細胞機能制御学部門

研究成果

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記事
2016

Akt1-mediated Gata3 phosphorylation controls the repression of IFNÎ 3 in memory-type Th2 cells

Hosokawa, H., Tanaka, T., Endo, Y., Kato, M., Shinoda, K., Suzuki, A., Motohashi, S., Matsumoto, M., Nakayama, K. I. & Nakayama, T., 4 7 2016, : : Nature communications. 7, 11289.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Autonomous translational pausing is required for XBP1u mRNA recruitment to the ER via the SRP pathway

Kanda, S., Yanagitani, K., Yokota, Y., Esaki, Y. & Kohno, K., 10 4 2016, : : Proceedings of the National Academy of Sciences of the United States of America. 113, 40, p. E5886-E5895

研究成果: ジャーナルへの寄稿記事

公開
15 引用 (Scopus)

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T. & Nakayama, K. I., 1 1 2016, : : Nature. 537, 7622, p. 675-679 5 p.

研究成果: ジャーナルへの寄稿記事

82 引用 (Scopus)

Endosomal escape efficiency of fusogenic B18 and B55 peptides fused with anti-EGFR single chain Fv as estimated by nuclear translocation

Niikura, K., Horisawa, K. & Doi, N., 1 1 2016, : : Journal of biochemistry. 159, 1, p. 123-132 10 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

FBXL12 regulates T-cell differentiation in a cell-autonomous manner

Nita, A., Nishiyama, M., Muto, Y. & Nakayama, K., 5 1 2016, : : Genes to Cells. 21, 5, p. 517-524 8 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors

Kitade, S., Onoyama, I., Kobayashi, H., Yagi, H., Yoshida, S., Kato, M., Tsunematsu, R., Asanoma, K., Sonoda, K., Wake, N., Hata, K., Nakayama, K. I. & Kato, K., 10 1 2016, : : Cancer Science. 107, 10, p. 1399-1405 7 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Generation of a novel transgenic rat model for tracing extracellular vesicles in body fluids

Yoshimura, A., Kawamata, M., Yoshioka, Y., Katsuda, T., Kikuchi, H., Nagai, Y., Adachi, N., Numakawa, T., Kunugi, H., Ochiya, T. & Tamai, Y., 8 19 2016, : : Scientific reports. 6, 31172.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Identification of low-abundance proteins in serum via the isolation of HSP72 complexes

Tanaka, M., Shiota, M., Nakao, T., Uemura, R., Nishi, S., Ohkawa, Y., Matsumoto, M., Yamaguchi, M., Osada-Oka, M., Inagaki, A., Takahashi, K., Nakayama, K. I., Gi, M., Izumi, Y., Miura, K. & Iwao, H., 3 16 2016, : : Journal of Proteomics. 136, p. 214-221 8 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

In vitro selection of bispecific diabody fragments using covalent bicistronic DNA display

Nakayama, M., Komiya, S., Fujiwara, K., Horisawa, K. & Doi, N., 9 16 2016, : : Biochemical and Biophysical Research Communications. 478, 2, p. 606-611 6 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma

Terada, M., Horisawa, K., Miura, S., Takashima, Y., Ohkawa, Y., Sekiya, S., Matsuda-Ito, K. & Suzuki, A., 10 4 2016, : : Scientific reports. 6, 34691.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Linear ubiquitination by LUBEL has a role in Drosophila heat stress response

Asaoka, T., Almagro, J., Ehrhardt, C., Tsai, I., Schleiffer, A., Deszcz, L., Junttila, S., Ringrose, L., Mechtler, K., Kavirayani, A., Gyenesei, A., Hofmann, K., Duchek, P., Rittinger, K. & Ikeda, F., 11 1 2016, : : EMBO Reports. 17, 11, p. 1624-1640 17 p.

研究成果: ジャーナルへの寄稿記事

公開
11 引用 (Scopus)

Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment

Sekiya, S., Miura, S., Matsuda-Ito, K. & Suzuki, A., 12 13 2016, : : Stem Cell Reports. 7, 6, p. 1130-1139 10 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith–Wiedemann syndrome

Duquesnes, N., Callot, C., Jeannot, P., Daburon, V., Nakayama, K. I., Manenti, S., Davy, A. & Besson, A., 7 1 2016, : : Journal of Pathology. 239, 3, p. 250-261 12 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling

Hatano, A., Matsumoto, M. & Nakayama, K. I., 10 1 2016, : : Genes to Cells. 21, 10, p. 1095-1112 18 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells

Takahashi, K., Tanaka, M., Yashiro, M., Matsumoto, M., Ohtsuka, A., Nakayama, K. I., Izumi, Y., Nagayama, K., Miura, K., Iwao, H. & Shiota, M., 8 1 2016, : : Cancer Letters. 378, 1, p. 8-15 8 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

PURE mRNA display for in vitro selection of single-chain antibodies

Nagumo, Y., Fujiwara, K., Horisawa, K., Yanagawa, H. & Doi, N., 5 1 2016, : : Journal of biochemistry. 159, 5, p. 519-526 8 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Ribophorin ii is involved in the tissue factor expression mediated by phosphatidylserinedependent antiprothrombin antibody on monocytes

Fujieda, Y., Amengual, O., Matsumoto, M., Kuroki, K., Takahashi, H., Kono, M., Kurita, T., Otomo, K., Kato, M., Oku, K., Bohgaki, T., Horita, T., Yasuda, S., Maenaka, K., Hatakeyama, S., Nakayama, K. & Atsumi, T., 6 1 2016, : : Rheumatology (United Kingdom). 55, 6, p. 1117-1126 10 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Role of apolipoprotein B100 and oxidized low-density lipoprotein in the monocyte tissue factor induction mediated by anti-β2 glycoprotein i antibodies

Otomo, K., Amengual, O., Fujieda, Y., Nakagawa, H., Kato, M., Oku, K., Horita, T., Yasuda, S., Matsumoto, M., Nakayama, K. I., Hatakeyama, S., Koike, T. & Atsumi, T., 10 1 2016, : : Lupus. 25, 12, p. 1288-1298 11 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Suppression of lethal-7b and miR-125a/b Maturation by Lin28b Enables Maintenance of Stem Cell Properties in Hepatoblasts

Takashima, Y., Terada, M., Udono, M., Miura, S., Yamamoto, J. & Suzuki, A., 7 1 2016, : : Hepatology. 64, 1, p. 245-260 16 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes

Mizushima, W., Takahashi, H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K. I., Tsutsui, H. & Hatakeyama, S., 11 1 2016, : : Journal of Molecular and Cellular Cardiology. 100, p. 43-53 11 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

Tortola, L., Nitsch, R., Bertrand, M. J. M., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, L. M., Daugaard, M., Klug, H., Wirnsberger, G., Wimmer, R., Perlot, T., Sarao, R., Rao, S., Hanada, T., Takahashi, N., Kernbauer, E., Demiröz, D., Superti-Furga, G. および7人, Decker, T., Pichler, A., Ikeda, F., Kroemer, G., Vandenabeele, P., Sorensen, P. H. & Penninger, J. M., 5 17 2016, : : Cell Reports. 15, 7, p. 1481-1492 12 p.

研究成果: ジャーナルへの寄稿記事

公開
14 引用 (Scopus)

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels

Inoue, D., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K. I. & Kitamura, T., 3 1 2016, : : Experimental Hematology. 44, 3, p. 172-176.e1

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., Shiiya, N. & Kitagawa, M., 1 1 2016, : : Molecular and cellular biology. 36, 3, p. 394-406 13 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)
2015

Dynamic three-dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

Takashima, Y., Terada, M., Kawabata, M. & Suzuki, A., 3 1 2015, : : Hepatology. 61, 3, p. 1003-1011 9 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

Yumimoto, K., Akiyoshi, S., Ueo, H., Sagara, Y., Onoyama, I., Ueo, H., Ohno, S., Mori, M., Mimori, K. & Nakayama, K. I., 2 2 2015, : : Journal of Clinical Investigation. 125, 2, p. 621-635 15 p.

研究成果: ジャーナルへの寄稿記事

52 引用 (Scopus)

FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development

Nishiyama, M., Nita, A., Yumimoto, K. & Nakayama, K. I., 11 2015, : : STEM CELLS. 33, 11, p. 3327-3340 14 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1

Watanabe, K., Yumimoto, K. & Nakayama, K. I., 8 1 2015, : : Genes to Cells. 20, 8, p. 667-674 8 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Yumimoto, K. & Nakayama, K. I., 8 3 2015, : : OncoImmunology. 4, 8

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Linear ubiquitination signals in adaptive immune responses

Ikeda, F., 7 1 2015, : : Immunological Reviews. 266, 1, p. 222-236 15 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner

Yanagida, A., Chikada, H., Ito, K., Umino, A., Kato-Itoh, M., Yamazaki, Y., Sato, H., Kobayashi, T., Yamaguchi, T., Nakayama, K. I., Nakauchi, H. & Kamiya, A., 11 15 2015, : : Developmental Biology. 407, 2, p. 331-343 13 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Maternal TET3 is dispensable for embryonic development but is required for neonatal growth

Tsukada, Y. I., Akiyama, T. & Nakayama, K. I., 10 28 2015, : : Scientific reports. 5, 15876.

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

New Insights into the Role of Ubiquitin Networks in the Regulation of Antiapoptosis Pathways

Asaoka, T. & Ikeda, F., 1 1 2015, : : International Review of Cell and Molecular Biology. 318, p. 121-158 38 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: Involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA-binding protein 2

Nakajima, T., Kitagawa, K., Ohhata, T., Sakai, S., Uchida, C., Shibata, K., Minegishi, N., Yumimoto, K., Nakayama, K. I., Masumoto, K., Katou, F., Niida, H. & Kitagawa, M., 4 17 2015, : : Journal of Biological Chemistry. 290, 16, p. 10368-10381 14 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Role of the Atg9a gene in intrauterine growth and survival of fetal mice

Kojima, T., Yamada, T., Akaishi, R., Furuta, I., Saitoh, T., Nakabayashi, K., Nakayama, K. I., Nakayama, K., Akira, S. & Minakami, H., 9 1 2015, : : Reproductive Biology. 15, 3, p. 131-138 8 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

SKP2 inactivation suppresses prostate tumorigenesis by mediating JARID1B ubiquitination

Lu, W., Liu, S., Li, B., Xie, Y., Adhiambo, C., Yang, Q., Ballard, B. R., Nakayama, K. I., Matusik, R. J. & Chen, Z., 1 1 2015, : : Oncotarget. 6, 2, p. 771-788 18 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Slowly dividing neural progenitors are an embryonic origin of adult neural stem cells

Furutachi, S., Miya, H., Watanabe, T., Kawai, H., Yamasaki, N., Harada, Y., Imayoshi, I., Nelson, M., Nakayama, K. I., Hirabayashi, Y. & Gotoh, Y., 4 28 2015, : : Nature Neuroscience. 18, 5, p. 657-665 9 p.

研究成果: ジャーナルへの寄稿記事

117 引用 (Scopus)
18 引用 (Scopus)

Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth

Tane, S., Okayama, H., Ikenishi, A., Amemiya, Y., Nakayama, K. & Takeuchi, T., 10 16 2015, : : Biochemical and Biophysical Research Communications. 466, 2, p. 147-154 8 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)
2014
公開
2 引用 (Scopus)

CDK inhibitors, p21Cip1 and p27Kip1, participate in cell cycle exit of mammalian cardiomyocytes

Tane, S., Ikenishi, A., Okayama, H., Iwamoto, N., Nakayama, K. I. & Takeuchi, T., 1 17 2014, : : Biochemical and Biophysical Research Communications. 443, 3, p. 1105-1109 5 p.

研究成果: ジャーナルへの寄稿記事

37 引用 (Scopus)

Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development

Kitagawa, K., Shibat, K., Matsumoto, A., Matsumoto, M., Ohhata, T., Nakayama, K. I., Niida, H. & Kitagawa, M., 7 2014, : : Molecular and cellular biology. 34, 14, p. 2732-2744 13 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)
60 引用 (Scopus)

HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism

Moroishi, T., Yamauchi, T., Nishiyama, M. & Nakayama, K. I., 6 6 2014, : : Journal of Biological Chemistry. 289, 23, p. 16430-16441 12 p.

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

Identification and characterization of a neuron-specific isoform of protrudin

Ohnishi, T., Shirane, M., Hashimoto, Y., Saita, S. & Nakayama, K. I., 2 1 2014, : : Genes to Cells. 19, 2, p. 97-111 15 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24

Yamauchi, T., Nishiyama, M., Moroishi, T., Yumimoto, K. & Nakayama, K. I., 1 1 2014, : : Molecular and cellular biology. 34, 17, p. 3321-3340 20 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

P27 is regulated independently of Skp2 in the absence of Cdk2

Kotoshiba, S., Gopinathan, L., Pfeiffenberger, E., Rahim, A., Vardy, L. A., Nakayama, K., Nakayama, K. I. & Kaldis, P., 2 1 2014, : : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 2, p. 436-445 10 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

P57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling

Matsumoto, A., Takeishi, S. & Nakayama, K. I., 5 29 2014, : : Blood. 123, 22, p. 3429-3439 11 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia

Hashimoto, Y., Shirane, M., Matsuzaki, F., Saita, S., Ohnishi, T. & Nakayama, K. I., 1 1 2014, : : Journal of Biological Chemistry. 289, 19, p. 12946-12961 16 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Reconstruction of insulin signal flow from phosphoproteome and metabolome data

Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K. I., Kashikura, K., Endo, K., Ikeda, K., Soga, T. & Kuroda, S., 8 21 2014, : : Cell Reports. 8, 4, p. 1171-1183 13 p.

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

Role of the ANKMY2-FKBP38 axis in regulation of the sonic hedgehog (Shh) signaling pathway

Saita, S., Shirane, M., Ishitani, T., Shimizu, N. & Nakayama, K. I., 9 12 2014, : : Journal of Biological Chemistry. 289, 37, p. 25639-25654 16 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)