細胞機能制御学部門

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Zoledronic Acid Enhances Lipopolysaccharide-Stimulated Proinflammatory Reactions through Controlled Expression of SOCS1 in Macrophages

Muratsu, D., Yoshiga, D., Taketomi, T., Onimura, T., Seki, Y., Matsumoto, A. & Nakamura, S., 7 9 2013, : : PloS one. 8, 7, e67906.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

ZFP36L1 and ZFP36L2 control LDLR mRNA stability via the ERK-RSK pathway

Adachi, S., Homoto, M., Tanaka, R., Hioki, Y., Murakami, H., Suga, H., Matsumoto, M., Nakayama, K. I., Hatta, T., Iemura, S. I. & Natsume, T., 1 1 2014, : : Nucleic acids research. 42, 15, p. 10037-10049 13 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Zfp281 Shapes the Transcriptome of Trophoblast Stem Cells and Is Essential for Placental Development

Ishiuchi, T., Ohishi, H., Sato, T., Kamimura, S., Yorino, M., Abe, S., Suzuki, A., Wakayama, T., Suyama, M. & Sasaki, H., 5 7 2019, : : Cell Reports. 27, 6, p. 1742-1754.e6

研究成果: ジャーナルへの寄稿記事

公開
4 引用 (Scopus)

What determines the specificity and outcomes of Ubiquitin signaling?

Ikeda, F., Crosetto, N. & Dikic, I., 11 24 2010, : : Cell. 143, 5, p. 677-681 5 p.

研究成果: ジャーナルへの寄稿記事

公開
107 引用 (Scopus)

VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases

Kamura, T., Maenaka, K., Kotoshiba, S., Matsumoto, M., Kohda, D., Conaway, R. C., Conaway, J. W. & Nakayama, K. I., 12 15 2004, : : Genes and Development. 18, 24, p. 3055-3065 11 p.

研究成果: ジャーナルへの寄稿記事

316 引用 (Scopus)

UV damage-induced phosphorylation of HBO1 triggers CRL4DDB2-mediated degradation to regulate cell proliferation

Matsunuma, R., Niida, H., Ohhata, T., Kitagawa, K., Sakai, S., Uchida, C., Shiotani, B., Matsumoto, M., Nakayama, K. I., Ogura, H., Shiiya, N. & Kitagawa, M., 1 1 2016, : : Molecular and cellular biology. 36, 3, p. 394-406 13 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Up-regulation of GPR48 induced by down-regulation of p27Kip1 enhances carcinoma cell invasiveness and metastasis

Gao, Y., Kitagawa, K., Hiramatsu, Y., Kikuchi, H., Isobe, T., Shimada, M., Uchida, C., Hattori, T., Oda, T., Nakayama, K., Nakayama, K. I., Tanaka, T., Konno, H. & Kitagawa, M., 12 15 2006, : : Cancer Research. 66, 24, p. 11623-11631 9 p.

研究成果: ジャーナルへの寄稿記事

59 引用 (Scopus)

U Box Proteins as a New Family of Ubiquitin-Protein Ligases

Hatakeyama, S., Yada, M., Matsumoto, M., Ishida, N. & Nakayama, K. I., 8 31 2001, : : Journal of Biological Chemistry. 276, 35, p. 33111-33120 10 p.

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428 引用 (Scopus)

Ubiquitylation of RAG-2 by Skp2-SCF links destruction of the V(D)J recombinase to the cell cycle

Jiang, H., Chang, F. C., Ross, A. E., Lee, J., Nakayama, K., Nakayama, K. & Desiderio, S., 6 10 2005, : : Molecular Cell. 18, 6, p. 699-709 11 p.

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87 引用 (Scopus)

Ubiquitylation and degradation of serum-inducible kinase by hVPS18, a RING-H2 type ubiquitin ligase

Yogosawa, S., Hatakeyama, S., Nakayama, K., Miyoshi, H., Kohsaka, S. & Akazawa, C., 12 16 2005, : : Journal of Biological Chemistry. 280, 50, p. 41619-41627 9 p.

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25 引用 (Scopus)

Ubiquitin ligase SPSB4 diminishes cell repulsive responses mediated by EphB2

Okumura, F., Joo-Okumura, A., Obara, K., Petersen, A., Nishikimi, A., Fukui, Y., Nakatsukasa, K. & Kamura, T., 11 15 2017, : : Molecular biology of the cell. 28, 24, p. 3532-3541 10 p.

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3 引用 (Scopus)

Ubiquitin-dependent proteolysis by SCF complex

Nakayama, K. & Nakayama, K. I., 12 1 2000, : : Seikagaku. 72, 2, p. 113-117 5 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoé, K., Good, R. A. & Nakayama, K. I., 3 30 1999, : : Proceedings of the National Academy of Sciences of the United States of America. 96, 7, p. 3859-3863 5 p.

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168 引用 (Scopus)

UBE4B promotes Hdm2-mediated degradation of the tumor suppressor p53

Wu, H., Pomeroy, S. L., Ferreira, M., Teider, N., Mariani, J., Nakayama, K. I., Hatakeyama, S., Tron, V. A., Saltibus, L. F., Spyracopoulos, L. & Leng, R. P., 3 1 2011, : : Nature medicine. 17, 3, p. 347-355 9 p.

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64 引用 (Scopus)

Tyrosine kinase 2 plays critical roles in the pathogenic CD4 T cell responses for the development of experimental autoimmune encephalomyelitis

Oyamada, A., Ikebe, H., Itsumi, M., Saiwai, H., Okada, S., Shimoda, K., Iwakura, Y., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., 12 1 2009, : : Journal of Immunology. 183, 11, p. 7539-7546 8 p.

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35 引用 (Scopus)

Tyk2-signaling plays an important role in host defense against Escherichia coli through IL-23-induced IL-17 production by γδ T cells

Nakamura, R., Shibata, K., Yamada, H., Shimoda, K., Nakayama, K. & Yoshikai, Y., 8 1 2008, : : Journal of Immunology. 181, 3, p. 2071-2075 5 p.

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49 引用 (Scopus)

Tyk2 signaling in host environment plays an important role in contraction of antigen-specific CD8+ T cells following a microbial infection

Li, W., Yamada, H., Yajima, T., Nakagawa, R., Shimoda, K., Nakayama, K. & Yoshikai, Y., 4 1 2007, : : Journal of Immunology. 178, 7, p. 4482-4488 7 p.

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4 引用 (Scopus)

Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function

Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S., Shibata, S., Asano, Y., Gondo, H., Sekiguchi, K., Nakayama, K., Nakayama, T., Okamura, T., Okamura, S., Niho, Y. & Nakayama, K. I., 1 1 2000, : : Immunity. 13, 4, p. 561-571 11 p.

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238 引用 (Scopus)

Tyk2 is essential for IFN-α-induced gene expression in mast cells

Mori, Y., Hirose, K., Suzuki, K., Nakajima, H., Seto, Y., Ikeda, K., Shimoda, K., Nakayama, K. I., Saito, Y. & Iwamoto, I., 6 15 2004, : : International Archives of Allergy and Immunology. 134, SUPPL. 1, p. 25-29 5 p.

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9 引用 (Scopus)

Tyk2-dependent bystander activation of conventional and nonconventional Th1 cell subsets contributes to innate host defense against listeria monocytogenes infection

Hashiguchi, T., Oyamada, A., Sakuraba, K., Shimoda, K., Nakayama, K. I., Iwamoto, Y., Yoshikai, Y. & Yamada, H., 5 15 2014, : : Journal of Immunology. 192, 10, p. 4739-4747 9 p.

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8 引用 (Scopus)

Two inhibitory systems and CKIs regulate cell cycle exit of mammalian cardiomyocytes after birth

Tane, S., Okayama, H., Ikenishi, A., Amemiya, Y., Nakayama, K. & Takeuchi, T., 10 16 2015, : : Biochemical and Biophysical Research Communications. 466, 2, p. 147-154 8 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis

Nishitani, H., Sugimoto, N., Roukos, V., Nakanishi, Y., Saijo, M., Obuse, C., Tsurimoto, T., Nakayama, K. I., Nakayama, K., Fujita, M., Lygerou, Z. & Nishimoto, T., 3 8 2006, : : EMBO Journal. 25, 5, p. 1126-1136 11 p.

研究成果: ジャーナルへの寄稿記事

279 引用 (Scopus)

Two distinct knockout approaches highlight a critical role for p53 in rat development

Kawamata, M. & Ochiya, T., 12 1 2012, : : Scientific reports. 2, 945.

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11 引用 (Scopus)

Truncation mutants of ASXL1 observed in myeloid malignancies are expressed at detectable protein levels

Inoue, D., Matsumoto, M., Nagase, R., Saika, M., Fujino, T., Nakayama, K. I. & Kitamura, T., 3 1 2016, : : Experimental Hematology. 44, 3, p. 172-176.e1

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24 引用 (Scopus)

TRIM8 regulates Nanog via Hsp90β-mediated nuclear translocation of STAT3 in embryonic stem cells

Okumura, F., Okumura, A. J., Matsumoto, M., Nakayama, K. I. & Hatakeyama, S., 10 1 2011, : : Biochimica et Biophysica Acta - Molecular Cell Research. 1813, 10, p. 1784-1792 9 p.

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18 引用 (Scopus)

TRIM8 modulates STAT3 activity through negative regulation of PIAS3

Okumura, F., Matsunaga, Y., Katayama, Y., Nakayama, K. I. & Hatakeyama, S., 7 1 2010, : : Journal of Cell Science. 123, 13, p. 2238-2245 8 p.

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45 引用 (Scopus)

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 2018, : : iScience. 7, p. 212-229

研究成果: ジャーナルへの寄稿記事

Trans-omic Analysis Reveals Selective Responses to Induced and Basal Insulin across Signaling, Transcriptional, and Metabolic Networks

Kawata, K., Hatano, A., Yugi, K., Kubota, H., Sano, T., Fujii, M., Tomizawa, Y., Kokaji, T., Tanaka, K. Y., Uda, S., Suzuki, Y., Matsumoto, M., Nakayama, K. I., Saitoh, K., Kato, K., Ueno, A., Ohishi, M., Hirayama, A., Soga, T. & Kuroda, S., 9 28 2018, : : iScience. 7, p. 212-229 18 p.

研究成果: ジャーナルへの寄稿記事

公開
7 引用 (Scopus)

Transcription factors interfering with dedifferentiation induce cell type-specific transcriptional profiles

Hikichi, T., Matoba, R., Ikeda, T., Watanabe, A., Yamamoto, T., Yoshitake, S., Tamura-Nakano, M., Kimura, T., Kamon, M., Shimura, M., Kawakami, K., Okuda, A., Okochi, H., Inoue, T., Suzuki, A. & Masui, S., 4 16 2013, : : Proceedings of the National Academy of Sciences of the United States of America. 110, 16, p. 6412-6417 6 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Transcription Factor PU.1 Represses and Activates Gene Expression in Early T Cells by Redirecting Partner Transcription Factor Binding

Hosokawa, H., Ungerbäck, J., Wang, X., Matsumoto, M., Nakayama, K. I., Cohen, S. M., Tanaka, T. & Rothenberg, E. V., 6 19 2018, : : Immunity. 48, 6, p. 1119-1134.e7

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19 引用 (Scopus)

Transcriptional up-regulation of MMP12 and MMP13 by asbestos occurs via a PKCδ-dependent pathway in murine lung

Shukla, A., Barrett, T. F., Nakayama, K., Nakayama, K., Mossman, B. T. & Lounsbury, K. M., 5 2006, : : FASEB Journal. 20, 7

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)

TMEM55B contributes to lysosomal homeostasis and amino acid–induced mTORC1 activation

Hashimoto, Y., Shirane, M. & Nakayama, K. I., 6 2018, : : Genes to Cells. 23, 6, p. 418-434 17 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)
19 引用 (Scopus)

The Tumor Suppressor Hace1 Is a Critical Regulator of TNFR1-Mediated Cell Fate

Tortola, L., Nitsch, R., Bertrand, M. J. M., Kogler, M., Redouane, Y., Kozieradzki, I., Uribesalgo, I., Fennell, L. M., Daugaard, M., Klug, H., Wirnsberger, G., Wimmer, R., Perlot, T., Sarao, R., Rao, S., Hanada, T., Takahashi, N., Kernbauer, E., Demiröz, D., Superti-Furga, G. および7人, Decker, T., Pichler, A., Ikeda, F., Kroemer, G., Vandenabeele, P., Sorensen, P. H. & Penninger, J. M., 5 17 2016, : : Cell Reports. 15, 7, p. 1481-1492 12 p.

研究成果: ジャーナルへの寄稿記事

公開
15 引用 (Scopus)

The SOCS Box of SOCS-1 Accelerates Ubiquitin-dependent Proteolysis of TEL-JAK2

Kamizono, S., Hanada, T., Yasukawa, H., Minoguchi, S., Kato, R., Minoguchi, M., Hattori, K., Hatakeyama, S., Yada, M., Morita, S., Kitamura, T., Kato, H., Nakayama, K. I. & Yoshimura, A., 4 20 2001, : : Journal of Biological Chemistry. 276, 16, p. 12530-12538 9 p.

研究成果: ジャーナルへの寄稿記事

248 引用 (Scopus)

The Skp2-SCF E3 ligase regulates akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis

Chan, C. H., Li, C. F., Yang, W. L., Gao, Y., Lee, S. W., Feng, Z., Huang, H. Y., Tsai, K. K. C., Flores, L. G., Shao, Y., Hazle, J. D., Yu, D., Wei, W., Sarbassov, D., Hung, M. C., Nakayama, K. I. & Lin, H. K., 5 25 2012, : : Cell. 149, 5, p. 1098-1111 14 p.

研究成果: ジャーナルへの寄稿記事

201 引用 (Scopus)

The SKP2 E3 ligase regulates basal homeostasis and stress-induced regeneration of HSCs

Rodriguez, S., Wang, L., Mumaw, C., Srour, E. F., Lo Celso, C., Nakayama, K. I. & Carlesso, N., 6 16 2011, : : Blood. 117, 24, p. 6509-6519 11 p.

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29 引用 (Scopus)

The second phase activation of protein kinase C δ at late G1 is required for DNA synthesis in serum-induced cell cycle progression

Kitamura, K., Mizuno, K., Etoh, A., Akita, Y., Miyamoto, A., Nakayama, K. & Ohno, S., 4 1 2003, : : Genes to Cells. 8, 4, p. 311-324 14 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

The SCFβ-TRCP E3 ubiquitin ligase complex targets Lipin1 for ubiquitination and degradation to promote hepatic lipogenesis

Shimizu, K., Fukushima, H., Ogura, K., Lien, E. C., Nihira, N. T., Zhang, J., North, B. J., Guo, A., Nagashima, K., Nakagawa, T., Hoshikawa, S., Watahiki, A., Okabe, K., Yamada, A., Toker, A., Asara, J. M., Fukumoto, S., Nakayama, K. I., Nakayama, K., Inuzuka, H. および1人, Wei, W., 1 3 2017, : : Science Signaling. 10, 460

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

The role of β-TrCP1 and β-TrCP2 in circadian rhythm generation by mediating degradation of clock protein PER2

Ohsaki, K., Oishi, K., Kozono, Y., Nakayama, K., Nakayama, K. & Ishida, N., 11 1 2008, : : Journal of biochemistry. 144, 5, p. 609-618 10 p.

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

The reduction of cell death and proliferation by p27 Kip1 minimizes DNA damage in an experimental model of genotoxicity

Ranchal, I., González, R., Bello, R. I., Ferrín, G., Hidalgo, A. B., Linares, C. I., Aguilar-Melero, P., González-Rubio, S., Barrera, P., Marchal, T., Nakayama, K. I., De La Mata, M. & Muntané, J., 11 15 2009, : : International Journal of Cancer. 125, 10, p. 2270-2280 11 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment

Takii, R., Fujimoto, M., Matsumoto, M., Srivastava, P., Katiyar, A., Nakayama, K. I. & Nakai, A., 12 16 2019, : : EMBO Journal. 38, 24, e102566.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

The pathophysiologic role of the protein kinase Cδ pathway in the intervertebral discs of rabbits and mice: In vitro, ex vivo, and in vivo studies

Ellman, M. B., Kim, J. S., An, H. S., Kroin, J. S., Li, X., Chen, D., Yan, D., Buechter, D. D., Nakayama, K., Liu, B., Morgan, S. & Im, H. J., 6 1 2012, : : Arthritis and rheumatism. 64, 6, p. 1950-1959 10 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

The Parkin-coregulated gene product PACRG promotes TNF signaling by stabilizing LUBAC

Meschede, J., Šadić, M., Furthmann, N., Miedema, T., Sehr, D. A., Müller-Rischart, A. K., Bader, V., Berlemann, L. A., Pilsl, A., Schlierf, A., Barkovits, K., Kachholz, B., Rittinger, K., Ikeda, F., Marcus, K., Schaefer, L., Tatzelt, J. & Winklhofer, K. F., 2 4 2020, : : Science Signaling. 13, 617, eaav1256.

研究成果: ジャーナルへの寄稿記事

The Papillomavirus E7 Oncoprotein Is Ubiquitinated by UbcH7 and Cullin 1- and Skp2-Containing E3 Ligase

Oh, K. J., Kalinina, A., Wang, J., Nakayama, K., Nakayama, K. I. & Bagchi, S., 5 1 2004, : : Journal of virology. 78, 10, p. 5338-5346 9 p.

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60 引用 (Scopus)

The novel heart-specific RING finger protein 207 is involved in energy metabolism in cardiomyocytes

Mizushima, W., Takahashi, H., Watanabe, M., Kinugawa, S., Matsushima, S., Takada, S., Yokota, T., Furihata, T., Matsumoto, J., Tsuda, M., Chiba, I., Nagashima, S., Yanagi, S., Matsumoto, M., Nakayama, K. I., Tsutsui, H. & Hatakeyama, S., 11 1 2016, : : Journal of Molecular and Cellular Cardiology. 100, p. 43-53 11 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

The ISG15 isopeptidase UBP43 is regulated by proteolysis via the SCF Skp2 ubiquitin ligase

Tokarz, S., Berset, C., La Rue, J., Friedman, K., Nakayama, K. I., Nakayama, K., Zhang, D. E. & Lanker, S., 11 5 2004, : : Journal of Biological Chemistry. 279, 45, p. 46424-46430 7 p.

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35 引用 (Scopus)

The FBXL5-IRP2 axis is integral to control of iron metabolism in vivo

Moroishi, T., Nishiyama, M., Takeda, Y., Iwai, K. & Nakayama, K. I., 9 7 2011, : : Cell metabolism. 14, 3, p. 339-351 13 p.

研究成果: ジャーナルへの寄稿記事

73 引用 (Scopus)

The F box protein S phase kinase-associated protein 2 regulates adipose mass and adipocyte number in vivo

Cooke, P. S., Holsberger, D. R., Cimafranca, M. A., Meling, D. D., Beals, C. M., Nakayama, K., Nakayama, K. I. & Kiyokawa, H., 6 1 2007, : : Obesity. 15, 6, p. 1400-1408 9 p.

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11 引用 (Scopus)

The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription

Von Der Lehr, N., Johansson, S., Wu, S., Bahram, F., Castell, A., Cetinkaya, C., Hydbring, P., Weidung, I., Nakayama, K., Nakayama, K. I., Söderberg, O., Kerppola, T. K. & Larsson, L. G., 5 1 2003, : : Molecular Cell. 11, 5, p. 1189-1200 12 p.

研究成果: ジャーナルへの寄稿記事

357 引用 (Scopus)