検査部・医病

研究成果 2007 2019

2019
3 引用 (Scopus)

Development and validation of the 22-item Tarumi's Modern-Type Depression Trait Scale: Avoidance of Social Roles, Complaint, and Low Self-Esteem (TACS-22)

Kato, T., Katsuki, R., Kubo, H., Shimokawa, N., Sato-Kasai, M., Hayakawa, K., Kuwano, N., Umene-Nakano, W., Tateno, M., Setoyama, D., Kang, D., Watabe, M., Sakamoto, S., Teo, A. R. & Kanba, S., 1 1 2019, : : Psychiatry and clinical neurosciences. 73, 8, p. 448-457 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Self Concept
Depression
Personality
Psychometrics
Japan
3 引用 (Scopus)

Suicide and microglia: Recent findings and future perspectives based on human studies

Suzuki, H., Ohgidani, M., Kuwano, N., Chrétien, F., Lorin de la Grandmaison, G., Onaya, M., Tominaga, I., Setoyama, D., Kang, D., Mimura, M., Kanba, S. & Kato, T., 1 29 2019, : : Frontiers in Cellular Neuroscience. 13, p. 1-10 10 p., 31.

研究成果: ジャーナルへの寄稿記事

公開
Microglia
Suicide
Psychiatry
Kynurenine
Suicidal Ideation
2018
4 引用 (Scopus)

Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA

Matsuda, S., Yasukawa, T., Sakaguchi, Y., Ichiyanagi, K., Unoki, M., Gotou, K., Fukuda, K., Sasaki, H., Suzuki, T. & Kang, D., 2018, : : Scientific Reports. 8, 1

研究成果: ジャーナルへの寄稿記事

公開
2 引用 (Scopus)

Analysis of spatiotemporal metabolomic dynamics for sensitively monitoring biological alterations in cisplatin-induced acute kidney injury

Irie, M., Hayakawa, E., Fujimura, Y., Honda, Y., Setoyama, D., Wariishi, H., Hyodo, F. & Miura, D., 1 29 2018, : : Biochemical and Biophysical Research Communications. 496, 1, p. 140-146 7 p.

研究成果: ジャーナルへの寄稿記事

Spatio-Temporal Analysis
Metabolomics
Environmental Monitoring
Acute Kidney Injury
Cisplatin
1 引用 (Scopus)

Mitochondrial p32/C1qbp Is a Critical Regulator of Dendritic Cell Metabolism and Maturation

Gotou, K., Morisaki, T., Setoyama, D., Sasaki, K., Yagi, M., Igami, K., Mizuguchi, S., Uchiumi, T., Fukui, Y. & Kang, D., 11 13 2018, : : Cell Reports. 25, 7, p. 1800-1815.e4

研究成果: ジャーナルへの寄稿記事

Metabolism
Dendritic Cells
Pyruvic Acid
Citric Acid
Oxidoreductases
10 引用 (Scopus)

Tryptophan-kynurenine and lipid related metabolites as blood biomarkers for first-episode drug-naïve patients with major depressive disorder: An exploratory pilot case-control study

Kuwano, N., Kato, T., Setoyama, D., Sato-Kasai, M., Shimokawa, N., Hayakawa, K., Ohgidani, M., Sagata, N., Kubo, H., Kishimoto, J., Kang, D. & Kanba, S., 4 15 2018, : : Journal of Affective Disorders. 231, p. 74-82 9 p.

研究成果: ジャーナルへの寄稿記事

Kynurenine
Major Depressive Disorder
Tryptophan
Case-Control Studies
Biomarkers
2017
6 引用 (Scopus)

Cardiomyocyte-specific loss of mitochondrial p32/C1qbp causes cardiomyopathy and activates stress responses

Saito, T., Uchiumi, T., Yagi, M., Amamoto, R., Setoyama, D., Matsushima, Y. & Kang, D., 8 1 2017, : : Cardiovascular research. 113, 10, p. 1173-1185 13 p.

研究成果: ジャーナルへの寄稿記事

Takotsubo Cardiomyopathy
Cardiac Myocytes
Mitochondria
Mitochondrial Proteins
Sirolimus
9 引用 (Scopus)
Endoplasmic Reticulum Stress
Neoplastic Stem Cells
Doxycycline
Stem Cells
Apoptosis
1 引用 (Scopus)

Dysregulated gene expressions of MEX3D, FOS and BCL2 in human induced-neuronal (iN) cells from NF1 patients: A pilot study

Sagata, N., Kato, T., Kano, S. I., Ohgidani, M., Shimokawa, N., Sato-Kasai, M., Hayakawa, K., Kuwano, N., Wilson, A. M., Ishizuka, K., Kato, S., Nakahara, T., Nakahara-Kido, M., Setoyama, D., Sakai, Y., Ohga, S., Furue, M., Sawa, A. & Kanba, S., 12 1 2017, : : Scientific reports. 7, 1, 13905.

研究成果: ジャーナルへの寄稿記事

Neurofibromatosis 1
Gene Expression
Messenger RNA
Phenotype
Induced Pluripotent Stem Cells
2 引用 (Scopus)
Leukoencephalopathies
Oligodendroglia
Axons
Electron Transport
Central Nervous System
4 引用 (Scopus)

p32 is Required for Appropriate Interleukin-6 Production Upon LPS Stimulation and Protects Mice from Endotoxin Shock

Sasaki, K., Gotou, K., Miake, S., Setoyama, D., Yagi, M., Igami, K., Uchiumi, T. & Kang, D., 6 1 2017, : : EBioMedicine. 20, p. 161-172 12 p.

研究成果: ジャーナルへの寄稿記事

Endotoxins
Lipopolysaccharides
Shock
Interleukin-6
Fibroblasts
18 引用 (Scopus)

Targeting Ras-Driven Cancer Cell Survival and Invasion through Selective Inhibition of DOCK1

Tajiri, H., Uruno, T., Shirai, T., Takaya, D., Matsunaga, S., Setoyama, D., Watanabe, M., Kukimoto-Niino, M., Oisaki, K., Ushijima, M., Sanematsu, F., Honma, T., Terada, T., Oki, E., Shirasawa, S., Maehara, Y., Kang, D., Côté, J. F., Yokoyama, S., Kanai, M. および1人, Fukui, Y., 5 2 2017, : : Cell Reports. 19, 5, p. 969-980 12 p.

研究成果: ジャーナルへの寄稿記事

Nutrients
Cell Survival
Cells
Pyridones
Guanine Nucleotide Exchange Factors
2016
30 引用 (Scopus)

Plasma metabolites predict severity of depression and suicidal ideation in psychiatric patients-a multicenter pilot analysis

Setoyama, D., Kato, T., Hashimoto, R., Kunugi, H., Hattori, K., Hayakawa, K., Sato-Kasai, M., Shimokawa, N., Kaneko, S., Yoshida, S., Goto, Y. I., Yasuda, Y., Yamamori, H., Ohgidani, M., Sagata, N., Miura, D., Kang, D. & Kanba, S., 12 1 2016, : : PloS one. 11, 12, e0165267.

研究成果: ジャーナルへの寄稿記事

Suicidal Ideation
Metabolites
Psychiatry
Depression
metabolites
2 引用 (Scopus)

Serum depletion induced cancer stem cell-like phenotype due to nitric oxide synthesis in oncogenic HRas transformed cells

Monji, K., Uchiumi, T., Hoshizawa, S., Yagi, M., Matsumoto, T., Setoyama, D., Matsushima, Y., Gotou, K., Amamoto, R. & Kang, D., 1 1 2016, : : Oncotarget. 7, 46, p. 75221-75234 14 p.

研究成果: ジャーナルへの寄稿記事

Neoplastic Stem Cells
Oxygen Consumption
Nitric Oxide
Phenotype
Serum
2015
32 引用 (Scopus)

Disruption of mitochondrial fission in the liver protects mice from diet-induced obesity and metabolic deterioration

Wang, L., Ishihara, T., Ibayashi, Y., Tatsushima, K., Setoyama, D., Hanada, Y., Takeichi, Y., Sakamoto, S., Yokota, S., Mihara, K., Kang, D., Ishihara, N., Takayanagi, R. & Nomura, M., 10 24 2015, : : Diabetologia. 58, 10, p. 2371-2380 10 p.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Dynamics
Endoplasmic Reticulum Stress
Endoplasmic Reticulum
Mitochondria
Obesity
10 引用 (Scopus)

Identification of 3-Methylbutanoyl Glycosides in Green Coffea arabica Beans as Causative Determinants for the Quality of Coffee Flavors

Iwasa, K., Setoyama, D., Shimizu, H., Seta, H., Fujimura, Y., Miura, D., Wariishi, H., Nagai, C. & Nakahara, K., 4 15 2015, : : Journal of Agricultural and Food Chemistry. 63, 14, p. 3742-3751 10 p.

研究成果: ジャーナルへの寄稿記事

Coffea
Coffee
Beverages
Flavors
Coffea arabica

Mass Spectrometry Based Metabolic Study; Application to Mitochondria Dysfunction Model for Biomarker Discovery

Setoyama, D. & Kang, D., 10 1 2015, : : Fukuoka Acta Medica. 106, 10, p. 267-272 6 p.

研究成果: ジャーナルへの寄稿評論記事

Small Molecule Libraries
Signal Transduction
Mass Spectrometry
Mitochondria
Biomarkers
2014

A case of bleeding duodenal ulcer with pemphigus vulgaris during steroid therapy

Niho, K., Nakasya, A., Ijichi, A., Tsujita, J., Gotou, K., Shinozaki, H. & Matsumoto, M., 1 1 2014, : : Clinical Journal of Gastroenterology. 7, 3, p. 223-227 5 p.

研究成果: ジャーナルへの寄稿記事

Pemphigus
Duodenal Ulcer
Steroids
Hemorrhage
Blister
44 引用 (Scopus)

Direct induction of ramified microglia-like cells from human monocytes: Dynamic microglial dysfunction in Nasu-Hakola disease

Ohgidani, M., Kato, T., Setoyama, D., Sagata, N., Hashimoto, R., Shigenobu, K., Yoshida, T., Hayakawa, K., Shimokawa, N., Miura, D., Utsumi, H. & Kanba, S., 5 14 2014, : : Scientific reports. 4, 4957.

研究成果: ジャーナルへの寄稿記事

Microglia
Monocytes
Cytokines
Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy
Brain Diseases
9 引用 (Scopus)

Mass spectrometry-based metabolic profiling of gemcitabine-sensitive and gemcitabine-resistant pancreatic cancer cells

Fujimura, Y., Ikenaga, N., Ouchida, K., Setoyama, D., Irie, M., Miura, D., Wariishi, H., Murata, M., Mizumoto, K., Hashizume, M. & Tanaka, M., 3 1 2014, : : Pancreas. 43, 2, p. 311-318 8 p.

研究成果: ジャーナルへの寄稿記事

gemcitabine
Pancreatic Neoplasms
Mass Spectrometry
Cell Line
Metabolome
2013
7 引用 (Scopus)

High-Throughput Metabolic Profiling of Diverse Green Coffea arabica Beans Identified Tryptophan as a Universal Discrimination Factor for Immature Beans

Setoyama, D., Iwasa, K., Seta, H., Shimizu, H., Fujimura, Y., Miura, D., Wariishi, H., Nagai, C. & Nakahara, K., 8 1 2013, : : PloS one. 8, 8, e70098.

研究成果: ジャーナルへの寄稿記事

Coffea
Coffee
Coffea arabica
metabolomics
Tryptophan
22 引用 (Scopus)

Metabolomics reveals that carnitine palmitoyltransferase-1 is a novel target for oxidative inactivation in human cells

Setoyama, D., Fujimura, Y. & Miura, D., 12 1 2013, : : Genes to Cells. 18, 12, p. 1107-1119 13 p.

研究成果: ジャーナルへの寄稿記事

Carnitine O-Palmitoyltransferase
Metabolomics
Oxidative Stress
Reactive Oxygen Species
Metabolome
2012
37 引用 (Scopus)

Blockade of inflammatory responses by a small-molecule inhibitor of the Rac activator DOCK2

Nishikimi, A., Uruno, T., Duan, X., Cao, Q., Okamura, Y., Saitoh, T., Saito, N., Sakaoka, S., Du, Y., Suenaga, A., Kukimoto-Niino, M., Miyano, K., Gotou, K., Okabe, T., Sanematsu, F., Tanaka, Y., Sumimoto, H., Honma, T., Yokoyama, S., Nagano, T. および3人, Kohda, D., Kanai, M. & Fukui, Y., 4 20 2012, : : Chemistry and Biology. 19, 4, p. 488-497 10 p.

研究成果: ジャーナルへの寄稿記事

PDZ Domains
Lymphocytes
Chemical activation
Guanine Nucleotide Exchange Factors
Antigen Receptors
59 引用 (Scopus)

Human MTH3 (NUDT18) protein hydrolyzes oxidized forms of guanosine and deoxyguanosine diphosphates: Comparison with MTH1 and MTH2

Takagi, Y., Setoyama, D., Ito, R., Kamiya, H., Yamagata, Y. & Sekiguchi, M., 6 15 2012, : : Journal of Biological Chemistry. 287, 25, p. 21541-21549 9 p.

研究成果: ジャーナルへの寄稿記事

Deoxyguanosine
Guanosine
Diphosphates
Nucleosides
Ribonucleotides
2011
16 引用 (Scopus)

Cleavage of oxidized guanine nucleotide and ADP sugar by human NUDT5 protein

Ito, R., Sekiguchi, M., Setoyama, D., Nakatsu, Y., Yamagata, Y. & Hayakawa, H., 6 1 2011, : : Journal of biochemistry. 149, 6, p. 731-738 8 p.

研究成果: ジャーナルへの寄稿記事

Adenosine Diphosphate Sugars
Adenosine Diphosphate Ribose
Guanine Nucleotides
Adenosine Monophosphate
Sugar Phosphates
2010
73 引用 (Scopus)

Selective control of type I IFN induction by the Rac activator DOCK2 during TLR-mediated plasmacytoid dendritic cell activation

Gotou, K., Tanaka, Y., Nishikimi, A., Nakamura, R., Yamada, H., Maeda, N., Ishikawa, T., Hoshino, K., Uruno, T., Cao, Q., Higashi, S., Kawaguchi, Y., Enjoji, M., Takayanagi, R., Kaisho, T., Yoshikai, Y. & Fukui, Y., 4 12 2010, : : Journal of Experimental Medicine. 207, 4, p. 721-730 10 p.

研究成果: ジャーナルへの寄稿記事

Dendritic Cells
Autoimmune Diseases
Nucleic Acids
Antiviral Agents
Immunity
2008
44 引用 (Scopus)

Differential requirement for D0CK2 in migration of plasmacytoid dendritic cells versus myeloid dendritic cells

Gotou, K., Tanaka, Y., Nishikimi, A., Inayoshi, A., Enjoji, M., Takayanagi, R., Sasazuki, T. & Fukui, Y., 3 15 2008, : : Blood. 111, 6, p. 2973-2976 4 p.

研究成果: ジャーナルへの寄稿記事

Myeloid Cells
Dendritic Cells
Chemotaxis
Spleen
Chemical activation
2007
46 引用 (Scopus)

Mechanism of degradation of CPEB during Xenopus oocyte maturation

Setoyama, D., Yamashita, M. & Sagata, N., 11 13 2007, : : Proceedings of the National Academy of Sciences of the United States of America. 104, 46, p. 18001-18006 6 p.

研究成果: ジャーナルへの寄稿記事

Xenopus
Oocytes
Phosphorylation
Ubiquitin-Protein Ligases
Stored Messenger RNA
47 引用 (Scopus)

T helper type 2 differentiation and intracellular trafficking of the interleukin 4 receptor-α subunit controlled by the Rac activator Dock2

Tanaka, Y., Hamano, S., Gotou, K., Murata, Y., Kunisaki, Y., Nishikimi, A., Takii, R., Kawaguchi, M., Inayoshi, A., Masuko, S., Himeno, K., Sasazuki, T. & Fukui, Y., 10 1 2007, : : Nature Immunology. 8, 10, p. 1067-1075 9 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-4 Receptors
T-Cell Antigen Receptor
T-Lymphocytes
Down-Regulation
Stathmin