先端医療医学部門

研究成果 1980 2020

2019

2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation

Morishige, S., Takahashi-Yanaga, F., Ishikane, S., Arioka, M., Igawa, K., Kuroo, A., Tomooka, K., Shiose, A. & Sasaguri, T., 10 2019, : : Biochemical Pharmacology. 168, p. 82-90 9 p.

研究成果: ジャーナルへの寄稿記事

Glycogen Synthase Kinase 3
Phosphorylation
Cardiomegaly
Fibroblasts
Isoproterenol

A case of acute exacerbation of chronic adrenal insufficiency due to ipilimumab treatment for advanced melanoma

Sakaguchi, C., Yano, S., Ashida, K., Wada, N., Ohe, K., Nagata, H., Matsuda, Y., Sakamoto, S., Sakamoto, R., Ohnaka, K., Uchi, H., Furue, M., Nomura, M. & Ogawa, Y., 1 1 2019, : : American Journal of Case Reports. 20, p. 106-110 5 p.

研究成果: ジャーナルへの寄稿記事

Adrenal Insufficiency
Melanoma
Therapeutics
Programmed Cell Death 1 Receptor
ipilimumab
2 引用 (Scopus)
公開
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Diabetic Retinopathy
Hypercholesterolemia
LDL Cholesterol
Therapeutics

Architecture of the Japan ischemic heart disease multimodal prospective data acquisition for precision treatment (J-IMPACT) system

Matoba, T., Kohro, T., Fujita, H., Nakayama, M., Kiyosue, A., Miyamoto, Y., Nishimura, K., Hashimoto, H., Antoku, Y., Nakashima, N., Ohe, K., Ogawa, H., Tsutsui, H. & Nagai, R., 1 1 2019, : : International heart journal. 60, 2, p. 264-270 7 p.

研究成果: ジャーナルへの寄稿記事

公開
Percutaneous Coronary Intervention
Myocardial Ischemia
Japan
Coronary Angiography
Information Systems

Assessment of coronary flow velocity reserve in the left main trunk using phase-contrast MR imaging at 3T: Comparison with 15O-labeled water positron emission tomography

Kikuchi, Y., Naya, M., Manabe, N. O., Manabe, O., Sugimori, H., Kudo, K., Kato, F., Aikawa, T., Tsutsui, H., Tamaki, N. & Shirato, H., 1 1 2019, : : Magnetic Resonance in Medical Sciences. 18, 2, p. 134-141 8 p.

研究成果: ジャーナルへの寄稿記事

公開
Positron-Emission Tomography
Coronary Artery Disease
Water
Arteries
Contrast Media

Association between prehospital supraglottic airway compared with bag-mask ventilation and Glasgow–Pittsburgh cerebral performance category 1 in patients with out-of-hospital cardiac arrest

Jinno, K., Hifumi, T., Okazaki, T., Kuroda, Y., Tahara, Y., Yonemoto, N., Nonogi, H., Nagao, K., Ikeda, T., Sato, N. & Tsutsui, H., 1 1 2019, : : Circulation Journal. 83, 12, p. 2479-2486 8 p.

研究成果: ジャーナルへの寄稿記事

公開
Out-of-Hospital Cardiac Arrest
Masks
Epinephrine
Emergency Medical Services
Registries
2 引用 (Scopus)

Baseline demographics and clinical characteristics in the all nippon af in the elderly (ANAFIE) registry

Koretsune, Y., Yamashita, T., Akao, M., Atarashi, H., Ikeda, T., Okumura, K., Shimizu, W., Tsutsui, H., Toyoda, K., Hirayama, A., Yasaka, M., Yamaguchi, T., Teramukai, S., Kimura, T., Kaburagi, J., Takita, A. & Inoue, H., 1 1 2019, : : Circulation Journal. 83, 7, p. 1538-1545 8 p.

研究成果: ジャーナルへの寄稿記事

公開
Registries
Demography
Anticoagulants
Atrial Fibrillation
Prospective Studies

Blockade of L-type Ca2+ channel attenuates doxorubicin-induced cardiomyopathy via suppression of CaMKII-NF-κB pathway

Ikeda, S., Matsushima, S., Okabe, K., Ikeda, M., Ishikita, A., Tadokoro, T., Enzan, N., Yamamoto, T., Sada, M., Deguchi, H., Morimoto, S., Ide, T. & Tsutsui, H., 12 1 2019, : : Scientific reports. 9, 1, 9850.

研究成果: ジャーナルへの寄稿記事

公開
Calcium-Calmodulin-Dependent Protein Kinase Type 2
NF-kappa B
Cardiomyopathies
Doxorubicin
Cardiac Myocytes
1 引用 (Scopus)

Brain perivascular macrophages contribute to the development of hypertension in stroke-prone spontaneously hypertensive rats via sympathetic activation

Iyonaga, T., Shinohara, K., Mastuura, T., Hirooka, Y. & Tsutsui, H., 1 1 2019, (受理済み/印刷中) : : Hypertension Research.

研究成果: ジャーナルへの寄稿記事

Inbred SHR Rats
Stroke
Macrophages
Hypertension
Clodronic Acid
1 引用 (Scopus)

Cardioprotective effect of renin–angiotensin inhibitors and β-blockers in trastuzumab-related cardiotoxicity

Ohtani, K., Ide, T., Hiasa, K. I., Sakamoto, I., Yamashita, N., Kubo, M. & Tsutsui, H., 10 1 2019, : : Clinical Research in Cardiology. 108, 10, p. 1128-1139 12 p.

研究成果: ジャーナルへの寄稿記事

Anthracyclines
Left Ventricular Dysfunction
Breast Neoplasms
Heart Failure
Cardiotoxicity
Purkinje Fibers
Catheter Ablation
Ventricular Tachycardia
Verapamil
Electrodes

Characteristics and in-hospital mortality of patients with myocardial infarction in the absence of obstructive coronary artery disease in super-aging society

JROAD Investigators, 1 1 2019, (受理済み/印刷中) : : International Journal of Cardiology. 301, p. 108-113 6 p.

研究成果: ジャーナルへの寄稿記事

Hospital Mortality
Coronary Artery Disease
Myocardial Infarction
Coronary Vessels
Cerebrovascular Disorders

Cilostazol is useful for the treatment of sinus bradycardia and associated hemodynamic deterioration following heart transplantation

Uchikawa, T., Fujino, T., Higo, T., Ohtani, K., Shiose, A. & Tsutsui, H., 1 1 2019, : : International heart journal. 60, 5, p. 1222-1225 4 p.

研究成果: ジャーナルへの寄稿記事

公開
Heart Transplantation
Bradycardia
Hemodynamics
Heart Rate
Isoproterenol

Colorectal endoscopic submucosal dissection using novel articulating devices: a comparative study in a live porcine model

Okamoto, Y., Nakadate, R., Nakamura, S., Arata, J., Oguri, S., Moriyama, T., Esaki, M., Iwasa, T., Ohuchida, K., Akahoshi, T., Ikeda, T., Kitazono, T. & Hashizume, M., 2 15 2019, : : Surgical endoscopy. 33, 2, p. 651-657 7 p.

研究成果: ジャーナルへの寄稿記事

Swine
Equipment and Supplies
Endoscopic Mucosal Resection
Anal Canal
Colon
公開
Aortic Valve
Surgical Instruments
Pressure
Stroke
Stroke Volume

Congenitally Corrected Transposition of the Great Arteries( TGA) in Adult

Tatewaki, H., Sakamoto, I., Hirayama, K. & Shiose, A., 4 1 2019, : : Kyobu geka. The Japanese journal of thoracic surgery. 72, 4, p. 269-274 6 p.

研究成果: ジャーナルへの寄稿記事

Heart Ventricles
Tricuspid Valve
Ventricular Heart Septal Defects
Reoperation
Pulmonary Artery
Mandibular Advancement
Obstructive Sleep Apnea
Blood Pressure
Equipment and Supplies
Sleep

Diabetes mellitus attenuates the pressure response against hypotensive stress by impairing the sympathetic regulation of the baroreflex afferent arc

Kamada, K., Saku, K., Tohyama, T., Kawada, T., Mannoji, H., Abe, K., Nishikawa, T., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., 1 2019, : : American Journal of Physiology - Heart and Circulatory Physiology. 316, 1, p. H35-H44

研究成果: ジャーナルへの寄稿記事

Baroreflex
Diabetes Mellitus
Arterial Pressure
Pressure
Type 2 Diabetes Mellitus
Heart-Assist Devices
Suction
Transplants
2 引用 (Scopus)

Early therapeutic effects of adaptive servo-ventilation on cardiac sympathetic nervous function in patients with heart failure evaluated using a combination of 11C-HED PET and 123I-MIBG SPECT

Tokuda, Y., Sakakibara, M., Yoshinaga, K., Yamada, S., Kamiya, K., Asakawa, N., Yoshitani, T., Noguchi, K., Manabe, O., Tamaki, N. & Tsutsui, H., 8 15 2019, : : Journal of Nuclear Cardiology. 26, 4, p. 1079-1089 11 p.

研究成果: ジャーナルへの寄稿記事

Therapeutic Uses
Single-Photon Emission-Computed Tomography
Ventilation
Heart Failure
Brain Natriuretic Peptide
Vasodilator Agents
Nitrates
Heart Failure
Databases
Hospitalization
1 引用 (Scopus)

Effects of coronary revascularization on global coronary flow reserve in stable coronary artery disease

Aikawa, T., Naya, M., Obara, M., Manabe, O., Magota, K., Koyanagawa, K., Asakawa, N., Ito, Y. M., Shiga, T., Katoh, C., Anzai, T., Tsutsui, H., Murthy, V. L. & Tamaki, N., 1 1 2019, : : Cardiovascular research. 115, 1, p. 119-129 11 p.

研究成果: ジャーナルへの寄稿記事

Coronary Artery Bypass
Percutaneous Coronary Intervention
Coronary Artery Disease
Positron-Emission Tomography
Multicenter Studies
1 引用 (Scopus)

Efficacy and safety of ivabradine in Japanese patients with chronic heart failure ― J-SHIFT study ―

behalf of the J-SHIFT Study Investigators, 1 1 2019, : : Circulation Journal. 83, 10, p. 2049-2060 12 p.

研究成果: ジャーナルへの寄稿記事

公開
ivabradine
Heart Failure
Safety
Placebos
Heart Rate
1 引用 (Scopus)
Tetralogy of Fallot
Liver Cirrhosis
Carcinoma
Liver
Hyaluronic Acid
1 引用 (Scopus)

Estimation of the baroreflex total loop gain by the power spectral analysis of continuous arterial pressure recordings

Mannoji, H., Saku, K., Nishikawa, T., Tohyama, T., Kamada, K., Abe, K., Sunagawa, G., Kishi, T., Sunagawa, K. & Tsutsui, H., 4 2019, : : American Journal of Physiology - Heart and Circulatory Physiology. 316, 4, p. H828-H839

研究成果: ジャーナルへの寄稿記事

Baroreflex
Arterial Pressure
Denervation
Pressure
Carotid Sinus

Evaluation of the effect of sodium–glucose co-transporter 2 inhibition with empagliflozin on morbidity and mortality of patients with chronic heart failure and a reduced ejection fraction: rationale for and design of the EMPEROR-Reduced trial

on behalf of the EMPEROR-Reduced Trial Committees and Investigators, Executive Committee, National Coordinators, Consulting Statistician, Clinical Events Committee, Scientific Excellence Committee & Data Monitoring Committee, 10 1 2019, : : European Journal of Heart Failure. 21, 10, p. 1270-1278 9 p.

研究成果: ジャーナルへの寄稿記事

公開
Symporters
Heart Failure
Morbidity
Mortality
Hospitalization
公開
Symporters
Heart Failure
Morbidity
Mortality
Hospitalization
公開
Heart-Assist Devices
Thrombosis
Transplants
Architectural Accessibility
Heart Failure

Folding procedure to diminish type 3 endoleakage after open stent graft surgery with TEVAR extension

Onzuka, T., Furukawa, K., Tayama, E., Morita, S. & Shiose, A., 11 1 2019, : : General thoracic and cardiovascular surgery. 67, 11, p. 999-1000 2 p.

研究成果: ジャーナルへの寄稿記事

Thoracic Surgery
Stents
Transplants
Polyethylene Terephthalates
Thorax

Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

Kawamura, Y., Nakaoka, H., Nakayama, A., Okada, Y., Yamamoto, K., Higashino, T., Sakiyama, M., Shimizu, T., Ooyama, H., Ooyama, K., Nagase, M., Hidaka, Y., Shirahama, Y., Hosomichi, K., Nishida, Y., Shimoshikiryo, I., Hishida, A., Katsuura-Kamano, S., Shimizu, S., Kawaguchi, M. および29人, Uemura, H., Ibusuki, R., Hara, M., Naito, M., Takao, M., Nakajima, M., Iwasawa, S., Nakashima, H., Ohnaka, K., Nakamura, T., Stiburkova, B., Merriman, T. R., Nakatochi, M., Ichihara, S., Yokota, M., Takada, T., Saitoh, T., Kamatani, Y., Takahashi, A., Arisawa, K., Takezaki, T., Tanaka, K., Wakai, K., Kubo, M., Hosoya, T., Ichida, K., Inoue, I., Shinomiya, N. & Matsuo, H., 10 1 2019, : : Annals of the Rheumatic Diseases. 78, 10, p. 1430-1437 8 p.

研究成果: ジャーナルへの寄稿記事

公開
Gout
Genome-Wide Association Study
Genes
Uric Acid
Crystals

Heart Failure Practice in Japan: Successful at Present, but Challenging in the Future

Tsutsui, H., 3 2019, : : Journal of Cardiac Failure. 25, 3, p. 145-146 2 p.

研究成果: ジャーナルへの寄稿編集

Japan
Heart Failure
6 引用 (Scopus)

Heart failure with reduced ejection fraction: comparison of patient characteristics and clinical outcomes within Asia and between Asia, Europe and the Americas

Dewan, P., Jhund, P. S., Shen, L., Petrie, M. C., Abraham, W. T., Atif Ali, M., Chen, C. H., Desai, A. S., Dickstein, K., Huang, J., Kiatchoosakun, S., Kim, K. S., Køber, L., Lai, W. T., Liao, Y., Mogensen, U. M., Oh, B. H., Packer, M., Rouleau, J. L., Shi, V. および7人, Sibulo, A. S., Solomon, S. D., Sritara, P., Swedberg, K., Tsutsui, H., Zile, M. R. & McMurray, J. J. V., 5 2019, : : European Journal of Heart Failure. 21, 5, p. 577-587 11 p.

研究成果: ジャーナルへの寄稿記事

公開
Heart Failure
North America
Philippines
China
Taiwan
1 引用 (Scopus)

Hospitalization costs for patients with acute congestive heart failure in Japan

Kanaoka, K., Okayama, S., Nakai, M., Sumita, Y., Nishimura, K., Kawakami, R., Okura, H., Miyamoto, Y., Yasuda, S., Tsutsui, H., Komuro, I., Ogawa, H. & Saito, Y., 1 1 2019, : : Circulation Journal. 83, 5, p. 1025-1031 7 p.

研究成果: ジャーナルへの寄稿記事

公開
Japan
Hospitalization
Heart Failure
Costs and Cost Analysis
Acute Disease

Hypoxia-inducible factor-1 α deletion in myeloid lineage attenuates hypoxia-induced pulmonary hypertension

Kojima, H., Tokunou, T., Takahara, Y., Sunagawa, K., Hirooka, Y., Ichiki, T. & Tsutsui, H., 4 2019, : : Physiological Reports. 7, 7, e14025.

研究成果: ジャーナルへの寄稿記事

公開
Hypoxia-Inducible Factor 1
Pulmonary Hypertension
Knockout Mice
Lung
Macrophages

Impact of population density on mortality in patients hospitalized for heart failure – JROAD-DPC Registry Analysis –

Konishi, M., Matsuzawa, Y., Ebina, T., Kosuge, M., Gohbara, M., Nishimura, K., Nakai, M., Miyamoto, Y., Saito, Y., Tsutsui, H., Komuro, I., Ogawa, H., Tamura, K. & Kimura, K., 1 1 2019, (受理済み/印刷中) : : Journal of Cardiology.

研究成果: ジャーナルへの寄稿記事

Population Density
Hospital Mortality
Vascular Diseases
Registries
Heart Diseases
1 引用 (Scopus)

Implication of preoperative existence of atrial fibrillation on hemocompatibility-related adverse events during left ventricular assist device support

Imamura, T., Kinugawa, K., Ono, M., Kinoshita, O., Fukushima, N., Shiose, A., Matsui, Y., Yamazaki, K., Saiki, Y., Usui, A., Niinami, H., Matsumiya, G., Arai, H. & Sawa, Y., 1 1 2019, : : Circulation Journal. 83, 6, p. 1286-1292 7 p.

研究成果: ジャーナルへの寄稿記事

公開
Heart-Assist Devices
Atrial Fibrillation
Propensity Score
Registries
Thrombosis

Inconsistency in the standard of care-toward evidence-based management of exertional heat stroke

Hosokawa, Y., Nagata, T. & Hasegawa, M., 1 1 2019, : : Frontiers in Physiology. 10, FEB, 108.

研究成果: ジャーナルへの寄稿評論記事

公開
Heat Stroke
Standard of Care
Extreme Heat
Tokyo
Hot Temperature
2 引用 (Scopus)

Inhibition of TLR9-NF-κB-mediated sterile inflammation improves pressure overload-induced right ventricular dysfunction in rats

Yoshida, K., Abe, K., Ishikawa, M., Saku, K., Shinoda-Sakamoto, M., Ishikawa, T., Watanabe, T., Oka, M., Sunagawa, K. & Tsutsui, H., 3 1 2019, : : Cardiovascular research. 115, 3, p. 658-668 11 p.

研究成果: ジャーナルへの寄稿記事

Toll-Like Receptor 9
Right Ventricular Dysfunction
Pulmonary Artery
Inflammation
Pressure

Involvement of different receptor subtypes in prostaglandin E2-induced contraction and relaxation in the lower esophageal sphincter and esophageal body

Bai, X., Ihara, E., Otsuka, Y., Tsuruta, S., Hirano, K., Tanaka, Y., Ogino, H., Hirano, M., Chinen, T., Akiho, H., Nakamura, K., Oda, Y. & Ogawa, Y., 8 15 2019, : : European Journal of Pharmacology. 857, 172405.

研究成果: ジャーナルへの寄稿記事

Lower Esophageal Sphincter
Dinoprostone
Smooth Muscle
Gastroesophageal Reflux
Muscle Contraction
3 引用 (Scopus)

Ivabradine for the treatment of cardiovascular diseases

Ide, T., Ohtani, K., Higo, T., Tanaka, M., Kawasaki, Y. & Tsutsui, H., 2 2019, : : Circulation Journal. 83, 2, p. 252-260 9 p.

研究成果: ジャーナルへの寄稿評論記事

ivabradine
Cardiovascular Diseases
Hyperpolarization-Activated Cyclic Nucleotide-Gated Channels
Sinoatrial Node
Heart Failure

Japanese periodical nationwide epidemiologic survey of aberrant portal hemodynamics

Ohfuji, S., Furuichi, Y., Akahoshi, T., Kage, M., Obara, K., Hashizume, M., Matsuura, T., Fukushima, W. & Nakamura, Y., 8 1 2019, : : Hepatology Research. 49, 8, p. 890-901 12 p.

研究成果: ジャーナルへの寄稿記事

公開
Hemodynamics
Japan
Pediatrics
Epidemiologic Methods
Surveys and Questionnaires

Jarvik 2000 axial flow ventricular assist device in right single ventricle after Fontan operation

Tanoue, Y., Fujino, T., Tatewaki, H. & Shiose, A., 12 1 2019, : : Journal of Artificial Organs. 22, 4, p. 338-340 3 p.

研究成果: ジャーナルへの寄稿記事

Fontan Procedure
Heart-Assist Devices
Axial flow
Heart Ventricles
Dextrocardia

JCS 2016 guideline on diagnosis and treatment of cardiac sarcoidosis ― digest version ―

Terasaki, F., Azuma, A., Anzai, T., Ishizaka, N., Ishida, Y., Isobe, M., Inomata, T., Ishibashi-Ueda, H., Eishi, Y., Kitakaze, M., Kusano, K., Sakata, Y., Shijubo, N., Tsuchida, A., Tsutsui, H., Nakajima, T., Nakatani, S., Horii, T., Yazaki, Y., Yamaguchi, E. および18人, Yamaguchi, T., Ide, T., Okamura, H., Kato, Y., Goya, M., Sakakibara, M., Soejima, K., Nagai, T., Nakamura, H., Noda, T., Hasegawa, T., Morita, H., Ohe, T., Kihara, Y., Saito, Y., Sugiyama, Y., Morimoto, S. I. & Yamashina, A., 1 1 2019, : : Circulation Journal. 83, 11, p. 2329-2388 60 p.

研究成果: ジャーナルへの寄稿評論記事

公開
Sarcoidosis
Guidelines

JCS 2017/JHFS 2017 guideline on diagnosis and treatment of acute and chronic heart failure ― digest version ―

behalf of the Japanese Circulation Society and the Japanese Heart Failure Society Joint Working Group, 1 1 2019, : : Circulation Journal. 83, 10, p. 2084-2184 101 p.

研究成果: ジャーナルへの寄稿記事

公開
Heart Failure
Guidelines
6 引用 (Scopus)

JCS 2018 guideline on diagnosis and treatment of acute coronary syndrome

on behalf of the Japanese Circulation Society Joint Working Group, 1 1 2019, : : Circulation Journal. 83, 5, p. 1085-1196 112 p.

研究成果: ジャーナルへの寄稿記事

公開
Acute Coronary Syndrome
Guidelines
1 引用 (Scopus)

Left atrial involvement of cardiac sarcoidosis manifesting as left atrial re-entrant tachycardia

Enzan, N., Ohtani, K., Nagaoka, K., Sakamoto, I. & Tsutsui, H., 8 1 2019, : : European heart journal cardiovascular Imaging. 20, 8, 1 p., jez051.

研究成果: ジャーナルへの寄稿コメント/討論

Sarcoidosis
Tachycardia

Liprin-α4 as a new therapeutic target for SCLC as an upstream mediator of HIF1α

Onishi, H., Yamasaki, A., Nakamura, K., Ichimiya, S., Yanai, K., Umebayashi, M., Nagai, S. & Morisaki, T., 3 1 2019, : : Anticancer research. 39, 3, p. 1179-1184 6 p.

研究成果: ジャーナルへの寄稿記事

Small Cell Lung Carcinoma
Cell Hypoxia
Cisplatin
CD45 Antigens
Hypoxia-Inducible Factor 1
3 引用 (Scopus)

Mechano-chronotropic Unloading During the Acute Phase of Myocardial Infarction Markedly Reduces Infarct Size via the Suppression of Myocardial Oxygen Consumption

Sunagawa, G., Saku, K., Arimura, T., Nishikawa, T., Mannoji, H., Kamada, K., Abe, K., Kishi, T., Tsutsui, H. & Sunagawa, K., 4 15 2019, : : Journal of Cardiovascular Translational Research. 12, 2, p. 124-134 11 p.

研究成果: ジャーナルへの寄稿記事

ivabradine
Oxygen Consumption
Myocardial Infarction
Ischemia
Reperfusion

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J-I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., 6 1 2019, : : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

研究成果: ジャーナルへの寄稿記事

Myocardial Reperfusion Injury
Toll-Like Receptor 4
Reperfusion Injury
Nanoparticles
Myocardial Ischemia