免疫・膠原病・感染症内科

研究成果 1997 2019

フィルター
記事
2004
64 引用 (Scopus)

Association between IFNA genotype and the risk of sarcoidosis

Akahoshi, M., Ishihara, M., Remus, N., Uno, K., Miyake, K., Hirota, T., Nakashima, K., Matsuda, A., Kanda, M., Enomoto, T., Ohno, S., Nakashima, H., Casanova, J. L., Hopkin, J. M., Tamari, M., Mao, X. Q. & Shirakawa, T., 4 1 2004, : : Human Genetics. 114, 5, p. 503-509 7 p.

研究成果: ジャーナルへの寄稿記事

Sarcoidosis
Genotype
Alleles
Tuberculosis
Genes
12 引用 (Scopus)

Association of A Four-Amino Acid Residue Insertion Polymorphism of the HS1 Gene with Systemic Lupus Erythematosus: Molecular and Functional Analysis

Otsuka, J., Horiuchi, T., Yoshizawa, S., Tsukamoto, H., Sawabe, T., Kikuchi, Y., Himeji, D., Koyama, T., Mitoma, H., Watanabe, T. & Harada, M., 3 1 2004, : : Arthritis and rheumatism. 50, 3, p. 871-881 11 p.

研究成果: ジャーナルへの寄稿記事

Systemic Lupus Erythematosus
B-Lymphocytes
Amino Acids
Genes
Proline
24 引用 (Scopus)

Human cord blood- and bone marrow-derived CD34+ cells regenerate gastrointestinal epithelial cells

Ishikawa, F., Yasukawa, M., Yoshida, S., Nakamura, K. I., Nagatoshi, Y., Kanemaru, T., Shimoda, K., Shimoda, S., Miyamoto, T., Okamura, J., Shultz, L. D. & Harada, M., 12 1 2004, : : FASEB Journal. 18, 15, p. 1958-1960 3 p.

研究成果: ジャーナルへの寄稿記事

CD34 Antigens
Inbred NOD Mouse
SCID Mice
Hematopoietic Stem Cell Transplantation
Intestinal Mucosa
24 引用 (Scopus)

MPO-ANCA-positive Wegener's granulomatosis presenting with hypertrophic cranial pachymeningitis: Case report and review of the literature

Akahoshi, M., Yoshimoto, G., Nakashima, H., Miyake, K., Inoue, Y., Tanaka, Y., Tsukamoto, H., Horiuchi, T., Otsuka, T. & Harada, M., 6 1 2004, : : Modern Rheumatology. 14, 2, p. 179-183 5 p.

研究成果: ジャーナルへの寄稿記事

Antineutrophil Cytoplasmic Antibodies
Granulomatosis with Polyangiitis
Meningitis
Cranial Nerve Diseases
Headache Disorders
6 引用 (Scopus)

Myeloid/natural killer cell blast crisis representing an additional translocation, t(3;7)(q26;q21) in Philadelphia-positive chronic myelogenous leukemia

Henzan, H., Yoshimoto, G., Okeda, A., Nagasaki, Y., Hirano, G., Takase, K., Tanimoto, T., Miyamoto, T., Fukuda, T., Nagafuji, K. & Harada, M., 12 1 2004, : : Annals of Hematology. 83, 12, p. 784-788 5 p.

研究成果: ジャーナルへの寄稿記事

Blast Crisis
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Natural Killer Cells
Philadelphia Chromosome
Cytogenetic Analysis
20 引用 (Scopus)

Novel mutations in TNFRSF1A in patients with typical tumor necrosis factor receptor-associated periodic syndrome and with systemic lupus erythematosus in Japanese.

Horiuchi, T., Tsukamoto, H., Mitoma, H., Miyagawa, H., Tamimoto, Y., Yoshizawa, S., Harada, M., Hayashi, K., Hashimura, C., Oribe, M. & Okamura, S., 1 1 2004, : : International journal of molecular medicine. 14, 5, p. 813-818 6 p.

研究成果: ジャーナルへの寄稿記事

Systemic Lupus Erythematosus
Mutation
Rheumatoid Arthritis
Missense Mutation
Autosomal Dominant Familial Periodic Fever
28 引用 (Scopus)

Novel Regulatory Mechanisms of CD40-Induced Prostanoid Synthesis by IL-4 and IL-10 in Human Monocytes

Inoue, Y., Otsuka, T., Niiro, H., Nagano, S., Arinobu, Y., Ogami, E., Akahoshi, M., Miyake, K., Ninomiya, I., Shimizu, S., Nakashima, H. & Harada, M., 2 15 2004, : : Journal of Immunology. 172, 4, p. 2147-2154 8 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-4
Interleukin-10
Prostaglandins
Monocytes
Phosphotransferases
2003
92 引用 (Scopus)

Influence of interleukin-12 receptor β1 polymorphisms on tuberculosis

Akahoshi, M., Nakashima, H., Miyake, K., Inoue, Y., Shimizu, S., Tanaka, Y., Okada, K., Otsuka, T. & Harada, M., 3 1 2003, : : Human Genetics. 112, 3, p. 237-243 7 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-12 Receptors
Tuberculosis
Alleles
Interleukin-12
Genes
78 引用 (Scopus)

Molecular mimicry of mitochondrial and nuclear autoantigens in primary biliary cirrhosis

Shimoda, S., Nakamura, M., Ishibashi, H., Kawano, A., Kamihira, T., Sakamoto, N., Matsushita, S., Tanaka, A., Worman, H. J., Gershwin, M. E. & Harada, M., 7 1 2003, : : Gastroenterology. 124, 7, p. 1915-1925 11 p.

研究成果: ジャーナルへの寄稿記事

Molecular Mimicry
Biliary Liver Cirrhosis
Autoantigens
Peptides
Antinuclear Antibodies
3 引用 (Scopus)

Mutation detection using RT-PCR-RFLP.

Nakashima, H., Akahoshi, M. & Tanaka, Y., 2003, : : Methods in molecular biology (Clifton, N.J.). 226, p. 319-322 4 p.

研究成果: ジャーナルへの寄稿記事

DNA Primers
Reverse Transcriptase Polymerase Chain Reaction
Restriction Fragment Length Polymorphisms
Complementary DNA
Polymerase Chain Reaction
23 引用 (Scopus)

Promiscuous T cells selected by Escherichia coli: OGDC-E2 in primary biliary cirrhosis

Tanimoto, H., Shimoda, S., Nakamura, M., Ishibashi, H., Kawano, A., Kamihira, T., Matsushita, S., Gershwin, M. E. & Harada, M., 5 2003, : : Journal of Autoimmunity. 20, 3, p. 255-263 9 p.

研究成果: ジャーナルへの寄稿記事

dihydrolipoamide succinyltransferase
Biliary Liver Cirrhosis
Escherichia coli
T-Lymphocytes
Clone Cells
19 引用 (Scopus)

Strong polarization toward th1 immune response in ANCA-associated glomerulonephritis

Masutani, K., Tokumoto, M., Nakashima, H., Tsuruya, K., Kashiwagi, M., Kudoh, Y., Fukuda, K., Kanai, H., Akahoshi, M., Otsuka, T., Hirakata, H. & Ida, M., 6 1 2003, : : Clinical nephrology. 59, 6, p. 395-405 11 p.

研究成果: ジャーナルへの寄稿記事

Antineutrophil Cytoplasmic Antibodies
Glomerulonephritis
Osteopontin
Macrophages
T-Lymphocytes
6 引用 (Scopus)

Systemic vasculitis associated with α1-antitrypsin deficiency

Takii, Y., Inoue, H., Karashima, E., Akahoshi, M., Furugo, I., Hattori, S., Yamanaka, M., Kinoshita, S., Hamasaki, N., Shimoda, K., Nakashima, H., Tsukamoto, H., Horiuchi, T., Otsuka, T. & Harada, M., 7 1 2003, : : Internal Medicine. 42, 7, p. 619-623 5 p.

研究成果: ジャーナルへの寄稿記事

Systemic Vasculitis
Peptide Hydrolases
Protease Inhibitors
Leukocyte Elastase
Serine Proteases
2002
113 引用 (Scopus)

Association between IL-4 genotype and IL-4 production in the Japanese population

Nakashima, H., Miyake, K., Inoue, Y., Shimizu, S., Akahoshi, M., Tanaka, Y., Otsuka, T. & Harada, M., 4 1 2002, : : Genes and Immunity. 3, 2, p. 107-109 3 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-4
Genotype
Population
Haplotypes
Cytokines
61 引用 (Scopus)

Genetically determined interferon-γ production influences the histological phenotype of lupus nephritis

Miyake, K., Nakashima, H., Akahoshi, M., Inoue, Y., Nagano, S., Tanaka, Y., Masutani, K., Hirakata, H., Gondo, H., Otsuka, T. & Harada, M., 6 8 2002, : : Rheumatology. 41, 5, p. 518-524 7 p.

研究成果: ジャーナルへの寄稿記事

Lupus Nephritis
Interferons
Phenotype
Genotype
Genes
44 引用 (Scopus)

Molecular mechanisms of lipopolysaccharide-induced cyclooxygenase-2 expression in human neutrophils: Involvement of the mitogen-activated protein kinase pathway and regulation by anti-inflammatory cytokines

Nagano, S., Otsuka, T., Niiro, H., Yamaoka, K., Arinobu, Y., Ogami, E., Akahoshi, M., Inoue, Y., Miyake, K., Nakashima, H., Niho, Y. & Harada, M., 8 7 2002, : : International Immunology. 14, 7, p. 733-740 8 p.

研究成果: ジャーナルへの寄稿記事

Cyclooxygenase 2
Mitogen-Activated Protein Kinases
Lipopolysaccharides
Neutrophils
Anti-Inflammatory Agents
2001
106 引用 (Scopus)

Association of tumor necrosis factor receptor type II polymorphism 196R with systemic lupus erythematosus in the Japanese molecular and functional analysis

Morita, C., Horiuchi, T., Tsukamoto, H., Hatta, N., Kikuchi, Y., Arinobu, Y., Otsuka, T., Sawabe, T., Harashima, S. I., Nagasawa, K. & Niho, Y., 12 1 2001, : : Arthritis and rheumatism. 44, 12, p. 2819-2827 9 p.

研究成果: ジャーナルへの寄稿記事

Receptors, Tumor Necrosis Factor, Type II
Tumor Necrosis Factor Receptors
Systemic Lupus Erythematosus
Exons
HeLa Cells
181 引用 (Scopus)

Predominance of Th1 Immune Response in Diffuse Proliferative Lupus Nephritis

Masutani, K., Akahoshi, M., Tsuruya, K., Tokumoto, M., Ninomiya, T., Kohsaka, T., Fukuda, K., Kanai, H., Nakashima, H., Otsuka, T. & Hirakata, H., 9 2001, : : Arthritis and rheumatism. 44, 9, p. 2097-2106 10 p.

研究成果: ジャーナルへの寄稿記事

Lupus Nephritis
Systemic Lupus Erythematosus
Kidney
Nephritis
Th1-Th2 Balance
2000
9 引用 (Scopus)

Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells

Arinobu, Y., Sugimoto, R., Akaiwa, M., Arima, K., Otsuka, T., Hamasaki, N. & Izuhara, K., 10 22 2000, : : Biochemical and Biophysical Research Communications. 277, 2, p. 317-324 8 p.

研究成果: ジャーナルへの寄稿記事

T-cells
Interleukin-13
Transcription
Transducers
Interleukin-4
370 引用 (Scopus)

Genetic variants of IL-13 signalling and human asthma and atopy

Heinzmann, A., Mao, X. Q., Akaiwa, M., Kreomer, R. T., Gao, P. S., Ohshima, K., Umeshita, R., Abe, Y., Braun, S., Yamashita, T., Roberts, M. H., Sugimoto, R., Arima, K., Arinobu, Y., Yu, B., Kruse, S., Enomoto, T., Dake, Y., Kawai, M., Shimazu, S. および12人, Sasaki, S., Adra, C. N., Kitaichi, M., Inoue, H., Yamauchi, K., Tomichi, N., Kurimoto, F., Hamasaki, N., Hopkin, J. M., Izuhara, K., Shirakawa, T. & Deichmann, K. A., 3 1 2000, : : Human Molecular Genetics. 9, 4, p. 549-559 11 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-13
Asthma
Immunoglobulin E
Smooth Muscle
Chromosomes
1999
66 引用 (Scopus)

Antagonistic effects of an alternative splice variant of human IL-4, IL- 4δ2, on IL-4 activities in human monocytes and B cells

Arinobu, Y., Atamas, S. P., Otsuka, T., Niiro, H., Yamaoka, K., Mitsuyasu, H., Niho, Y., Hamasaki, N., White, B. & Izuhara, K., 2 1 1999, : : Cellular Immunology. 191, 2, p. 161-167 7 p.

研究成果: ジャーナルへの寄稿記事

Human Activities
Interleukin-4
Monocytes
B-Lymphocytes
Cytokines
6 引用 (Scopus)

Association of the interleukin-4 receptor α chain with p47(phox), an activator of the phagocyte NADPH oxidase in B cells

Izuhara, K., Arinobu, Y., Sumimoto, H., Nunoi, H., Takeya, R., Higuchi, K., Takeshige, K., Hamasaki, N. & Harada, N., 1 1 1999, : : Molecular Immunology. 36, 1, p. 45-52 8 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-4 Receptors
NADPH Oxidase
Interleukins
Phagocytes
B-Lymphocytes
159 引用 (Scopus)

Cutting edge: Dominant effect of Ile50Val variant of the human IL-4 receptor α-chain in IgE synthesis

Mitsuyasu, H., Yanagihara, Y., Mao, X. Q., Gao, P. S., Arinobu, Y., Ihara, K., Takabayashi, A., Hara, T., Enomoto, T., Sasaki, S., Kawai, M., Hamasaki, N., Shirakawa, T., Hopkin, J. M. & Izuhara, K., 2 1 1999, : : Journal of Immunology. 162, 3, p. 1227-1231 5 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-4 Receptors
Interleukin-4
Immunoglobulin E
Transcriptional Activation
Asthma
63 引用 (Scopus)

Differential response of macrophage subpopulations to myelin degradation in the injured rat sciatic nerve

Hirata, K., Mitoma, H., Ueno, N., He, J. W. & Kawabuchi, M., 12 1 1999, : : Journal of Neurocytology. 28, 8, p. 685-695 11 p.

研究成果: ジャーナルへの寄稿記事

Sciatic Nerve
Myelin Sheath
Macrophages
Phagocytosis
Confocal Microscopy
16 引用 (Scopus)

Polymorphisms within the interleukin-10 receptor cDNA gene (IL10R) in Japanese patients with systemic lupus erythematosus

Nakashima, H., Akahoshi, M., Tanaka, Y., Yamaoka, K., Ogami, E., Nagano, S., Arinobu, Y., Niiro, H., Otsuka, T. & Niho, Y., 11 1999, : : Rheumatology. 38, 11, p. 1142-1144 3 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-10 Receptors
Systemic Lupus Erythematosus
Complementary DNA
Genotype
Genes
228 引用 (Scopus)

Th1/Th2 balance of peripheral T helper cells in systemic lupus erythematosus

Akahoshi, M., Nakashima, H., Tanaka, Y., Kohsaka, T., Nagano, S., Ohgami, E., Arinobu, Y., Yamaoka, K., Niiro, H., Shinozaki, M., Hirakata, H., Horiuchi, T., Otsuka, T. & Niho, Y., 8 1 1999, : : Arthritis and rheumatism. 42, 8, p. 1644-1648 5 p.

研究成果: ジャーナルへの寄稿記事

Th1-Th2 Balance
Helper-Inducer T-Lymphocytes
Systemic Lupus Erythematosus
Th2 Cells
Lupus Nephritis
53 引用 (Scopus)

The combination of polymorphisms within interferon-γ receptor I and receptor 2 associated with the risk of systemic lupus erythematosus

Nakashima, H., Inoue, H., Akahoshi, M., Tanaka, Y., Yamaoka, K., Ogami, E., Nagano, S., Arinobu, Y., Niiro, H., Otsuka, T. & Niho, Y., 6 18 1999, : : FEBS Letters. 453, 1-2, p. 187-190 4 p.

研究成果: ジャーナルへの寄稿記事

Interferon Receptors
Polymorphism
Systemic Lupus Erythematosus
Amino Acids
Genotype
2 引用 (Scopus)

Two polymorphisms within interleukin-3 (hlL3) gene detected by mismatch PCR/RFLP

Nakashima, H., Otsuka, T., Ohba, Y., Akahoshi, M., Nagano, S., Ogami, E., Arinobu, Y., Miyake, K., Inoue, Y., Niiro, H., Kaji, Y. & Niho, Y., 1 1 1999, : : Genes and Immunity. 1, 2, p. 156-158 3 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-3
Nucleic Acid Databases
Restriction Fragment Length Polymorphisms
Thymine
Cytosine
1998
46 引用 (Scopus)

Activation of STAT5 by lipopolysaccharide through granulocyte-macrophage colony-stimulating factor production in human monocytes

Yamaoka, K., Otsuka, T., Niiro, H., Arinobu, Y., Niho, Y., Hamasaki, N. & Izuhara, K., 1 15 1998, : : Journal of Immunology. 160, 2, p. 838-845 8 p.

研究成果: ジャーナルへの寄稿記事

Granulocyte-Macrophage Colony-Stimulating Factor
Lipopolysaccharides
Monocytes
Prostaglandin-Endoperoxide Synthases
Granulocytes
98 引用 (Scopus)

MAP kinase pathways as a route for regulatory mechanisms of IL-10 and IL-4 which inhibit COX-2 expression in human monocytes

Niiro, H., Otsuka, T., Ogami, E., Yamaoka, K., Nagano, S., Akahoshi, M., Nakashima, H., Arinobu, Y., Izuhara, K. & Niho, Y., 9 18 1998, : : Biochemical and Biophysical Research Communications. 250, 2, p. 200-205 6 p.

研究成果: ジャーナルへの寄稿記事

Cyclooxygenase 2
Interleukin-4
Interleukin-10
Lipopolysaccharides
Monocytes
31 引用 (Scopus)

Propylthiouracil-Induced severe hepatitis: A case report and review of the literature

Ichiki, Y., Akahoshi, M., Yamashita, N., Morita, C., Maruyama, T., Horiuchi, T., Hayashida, K., Ishibashi, H. & Niho, Y., 10 1 1998, : : Journal of gastroenterology. 33, 5, p. 747-750 4 p.

研究成果: ジャーナルへの寄稿記事

Propylthiouracil
Hepatitis
Liver
Lymphocytes
Necrosis
1997
8 引用 (Scopus)

Detection of polymorphisms within the human IL10 receptor cDNA gene sequence by RT-PCR RFLP

Tanaka, Y., Nakashima, H., Otsuka, T., Nemoto, Y., Niiro, H., Yamaoka, K., Ogami, E. I., Arinobu, Y., Tachida, H., Imamura, T. & Niho, Y., 9 25 1997, : : Immunogenetics. 46, 5, p. 439-441 3 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-10 Receptors
Interleukin Receptors
Single-Stranded Conformational Polymorphism
Gene Frequency
Restriction Fragment Length Polymorphisms