細胞機能制御学部門

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Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes

Shinkai, Y., Koyasu, S., Nakayama, K. I., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., 1 1 1993, : : Science. 259, 5096, p. 822-825 4 p.

研究成果: ジャーナルへの寄稿記事

344 引用 (Scopus)

Reproductive toxicity of ethylene glycol monoethyl ether in Aldh2 knockout mice

Wang, R. S., Ohtani, K., Suda, M., Kitagawa, K., Nakayama, K., Kawamoto, T. & Nakajima, T., 8 1 2007, : : Industrial health. 45, 4, p. 574-578 5 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

Renal damage in obstructive nephropathy is decreased in Skp2-deficient mice

Suzuki, S., Fukasawa, H., Kitagawa, K., Uchida, C., Hattori, T., Isobe, T., Oda, T., Misaki, T., Ohashi, N., Nakayama, K., Nakayama, K. I., Hishida, A., Yamamoto, T. & Kitagawa, M., 8 2007, : : American Journal of Pathology. 171, 2, p. 473-483 11 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

Regulation of the Level of Vesl-1S/Homer-1a Proteins by Ubiquitin-Proteasome Proteolytic Systems

Ageta, H., Kato, A., Hatakeyama, S., Nakayama, K. I., Isojima, Y. & Sugiyama, H., 5 11 2001, : : Journal of Biological Chemistry. 276, 19, p. 15893-15897 5 p.

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

Regulation of SV40 large T-antigen stability by reversible acetylation

Shimazu, T., Komatsu, Y., Nakayama, K. I., Fukazawa, H., Horinouchi, S. & Yoshida, M., 11 30 2006, : : Oncogene. 25, 56, p. 7391-7400 10 p.

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)

Regulation of GATA-binding protein 2 levels via ubiquitin-dependent degradation by Fbw7: Involvement of cyclin B-cyclin-dependent kinase 1-mediated phosphorylation of Thr176 in GATA-binding protein 2

Nakajima, T., Kitagawa, K., Ohhata, T., Sakai, S., Uchida, C., Shibata, K., Minegishi, N., Yumimoto, K., Nakayama, K. I., Masumoto, K., Katou, F., Niida, H. & Kitagawa, M., 4 17 2015, : : Journal of Biological Chemistry. 290, 16, p. 10368-10381 14 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Regulation of c-Myc ubiquitination controls chronic myelogenous leukemia initiation and progression

Reavie, L., Buckley, S. M., Loizou, E., Takeishi, S., Aranda-Orgilles, B., Ndiaye-Lobry, D., Abdel-Wahab, O., Ibrahim, S., Nakayama, K. I. & Aifantis, I., 3 18 2013, : : Cancer Cell. 23, 3, p. 362-375 14 p.

研究成果: ジャーナルへの寄稿記事

64 引用 (Scopus)

Regulation of apoptosis and neurite extension by FKBP38 is required for neural tube formation in the mouse

Shirane, M., Ogawa, M., Motoyama, J. & Nakayama, K. I., 6 1 2008, : : Genes to Cells. 13, 6, p. 635-651 17 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

Regulation of APC/C Cdc20 activity by RASSF1A-APC/C Cdc20 circuitry

Chow, C., Wong, N., Pagano, M., Lun, S. W. M., Nakayama, K. I., Nakayama, K. & Lo, K. W., 4 12 2012, : : Oncogene. 31, 15, p. 1975-1987 13 p.

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

Recovery of liver mass without proliferation of hepatocytes after partial hepatectomy in Skp2-deficient mice

Minamishima, Y. A., Nakayama, K. & Nakayama, K., 2002, : : Cancer Research. 62, 4, p. 995-999 5 p.

研究成果: ジャーナルへの寄稿記事

55 引用 (Scopus)

Reconstruction of insulin signal flow from phosphoproteome and metabolome data

Yugi, K., Kubota, H., Toyoshima, Y., Noguchi, R., Kawata, K., Komori, Y., Uda, S., Kunida, K., Tomizawa, Y., Funato, Y., Miki, H., Matsumoto, M., Nakayama, K. I., Kashikura, K., Endo, K., Ikeda, K., Soga, T. & Kuroda, S., 8 21 2014, : : Cell Reports. 8, 4, p. 1171-1183 13 p.

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

Reconstruction of global regulatory network from signaling to cellular functions using phosphoproteomic data

Kawata, K., Yugi, K., Hatano, A., Kokaji, T., Tomizawa, Y., Fujii, M., Uda, S., Kubota, H., Matsumoto, M., Nakayama, K. I. & Kuroda, S., 1 2019, : : Genes to Cells. 24, 1, p. 82-93 12 p.

研究成果: ジャーナルへの寄稿記事

PURE mRNA display for in vitro selection of single-chain antibodies

Nagumo, Y., Fujiwara, K., Horisawa, K., Yanagawa, H. & Doi, N., 5 1 2016, : : Journal of biochemistry. 159, 5, p. 519-526 8 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Protrudin serves as an adaptor molecule that connects KIF5 and its cargoes in vesicular transport during process formation

Matsuzaki, F., Shirane, M., Matsumoto, M. & Nakayama, K. I., 12 1 2011, : : Molecular biology of the cell. 22, 23, p. 4602-4620 19 p.

研究成果: ジャーナルへの寄稿記事

51 引用 (Scopus)

Protrudin regulates membrane recycling system

Shirane, M., 12 1 2007, : : Seikagaku. 79, 8, p. 794-796 3 p.

研究成果: ジャーナルへの寄稿記事

Protrudin regulates endoplasmic reticulum morphology and function associated with the pathogenesis of hereditary spastic paraplegia

Hashimoto, Y., Shirane, M., Matsuzaki, F., Saita, S., Ohnishi, T. & Nakayama, K. I., 1 1 2014, : : Journal of Biological Chemistry. 289, 19, p. 12946-12961 16 p.

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)

Protrudin induces neurite formation by directional membrane trafficking

Shirane, M. & Nakayama, K. I., 11 3 2006, : : Science. 314, 5800, p. 818-821 4 p.

研究成果: ジャーナルへの寄稿記事

128 引用 (Scopus)

Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin

Oshikawa, K., Matsumoto, M., Oyamada, K. & Nakayama, K. I., 2 3 2012, : : Journal of Proteome Research. 11, 2, p. 796-807 12 p.

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

Proteome of ubiquitin/MVB pathway: Possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation

Tachiyama, R., Ishikawa, D., Matsumoto, M., Nakayama, K. I., Yoshimori, T., Yokota, S., Himeno, M., Tanaka, Y. & Fujita, H., 4 1 2011, : : Genes to Cells. 16, 4, p. 448-466 19 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

Protein kinase Cδ plays a non-redundant role in insulin secretion in pancreatic β cells

Uchida, T., Iwashita, N., Ohara-Imaizumi, M., Ogihara, T., Nagai, S., Choi, J. B., Tamura, Y., Tada, N., Kawamori, R., Nakayama, K. I., Nagamatsu, S. & Watada, H., 1 26 2007, : : Journal of Biological Chemistry. 282, 4, p. 2707-2716 10 p.

研究成果: ジャーナルへの寄稿記事

52 引用 (Scopus)

Protein kinase C-δ phosphorylates Ebp1 and prevents its proteolytic degradation, enhancing cell survival

Liu, Z., Liu, X., Nakayama, K., Nakayama, K. & Ye, K., 3 1 2007, : : Journal of Neurochemistry. 100, 5, p. 1278-1288 11 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Protein kinase C-δ and phosphatidylinositol 3-Kinase/Akt activate mammalian target of rapamycin to modulate NF-κB activation and intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells

Minhajuddin, M., Bijli, K. M., Fazal, F., Sassano, A., Nakayama, K. I., Hay, N., Platanias, L. C. & Rahman, A., 2 13 2009, : : Journal of Biological Chemistry. 284, 7, p. 4052-4061 10 p.

研究成果: ジャーナルへの寄稿記事

53 引用 (Scopus)

Protein kinase C δ activates topoisomerase IIα to induce apoptotic cell death in response to DNA damage

Yoshida, K., Yamaguchi, T., Shinagawa, H., Taira, N., Nakayama, K. I. & Miki, Y., 5 1 2006, : : Molecular and cellular biology. 26, 9, p. 3414-3431 18 p.

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

Protein kinase C-delta deficiency perturbs bone homeostasis by selective uncoupling of cathepsin K secretion and ruffled border formation in osteoclasts

Cremasco, V., Decker, C. E., Stumpo, D., Blackshear, P. J., Nakayama, K., Nakayama, K., Lupu, T. S., Graham, D. B., Novack, D. V. & Faccio, R., 12 1 2012, : : Journal of Bone and Mineral Research. 27, 12, p. 2452-2463 12 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

Protection of stromal cell-derived factor 2 by heat shock protein 72 prevents oxaliplatin-induced cell death in oxaliplatin-resistant human gastric cancer cells

Takahashi, K., Tanaka, M., Yashiro, M., Matsumoto, M., Ohtsuka, A., Nakayama, K. I., Izumi, Y., Nagayama, K., Miura, K., Iwao, H. & Shiota, M., 8 1 2016, : : Cancer Letters. 378, 1, p. 8-15 8 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Promotion of neurite extension by protrudin requires its interaction with vesicle-associated membrane protein-associated protein

Saita, S., Shirane, M., Natume, T., Iemura, S. I. & Nakayama, K. I., 5 15 2009, : : Journal of Biological Chemistry. 284, 20, p. 13766-13777 12 p.

研究成果: ジャーナルへの寄稿記事

44 引用 (Scopus)

Prolonged inhibition of hepatocellular carcinoma cell proliferation by combinatorial expression of defined transcription factors

Takashima, Y., Horisawa, K., Udono, M., Ohkawa, Y. & Suzuki, A., 11 2018, : : Cancer Science. 109, 11, p. 3543-3553 11 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis

Matsuhisa, K., Saito, A., Cai, L., Kaneko, M., Okamoto, T., Sakaue, F., Asada, R., Urano, F., Yanagida, K., Okochi, M., Kudo, Y., Matsumoto, M., Nakayama, K. I. & Imaizumi, K., 1 1 2020, : : FASEB Journal. 34, 1, p. 865-880 16 p.

研究成果: ジャーナルへの寄稿記事

公開

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K. I., 1 1 2019, : : JCI Insight. 4, 4, e125138.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Preferential interaction of TIP120A with Cul1 that is not modified by NEDD8 and not associated with Skp1

Oshikawa, K., Matsumoto, M., Yada, M., Kamura, T., Hatakeyama, S. & Nakayama, K. I., 4 18 2003, : : Biochemical and Biophysical Research Communications. 303, 4, p. 1209-1216 8 p.

研究成果: ジャーナルへの寄稿記事

52 引用 (Scopus)

Preferential inhibition of bone metastases by 5′-deoxy-5- fluorouridine and capecitabine in the 4T1/luc mouse breast cancer model

Hiraga, T., Hata, K., Ikeda, F., Kitagaki, J., Fujimoto-Ouchi, K., Tanaka, Y. & Yoneda, T., 9 2005, : : Oncology reports. 14, 3, p. 695-699 5 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

pRb phosphorylation is regulated differentially by cyclin-dependent kinase (Cdk) 2 and Cdk4 in retinoic acid-induced neuronal differentiation of P19 cells

Watanabe, Y., Watanabe, T., Kitagawa, M., Taya, Y., Nakayama, K. I. & Motoyama, N., 9 25 1999, : : Brain Research. 842, 2, p. 342-350 9 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

Polymorphism analysis of the upstream region of the human N-methyl-D-aspartate receptor subunit NR1 gene (GRIN1): Implications for schizophrenia

Tani, A., Kikuta, R., Itoh, K., Joo, A., Shibata, H., Ninomiya, H., Tashiro, N. & Fukumaki, Y., 11 1 2002, : : Schizophrenia research. 58, 1, p. 83-86 4 p.

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

Plasma gelsolin facilitates interaction between β2 glycoprotein I and α5β1 integrin

Bohgaki, M., Matsumoto, M., Atsumi, T., Kondo, T., Yasuda, S., Horita, T., Nakayama, K. I., Okumura, F., Hatakeyama, S. & Koike, T., 1 1 2011, : : Journal of Cellular and Molecular Medicine. 15, 1, p. 141-151 11 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

PKM1 Confers Metabolic Advantages and Promotes Cell-Autonomous Tumor Cell Growth

Morita, M., Sato, T., Nomura, M., Sakamoto, Y., Inoue, Y., Tanaka, R., Ito, S., Kurosawa, K., Yamaguchi, K., Sugiura, Y., Takizaki, H., Yamashita, Y., Katakura, R., Sato, I., Kawai, M., Okada, Y., Watanabe, H., Kondoh, G., Matsumoto, S., Kishimoto, A. および12人, Obata, M., Matsumoto, M., Fukuhara, T., Motohashi, H., Suematsu, M., Komatsu, M., Nakayama, K. I., Watanabe, T., Soga, T., Shima, H., Maemondo, M. & Tanuma, N., 3 12 2018, : : Cancer Cell. 33, 3, p. 355-367.e7

研究成果: ジャーナルへの寄稿記事

30 引用 (Scopus)

PKCδ regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation

Pula, G., Schuh, K., Nakayama, K., Nakayama, K. I., Walter, U. & Poole, A. W., 12 15 2006, : : Blood. 108, 13, p. 4035-4044 10 p.

研究成果: ジャーナルへの寄稿記事

80 引用 (Scopus)

PKCδ mediates Nrf2-dependent protection of neuronal cells from NO-induced apoptosis

Zhang, J., Hung, A. C., Ng, P. Y., Nakayama, K., Hu, Y., Li, B., Porter, A. G. & Dhakshinamoorthy, S., 9 4 2009, : : Biochemical and Biophysical Research Communications. 386, 4, p. 750-756 7 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

PKCδ is necessary for Smad3 expression and transforming growth factor β-induced fibronectin synthesis in vascular smooth muscle cells

Ryer, E. J., Hom, R. P., Sakakibara, K., Nakayama, K., Nakayama, K., Faries, P. L., Liu, B. & Kent, K. C., 4 1 2006, : : Arteriosclerosis, thrombosis, and vascular biology. 26, 4, p. 780-786 7 p.

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)

PKCδ inhibition enhances tyrosine hydroxylase phosphorylation in mice after methamphetamine treatment

Shin, E. J., Duong, C. X., Nguyen, X. K. T., Bing, G., Bach, J. H., Park, D. H., Nakayama, K., Ali, S. F., Kanthasamy, A. G., Cadet, J. L., Nabeshima, T. & Kim, H. C., 8 1 2011, : : Neurochemistry International. 59, 1, p. 39-50 12 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Shinkai, Y., Koyasu, S., Nakayama, K. I., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., 3 1 2019, : : Journal of immunology (Baltimore, Md. : 1950). 202, 5, p. 1317-1320 4 p.

研究成果: ジャーナルへの寄稿記事

Phosphorylation of β-catenin by cyclic AMP-dependent protein kinase stabilizes β-catenin through inhibition of its ubiquitination

Hino, S. I., Tanji, C., Nakayama, K. I. & Kikuchi, A., 10 1 2005, : : Molecular and cellular biology. 25, 20, p. 9063-9072 10 p.

研究成果: ジャーナルへの寄稿記事

274 引用 (Scopus)

Phosphorylation of the chromodomain changes the binding specificity of Cbx2 for methylated histone H3

Hatano, A., Matsumoto, M., Higashinakagawa, T. & Nakayama, K. I., 6 18 2010, : : Biochemical and Biophysical Research Communications. 397, 1, p. 93-99 7 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export

Ishida, N., Hara, T., Kamura, T., Yoshida, M., Nakayama, K. & Nakayama, K. I., 4 26 2002, : : Journal of Biological Chemistry. 277, 17, p. 14355-14358 4 p.

研究成果: ジャーナルへの寄稿記事

230 引用 (Scopus)

Phosphorylation of p27(KIP1) in the mitotic cells of the corneal epithelium

Kase, S., Yoshida, K., Ohgami, K., Shiratori, K., Ohno, S. & Nakayama, K. I., 5 1 2006, : : Current Eye Research. 31, 4, p. 307-312 6 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Phosphorylation of Noxo1 at threonine 341 regulates its interaction with Noxa1 and the superoxide-producing activity of Nox1

Yamamoto, A., Takeya, R., Matsumoto, M., Nakayama, K. I. & Sumimoto, H., 10 1 2013, : : FEBS Journal. 280, 20, p. 5145-5159 15 p.

研究成果: ジャーナルへの寄稿記事

20 引用 (Scopus)

Phosphorylation of extracellular signal-regulated kinase and p27(KIP1) after retinal detachment

Kase, S., Yoshida, K., Harada, T., Harada, C., Namekata, K., Suzuki, Y., Ohgami, K., Shiratori, K., Nakayama, K. I. & Ohno, S., 3 1 2006, : : Graefe's Archive for Clinical and Experimental Ophthalmology. 244, 3, p. 352-358 7 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB

Lin, H. K., Wang, G., Chen, Z., Teruya-Feldstein, J., Liu, Y., Chan, C. H., Yang, W. L., Erdjument-Bromage, H., Nakayama, K. I., Nimer, S., Tempst, P. & Pandolfi, P. P., 3 9 2009, : : Nature Cell Biology. 11, 4, p. 420-432 13 p.

研究成果: ジャーナルへの寄稿記事

179 引用 (Scopus)

Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7

Yada, M., Hatakeyama, S., Kamura, T., Nishiyama, M., Tsunematsu, R., Imaki, H., Ishida, N., Okumura, F., Nakayama, K. & Nakayama, K. I., 5 19 2004, : : EMBO Journal. 23, 10, p. 2116-2125 10 p.

研究成果: ジャーナルへの寄稿記事

497 引用 (Scopus)

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

Ishida, N., Kitagawa, M., Hatakeyama, S. & Nakayama, K., 8 18 2000, : : Journal of Biological Chemistry. 275, 33, p. 25146-25154 9 p.

研究成果: ジャーナルへの寄稿記事

173 引用 (Scopus)

Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling

Hatano, A., Matsumoto, M. & Nakayama, K. I., 10 1 2016, : : Genes to Cells. 21, 10, p. 1095-1112 18 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)