細胞機能制御学部門

研究成果 1989 2020

フィルター
記事
128 引用 (Scopus)

SOCS1 is a suppressor of liver fibrosis and hepatitis-induced carcinogenesis

Yoshida, T., Ogata, H., Kamio, M., Joo, A., Shiraishi, H., Tokunaga, Y., Sata, M., Nagai, H. & Yoshimura, A., 6 21 2004, : : Journal of Experimental Medicine. 199, 12, p. 1701-1707 7 p.

研究成果: ジャーナルへの寄稿記事

Liver Cirrhosis
Hepatitis
Carcinogenesis
Cytokines
Hepatocellular Carcinoma
82 引用 (Scopus)

Spatial and temporal expression patterns of the cyclin-dependent kinase (CDK) inhibitors p27Kip1 and p57Kip2 during mouse development

Nagahama, H., Hatakeyama, S., Nakayama, K., Nagata, M., Tomita, K. & Nakayama, K., 3 19 2001, : : Anatomy and Embryology. 203, 2, p. 77-87 11 p.

研究成果: ジャーナルへの寄稿記事

Cyclin-Dependent Kinases
Embryonic Development
Cyclin-Dependent Kinase Inhibitor p57
Phenotype
Palate
460 引用 (Scopus)

Specific Recognition of Linear Ubiquitin Chains by NEMO Is Important for NF-κB Activation

Rahighi, S., Ikeda, F., Kawasaki, M., Akutsu, M., Suzuki, N., Kato, R., Kensche, T., Uejima, T., Bloor, S., Komander, D., Randow, F., Wakatsuki, S. & Dikic, I., 3 20 2009, : : Cell. 136, 6, p. 1098-1109 12 p.

研究成果: ジャーナルへの寄稿記事

公開
Ubiquitin
Modulators
Chemical activation
Dimers
Ectodermal Dysplasia
30 引用 (Scopus)

S-phase kinase-associated protein-2 (Skp2) promotes vascular smooth muscle cell proliferation and neointima formation in vivo

Wu, Y. J., Sala-Newby, G. B., Shu, K. T., Yeh, H. I., Nakayama, K., Nakayama, K., Newby, A. C. & Bond, M., 11 1 2009, : : Journal of Vascular Surgery. 50, 5, p. 1135-1142 8 p.

研究成果: ジャーナルへの寄稿記事

S-Phase Kinase-Associated Proteins
Neointima
Vascular Smooth Muscle
Smooth Muscle Myocytes
Cell Proliferation
5 引用 (Scopus)

SRRM4-dependent neuron-specific alternative splicing of protrudin transcripts regulates neurite outgrowth

Ohnishi, T., Shirane, M. & Nakayama, K. I., 1 20 2017, : : Scientific reports. 7, 41130.

研究成果: ジャーナルへの寄稿記事

Alternative Splicing
Exons
Neurons
Nervous System
RNA Precursors
49 引用 (Scopus)

STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif

Minoguchi, M., Minoguchi, S., Aki, D., Joo, A., Yamamoto, T., Yumioka, T., Matsuda, T. & Yoshimura, A., 3 28 2003, : : Journal of Biological Chemistry. 278, 13, p. 11182-11189 8 p.

研究成果: ジャーナルへの寄稿記事

公開
Signal Transducing Adaptor Proteins
STAT3 Transcription Factor
Acute-Phase Reaction
Chemical activation
Molecules
40 引用 (Scopus)

STAT3 and MITF cooperatively induce cellular transformation through upregulation of c-fos expression

Joo, A., Aburatani, H., Morii, E., Iba, H. & Yoshimura, A., 1 22 2004, : : Oncogene. 23, 3, p. 726-734 9 p.

研究成果: ジャーナルへの寄稿記事

公開
Microphthalmia-Associated Transcription Factor
Up-Regulation
NIH 3T3 Cells
Transcription Factors
STAT Transcription Factors
16 引用 (Scopus)

Structural basis for the assembly of the Ragulator-Rag GTPase complex

Yonehara, R., Nada, S., Nakai, T., Nakai, M., Kitamura, A., Ogawa, A., Nakatsumi, H., Nakayama, K. I., Li, S., Standley, D. M., Yamashita, E., Nakagawa, A. & Okada, M., 12 1 2017, : : Nature communications. 8, 1, 1625.

研究成果: ジャーナルへの寄稿記事

lysosomes
GTP Phosphohydrolases
assembly
Lysosomes
nutrients
16 引用 (Scopus)

Structure and expression of the gene encoding mouse F-box protein, Fwd2

Miura, M., Hatakeyama, S., Hattori, K. & Nakayama, K. I., 11 15 1999, : : Genomics. 62, 1, p. 50-58 9 p.

研究成果: ジャーナルへの寄稿記事

SKP Cullin F-Box Protein Ligases
F-Box Proteins
Gene Expression
Complementary DNA
Cullin Proteins
43 引用 (Scopus)

Structure and polymorphisms of the human metabotropic glutamate receptor type 2 gene (GRM2): Analysis of association with schizophrenia

Joo, A., Shibata, H., Ninomiya, H., Kawasaki, H., Tashiro, N. & Fukumaki, Y., 3 14 2001, : : Molecular Psychiatry. 6, 2, p. 186-192 7 p.

研究成果: ジャーナルへの寄稿記事

Schizophrenia
Genes
Exons
eglumetad
Radiation Hybrid Mapping
51 引用 (Scopus)

Subcellular expression of autoimmune regulator is organized in a spatiotemporal manner

Akiyoshi, H., Hatakeyama, S., Pitkänen, J., Mouri, Y., Doucas, V., Kudoh, J., Tsurugaya, K., Uchida, D., Matsushima, A., Oshikawa, K., Nakayama, K., Shimizu, N., Peterson, P. & Matsumoto, M., 8 6 2004, : : Journal of Biological Chemistry. 279, 32, p. 33984-33991 8 p.

研究成果: ジャーナルへの寄稿記事

Proteasome Endopeptidase Complex
Cells
Nuclear Matrix
Cell Line
Cyclic AMP Response Element-Binding Protein
13 引用 (Scopus)

Substrate binding promotes formation of the Skp1-Cul1-Fbxl3 (SCF Fbxl3) protein complex

Yumimoto, K., Muneoka, T., Tsuboi, T. & Nakayama, K. I., 11 8 2013, : : Journal of Biological Chemistry. 288, 45, p. 32766-32776 11 p.

研究成果: ジャーナルへの寄稿記事

F-Box Proteins
Substrates
Proteins
Cryptochromes
Circadian Clocks
25 引用 (Scopus)

Sulfobacins A and B, Novel von Willebrand Factor Receptor Antagonists: I. Production, Isolation, Characterization and Biological Activities

Kamiyama, T., Umino, T., Satoh, T., Sawairi, S., Shirane, M., Ohshima, S. & Yokose, K., 1 1 1995, : : The Journal of Antibiotics. 48, 9, p. 924-928 5 p.

研究成果: ジャーナルへの寄稿記事

Aurintricarboxylic Acid
Chryseobacterium
Ristocetin
Flavobacterium
Silica Gel
94 引用 (Scopus)

Suppression of apoptosis in the protein kinase Cδ null mouse in vivo

Humphries, M. J., Limesand, K. H., Schneider, J. C., Nakayama, K. I., Anderson, S. M. & Reyland, M. E., 4 7 2006, : : Journal of Biological Chemistry. 281, 14, p. 9728-9737 10 p.

研究成果: ジャーナルへの寄稿記事

Protein Kinase C
Apoptosis
Parotid Gland
Chemical activation
JNK Mitogen-Activated Protein Kinases
47 引用 (Scopus)

Suppression of cell migration by protein kinase Cδ

Jackson, D., Zheng, Y., Lyo, D., Shen, Y., Nakayama, K., Nakayama, K. I., Humphries, M. J., Reyland, M. E. & Foster, D. A., 4 21 2005, : : Oncogene. 24, 18, p. 3067-3072 6 p.

研究成果: ジャーナルへの寄稿記事

Protein Kinase C
Cell Movement
Fibroblasts
MCF-7 Cells
Eels
32 引用 (Scopus)

Suppression of centrosome amplification after DNA damage depends on p27 accumulation

Sugihara, E., Kanai, M., Saito, S., Nitta, T., Toyoshima, H., Nakayama, K., Nakayama, K. I., Fukasawa, K., Schwab, M., Saya, H. & Miwa, M., 4 15 2006, : : Cancer Research. 66, 8, p. 4020-4029 10 p.

研究成果: ジャーナルへの寄稿記事

Centrosome
DNA Damage
Cyclin-Dependent Kinase 2
SKP Cullin F-Box Protein Ligases
F-Box Proteins
26 引用 (Scopus)

Suppression of lethal-7b and miR-125a/b Maturation by Lin28b Enables Maintenance of Stem Cell Properties in Hepatoblasts

Takashima, Y., Terada, M., Udono, M., Miura, S., Yamamoto, J. & Suzuki, A., 7 1 2016, : : Hepatology. 64, 1, p. 245-260 16 p.

研究成果: ジャーナルへの寄稿記事

MicroRNAs
Stem Cells
Maintenance
Hepatocytes
Liver
41 引用 (Scopus)

Targeted destruction of c-Myc by an engineered ubiquitin ligase suppresses cell transformation and tumor formation

Hatakeyama, S., Watanabe, M., Fujii, Y. & Nakayama, K. I., 9 1 2005, : : Cancer Research. 65, 17, p. 7874-7879 6 p.

研究成果: ジャーナルへの寄稿記事

Ligases
Ubiquitin
Oncogene Proteins
Neoplasms
NIH 3T3 Cells
591 引用 (Scopus)

Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication

Nakayama, K., Nagahama, H., Minamishima, Y. A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., Nakayama, K. I. & Hatakeyama, S., 5 2 2000, : : EMBO Journal. 19, 9, p. 2069-2081 13 p.

研究成果: ジャーナルへの寄稿記事

Cyclin E
Centrosome
Polyploidy
SKP Cullin F-Box Protein Ligases
Ubiquitin
160 引用 (Scopus)

Targeting the p27 E3 ligase SCF Skp2 results in p27and Skp2-mediated cell-cycle arrest and activation of autophagy

Chen, Q., Xie, W., Kuhn, D. J., Voorhees, P. M., Lopez-Girona, A., Mendy, D., Corral, L. G., Krenitsky, V. P., Xu, W., Parseval, L. M. D., Webb, D. R., Mercurio, F., Nakayama, K. I., Nakayama, K. & Orlowski, R. Z., 5 1 2008, : : Blood. 111, 9, p. 4690-4699 10 p.

研究成果: ジャーナルへの寄稿記事

Proteasome Inhibitors
Ubiquitin-Protein Ligases
Autophagy
Ligases
Cell Cycle Checkpoints
83 引用 (Scopus)

Tbx3 controls the fate of hepatic progenitor cells in liver development by suppressing p19ARF expression

Suzuki, A., Sekiya, S., Büscher, D., Belmonte, J. C. I. & Taniguchi, H., 5 1 2008, : : Development. 135, 9, p. 1589-1595 7 p.

研究成果: ジャーナルへの寄稿記事

Hepatocytes
Stem Cells
Liver
Organogenesis
Cell Differentiation
12 引用 (Scopus)

The amelioration of renal damage in Skp2-deficient mice canceled by p27Kip1 deficiency in Skp2-/- p27-/- mice

Suzuki, S., Fukasawa, H., Misaki, T., Togawa, A., Ohashi, N., Kitagawa, K., Kotake, Y., Liu, N., Niida, H., Nakayama, K., Nakayama, K. I., Yamamoto, T. & Kitagawa, M., 4 27 2012, : : PloS one. 7, 4, e36249.

研究成果: ジャーナルへの寄稿記事

Ureteral Obstruction
kidneys
Kidney
Cyclin A
Cyclin E

The Autism-Related Protein CHD8 Cooperates with C/EBPβ to Regulate Adipogenesis

Kita, Y., Katayama, Y., Shiraishi, T., Oka, T., Sato, T., Suyama, M., Ohkawa, Y., Miyata, K., Oike, Y., Shirane, M., Nishiyama, M. & Nakayama, K. I., 5 15 2018, : : Cell Reports. 23, 7, p. 1988-2000 13 p.

研究成果: ジャーナルへの寄稿記事

CCAAT-Enhancer-Binding Proteins
Adipogenesis
Autistic Disorder
White Adipose Tissue
Peroxisome Proliferator-Activated Receptors
68 引用 (Scopus)

The cyclin-dependent kinase inhibitors p57 and p27 regulate neuronal migration in the developing mouse neocortex

Itoh, Y., Masuyama, N., Nakayama, K., Nakayama, K. I. & Gotoh, Y., 1 5 2007, : : Journal of Biological Chemistry. 282, 1, p. 390-396 7 p.

研究成果: ジャーナルへの寄稿記事

Cyclin-Dependent Kinase Inhibitor p57
Cyclin-Dependent Kinase Inhibitor p27
Neocortex
Cerebral Cortex
Cells
78 引用 (Scopus)

The E3 Ligase TTC3 Facilitates Ubiquitination and Degradation of Phosphorylated Akt

Suizu, F., Hiramuki, Y., Okumura, F., Matsuda, M., Okumura, A. J., Hirata, N., Narita, M., Kohno, T., Yokota, J., Bohgaki, M., Obuse, C., Hatakeyama, S., Obata, T. & Noguchi, M., 12 15 2009, : : Developmental Cell. 17, 6, p. 800-810 11 p.

研究成果: ジャーナルへの寄稿記事

公開
Phosphorylation
Ubiquitin-Protein Ligases
Ubiquitination
Down Syndrome
RING Finger Domains
354 引用 (Scopus)

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

Von Der Lehr, N., Johansson, S., Wu, S., Bahram, F., Castell, A., Cetinkaya, C., Hydbring, P., Weidung, I., Nakayama, K., Nakayama, K. I., Söderberg, O., Kerppola, T. K. & Larsson, L. G., 5 1 2003, : : Molecular Cell. 11, 5, p. 1189-1200 12 p.

研究成果: ジャーナルへの寄稿記事

F-Box Proteins
myc Genes
Ubiquitination
Phase Transition
Proteasome Endopeptidase Complex
10 引用 (Scopus)

The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo

Cooke, P. S., Holsberger, D. R., Cimafranca, M. A., Meling, D. D., Beals, C. M., Nakayama, K., Nakayama, K. I. & Kiyokawa, H., 6 1 2007, : : Obesity. 15, 6, p. 1400-1408 9 p.

研究成果: ジャーナルへの寄稿記事

S-Phase Kinase-Associated Proteins
F-Box Proteins
Protein S
Adipocytes
Adipogenesis
72 引用 (Scopus)

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K. I., 9 7 2011, : : Cell metabolism. 14, 3, p. 339-351 13 p.

研究成果: ジャーナルへの寄稿記事

Iron Regulatory Protein 2
Iron
Liver
Homeostasis
Acute Liver Failure
33 引用 (Scopus)

The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCF Skp2 ubiquitin ligase

Tokarz, S., Berset, C., La Rue, J., Friedman, K., Nakayama, K., Nakayama, K., Zhang, D. E. & Lanker, S., 11 5 2004, : : Journal of Biological Chemistry. 279, 45, p. 46424-46430 7 p.

研究成果: ジャーナルへの寄稿記事

SKP Cullin F-Box Protein Ligases
Proteolysis
Interferon Type I
Ubiquitination
Ligases
7 引用 (Scopus)

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes

Mizushima, W., Takahashi, H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K. I., Tsutsui, H. & Hatakeyama, S., 11 1 2016, : : Journal of Molecular and Cellular Cardiology. 100, p. 43-53 11 p.

研究成果: ジャーナルへの寄稿記事

Cardiac Myocytes
Energy Metabolism
Fingers
Proteins
Heart Failure
57 引用 (Scopus)

The Papillomavirus E7 Oncoprotein Is Ubiquitinated by UbcH7 and Cullin 1- and Skp2-Containing E3 Ligase

Oh, K. J., Kalinina, A., Wang, J., Nakayama, K., Nakayama, K. I. & Bagchi, S., 5 1 2004, : : Journal of virology. 78, 10, p. 5338-5346 9 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin-Protein Ligases
Papillomaviridae
Oncogene Proteins
Ubiquitin
ligases
26 引用 (Scopus)

The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: In vitro, ex vivo, and in vivo studies

Ellman, M. B., Kim, J. S., An, H. S., Kroin, J. S., Li, X., Chen, D., Yan, D., Buechter, D. D., Nakayama, K., Liu, B., Morgan, S. & Im, H. J., 6 1 2012, : : Arthritis and rheumatism. 64, 6, p. 1950-1959 10 p.

研究成果: ジャーナルへの寄稿記事

Intervertebral Disc
Protein Kinase C
Rabbits
Intervertebral Disc Degeneration
Knockout Mice

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

Takii, R., Fujimoto, M., Matsumoto, M., Srivastava, P., Katiyar, A., Nakayama, K. I. & Nakai, A., 12 16 2019, : : EMBO Journal. 38, 24, e102566.

研究成果: ジャーナルへの寄稿記事

Heat-Shock Response
RNA Polymerase II
Proteins
Shock
Phosphorylation
35 引用 (Scopus)

The role of β-TrCP1 and β-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2

Ohsaki, K., Oishi, K., Kozono, Y., Nakayama, K., Nakayama, K. & Ishida, N., 11 1 2008, : : Journal of biochemistry. 144, 5, p. 609-618 10 p.

研究成果: ジャーナルへの寄稿記事

Circadian Rhythm
Proteolysis
Clocks
Circadian Clocks
Suprachiasmatic Nucleus
13 引用 (Scopus)

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Shimizu, K., Fukushima, H., Ogura, K., Lien, E. C., Nihira, N. T., Zhang, J., North, B. J., Guo, A., Nagashima, K., Nakagawa, T., Hoshikawa, S., Watahiki, A., Okabe, K., Yamada, A., Toker, A., Asara, J. M., Fukumoto, S., Nakayama, K. I., Nakayama, K., Inuzuka, H. および1人, Wei, W., 1 3 2017, : : Science Signaling. 10, 460

研究成果: ジャーナルへの寄稿記事

Lipogenesis
Ubiquitin-Protein Ligases
Ubiquitination
Sterol Regulatory Element Binding Proteins
Degradation
17 引用 (Scopus)

The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression

Kitamura, K., Mizuno, K., Etoh, A., Akita, Y., Miyamoto, A., Nakayama, K. & Ohno, S., 4 1 2003, : : Genes to Cells. 8, 4, p. 311-324 14 p.

研究成果: ジャーナルへの寄稿記事

Protein Kinase C
Cell Cycle
DNA
Serum
Cell Division
29 引用 (Scopus)

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Rodriguez, S., Wang, L., Mumaw, C., Srour, E. F., Lo Celso, C., Nakayama, K. I. & Carlesso, N., 6 16 2011, : : Blood. 117, 24, p. 6509-6519 11 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin-Protein Ligases
Regeneration
Cell Cycle
Homeostasis
Cells
195 引用 (Scopus)

The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D., Hung, M. C., Nakayama, K. I. & Lin, H. K., 5 25 2012, : : Cell. 149, 5, p. 1098-1111 14 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin-Protein Ligases
Ubiquitination
Glycolysis
TNF Receptor-Associated Factor 6
Carcinogenesis
247 引用 (Scopus)

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2

Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Hatakeyama, S., Yada, M., Morita, S., Kitamura, T., Kato, H., Nakayama, K. I. & Yoshimura, A., 4 20 2001, : : Journal of Biological Chemistry. 276, 16, p. 12530-12538 9 p.

研究成果: ジャーナルへの寄稿記事

Cullin Proteins
Proteolysis
Ubiquitin
Protein-Tyrosine Kinases
Genes
5 引用 (Scopus)

The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles

Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., Odaka, H., Numakawa, T., Kunugi, H., Ochiya, T. & Tamai, Y., 1 2018, : : DMM Disease Models and Mechanisms. 11, 1, dmm028779.

研究成果: ジャーナルへの寄稿記事

Transgenic Rats
Neural Stem Cells
Stem cells
Rats
Brain
14 引用 (Scopus)

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

Tortola, L., Nitsch, R., Bertrand, M. J. M., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, L. M., Daugaard, M., Klug, H., Wirnsberger, G., Wimmer, R., Perlot, T., Sarao, R., Rao, S., Hanada, T., Takahashi, N., Kernbauer, E., Demiröz, D., Superti-Furga, G. および7人, Decker, T., Pichler, A., Ikeda, F., Kroemer, G., Vandenabeele, P., Sorensen, P. H. & Penninger, J. M., 5 17 2016, : : Cell Reports. 15, 7, p. 1481-1492 12 p.

研究成果: ジャーナルへの寄稿記事

公開
Receptors, Tumor Necrosis Factor, Type I
Tumors
Phosphotransferases
Neoplasms
Ubiquitin-Protein Ligases
18 引用 (Scopus)
Histones
Chromatin
Pseudogenes
Genome
Genes
1 引用 (Scopus)

TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation

Hashimoto, Y., Shirane, M. & Nakayama, K. I., 6 2018, : : Genes to Cells. 23, 6, p. 418-434 17 p.

研究成果: ジャーナルへの寄稿記事

Vacuolar Proton-Translocating ATPases
Homeostasis
Protons
Membranes
Lipids
11 引用 (Scopus)

Toward high-throughput screening of NAD(P)-dependent oxidoreductases using boron-doped diamond microelectrodes and microfluidic devices

Oyobiki, R., Kato, T., Katayama, M., Sugitani, A., Watanabe, T., Einaga, Y., Matsumoto, Y., Horisawa, K. & Doi, N., 10 7 2014, : : Analytical chemistry. 86, 19, p. 9570-9575 6 p.

研究成果: ジャーナルへの寄稿記事

Diamond
Boron
Microelectrodes
Microfluidics
NAD
34 引用 (Scopus)

Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCδ-dependent pathway in murine lung

Shukla, A., Barrett, T. F., Nakayama, K., Nakayama, K., Mossman, B. T. & Lounsbury, K. M., 5 2006, : : FASEB Journal. 20, 7

研究成果: ジャーナルへの寄稿記事

asbestos
Asbestos
Up-Regulation
lungs
Lung
17 引用 (Scopus)

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., 6 19 2018, : : Immunity. 48, 6, p. 1119-1134.e7

研究成果: ジャーナルへの寄稿記事

Transcription Factors
T-Lymphocytes
Gene Expression
Genes
Binding Sites
23 引用 (Scopus)

Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles

Hikichi, T., Matoba, R., Ikeda, T., Watanabe, A., Yamamoto, T., Yoshitake, S., Tamura-Nakano, M., Kimura, T., Kamon, M., Shimura, M., Kawakami, K., Okuda, A., Okochi, H., Inoue, T., Suzuki, A. & Masui, S., 4 16 2013, : : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6412-6417 6 p.

研究成果: ジャーナルへの寄稿記事

Cell Dedifferentiation
Transcription Factors
Hepatocytes
Maintenance
Cell Line

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, : : iScience. 7, p. 212-229

研究成果: ジャーナルへの寄稿記事

Gene Regulatory Networks
Metabolic Networks and Pathways
Insulin
Immediate-Early Genes
Metabolomics
7 引用 (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 9 28 2018, : : iScience. 7, p. 212-229 18 p.

研究成果: ジャーナルへの寄稿記事

公開
Gene Regulatory Networks
Metabolic Networks and Pathways
insulin
Insulin
Immediate-Early Genes
45 引用 (Scopus)

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K. I. & Hatakeyama, S., 7 1 2010, : : Journal of Cell Science. 123, 13, p. 2238-2245 8 p.

研究成果: ジャーナルへの寄稿記事

Proteins
RING Finger Domains
Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis