細胞機能制御学部門

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Phosphoproteomics analyses show subnetwork systems in T-cell receptor signaling

Hatano, A., Matsumoto, M. & Nakayama, K. I., 10 1 2016, : : Genes to Cells. 21, 10, p. 1095-1112 18 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Phospholipase C-related but catalytically inactive protein is required for insulin-induced cell surface expression of γ-aminobutyric acid type A receptors

Fujii, M., Kanematsu, T., Ishibashi, H., Fukami, K., Takenawa, T., Nakayama, K. I., Moss, S. J., Nabekura, J. & Hirata, M., 2 12 2010, : : Journal of Biological Chemistry. 285, 7, p. 4837-4846 10 p.

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

Phosholipase C-related inactive protein is involved in trafficking of γ2 subunit-containing GABAA receptors to the cell surface

Mizokami, A., Kanematsu, T., Ishibashi, H., Yamaguchi, T., Tanida, I., Takenaka, K., Nakayama, K. I., Fukami, K., Takenawa, T., Kominami, E., Moss, S. J., Yamamoto, T., Nabekura, J. & Hirata, M., 2 14 2007, : : Journal of Neuroscience. 27, 7, p. 1692-1701 10 p.

研究成果: ジャーナルへの寄稿記事

72 引用 (Scopus)

Phase I dose-escalation trial to repurpose propagermanium, an oral CCL2 inhibitor, in patients with breast cancer

Masuda, T., Noda, M., Kogawa, T., Kitagawa, D., Hayashi, N., Jomori, T., Nakanishi, Y., Nakayama, K. I., Ohno, S. & Mimori, K., 3 1 2020, : : Cancer Science. 111, 3, p. 924-931 8 p.

研究成果: ジャーナルへの寄稿記事

公開
1 引用 (Scopus)

Peroxisome biogenesis deficiency attenuates the BDNF-TrkB pathway-mediated development of the cerebellum

Abe, Y., Honsho, M., Itoh, R., Kawaguchi, R., Fujitani, M., Fujiwara, K., Hirokane, M., Matsuzaki, T., Nakayama, K., Ohgi, R., Marutani, T., Nakayama, K. I., Yamashita, T. & Fujiki, Y., 1 1 2018, : : Life Science Alliance. 1, 6

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Partial impairment of interleukin-12 (IL-12) and IL-18 signaling in Tyk2-deficient mice

Shimoda, K., Tsutsui, H., Aoki, K., Kato, K., Matsuda, T., Numata, A., Takase, K., Yamamoto, T., Nukina, H., Hoshino, T., Asano, Y., Gondo, H., Okamura, T., Okamura, S., Nakayama, K. I., Nakanishi, K., Niho, Y. & Harada, M., 3 15 2002, : : Blood. 99, 6, p. 2094-2099 6 p.

研究成果: ジャーナルへの寄稿記事

59 引用 (Scopus)

P57 regulates T-cell development and prevents lymphomagenesis by balancing p53 activity and pre-TCR signaling

Matsumoto, A., Takeishi, S. & Nakayama, K. I., 5 29 2014, : : Blood. 123, 22, p. 3429-3439 11 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

p57KIP2 Modulates Stress-activated Signaling by Inhibiting c-Jun NH2-terminal Kinase/Stress-activated Protein Kinase

Chang, T. S., Kim, M. J., Ryoo, K., Park, J., Eom, S. J., Shim, J., Nakayama, K. I., Nakayama, K., Tomita, M., Takahashi, K., Lee, M. J. & Choi, E. J., 11 28 2003, : : Journal of Biological Chemistry. 278, 48, p. 48092-48098 7 p.

研究成果: ジャーナルへの寄稿記事

52 引用 (Scopus)

p57Kip2 knock-in mouse reveals CDK-independent contribution in the development of Beckwith–Wiedemann syndrome

Duquesnes, N., Callot, C., Jeannot, P., Daburon, V., Nakayama, K. I., Manenti, S., Davy, A. & Besson, A., 7 1 2016, : : Journal of Pathology. 239, 3, p. 250-261 12 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

P57 Kip2 and p27 Kip1 cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70

Zou, P., Yoshihara, H., Hosokawa, K., Tai, I., Shinmyozu, K., Tsukahara, F., Maru, Y., Nakayama, K., Nakayama, K. I. & Suda, T., 9 2 2011, : : Cell stem cell. 9, 3, p. 247-261 15 p.

研究成果: ジャーナルへの寄稿記事

167 引用 (Scopus)

P57 Is required for quiescence and maintenance of adult hematopoietic stem cells

Matsumoto, A., Takeishi, S., Kanie, T., Susaki, E., Onoyama, I., Tateishi, Y., Nakayama, K. & Nakayama, K. I., 9 2 2011, : : Cell stem cell. 9, 3, p. 262-271 10 p.

研究成果: ジャーナルへの寄稿記事

170 引用 (Scopus)

P57 controls adult neural stem cell quiescence and modulates the pace of lifelong neurogenesis

Furutachi, S., Matsumoto, A., Nakayama, K. I. & Gotoh, Y., 4 3 2013, : : EMBO Journal. 32, 7, p. 970-981 12 p.

研究成果: ジャーナルへの寄稿記事

74 引用 (Scopus)

P53-altered FBXW7 expression determines poor prognosis in gastric cancer cases

Yokobori, T., Mimori, K., Iwatsuki, M., Ishii, H., Onoyama, I., Fukagawa, T., Kuwano, H., Nakayama, K. I. & Mori, M., 5 1 2009, : : Cancer Research. 69, 9, p. 3788-3794 7 p.

研究成果: ジャーナルへの寄稿記事

110 引用 (Scopus)

p27 modulates tropism of mesenchymal stem cells toward brain tumors

Gao, Y., Gu, C., Li, S., Tokuyama, T., Yokota, N., Nakayama, K. I., Kitagawa, M. & Namba, H., 7 1 2010, : : Experimental and Therapeutic Medicine. 1, 4, p. 695-699 5 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

P27 is regulated independently of Skp2 in the absence of Cdk2

Kotoshiba, S., Gopinathan, L., Pfeiffenberger, E., Rahim, A., Vardy, L. A., Nakayama, K., Nakayama, K. I. & Kaldis, P., 2 1 2014, : : Biochimica et Biophysica Acta - Molecular Cell Research. 1843, 2, p. 436-445 10 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

p107 inhibits G1 to S phase progression by down-regulating expression of the F-box protein Skp2

Rodier, G., Makris, C., Coulombe, P., Scime, A., Nakayama, K., Nakayama, K. I. & Meloche, S., 1 3 2005, : : Journal of Cell Biology. 168, 1, p. 55-66 12 p.

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

Opposing functions of Fbxw7 in keratinocyte growth, differentiation and skin tumorigenesis mediated through negative regulation of c-Myc and Notch

Ishikawa, Y., Hosogane, M., Okuyama, R., Aoyama, S., Onoyama, I., Nakayama, K. I. & Nakayama, K., 4 11 2013, : : Oncogene. 32, 15, p. 1921-1932 12 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

Nucleolar structure and function are regulated by the deubiquitylating enzyme USP36

Endo, A., Matsumoto, M., Inada, T., Yamamoto, A., Nakayama, K. I., Kitamura, N. & Komada, M., 3 1 2009, : : Journal of cell science. 122, 5, p. 678-686 9 p.

研究成果: ジャーナルへの寄稿記事

46 引用 (Scopus)

Nuclear–cytoplasmic shuttling protein PP2AB56 contributes to mTORC1-dependent dephosphorylation of FOXK1

Nakatsumi, H., Oka, T., Higa, T., Shirane, M. & Nakayama, K. I., 7 2018, : : Genes to Cells. 23, 7, p. 599-605 7 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

nPKCε, a P2Y2-R downstream effector in regulated mucin secretion from airway goblet cells

Ehre, C., Zhu, Y., Abdullah, L. H., Olsen, J., Nakayama, K. I., Nakayama, K., Messing, R. O. & Davis, C. W., 11 1 2007, : : American Journal of Physiology - Cell Physiology. 293, 5, p. C1445-C1454

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

Notch-dependent cell cycle arrest and apoptosis in mouse embryonic fibroblasts lacking Fbxw7

Ishikawa, Y., Onoyama, I., Nakayama, K. I. & Nakayama, K., 10 16 2008, : : Oncogene. 27, 47, p. 6164-6174 11 p.

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)

NOTCH2 Hajdu-Cheney Mutations Escape SCFFBW7-Dependent Proteolysis to Promote Osteoporosis

Fukushima, H., Shimizu, K., Watahiki, A., Hoshikawa, S., Kosho, T., Oba, D., Sakano, S., Arakaki, M., Yamada, A., Nagashima, K., Okabe, K., Fukumoto, S., Jimi, E., Bigas, A., Nakayama, K. I., Nakayama, K., Aoki, Y., Wei, W. & Inuzuka, H., 11 16 2017, : : Molecular Cell. 68, 4, p. 645-658.e5

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)
90 引用 (Scopus)

Noncanonical Wnt Signaling through G Protein-Linked PKCδ Activation Promotes Bone Formation

Tu, X., Joeng, K. S., Nakayama, K. I., Nakayama, K., Rajagopal, J., Carroll, TJ. J., McMahon, A. P. & Long, F., 1 1 2007, : : Developmental Cell. 12, 1, p. 113-127 15 p.

研究成果: ジャーナルへの寄稿記事

218 引用 (Scopus)

Noncanonical Pathway for Regulation of CCL2 Expression by an mTORC1-FOXK1 Axis Promotes Recruitment of Tumor-Associated Macrophages

Nakatsumi, H., Matsumoto, M. & Nakayama, K. I., 11 28 2017, : : Cell Reports. 21, 9, p. 2471-2486 16 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)

New horizons in biological research developed by nextgeneration proteomics: Say good-bye to western blotting

Nakatsumi, H., Matsumoto, M. & Nakayama, K., 12 1 2012, : : Seikagaku. 84, 1, p. 53-57 5 p.

研究成果: ジャーナルへの寄稿記事

New High-Throughput Screening Identifies Compounds That Reduce Viability Specifically in Liver Cancer Cells That Express High Levels of SALL4 by Inhibiting Oxidative Phosphorylation

Tan, J. L., Li, F., Yeo, J. Z., Yong, K. J., Bassal, M. A., Ng, G. H., Lee, M. Y., Leong, C. Y., Tan, H. K., Wu, C. S., Liu, B. H., Chan, T. H., Tan, Z. H., Chan, Y. S., Wang, S., Lim, Z. H., Toh, T. B., Hooi, L., Low, K. N., Ma, S. および17人, Kong, N. R., Stein, A. J., Wu, Y., Thangavelu, M. T., Suzuki, A., Periyasamy, G., Asara, J. M., Dan, Y. Y., Bonney, G. K., Chow, E. K., Lu, G. D., Ng, H. H., Kanagasundaram, Y., Ng, S. B., Tam, W. L., Tenen, D. G. & Chai, L., 12 2019, : : Gastroenterology. 157, 6, p. 1615-1629.e17

研究成果: ジャーナルへの寄稿記事

公開
3 引用 (Scopus)

Negative feedback loop in the Bim-caspase-3 axis regulating apoptosis and activity of osteoclasts

Wakeyama, H., Akiyama, T., Takahashi, K., Amano, H., Kadono, Y., Nakamura, M., Oshima, Y., Itabe, H., Nakayama, K. I., Nakayama, K., Nakamura, K. & Tanaka, S., 10 1 2007, : : Journal of Bone and Mineral Research. 22, 10, p. 1631-1639 9 p.

研究成果: ジャーナルへの寄稿記事

30 引用 (Scopus)

Nedd4-interacting protein 2, a short half-life membrane protein degraded in lysosomes, negatively controls down-regulation of connexin43

Ohzono, C., Etoh, S., Matsumoto, M., Nakayama, K. I., Hirota, Y., Tanaka, Y. & Fujita, H., 6 17 2010, : : Biological and Pharmaceutical Bulletin. 33, 6, p. 951-957 7 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

NAK is an IκB kinase-activating kinase

Tojima, Y., Fujimoto, A., Delhase, M., Chen, Y., Hatekeyama, S., Nakayama, K. I., Kaneko, Y., Nimura, Y., Motoyama, N., Ikeda, K., Karin, M. & Nakanishi, M., 4 13 2000, : : Nature. 404, 6779, p. 778-782 5 p.

研究成果: ジャーナルへの寄稿記事

280 引用 (Scopus)

Myofibroblasts Derived from Hepatic Progenitor Cells Create the Tumor Microenvironment

Sekiya, S., Miura, S., Matsuda-Ito, K. & Suzuki, A., 12 13 2016, : : Stem Cell Reports. 7, 6, p. 1130-1139 10 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Multiple gene duplication and expression of mouse bcl-2-related genes, A1

Hatakeyama, S., Hamasaki, A., Negishi, I., Loh, D. Y., Sendo, F., Nakayama, K. & Nakayama, K. I., 5 26 1998, : : International immunology. 10, 5, p. 631-637 7 p.

研究成果: ジャーナルへの寄稿記事

63 引用 (Scopus)

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide.

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K., Clohessy, J. & Pandolfi, P. P., 2017, : : Nature. 541, 7636, p. 228 5 p., 541.

研究成果: ジャーナルへの寄稿記事

MTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

Matsumoto, A., Pasut, A., Matsumoto, M., Yamashita, R., Fung, J., Monteleone, E., Saghatelian, A., Nakayama, K. I., Clohessy, J. G. & Pandolfi, P. P., 1 12 2017, : : Nature. 541, 7636, p. 228-232 5 p.

研究成果: ジャーナルへの寄稿記事

178 引用 (Scopus)

Mouse Fbw7/Sel-10/Cdc4 Is Required for Notch Degradation during Vascular Development

Tsunematsu, R., Nakayama, K., Oike, Y., Nishiyama, M., Ishida, N., Hatakeyama, S., Bessho, Y., Kageyama, R., Suda, T. & Nakayama, K., 3 5 2004, : : Journal of Biological Chemistry. 279, 10, p. 9417-9423 7 p.

研究成果: ジャーナルへの寄稿記事

194 引用 (Scopus)

Morphologic and molecular analysis of estrogen-induced pituitary tumorigenesis in targeted disruption of transforming growth factor-β receptor type II and/or p27 mice

Ikeda, H., Yoshimoto, T., Shida, N., Miyoshi, I., Nakayama, K., Nakayama, K., Oshima, M. & Taketo, M. M., 1 1 2001, : : Endocrine. 16, 1, p. 55-65 11 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Molecular dissection of the interactions among IκBα, FWD1, and Skp1 required for ubiquitin-mediated proteolysis of IκBα

Hattori, K., Hatakeyama, S., Shirane, M., Matsumoto, M. & Nakayama, K. I., 10 15 1999, : : Journal of Biological Chemistry. 274, 42, p. 29641-29647 7 p.

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

Molecular dissection of the interaction between p27 and Kip1 ubiquitylation-promoting complex, the ubiquitin ligase that regulates proteolysis of p27 in G1 phase

Kotoshibai, S., Kamura, T., Hara, T., Ishida, N. & Nakayama, K., 5 6 2005, : : Journal of Biological Chemistry. 280, 18, p. 17694-17700 7 p.

研究成果: ジャーナルへの寄稿記事

67 引用 (Scopus)

Molecular clearance of ataxin-3 is regulated by a mammalian E4

Matsumoto, M., Yada, M., Hatakeyama, S., Ishimoto, H., Tanimura, T., Tsuji, S., Kakizuka, A., Kitagawa, M. & Nakayama, K. I., 2 11 2004, : : EMBO Journal. 23, 3, p. 659-669 11 p.

研究成果: ジャーナルへの寄稿記事

115 引用 (Scopus)

Molecular basis for the association of human E4B U box ubiquitin ligase with E2-conjugating enzymes UbcH5c and Ubc4

Benirschke, R. C., Thompson, J. R., Nominé, Y., Wasielewski, E., Juranić, N., Macura, S., Hatakeyama, S., Nakayama, K. I., Botuyan, M. V. & Mer, G., 8 1 2010, : : Structure. 18, 8, p. 955-965 11 p.

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)

Modulation of GABAA receptor phosphorylation and membrane trafficking by phospholipase C-related inactive protein/protein phosphatase 1 and 2A signaling complex underlying brain-derived neurotrophic factor-dependent regulation of GABAergic inhibition

Kanematsu, T., Yasunaga, A., Mizoguchi, Y., Kuratani, A., Kittler, J. T., Jovanovic, J. N., Takenaka, K., Nakayama, K. I., Fukami, K., Takenawa, T., Moss, S. J., Nabekura, J. & Hirata, M., 8 4 2006, : : Journal of Biological Chemistry. 281, 31, p. 22180-22189 10 p.

研究成果: ジャーナルへの寄稿記事

74 引用 (Scopus)

Modulation of astrocyte proliferation by cyclin-dependent kinase inhibitor p27Kip1

Koguchi, K., Nakatsuji, Y., Nakayama, K. & Sakoda, S., 3 4 2002, : : GLIA. 37, 2, p. 93-104 12 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence

Takahashi, A., Ohtani, N., Yamakoshi, K., Iida, S. I., Tahara, H., Nakayama, K., Nakayama, K. I., Ide, T., Saya, H. & Hara, E., 11 1 2006, : : Nature Cell Biology. 8, 11, p. 1291-1297 7 p.

研究成果: ジャーナルへの寄稿記事

309 引用 (Scopus)

miR-221 and miR-155 regulate human dendritic cell development, apoptosis, and IL-12 production through targeting of p27 kip1, KPC1, and SOCS-1

Lu, C., Huang, X., Zhang, X., Roensch, K., Cao, Q., Nakayama, K. I., Blazar, B. R., Zeng, Y. & Zhou, X., 4 21 2011, : : Blood. 117, 16, p. 4293-4303 11 p.

研究成果: ジャーナルへの寄稿記事

197 引用 (Scopus)

Mice lacking the schizophrenia-associated protein FEZ1 manifest hyperactivity and enhanced responsiveness to psychostimulants

Sakae, N., Yamasaki, N., Kitaichi, K., Fukuda, T., Yamada, M., Yoshikawa, H., Hiranita, T., Tatsumi, Y., Kira, J. I., Yamamoto, T., Miyakawa, T. & Nakayama, K. I., 10 13 2008, : : Human Molecular Genetics. 17, 20, p. 3191-3203 13 p.

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)

Mice Lacking p27Kip1 Display Increased Body Size, Multiple Organ Hyperplasia, Retinal Dysplasia, and Pituitary Tumors

Nakayama, K., Ishida, N., Shirane, M., Inomata, A., Inoue, T., Shishido, N., Horii, I., Loh, D. Y. & Nakayama, K. I., 5 31 1996, : : Cell. 85, 5, p. 707-720 14 p.

研究成果: ジャーナルへの寄稿記事

1412 引用 (Scopus)

Mice lacking a CDK inhibitor, p57(Kip2), exhibit skeletal abnormalities and growth retardation

Takahashi, K., Nakayama, K. I. & Nakayama, K., 1 1 2000, : : Journal of biochemistry. 127, 1, p. 73-83 11 p.

研究成果: ジャーナルへの寄稿記事

102 引用 (Scopus)

Mechanoregulation of proliferation

Jiang, X., Austin, P. F., Niederhoff, R. A., Manson, S. R., Riehm, J. J., Cook, B. L., Pengue, G., Chitaley, K., Nakayama, K., Nakayama, K. I. & Weintraub, S. J., 9 1 2009, : : Molecular and cellular biology. 29, 18, p. 5104-5114 11 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Mechanisms to control degradation of polyglutamine-containing protein

Nakayama, K. I., 11 1 2003, : : Clinical Neurology. 43, 11, p. 906-908 3 p.

研究成果: ジャーナルへの寄稿記事

MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24

Yamauchi, T., Nishiyama, M., Moroishi, T., Yumimoto, K. & Nakayama, K. I., 1 1 2014, : : Molecular and cellular biology. 34, 17, p. 3321-3340 20 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)