maeda, M., Koshiba, T., Itoh, T., Fukuda, M., Otera, H., Oka, T., Takano, H., Mizushima, N., Mihara, K. & Ishihara, N., 1 1 2013, : : Journal of Cell Science. 126, 1, p. 176-185 10 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Dynamics
HeLa Cells
GTP Phosphohydrolases
Mitochondrial Proteins
Cell Extracts
19 引用 (Scopus)

Heterogeneity in sexual bipotentiality and plasticity of granulosa cells in developing mouse ovaries

Harikae, K., Miura, K., Shinomura, M., Matoba, S., Hiramatsu, R., Tsunekawa, N., Kanai-Azuma, M., Kurohmaru, M., Morohashi, K-I. & Kanai, Y., 7 1 2013, : : Journal of Cell Science. 126, 13, p. 2834-2844 11 p.

研究成果: ジャーナルへの寄稿記事

Granulosa Cells
Ovary
Disorders of Sex Development
Ovarian Follicle
Sertoli Cells
35 引用 (Scopus)

Homeoproteins Six1 and Six4 regulate male sex determination and mouse gonadal development

Fujimoto, Y., Tanaka, S. S., Yamaguchi, Y. L., Kobayashi, H., Kuroki, S., Tachibana, M., Shinomura, M., Kanai, Y., Morohashi, K. I., Kawakami, K. & Nishinakamura, R., 8 26 2013, : : Developmental Cell. 26, 4, p. 416-430 15 p.

研究成果: ジャーナルへの寄稿記事

Homeodomain Proteins
Gonads
Transcription Factors
Genes
Chemical activation
216 引用 (Scopus)

New insights into the function and regulation of mitochondrial fission

Otera, H., Ishihara, N. & Mihara, K., 5 1 2013, : : Biochimica et Biophysica Acta - Molecular Cell Research. 1833, 5, p. 1256-1268 13 p.

研究成果: ジャーナルへの寄稿評論記事

Mitochondrial Dynamics
Nervous System Diseases
Dynamins
Membrane Fusion
Mitochondrial Genome
36 引用 (Scopus)

Regulation and physiologic functions of GTPases in mitochondrial fusion and fission in Mammals

Ishihara, N., Otera, H., Oka, T. & Mihara, K., 8 1 2013, : : Antioxidants and Redox Signaling. 19, 4, p. 389-399 11 p.

研究成果: ジャーナルへの寄稿評論記事

Mitochondrial Dynamics
Mammals
GTP Phosphohydrolases
Fusion reactions
Mitochondria
24 引用 (Scopus)

Steroid hormones and the development of reproductive organs

Morohashi, K-I., Baba, T. & Tanaka, M., 1 1 2013, : : Sexual Development. 7, 1-3, p. 61-79 19 p.

研究成果: ジャーナルへの寄稿評論記事

Steroids
Hormones
Steroid Receptors
Androgens
Cell Differentiation
2012
80 引用 (Scopus)

Cbx2, a polycomb group gene, is required for Sry gene expression in mice

Katoh-Fukui, Y., Miyabayashi, K., Komatsu, T., Owaki, A., Baba, T., Shima, Y., Kidokoro, T., Kanai, Y., Schedl, A., Wilhelm, D., Koopman, P., Okuno, Y. & Morohashi, K-I., 2 1 2012, : : Endocrinology. 153, 2, p. 913-924 12 p.

研究成果: ジャーナルへの寄稿記事

sry Genes
Gonads
Testis
Gene Expression
Knockout Mice

Erratum

Otera, H. & Fujiki, Y., 1 1 2012, : : Traffic. 13, 12, 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

1 引用 (Scopus)

Erratum: Identification of an enhancer in the Ad4BP/SF-1 gene specific for fetal leydig cells (Endocrinology (2012) 153, (417-425) DOI: 10.1210/en.2011-1407)

Shima, Y., Miyabayashi, K., Baba, T., Otake, H., Katsura, Y., Oka, S., Zubair, M. & Morohashi, K-I., 11 1 2012, : : Endocrinology. 153, 11, 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

Leydig Cells
Endocrinology
Genes

Erratum to Pex5p Imports Folded Tetrameric Catalase by Interaction with Pex13p. [Traffic 13, (2012), 1364-1377], DOI:10.1111/tra.12010

Otera, H. & Fujiki, Y., 1 1 2012, : : Traffic. 13, 12, p. 1693 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

Catalase
33 引用 (Scopus)

Identification of an enhancer in the Ad4BP/SF-1 gene specific for fetal leydig cells

Shima, Y., Miyabayashi, K., Baba, T., Otake, H., Oka, S., Zubair, M. & Morohashi, K-I., 1 1 2012, : : Endocrinology. 153, 1, p. 417-425 9 p.

研究成果: ジャーナルへの寄稿記事

Steroidogenic Factor 1
Leydig Cells
Genes
Gonads
Adrenal Glands
15 引用 (Scopus)

Mamld1 deficiency significantly reduces mRNA expression levels of multiple genes expressed in mouse fetal leydig cells but permits normal genital and reproductive development

Miyado, M., Nakamura, M., Miyado, K., Morohashi, K. I., Sano, S., Nagata, E., Fukami, M. & Ogata, T., 12 1 2012, : : Endocrinology. 153, 12, p. 6033-6040 8 p.

研究成果: ジャーナルへの寄稿記事

Leydig Cells
Messenger RNA
Knockout Mice
Genes
3-Hydroxysteroid Dehydrogenases
64 引用 (Scopus)

Mitochondrial dynamics: Functional link with apoptosis

Otera, H. & Mihara, K., 4 19 2012, : : International Journal of Cell Biology. 821676.

研究成果: ジャーナルへの寄稿評論記事

Mitochondrial Dynamics
Apoptosis
Mitochondria
GTP Phosphohydrolases
Lipid Metabolism
16 引用 (Scopus)

Pex5p imports folded tetrameric catalase by interaction with pex13p

Otera, H. & Fujiki, Y., 10 1 2012, : : Traffic. 13, 10, p. 1364-1377 14 p.

研究成果: ジャーナルへの寄稿記事

Catalase
Peroxisomes
Chloramphenicol O-Acetyltransferase
Protein Sorting Signals
Cytoplasm
14 引用 (Scopus)

SF-1 expression during adrenal development and tumourigenesis

Gardiner, J. R., Shima, Y., Morohashi, K-I. & Swain, A., 3 31 2012, : : Molecular and Cellular Endocrinology. 351, 1, p. 12-18 7 p.

研究成果: ジャーナルへの寄稿評論記事

Organogenesis
Transgenic Mice
Hyperplasia
Transcription Factors
Maintenance
10 引用 (Scopus)

Wnt family genes and their modulation in the ovary-independent and persistent vaginal epithelial cell proliferation and keratinization induced by neonatal diethylstilbestrol exposure in mice

Nakamura, T., Miyagawa, S., Katsu, Y., Watanabe, H., Mizutani, T., Sato, T., Morohashi, K-I., Takeuchi, T., Iguchi, T. & Ohta, Y., 6 14 2012, : : Toxicology. 296, 1-3, p. 13-19 7 p.

研究成果: ジャーナルへの寄稿記事

Diethylstilbestrol
Cell proliferation
Vagina
Ovary
Genes