研究成果 1980 2020

フィルター
記事
2020
Keratan Sulfate
Pilocarpine
Microglia
Status Epilepticus
Hippocampus
2019

Base-Resolution Methylome of Retinal Pigment Epithelial Cells Used in the First Trial of Human Induced Pluripotent Stem Cell-Based Autologous Transplantation

Araki, H., Miura, F., Watanabe, A., Morinaga, C., Kitaoka, F., Kitano, Y., Sakai, N., Shibata, Y., Terada, M., Goto, S., Yamanaka, S., Takahashi, M. & Ito, T., 10 8 2019, : : Stem Cell Reports. 13, 4, p. 761-774 14 p.

研究成果: ジャーナルへの寄稿記事

公開
Induced Pluripotent Stem Cells
Retinal Pigments
Autologous Transplantation
Stem cells
Epithelial Cells
2 引用 (Scopus)

Budding Uninhibited by Benzimidazole-1 Insufficiency Prevents Acute Renal Failure in Severe Sepsis by Maintaining Anticoagulant Functions of Vascular Endothelial Cells

Matsubara, Y., Matsumoto, T., Yoshiya, K., Yoshida, A., Ikeda, S., Furuyama, T., Nakatsu, Y., Tsuzuki, T., Nomura, M. & Maehara, Y., 3 1 2019, : : Shock. 51, 3, p. 364-371 8 p.

研究成果: ジャーナルへの寄稿記事

Acute Kidney Injury
Anticoagulants
Sepsis
Endothelial Cells
Thrombomodulin

Cis-control of Six1 expression in neural crest cells during craniofacial development

Wu, Z., Rao, Y., Zhang, S., Kim, E. J., Oki, S., Harada, H., Cheung, M. & Jung, H. S., 1 1 2019, (受理済み/印刷中) : : Developmental Dynamics.

研究成果: ジャーナルへの寄稿記事

Neural Crest
Binding Sites
Facial Bones
Mutation
Homeobox Genes
1 引用 (Scopus)
Cuprizone
Phytoestrogens
Genistein
Demyelinating Diseases
Hippocampus

Differential genomic destabilisation in human cells with pathogenic MSH2 mutations introduced by genome editing

Hayashida, G., Shioi, S., Hidaka, K., Fujikane, R., Hidaka, M., Tsurimoto, T., Tsuzuki, T., Oda, S. & Nakatsu, Y., 4 15 2019, : : Experimental Cell Research. 377, 1-2, p. 24-35 12 p.

研究成果: ジャーナルへの寄稿記事

公開
Microsatellite Instability
DNA Mismatch Repair
Mutation
Microsatellite Repeats
Hereditary Nonpolyposis Colorectal Neoplasms

Endocardium differentiation through Sox17 expression in endocardium precursor cells regulates heart development in mice

Saba, R., Kitajima, K., Rainbow, L., Engert, S., Uemura, M., Ishida, H., Kokkinopoulos, I., Shintani, Y., Miyagawa, S., Kanai, Y., Kanai-Azuma, M., Koopman, P., Meno, C., Kenny, J., Lickert, H., Saga, Y., Suzuki, K., Sawa, Y. & Yashiro, K., 12 1 2019, : : Scientific reports. 9, 1, 11953.

研究成果: ジャーナルへの寄稿記事

公開
Endocardium
Myocardium
Stem Cells
Embryonic Structures
Mesoderm

Ep 4 receptor-associated protein regulates gluconeogenesis in the liver and is associated with hyperglycemia in diabetic mice

Higuchi, S., Fujikawa, R., Nakatsuji, M., Yasui, M., Ikedo, T., Nagata, M., Mishima, K., Irie, K., Matsumoto, M., Yokode, M. & Minami, M., 3 1 2019, : : American Journal of Physiology - Endocrinology and Metabolism. 316, 3, p. E410-E417

研究成果: ジャーナルへの寄稿記事

Gluconeogenesis
Hyperglycemia
Liver
Hepatocytes
Proteins
公開
Single-Stranded DNA
Ligation
Genome
Libraries
DNA Nucleotidylexotransferase
1 引用 (Scopus)

Lipase/Oxovanadium Co-Catalyzed Dynamic Kinetic Resolution of Propargyl Alcohols: Competition between Racemization and Rearrangement

Kawanishi, S., Oki, S., Kundu, D. & Akai, S., 5 3 2019, : : Organic Letters. 21, 9, p. 2978-2982 5 p.

研究成果: ジャーナルへの寄稿記事

Lipase
alcohols
Magic
Kinetics
Enantiomers
8 引用 (Scopus)

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

Matsuda, T., Irie, T., Katsurabayashi, S., Hayashi, Y., Nagai, T., Hamazaki, N., Adefuin, A. M. D., Miura, F., Ito, T., Kimura, H., Shirahige, K., Takeda, T., Iwasaki, K., Imamura, T. & Nakashima, K., 2 6 2019, : : Neuron. 101, 3, p. 472-485.e7

研究成果: ジャーナルへの寄稿記事

Microglia
Epigenomics
Neurons
Transcription Factors
Genes
Neurogenesis
Ketamine
Antidepressive Agents
Hippocampus
N-Methyl-D-Aspartate Receptors
1 引用 (Scopus)

Replication stress triggers microsatellite destabilization and hypermutation leading to clonal expansion in vitro

Matsuno, Y., Atsumi, Y., Shimizu, A., Katayama, K., Fujimori, H., Hyodo, M., Minakawa, Y., Nakatsu, Y., Kaneko, S., Hamamoto, R., Shimamura, T., Miyano, S., Tsuzuki, T., Hanaoka, F. & Yoshioka, K. I., 12 1 2019, : : Nature communications. 10, 1, 3925.

研究成果: ジャーナルへの寄稿記事

公開
microsatellites
Microsatellite Instability
DNA Mismatch Repair
destabilization
Microsatellite Repeats

Sequential Inward Bending of Arterial Bifurcations is Associated with Intracranial Aneurysm Formation

Ikedo, T., Kataoka, H., Minami, M., Hayashi, K., Miyata, T., Nagata, M., Fujikawa, R., Yokode, M., Imai, H., Matsuda, T. & Miyamoto, S., 9 1 2019, : : World Neurosurgery. 129, p. e361-e366

研究成果: ジャーナルへの寄稿記事

Intracranial Aneurysm
Arteries
Blood Vessels
Macrophages
Magnetic Resonance Imaging
2 引用 (Scopus)

Spontaneous de novo germline mutations in humans and mice: rates, spectra, causes and consequences

Ohno, M., 1 1 2019, : : Genes and Genetic Systems. 94, 1, p. 13-22 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Germ-Line Mutation
Mutation
Mutation Rate
DNA-Directed DNA Polymerase
Mutagenesis
2 引用 (Scopus)

Update of the FANTOM web resource: Expansion to provide additional transcriptome atlases

Lizio, M., Abugessaisa, I., Noguchi, S., Kondo, A., Hasegawa, A., Hon, C. C., De Hoon, M., Severin, J., Oki, S., Hayashizaki, Y., Carninci, P., Kasukawa, T. & Kawaji, H., 1 8 2019, : : Nucleic acids research. 47, D1, p. D752-D758

研究成果: ジャーナルへの寄稿記事

Atlases
Transcriptome
Gene Expression
Long Noncoding RNA
RNA
2018
2 引用 (Scopus)

Behavioral defects in a DCTN1G71A transgenic mouse model of Perry syndrome

Mishima, T., Deshimaru, M., Watanabe, T., Kubota, K., Kinoshita-Kawada, M., Kawada, J., Takasaki, K., Uehara, Y., Jinno, S., Iwasaki, K. & Tsuboi, Y., 2 14 2018, : : Neuroscience Letters. 666, p. 98-103 6 p.

研究成果: ジャーナルへの寄稿記事

Transgenic Mice
Apathy
Parkinsonian Disorders
Microtubules
Mutation
17 引用 (Scopus)

ChIP-Atlas: a data-mining suite powered by full integration of public ChIP-seq data

Oki, S., Ohta, T., Shioi, G., Hatanaka, H., Ogasawara, O., Okuda, Y., Kawaji, H., Nakaki, R., Sese, J. & Meno, C., 12 1 2018, : : EMBO Reports. 19, 12, e46255.

研究成果: ジャーナルへの寄稿記事

Data Mining
Atlases
Chromatin Immunoprecipitation
Chromatin
Data mining
2 引用 (Scopus)

Differential cell surface recruitment of the superoxide-producing NADPH oxidases Nox1, Nox2 and Nox5: The role of the small GTPase Sar1

Kiyohara, T., Miyano, K., Kamakura, S., Hayase, J., Chishiki, K., Kohda, A. & Sumimoto, H., 6 1 2018, : : Genes to Cells. 23, 6, p. 480-493 14 p.

研究成果: ジャーナルへの寄稿記事

Monomeric GTP-Binding Proteins
NADPH Oxidase
Qa-SNARE Proteins
Superoxides
Endoplasmic Reticulum

DMS-seq for In Vivo Genome-Wide Mapping of Protein-DNA Interactions and Nucleosome Centers

Umeyama, T. & Ito, T., 7 1 2018, : : Current Protocols in Molecular Biology. 123, 1, e60.

研究成果: ジャーナルへの寄稿記事

Nucleosomes
Chromosome Mapping
DNA
Genome
Proteins

Effects of mismatches distant from the target position on gene correction with a 5′-tailed duplex

Suzuki, T., Yanai, Y., Nishigaki, N., Nakatsu, Y., Tsuzuki, T. & Kamiya, H., 5 1 2018, : : Journal of Bioscience and Bioengineering. 125, 5, p. 619-623 5 p.

研究成果: ジャーナルへの寄稿記事

Gene Order
Genes
DNA
Substitution reactions
Mutation
7 引用 (Scopus)

Epigenetic landscape influences the liver cancer genome architecture

Hama, N., Totoki, Y., Miura, F., Tatsuno, K., Saito-Adachi, M., Nakamura, H., Arai, Y., Hosoda, F., Urushidate, T., Ohashi, S., Mukai, W., Hiraoka, N., Aburatani, H., Ito, T. & Shibata, T., 12 1 2018, : : Nature communications. 9, 1, 1643.

研究成果: ジャーナルへの寄稿記事

genome
Liver Neoplasms
liver
Epigenomics
Liver

Epigenome mapping of human normal purified hepatocytes: Personal epigenome variation and genome-epigenome correlation

Arai, E., Miura, F., Totoki, Y., Yamashita, S., Tian, Y., Gotoh, M., Ojima, H., Nakagawa, H., Takahashi, Y., Nakamura, H., Hama, N., Kato, M., Kimura, H., Suzuki, Y., Ito, T., Shibata, T. & Kanai, Y., 7 2018, : : Epigenomics. 10, 7, p. 955-979 25 p.

研究成果: ジャーナルへの寄稿記事

Methylation
Hepatocytes
Histone Code
Genome
RNA Sequence Analysis
1 引用 (Scopus)

Imaging mass spectroscopy delineates the thinned and thickened walls of intracranial aneurysms

Ikedo, T., Minami, M., Kataoka, H., Hayashi, K., Nagata, M., Fujikawa, R., Yamazaki, F., Setou, M., Yokode, M. & Miyamoto, S., 1 1 2018, : : Biochemical and Biophysical Research Communications. 495, 1, p. 332-338 7 p.

研究成果: ジャーナルへの寄稿記事

Intracranial Aneurysm
Muscle
Mass Spectrometry
Smooth Muscle Myocytes
Spectroscopy
3 引用 (Scopus)

Increased synthesis of chondroitin sulfate proteoglycan promotes adult hippocampal neurogenesis in response to enriched environment

Yamada, J., Nadanaka, S., Kitagawa, H., Takeuchi, K. & Jinno, S., 9 26 2018, : : Journal of Neuroscience. 38, 39, p. 8496-8513 18 p.

研究成果: ジャーナルへの寄稿記事

Chondroitin Sulfate Proteoglycans
Neurogenesis
Dentate Gyrus
Digestion
Pharmacology
2 引用 (Scopus)

Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters

Nabeshima, R., Nishimura, O., Maeda, T., Shimizu, N., Ide, T., Yashiro, K., Sakai, Y., Meno, C., Kadota, M., Shiratori, H., Kuraku, S. & Hamada, H., 8 2 2018, : : eLife. 7, e36435.

研究成果: ジャーナルへの寄稿記事

Methylation
DNA Methylation
Embryonic Structures
Genes
Co-Repressor Proteins
3 引用 (Scopus)

LSD1 mediates metabolic reprogramming by glucocorticoids during myogenic differentiation

Anan, K., Hino, S., Shimizu, N., Sakamoto, A., Nagaoka, K., Takase, R., Kohrogi, K., Araki, H., Hino, Y., Usuki, S., Oki, S., Tanaka, H., Nakamura, K., Endo, F. & Nakao, M., 1 1 2018, : : Nucleic acids research. 46, 11, p. 5441-5454 14 p.

研究成果: ジャーナルへの寄稿記事

公開
Glucocorticoids
Lysine
Epigenomics
Myoblasts
Hormones
8 引用 (Scopus)

Mapping of histone-binding sites in histone replacement-completed spermatozoa

Yoshida, K., Muratani, M., Araki, H., Miura, F., Suzuki, T., Dohmae, N., Katou, Y., Shirahige, K., Ito, T. & Ishii, S., 12 1 2018, : : Nature communications. 9, 1, 3885.

研究成果: ジャーナルへの寄稿記事

spermatozoa
nuclease
genes
Histones
Spermatozoa

Maternal protein restriction alters the renal ptger1 DNA methylation state in SHRSP offspring

Miyoshi, M., Sato, M., Saito, K., Otani, L., Shirahige, K., Miura, F., Ito, T., Jia, H. & Kato, H., 10 5 2018, : : Nutrients. 10, 10, 1436.

研究成果: ジャーナルへの寄稿記事

Receptors, Prostaglandin E, EP1 Subtype
DNA methylation
DNA Methylation
prostaglandins
kidneys
3 引用 (Scopus)

Repression of Somatic Genes by Selective Recruitment of HDAC3 by BLIMP1 Is Essential for Mouse Primordial Germ Cell Fate Determination

Mochizuki, K., Hayashi, Y., Sekinaka, T., Otsuka, K., Ito-Matsuoka, Y., Kobayashi, H., Oki, S., Takehara, A., Kono, T., Osumi, N. & Matsui, Y., 9 4 2018, : : Cell Reports. 24, 10, p. 2682-2693.e6

研究成果: ジャーナルへの寄稿記事

Germ Cells
Genes
Cells
Histones
Developmental Genes
2 引用 (Scopus)

Triazole linking for preparation of a next-generation sequencing library from single-stranded DNA

Miura, F., Fujino, T., Kogashi, K., Shibata, Y., Miura, M., Isobe, H. & Ito, T., 9 19 2018, : : Nucleic acids research. 46, 16, p. e95

研究成果: ジャーナルへの寄稿記事

公開
Triazoles
Azides
Single-Stranded DNA
Ligation
Alkynes
Vesicular Glutamate Transport Protein 2
STAT3 Transcription Factor
Transcriptional Activation
Glutamic Acid
Spinal Cord
2017
3 引用 (Scopus)
Memantine
N-Methyl-D-Aspartate Receptors
Epitopes
Cats
Hippocampus
Memantine
N-Methyl-D-Aspartate Receptors
Epitopes
Cats
Hippocampus
2 引用 (Scopus)

Analysis of protein dynamics during cytokinesis in budding yeast

Okada, S., Wloka, C. & Bi, E., 2017, (受理済み/印刷中) : : Methods in Cell Biology.

研究成果: ジャーナルへの寄稿記事

Saccharomycetales
Cytokinesis
Proteins
Actomyosin
Constriction
6 引用 (Scopus)

Argininosuccinate Synthase 1-Deficiency Enhances the Cell Sensitivity to Arginine through Decreased DEPTOR Expression in Endometrial Cancer

Ohshima, K., Nojima, S., Tahara, S., Kurashige, M., Hori, Y., Hagiwara, K., Okuzaki, D., Oki, S., Wada, N., Ikeda, J. I., Kanai, Y. & Morii, E., 3 30 2017, : : Scientific reports. 7, 45504.

研究成果: ジャーナルへの寄稿記事

Argininosuccinate Synthase
Endometrial Neoplasms
Arginine
Neoplasms
Endometrioid Carcinoma
8 引用 (Scopus)

Basal filopodia and vascular mechanical stress organize fibronectin into pillars bridging the mesoderm-endoderm gap

Sato, Y., Nagatoshi, K., Hamano, A., Imamura, Y., Huss, D., Uchida, S. & Lansford, R., 1 15 2017, : : Development (Cambridge, England). 144, 2, p. 281-291 11 p.

研究成果: ジャーナルへの寄稿記事

Endoderm
Mechanical Stress
Pseudopodia
Mesoderm
Fibronectins
1 引用 (Scopus)

Behavioral abnormalities and reduced norepinephrine in EP4 receptor-associated protein (EPRAP)-deficient mice

Fujikawa, R., Higuchi, S., Ikedo, T., Nagata, M., Hayashi, K., Yang, T., Miyata, T., Yokode, M. & Minami, M., 4 29 2017, : : Biochemical and Biophysical Research Communications. 486, 2, p. 584-588 5 p.

研究成果: ジャーナルへの寄稿記事

Norepinephrine
Proteins
Inbred C57BL Mouse
Brain
Startle Reflex
13 引用 (Scopus)

Celecoxib and 2,5-dimethylcelecoxib inhibit intestinal cancer growth by suppressing the Wnt/β-catenin signaling pathway

Egashira, I., Takahashi-Yanaga, F., Nishida, R., arioka, M., Igawa, K., Tomooka, K., Nakatsu, Y., Tsuzuki, T., Nakabeppu, Y., Kitazono, T. & Sasaguri, T., 1 1 2017, : : Cancer Science. 108, 1, p. 108-115 8 p.

研究成果: ジャーナルへの寄稿記事

Celecoxib
Intestinal Neoplasms
Catenins
Wnt Signaling Pathway
Growth
9 引用 (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., 9 1 2017, : : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

研究成果: ジャーナルへの寄稿記事

DNA Helicases
Embryonic Stem Cells
Chromatin
Gene Expression
Histones
11 引用 (Scopus)

ChIP-seq analysis of genomic binding regions of five major transcription factors highlights a central role for ZIC2 in the mouse epiblast stem cell gene regulatory network

Matsuda, K., Mikami, T., Oki, S., Iida, H., Andrabi, M., Boss, J. M., Yamaguchi, K., Shigenobu, S. & Kondoh, H., 1 1 2017, : : Development (Cambridge). 144, 11, p. 1948-1958 11 p.

研究成果: ジャーナルへの寄稿記事

Germ Layers
Gene Regulatory Networks
Transcription Factors
Stem Cells
Embryonic Stem Cells
1 引用 (Scopus)

Deficiency in EP4 Receptor–Associated Protein Ameliorates Abnormal Anxiety-Like Behavior and Brain Inflammation in a Mouse Model of Alzheimer Disease

Fujikawa, R., Higuchi, S., Nakatsuji, M., Yasui, M., Ikedo, T., Nagata, M., Hayashi, K., Yokode, M. & Minami, M., 8 2017, : : American Journal of Pathology. 187, 8, p. 1848-1854 7 p.

研究成果: ジャーナルへの寄稿記事

Encephalitis
Alzheimer Disease
Anxiety
Proteins
Microglia
Amyotrophic Lateral Sclerosis
Neuroglia
Motor Neurons
Spinal Cord
Microglia
3 引用 (Scopus)
Amyotrophic Lateral Sclerosis
Neuroglia
Motor Neurons
Spinal Cord
Microglia
1 引用 (Scopus)
Vesicular Glutamate Transport Proteins
Amino Acid Transport System X-AG
Amyotrophic Lateral Sclerosis
Motor Neurons
Neuroglia
12 引用 (Scopus)

Dipeptidyl Peptidase-4 Inhibitor Anagliptin Prevents Intracranial Aneurysm Growth by Suppressing Macrophage Infiltration and Activation

Ikedo, T., Minami, M., Kataoka, H., Hayashi, K., Nagata, M., Fujikawa, R., Higuchi, S., Yasui, M., Aoki, T., Fukuda, M., Yokode, M. & Miyamoto, S., 6 19 2017, : : Journal of the American Heart Association. 6, 6

研究成果: ジャーナルへの寄稿記事

Dipeptidyl-Peptidase IV Inhibitors
Macrophage Activation
Intracranial Aneurysm
Mitogen-Activated Protein Kinase 7
Growth
4 引用 (Scopus)

DMS-Seq for In Vivo Genome-wide Mapping of Protein-DNA Interactions and Nucleosome Centers

Umeyama, T. & Ito, T., 10 3 2017, : : Cell Reports. 21, 1, p. 289-300 12 p.

研究成果: ジャーナルへの寄稿記事

Nucleosomes
Chromosome Mapping
Genes
DNA
Proteins
10 引用 (Scopus)

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells

Sanosaka, T., Imamura, T., Hamazaki, N., Chai, M. C., Igarashi, K., Ideta-Otsuka, M., Miura, F., Ito, T., Fujii, N., Ikeo, K. & Nakashima, K., 9 19 2017, : : Cell Reports. 20, 12, p. 2992-3003 12 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Stem cells
Epigenomics
Mental Competency
Neurons
9 引用 (Scopus)

High spatiotemporal resolution ECoG recording of somatosensory evoked potentials with flexible micro-electrode arrays

Kaiju, T., Doi, K., Yokota, M., Watanabe, K., Inoue, M., Ando, H., Takahashi, K., Yoshida, F., Hirata, M. & Suzuki, T., 4 11 2017, : : Frontiers in Neural Circuits. 11, 20.

研究成果: ジャーナルへの寄稿記事

Somatosensory Evoked Potentials
Fingers
Electrodes
Micro-Electrical-Mechanical Systems
Equipment and Supplies
6 引用 (Scopus)

Hof1 and Chs4 Interact via F-BAR Domain and Sel1-like Repeats to Control Extracellular Matrix Deposition during Cytokinesis

Oh, Y., Schreiter, J. H., Okada, H., Wloka, C., Okada, S., Yan, D., Duan, X. & Bi, E., 9 25 2017, : : Current Biology. 27, 18, p. 2878-2886.e5

研究成果: ジャーナルへの寄稿記事

Cytokinesis
cytokinesis
extracellular matrix
Extracellular Matrix
Chitin Synthase