細胞機能制御学部門

研究成果 1989 2019

フィルター
記事
2019
1 引用 (Scopus)

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K., 8 1 2019, : : EBioMedicine. 46, p. 150-159 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Genes
Breast Neoplasms
Survival
RNA Sequence Analysis
Organized Financing
2 引用 (Scopus)

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Muto, Y., Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y. & Nakayama, K., 4 1 2019, : : Journal of Experimental Medicine. 216, 4, p. 950-965 16 p.

研究成果: ジャーナルへの寄稿記事

公開
Carcinogenesis
Homeostasis
Iron
Iron Overload
Liver

Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., 10 1 2019, : : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

研究成果: ジャーナルへの寄稿記事

Prion Diseases
Human Growth Hormone
Pituitary Gland
Molecular Weight
Dura Mater

Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells

Terada, M., Kawamata, M., Kimura, R., Sekiya, S., Nagamatsu, G., Hayashi, K., Horisawa, K. & Suzuki, A., 1 1 2019, (受理済み/印刷中) : : Genesis. e23334.

研究成果: ジャーナルへの寄稿記事

Pluripotent Stem Cells
Germ Cells
Embryonic Stem Cells
Genetic Promoter Regions
Transgenic Mice
2 引用 (Scopus)

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Guarnerio, J., Zhang, Y., Cheloni, G., Panella, R., Mae Katon, J., Simpson, M., Matsumoto, A., Papa, A., Loretelli, C., Petri, A., Kauppinen, S., Garbutt, C., Petur Nielsen, G., Deshpande, V., Castillo-Martin, M., Cordon-Cardo, C., Dimitrios, S., Clohessy, J. G., Batish, M. & Pandolfi, P. P., 8 1 2019, : : Cell Research. 29, 8, p. 628-640 13 p.

研究成果: ジャーナルへの寄稿記事

Carcinogenesis
Neoplasms
Proteins
Angiogenesis Inducing Agents
Transcription Factors

Long-term maintenance of functional primary human hepatocytes using small molecules

Katsuda, T., Kawamata, M., Inoue, A., Yamaguchi, T., Abe, M. & Ochiya, T., 1 1 2019, (受理済み/印刷中) : : FEBS Letters.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP3A
Hepatocytes
Drug Discovery
Molecules
Cytochrome P-450 CYP1A2

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Shinkai, Y., Koyasu, S., Nakayama, K., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., 3 1 2019, : : Journal of immunology (Baltimore, Md. : 1950). 202, 5, p. 1317-1320 4 p.

研究成果: ジャーナルへの寄稿記事

Transgenes
T-Lymphocytes
4 引用 (Scopus)

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K. I., 2 21 2019, : : JCI Insight. 4, 4

研究成果: ジャーナルへの寄稿記事

Neoplasms
Breast Neoplasms
Drug Therapy
Paclitaxel
Heterografts

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., 1 2019, : : Genes to Cells. 24, 1, p. 82-93 12 p.

研究成果: ジャーナルへの寄稿記事

Insulin
Phosphorylation
Proteins
Protein Kinases
Hepatocellular Carcinoma

SCF Fbxw7 ubiquitylates KLF7 for degradation in a manner dependent on GSK-3-mediated phosphorylation

Sugiyama, S., Yumimoto, K., Inoue, I. & Nakayama, K., 5 1 2019, : : Genes to Cells. 24, 5, p. 354-365 12 p.

研究成果: ジャーナルへの寄稿記事

Glycogen Synthase Kinase 3
Ligases
Ubiquitin
SKP Cullin F-Box Protein Ligases
Maintenance
1 引用 (Scopus)

Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development

Ishiuchi, T., Ohishi, H., Sato, T., Kamimura, S., Yorino, M., Abe, S., Suzuki, A., Wakayama, T., Suyama, M. & Sasaki, H., 5 7 2019, : : Cell Reports. 27, 6, p. 1742-1754.e6

研究成果: ジャーナルへの寄稿記事

公開
Placentation
Trophoblasts
Stem cells
Transcriptome
Stem Cells
2018

Acetaldehyde administrationinduces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice

Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., Kitagawa, K., Nakayama, K., Matsumoto, A., Miki, T. & Kinoshita, H., 10 15 2018, : : Neuroscience Letters. 685, p. 50-54 5 p.

研究成果: ジャーナルへの寄稿記事

Acetaldehyde
Inbred C57BL Mouse
Knockout Mice
Dopamine
Serotonin
7 引用 (Scopus)

Bcl11b sets pro-T cell fate by site-specific cofactor recruitment and by repressing Id2 and Zbtb16

Hosokawa, H., Romero-Wolf, M., Yui, M. A., Ungerbäck, J., Quiloan, M. L. G., Matsumoto, M., Nakayama, K., Tanaka, T. & Rothenberg, E. V., 12 1 2018, : : Nature Immunology. 19, 12, p. 1427-1440 14 p.

研究成果: ジャーナルへの寄稿記事

T-Lymphocytes
Gene Regulatory Networks
Genes
Transcription Factors
Proteomics
2 引用 (Scopus)

Cell Aggregation Culture Induces Functional Differentiation of Induced Hepatocyte-like Cells through Activation of Hippo Signaling

Yamamoto, J., Udono, M., Miura, S., Sekiya, S. & Suzuki, A., 10 2 2018, : : Cell Reports. 25, 1, p. 183-198 16 p.

研究成果: ジャーナルへの寄稿記事

Cell Aggregation
Hepatocytes
Agglomeration
Cell Culture Techniques
Chemical activation
3 引用 (Scopus)
Autistic Disorder
Brain
Biological Phenomena
Therapeutics
Autism Spectrum Disorder
11 引用 (Scopus)

Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., Hong, C. P., Ock, C. Y., Kim, S. J. & Oshima, M., 3 1 2018, : : Cancer Research. 78, 5, p. 1334-1346 13 p.

研究成果: ジャーナルへの寄稿記事

Intestinal Neoplasms
Neoplasm Metastasis
Mutation
Colorectal Neoplasms
Organoids
11 引用 (Scopus)

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Hagihara, H., Catts, V. S., Katayama, Y., Shoji, H., Takagi, T., Huang, F. L., Nakao, A., Mori, Y., Huang, K. P., Ishii, S., Graef, I. A., Nakayama, K. I., Shannon Weickert, C. & Miyakawa, T., 2 1 2018, : : Neuropsychopharmacology. 43, 3, p. 459-468 10 p.

研究成果: ジャーナルへの寄稿記事

Endophenotypes
Psychiatry
Bipolar Disorder
Brain
Schizophrenia
3 引用 (Scopus)

Degradation of the endoplasmic reticulum–anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3

Nakayama, S., Yumimoto, K., Kawamura, A. & Nakayama, K., 1 1 2018, : : Journal of Biological Chemistry. 293, 15, p. 5705-5714 10 p.

研究成果: ジャーナルへの寄稿記事

Glycogen Synthase Kinase 3
Ligases
Myelin Sheath
Ubiquitin
Transcription Factors
2 引用 (Scopus)

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system

Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K., Matsumoto, M., Nakayama, K. I., Yoshida, K., Sugimoto, N. & Fujita, M., 8 1 2018, : : Journal of Cell Science. 131, 15

研究成果: ジャーナルへの寄稿記事

Ribosomal Proteins
Proteasome Endopeptidase Complex
Ubiquitin
Glutamic Acid
Down-Regulation
5 引用 (Scopus)

Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis

Mikamo, M., Kitagawa, K., Sakai, S., Uchida, C., Ohhata, T., Nishimoto, K., Niida, H., Suzuki, S., Nakayama, K. I., Inui, N., Suda, T. & Kitagawa, M., 2 6 2018, : : International journal of molecular sciences. 19, 2, 474.

研究成果: ジャーナルへの寄稿記事

fibrosis
Ubiquitin-Protein Ligases
Pulmonary Fibrosis
Bleomycin
Cells
1 引用 (Scopus)

Nuclear–cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1

Nakatsumi, H., Oka, T., Higa, T., Shirane, M. & Nakayama, K., 7 1 2018, : : Genes to Cells. 23, 7, p. 599-605 7 p.

研究成果: ジャーナルへの寄稿記事

Proteins
Protein Phosphatase 2
Signal Transduction
Forkhead Transcription Factors
mechanistic target of rapamycin complex 1
1 引用 (Scopus)

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum

Abe, Y., Honsho, M., Itoh, R., Kawaguchi, R., Fujitani, M., Fujiwara, K., Hirokane, M., Matsuzaki, T., Nakayama, K., Ohgi, R., Marutani, T., Nakayama, K., Yamashita, T. & Fujiki, Y., 1 1 2018, : : Life Science Alliance. 1, 6

研究成果: ジャーナルへの寄稿記事

neurotrophins
Peroxisomes
Brain-Derived Neurotrophic Factor
cerebellum
peroxisomes
20 引用 (Scopus)

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. および12人, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., 3 12 2018, : : Cancer Cell. 33, 3, p. 355-367.e7

研究成果: ジャーナルへの寄稿記事

Small Cell Lung Carcinoma
Growth
Neoplasms
Protein Isoforms
Neuroendocrine Tumors
4 引用 (Scopus)

Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors

Takashima, Y., Horisawa, K., Udono, M., Ohkawa, Y. & Suzuki, A., 11 1 2018, : : Cancer Science. 109, 11, p. 3543-3553 11 p.

研究成果: ジャーナルへの寄稿記事

Hepatocellular Carcinoma
Transcription Factor 3
Transcription Factors
Cell Proliferation
Cell Line

The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis

Kita, Y., Katayama, Y., Shiraishi, T., Oka, T., Sato, T., Suyama, M., Ohkawa, Y., Miyata, K., Oike, Y., Shirane, M., Nishiyama, M. & Nakayama, K. I., 5 15 2018, : : Cell Reports. 23, 7, p. 1988-2000 13 p.

研究成果: ジャーナルへの寄稿記事

CCAAT-Enhancer-Binding Proteins
Adipogenesis
Autistic Disorder
White Adipose Tissue
Peroxisome Proliferator-Activated Receptors
5 引用 (Scopus)

The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles

Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., Odaka, H., Numakawa, T., Kunugi, H., Ochiya, T. & Tamai, Y., 1 2018, : : DMM Disease Models and Mechanisms. 11, 1, dmm028779.

研究成果: ジャーナルへの寄稿記事

Transgenic Rats
Neural Stem Cells
Stem cells
Rats
Brain
1 引用 (Scopus)

TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation

Hashimoto, Y., Shirane, M. & Nakayama, K. I., 6 2018, : : Genes to Cells. 23, 6, p. 418-434 17 p.

研究成果: ジャーナルへの寄稿記事

Vacuolar Proton-Translocating ATPases
Homeostasis
Protons
Membranes
Lipids
14 引用 (Scopus)

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., 6 19 2018, : : Immunity. 48, 6, p. 1119-1134.e7

研究成果: ジャーナルへの寄稿記事

Transcription Factors
T-Lymphocytes
Gene Expression
Genes
Binding Sites

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, : : iScience. 7, p. 212-229

研究成果: ジャーナルへの寄稿記事

Gene Regulatory Networks
Metabolic Networks and Pathways
Insulin
Immediate-Early Genes
Metabolomics
7 引用 (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 9 28 2018, : : iScience. 7, p. 212-229 18 p.

研究成果: ジャーナルへの寄稿記事

公開
Gene Regulatory Networks
Metabolic Networks and Pathways
insulin
Insulin
Immediate-Early Genes
2017
24 引用 (Scopus)

A large-scale targeted proteomics assay resource based on an in vitro human proteome

Matsumoto, M., Matsuzaki, F., Oshikawa, K., Goshima, N., Mori, M., Kawamura, Y., Ogawa, K., Fukuda, E., Nakatsumi, H., Natsume, T., Fukui, K., Horimoto, K., Nagashima, T., Funayama, R., Nakayama, K. & Nakayama, K., 2 28 2017, : : Nature Methods. 14, 3, p. 251-258 8 p.

研究成果: ジャーナルへの寄稿記事

Proteome
Proteomics
Assays
Proteins
Monitoring
9 引用 (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., 9 1 2017, : : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

研究成果: ジャーナルへの寄稿記事

DNA Helicases
Embryonic Stem Cells
Chromatin
Gene Expression
Histones
45 引用 (Scopus)

Conversion of Terminally Committed Hepatocytes to Culturable Bipotent Progenitor Cells with Regenerative Capacity

Katsuda, T., Kawamata, M., Hagiwara, K., Takahashi, R. U., Yamamoto, Y., Camargo, F. D. & Ochiya, T., 1 5 2017, : : Cell stem cell. 20, 1, p. 41-55 15 p.

研究成果: ジャーナルへの寄稿記事

Hepatocytes
Stem Cells
Liver
Liver Regeneration
Regenerative Medicine
8 引用 (Scopus)

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T. & Nakayama, K. I., 7 17 2017, : : Nature communications. 8, 16114.

研究成果: ジャーナルへの寄稿記事

homeostasis
stem cells
Hematopoietic Stem Cells
Stem cells
maintenance
5 引用 (Scopus)

FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem progenitor cells

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A. & Nakayama, K., 4 1 2017, : : Molecular and cellular biology. 37, 8, e00470-16.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Stem Cells
Iron
Iron Regulatory Protein 2
Brain
10 引用 (Scopus)

Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming

Miura, S. & Suzuki, A., 10 5 2017, : : Cell stem cell. 21, 4, p. 456-471.e5

研究成果: ジャーナルへの寄稿記事

Organoids
Cell Lineage
Stem Cells
Intestines
Transcription Factors
11 引用 (Scopus)

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N. & Fujita, M., 1 1 2017, : : EMBO Reports. 18, 1, p. 123-137 15 p.

研究成果: ジャーナルへの寄稿記事

Glutamic Acid
Carcinogenesis
Ligases
Ubiquitin
WD40 Repeats
40 引用 (Scopus)

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

Zhang, S., Chen, Q., Liu, Q., Li, Y., Sun, X., Hong, L., Ji, S., Liu, C., Geng, J., Zhang, W., Lu, Z., Yin, Z. Y., Zeng, Y., Lin, K. H., Wu, Q., Li, Q., Nakayama, K., Nakayama, K. I., Deng, X., Johnson, R. L. および4人, Zhu, L., Gao, D., Chen, L. & Zhou, D., 5 8 2017, : : Cancer Cell. 31, 5, p. 669-684.e7

研究成果: ジャーナルへの寄稿記事

Polyploidy
Ploidies
Carcinogenesis
Cyclin-Dependent Kinase Inhibitor p27
Ubiquitin-Protein Ligases
1 引用 (Scopus)

In vitro reconstitution of breast cancer heterogeneity with multipotent cancer stem cells using small molecules

Kawamata, M., Katsuda, T., Yamada, Y. & Ochiya, T., 1 22 2017, : : Biochemical and Biophysical Research Communications. 482, 4, p. 750-757 8 p.

研究成果: ジャーナルへの寄稿記事

Multipotent Stem Cells
Neoplastic Stem Cells
Stem cells
Tumors
Breast Neoplasms
139 引用 (Scopus)

MTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J. G. & Pandolfi, P. P., 1 12 2017, : : Nature. 541, 7636, p. 228-232 5 p.

研究成果: ジャーナルへの寄稿記事

Long Noncoding RNA
Regeneration
Amino Acids
Muscles
Peptides

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J. & Pandolfi, P. P., 2017, : : Nature. 541, 7636, p. 228 5 p., 541.

研究成果: ジャーナルへの寄稿記事

Long Noncoding RNA
Regeneration
Amino Acids
Muscles
Peptides
14 引用 (Scopus)

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

Nakatsumi, H., Matsumoto, M. & Nakayama, K., 11 28 2017, : : Cell Reports. 21, 9, p. 2471-2486 16 p.

研究成果: ジャーナルへの寄稿記事

CC Chemokines
Macrophages
Tumors
Ligands
Neoplasms
10 引用 (Scopus)

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

Fukushima, H., Shimizu, K., Watahiki, A., Hoshikawa, S., Kosho, T., Oba, D., Sakano, S., Arakaki, M., Yamada, A., Nagashima, K., Okabe, K., Fukumoto, S., Jimi, E., Bigas, A., Nakayama, K., Nakayama, K., Aoki, Y., Wei, W. & Inuzuka, H., 11 16 2017, : : Molecular Cell. 68, 4, p. 645-658.e5

研究成果: ジャーナルへの寄稿記事

Hajdu-Cheney Syndrome
Proteolysis
Osteoporosis
Osteoclasts
Mutation
2 引用 (Scopus)

Sez6l2 regulates phosphorylation of ADD and neuritogenesis

Yaguchi, H., Yabe, I., Takahashi, H., Watanabe, M., Nomura, T., Kano, T., Matsumoto, M., Nakayama, K. I., Watanabe, M. & Hatakeyama, S., 12 9 2017, : : Biochemical and Biophysical Research Communications. 494, 1-2, p. 234-241 8 p.

研究成果: ジャーナルへの寄稿記事

Phosphorylation
Seizures
Glutamate Receptors
Cerebellar Ataxia
Signal transduction
5 引用 (Scopus)

SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth

Ohnishi, T., Shirane, M. & Nakayama, K. I., 1 20 2017, : : Scientific reports. 7, 41130.

研究成果: ジャーナルへの寄稿記事

Alternative Splicing
Exons
Neurons
Nervous System
RNA Precursors
16 引用 (Scopus)

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K., Li, S., Standley, D. M., Yamashita, E., Nakagawa, A. & Okada, M., 12 1 2017, : : Nature communications. 8, 1, 1625.

研究成果: ジャーナルへの寄稿記事

lysosomes
GTP Phosphohydrolases
assembly
Lysosomes
nutrients
12 引用 (Scopus)

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Shimizu, K., Fukushima, H., Ogura, K., Lien, E. C., Nihira, N. T., Zhang, J., North, B. J., Guo, A., Nagashima, K., Nakagawa, T., Hoshikawa, S., Watahiki, A., Okabe, K., Yamada, A., Toker, A., Asara, J. M., Fukumoto, S., Nakayama, K., Nakayama, K., Inuzuka, H. および1人, Wei, W., 1 3 2017, : : Science Signaling. 10, 460

研究成果: ジャーナルへの寄稿記事

Lipogenesis
Ubiquitin-Protein Ligases
Ubiquitination
Sterol Regulatory Element Binding Proteins
Degradation
2016
11 引用 (Scopus)

Akt1-mediated Gata3 phosphorylation controls the repression of IFNÎ 3 in memory-type Th2 cells

Hosokawa, H., Tanaka, T., Endo, Y., Kato, M., Shinoda, K., Suzuki, A., Motohashi, S., Matsumoto, M., Nakayama, K. I. & Nakayama, T., 4 7 2016, : : Nature communications. 7, 11289.

研究成果: ジャーナルへの寄稿記事

Th2 Cells
phosphorylation
Phosphorylation
Cytokines
Data storage equipment
11 引用 (Scopus)

An Essential Role for SHARPIN in the Regulation of Caspase 1 Activity in Sepsis

Nastase, M. V., Zeng-Brouwers, J., Frey, H., Hsieh, L. T. H., Poluzzi, C., Beckmann, J., Schroeder, N., Pfeilschifter, J., Lopez-Mosqueda, J., Mersmann, J., Ikeda, F., Iozzo, R. V., Dikic, I. & Schaefer, L., 5 1 2016, : : American Journal of Pathology. 186, 5, p. 1206-1220 15 p.

研究成果: ジャーナルへの寄稿記事

Caspase 1
Sepsis
Ubiquitin
Survival
GTP-Binding Protein Regulators
76 引用 (Scopus)

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T. & Nakayama, K. I., 1 1 2016, : : Nature. 537, 7622, p. 675-679 5 p.

研究成果: ジャーナルへの寄稿記事

Haploinsufficiency
Phenotype
Transcription Factors
Genes
Brain