細胞機能制御学部門

研究成果 1989 2020

フィルター
記事
17 引用 (Scopus)

The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression

Kitamura, K., Mizuno, K., Etoh, A., Akita, Y., Miyamoto, A., Nakayama, K. & Ohno, S., 4 1 2003, : : Genes to Cells. 8, 4, p. 311-324 14 p.

研究成果: ジャーナルへの寄稿記事

Protein Kinase C
Cell Cycle
DNA
Serum
Cell Division
29 引用 (Scopus)

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Rodriguez, S., Wang, L., Mumaw, C., Srour, E. F., Lo Celso, C., Nakayama, K. I. & Carlesso, N., 6 16 2011, : : Blood. 117, 24, p. 6509-6519 11 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin-Protein Ligases
Regeneration
Cell Cycle
Homeostasis
Cells
195 引用 (Scopus)

The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D., Hung, M. C., Nakayama, K. I. & Lin, H. K., 5 25 2012, : : Cell. 149, 5, p. 1098-1111 14 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin-Protein Ligases
Ubiquitination
Glycolysis
TNF Receptor-Associated Factor 6
Carcinogenesis
247 引用 (Scopus)

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2

Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Hatakeyama, S., Yada, M., Morita, S., Kitamura, T., Kato, H., Nakayama, K. I. & Yoshimura, A., 4 20 2001, : : Journal of Biological Chemistry. 276, 16, p. 12530-12538 9 p.

研究成果: ジャーナルへの寄稿記事

Cullin Proteins
Proteolysis
Ubiquitin
Protein-Tyrosine Kinases
Genes
5 引用 (Scopus)

The Sox2 promoter-driven CD63-GFP transgenic rat model allows tracking of neural stem cell-derived extracellular vesicles

Yoshimura, A., Adachi, N., Matsuno, H., Kawamata, M., Yoshioka, Y., Kikuchi, H., Odaka, H., Numakawa, T., Kunugi, H., Ochiya, T. & Tamai, Y., 1 2018, : : DMM Disease Models and Mechanisms. 11, 1, dmm028779.

研究成果: ジャーナルへの寄稿記事

Transgenic Rats
Neural Stem Cells
Stem cells
Rats
Brain
14 引用 (Scopus)

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

Tortola, L., Nitsch, R., Bertrand, M. J. M., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, L. M., Daugaard, M., Klug, H., Wirnsberger, G., Wimmer, R., Perlot, T., Sarao, R., Rao, S., Hanada, T., Takahashi, N., Kernbauer, E., Demiröz, D., Superti-Furga, G. および7人, Decker, T., Pichler, A., Ikeda, F., Kroemer, G., Vandenabeele, P., Sorensen, P. H. & Penninger, J. M., 5 17 2016, : : Cell Reports. 15, 7, p. 1481-1492 12 p.

研究成果: ジャーナルへの寄稿記事

公開
Receptors, Tumor Necrosis Factor, Type I
Tumors
Phosphotransferases
Neoplasms
Ubiquitin-Protein Ligases
18 引用 (Scopus)
Histones
Chromatin
Pseudogenes
Genome
Genes
1 引用 (Scopus)

TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation

Hashimoto, Y., Shirane, M. & Nakayama, K. I., 6 2018, : : Genes to Cells. 23, 6, p. 418-434 17 p.

研究成果: ジャーナルへの寄稿記事

Vacuolar Proton-Translocating ATPases
Homeostasis
Protons
Membranes
Lipids
11 引用 (Scopus)

Toward high-throughput screening of NAD(P)-dependent oxidoreductases using boron-doped diamond microelectrodes and microfluidic devices

Oyobiki, R., Kato, T., Katayama, M., Sugitani, A., Watanabe, T., Einaga, Y., Matsumoto, Y., Horisawa, K. & Doi, N., 10 7 2014, : : Analytical chemistry. 86, 19, p. 9570-9575 6 p.

研究成果: ジャーナルへの寄稿記事

Diamond
Boron
Microelectrodes
Microfluidics
NAD
34 引用 (Scopus)

Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCδ-dependent pathway in murine lung

Shukla, A., Barrett, T. F., Nakayama, K., Nakayama, K., Mossman, B. T. & Lounsbury, K. M., 5 2006, : : FASEB Journal. 20, 7

研究成果: ジャーナルへの寄稿記事

asbestos
Asbestos
Up-Regulation
lungs
Lung
17 引用 (Scopus)

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., 6 19 2018, : : Immunity. 48, 6, p. 1119-1134.e7

研究成果: ジャーナルへの寄稿記事

Transcription Factors
T-Lymphocytes
Gene Expression
Genes
Binding Sites
23 引用 (Scopus)

Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles

Hikichi, T., Matoba, R., Ikeda, T., Watanabe, A., Yamamoto, T., Yoshitake, S., Tamura-Nakano, M., Kimura, T., Kamon, M., Shimura, M., Kawakami, K., Okuda, A., Okochi, H., Inoue, T., Suzuki, A. & Masui, S., 4 16 2013, : : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6412-6417 6 p.

研究成果: ジャーナルへの寄稿記事

Cell Dedifferentiation
Transcription Factors
Hepatocytes
Maintenance
Cell Line

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, : : iScience. 7, p. 212-229

研究成果: ジャーナルへの寄稿記事

Gene Regulatory Networks
Metabolic Networks and Pathways
Insulin
Immediate-Early Genes
Metabolomics
7 引用 (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 9 28 2018, : : iScience. 7, p. 212-229 18 p.

研究成果: ジャーナルへの寄稿記事

公開
Gene Regulatory Networks
Metabolic Networks and Pathways
insulin
Insulin
Immediate-Early Genes
45 引用 (Scopus)

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K. I. & Hatakeyama, S., 7 1 2010, : : Journal of Cell Science. 123, 13, p. 2238-2245 8 p.

研究成果: ジャーナルへの寄稿記事

Proteins
RING Finger Domains
Proteasome Endopeptidase Complex
Ubiquitin
Proteolysis
18 引用 (Scopus)

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

Okumura, F., Okumura, A. J., Matsumoto, M., Nakayama, K. I. & Hatakeyama, S., 10 1 2011, : : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 10, p. 1784-1792 9 p.

研究成果: ジャーナルへの寄稿記事

Embryonic Stem Cells
Fingers
Down-Regulation
Proteins
22 引用 (Scopus)

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels

Inoue, D., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K. I. & Kitamura, T., 3 1 2016, : : Experimental Hematology. 44, 3, p. 172-176.e1

研究成果: ジャーナルへの寄稿記事

Mutation
Neoplasms
Proteins
Myelodysplastic Syndromes
Hematologic Neoplasms
279 引用 (Scopus)

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis

Nishitani, H., Sugimoto, N., Roukos, V., Nakanishi, Y., Saijo, M., Obuse, C., Tsurimoto, T., Nakayama, K. I., Nakayama, K., Fujita, M., Lygerou, Z. & Nishimoto, T., 3 8 2006, : : EMBO Journal. 25, 5, p. 1126-1136 11 p.

研究成果: ジャーナルへの寄稿記事

Proteolysis
Ubiquitin-Protein Ligases
G2 Phase
S Phase
Amino Acids
4 引用 (Scopus)

Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth

Tane, S., Okayama, H., Ikenishi, A., Amemiya, Y., Nakayama, K. & Takeuchi, T., 10 16 2015, : : Biochemical and Biophysical Research Communications. 466, 2, p. 147-154 8 p.

研究成果: ジャーナルへの寄稿記事

Cardiac Myocytes
Cell Cycle
Cells
Parturition
Cell Division
6 引用 (Scopus)

Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against listeria monocytogenes infection

Hashiguchi, T., Oyamada, A., Sakuraba, K., Shimoda, K., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., 5 15 2014, : : Journal of Immunology. 192, 10, p. 4739-4747 9 p.

研究成果: ジャーナルへの寄稿記事

TYK2 Kinase
Listeriosis
Th1 Cells
Listeria monocytogenes
Interleukin-12
8 引用 (Scopus)

Tyk2 is essential for IFN-α-induced gene expression in mast cells

Mori, Y., Hirose, K., Suzuki, K., Nakajima, H., Seto, Y., Ikeda, K., Shimoda, K., Nakayama, K. I., Saito, Y. & Iwamoto, I., 6 15 2004, : : International Archives of Allergy and Immunology. 134, SUPPL. 1, p. 25-29 5 p.

研究成果: ジャーナルへの寄稿記事

Mast Cells
Monocyte Chemoattractant Proteins
Gene Expression
Bone Marrow
Bacterial Infections
234 引用 (Scopus)

Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function

Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S., Shibata, S., Asano, Y., Gondo, H., Sekiguchi, K., Nakayama, K., Nakayama, T., Okamura, T., Okamura, S., Niho, Y. & Nakayama, K. I., 1 1 2000, : : Immunity. 13, 4, p. 561-571 11 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-12
Janus Kinases
T-Lymphocytes
Cytokine Receptors
Interleukin-10
4 引用 (Scopus)

Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection

Li, W., Yamada, H., Yajima, T., Nakagawa, R., Shimoda, K., Nakayama, K. & Yoshikai, Y., 4 1 2007, : : Journal of Immunology. 178, 7, p. 4482-4488 7 p.

研究成果: ジャーナルへの寄稿記事

TYK2 Kinase
CD8 Antigens
T-Lymphocytes
Infection
Listeria monocytogenes
48 引用 (Scopus)

Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by γδ T cells

Nakamura, R., Shibata, K., Yamada, H., Shimoda, K., Nakayama, K. & Yoshikai, Y., 8 1 2008, : : Journal of Immunology. 181, 3, p. 2071-2075 5 p.

研究成果: ジャーナルへの寄稿記事

TYK2 Kinase
Interleukin-23
Interleukin-17
Escherichia coli
T-Lymphocytes
33 引用 (Scopus)

Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis

Oyamada, A., Ikebe, H., Itsumi, M., Saiwai, H., Okada, S., Shimoda, K., Iwakura, Y., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., 12 1 2009, : : Journal of Immunology. 183, 11, p. 7539-7546 8 p.

研究成果: ジャーナルへの寄稿記事

TYK2 Kinase
Autoimmune Experimental Encephalomyelitis
T-Lymphocytes
Myelin-Oligodendrocyte Glycoprotein
Knockout Mice
64 引用 (Scopus)

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

Wu, H., Pomeroy, S. L., Ferreira, M., Teider, N., Mariani, J., Nakayama, K. I., Hatakeyama, S., Tron, V. A., Saltibus, L. F., Spyracopoulos, L. & Leng, R. P., 3 1 2011, : : Nature medicine. 17, 3, p. 347-355 9 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitination
Tumors
Degradation
Brain Neoplasms
Brain
158 引用 (Scopus)

Ubiquitin binding mediates the NF-κB inhibitory potential of ABIN proteins

Wagner, S., Carpentier, I., Rogov, V., Kreike, M., Ikeda, F., Löhr, F., Wu, C. J., Ashwell, J. D., Dötsch, V., Dikic, I. & Beyaert, R., 6 12 2008, : : Oncogene. 27, 26, p. 3739-3745 7 p.

研究成果: ジャーナルへの寄稿記事

公開
Ubiquitin
Proteins
Carcinogenesis
Phosphotransferases
Magnetic Resonance Spectroscopy
168 引用 (Scopus)

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoé, K., Good, R. A. & Nakayama, K. I., 3 30 1999, : : Proceedings of the National Academy of Sciences of the United States of America. 96, 7, p. 3859-3863 5 p.

研究成果: ジャーナルへの寄稿記事

F-Box Proteins
Ubiquitination
Ligases
Ubiquitin
SKP Cullin F-Box Protein Ligases

Ubiquitin-dependent proteolysis by SCF complex

Nakayama, K. & Nakayama, K. I., 12 1 2000, : : Seikagaku. 72, 2, p. 113-117 5 p.

研究成果: ジャーナルへの寄稿記事

Cysteine Endopeptidases
SKP Cullin F-Box Protein Ligases
Ubiquitins
Peptide Synthases
Multienzyme Complexes
3 引用 (Scopus)

Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2

Okumura, F., Joo-Okumura, A., Obara, K., Petersen, A., Nishikimi, A., Fukui, Y., Nakatsukasa, K. & Kamura, T., 11 15 2017, : : Molecular biology of the cell. 28, 24, p. 3532-3541 10 p.

研究成果: ジャーナルへの寄稿記事

Ligases
Ubiquitin
Matrix Metalloproteinases
EphB2 Receptors
Eph Family Receptors
25 引用 (Scopus)

Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase

Yogosawa, S., Hatakeyama, S., Nakayama, K., Miyoshi, H., Kohsaka, S. & Akazawa, C., 12 16 2005, : : Journal of Biological Chemistry. 280, 50, p. 41619-41627 9 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitination
Ligases
Ubiquitin
Sorting
Degradation
85 引用 (Scopus)

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle

Jiang, H., Chang, F. C., Ross, A. E., Lee, J., Nakayama, K., Nakayama, K. & Desiderio, S., 6 10 2005, : : Molecular Cell. 18, 6, p. 699-709 11 p.

研究成果: ジャーナルへの寄稿記事

VDJ Recombinases
Ubiquitination
Cell Cycle
S Phase
SKP Cullin F-Box Protein Ligases
428 引用 (Scopus)

U Box Proteins as a New Family of Ubiquitin-Protein Ligases

Hatakeyama, S., Yada, M., Matsumoto, M., Ishida, N. & Nakayama, K. I., 8 31 2001, : : Journal of Biological Chemistry. 276, 35, p. 33111-33120 10 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin-Protein Ligases
Ubiquitin
Fungal Proteins
Ubiquitination
Enzymes
59 引用 (Scopus)

Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis

Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C., Hattori, T., Oda, T., Nakayama, K., Nakayama, K. I., Tanaka, T., Konno, H. & Kitagawa, M., 12 15 2006, : : Cancer Research. 66, 24, p. 11623-11631 9 p.

研究成果: ジャーナルへの寄稿記事

G-Protein-Coupled Receptors
Up-Regulation
Down-Regulation
Neoplasm Metastasis
Carcinoma
15 引用 (Scopus)

Usefulness of flow-cytometric cell sorting for enrichment of hepatic stem and progenitor cells in the liver

Taniguchi, H., Suzuki, A., Zheng, Y., Kondo, R., Takada, Y., Fukunaga, K., Seino, K., Yuzawa, K., Otsuka, M., Fukao, K. & Nakauchi, H., 3 1 2000, : : Transplantation Proceedings. 32, 2, p. 249-251 3 p.

研究成果: ジャーナルへの寄稿記事

Inbred BALB C Mouse
Colony-Forming Units Assay
Hypoxanthine Phosphoribosyltransferase
Hepatocyte Growth Factor
Cell Separation
7 引用 (Scopus)

Use of cDNA Tiling Arrays for Identifying Protein Interactions Selected by In Vitro Display Technologies

Horisawa, K., Doi, N. & Yanagawa, H., 12 1 2008, : : PloS one. 3, 2, e0001646.

研究成果: ジャーナルへの寄稿記事

Oligonucleotide Array Sequence Analysis
Complementary DNA
Display devices
Technology
Messenger RNA
12 引用 (Scopus)

UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., Shiiya, N. & Kitagawa, M., 1 1 2016, : : Molecular and cellular biology. 36, 3, p. 394-406 13 p.

研究成果: ジャーナルへの寄稿記事

Histone Acetyltransferases
Phosphorylation
Cell Proliferation
Replication Origin
DNA Damage
21 引用 (Scopus)

Vasopressin-induced contraction of uterus is mediated solely by the oxytocin receptor in mice, but not in humans

Kawamata, M., Mitsui-Saito, M., Kimura, T., Takayanagi, Y., Yanagisawa, T. & Nishimori, K., 7 11 2003, : : European Journal of Pharmacology. 472, 3, p. 229-234 6 p.

研究成果: ジャーナルへの寄稿記事

Myometrium
Vasopressins
Uterus
Oxytocin
Oxytocin Receptors
313 引用 (Scopus)

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kamura, T., Maenaka, K., Kotoshiba, S., Matsumoto, M., Kohda, D., Conaway, R. C., Conaway, J. W. & Nakayama, K. I., 12 15 2004, : : Genes and Development. 18, 24, p. 3055-3065 11 p.

研究成果: ジャーナルへの寄稿記事

Suppressor of Cytokine Signaling Proteins
Ligases
Ubiquitin
Cullin Proteins
RNA Interference
107 引用 (Scopus)

What determines the specificity and outcomes of Ubiquitin signaling?

Ikeda, F., Crosetto, N. & Dikic, I., 11 24 2010, : : Cell. 143, 5, p. 677-681 5 p.

研究成果: ジャーナルへの寄稿記事

公開
Ubiquitin
Monitoring
4 引用 (Scopus)

Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development

Ishiuchi, T., Ohishi, H., Sato, T., Kamimura, S., Yorino, M., Abe, S., Suzuki, A., Wakayama, T., Suyama, M. & Sasaki, H., 5 7 2019, : : Cell Reports. 27, 6, p. 1742-1754.e6

研究成果: ジャーナルへの寄稿記事

公開
Placentation
Trophoblasts
Stem cells
Transcriptome
Stem Cells
24 引用 (Scopus)

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway

Adachi, S., Homoto, M., Tanaka, R., Hioki, Y., Murakami, H., Suga, H., Matsumoto, M., Nakayama, K. I., Hatta, T., Iemura, S. I. & Natsume, T., 1 1 2014, : : Nucleic acids research. 42, 15, p. 10037-10049 13 p.

研究成果: ジャーナルへの寄稿記事

LDL Receptors
RNA Stability
Phosphotransferases
Messenger RNA
Antisense Oligonucleotides
24 引用 (Scopus)

Zoledronic Acid Enhances Lipopolysaccharide-Stimulated Proinflammatory Reactions through Controlled Expression of SOCS1 in Macrophages

Muratsu, D., Yoshiga, D., Taketomi, T., Onimura, T., Seki, Y., Matsumoto, A. & Nakamura, S., 7 9 2013, : : PloS one. 8, 7, e67906.

研究成果: ジャーナルへの寄稿記事

zoledronic acid
Bisphosphonate-Associated Osteonecrosis of the Jaw
Macrophages
Diphosphonates
jaws