細胞機能制御学部門

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Loss of Protein Kinase C-δ Protects against LPS-Induced Osteolysis Owing to an Intrinsic Defect in Osteoclastic Bone Resorption

Khor, E. C., Abel, T., Tickner, J., Chim, S. M., Wang, C., Cheng, T., Ng, B., Ng, P. Y., Teguh, D. A., Kenny, J., Yang, X., Chen, H., Nakayama, K. I., Nakayama, K., Pavlos, N., Zheng, M. H. & Xu, J., 8 8 2013, : : PloS one. 8, 8, e70815.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Loss of protein kinase C delta alters mammary gland development and apoptosis

Allen-Petersen, B. L., Miller, M. R., Neville, M. C., Anderson, S. M., Nakayama, K. I. & Reyland, M. E., 1 1 2010, : : Cell Death and Disease. 1, 1, e17.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Loss of FBXW7, a cell cycle regulating gene, in colorectal cancer: Clinical significance

Iwatsuki, M., Mimori, K., Lshii, H., Yokobori, T., Takatsuno, Y., Sato, T., Toh, H., Onoyama, I., Nakayama, K. I., Baba, H. & Mori, M., 4 15 2010, : : International Journal of Cancer. 126, 8, p. 1828-1837 10 p.

研究成果: ジャーナルへの寄稿記事

98 引用 (Scopus)

Long-term maintenance of functional primary human hepatocytes using small molecules

Katsuda, T., Kawamata, M., Inoue, A., Yamaguchi, T., Abe, M. & Ochiya, T., 1 1 2020, : : FEBS Letters. 594, 1, p. 114-125 12 p.

研究成果: ジャーナルへの寄稿記事

Liver maturation deficiency in p57Kip2-/- mice occurs in a hepatocytic p57Kip2 expression-independent manner

Yanagida, A., Chikada, H., Ito, K., Umino, A., Kato-Itoh, M., Yamazaki, Y., Sato, H., Kobayashi, T., Yamaguchi, T., Nakayama, K. I., Nakauchi, H. & Kamiya, A., 11 15 2015, : : Developmental Biology. 407, 2, p. 331-343 13 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

Linear ubiquitination signals in adaptive immune responses

Ikeda, F., 7 1 2015, : : Immunological Reviews. 266, 1, p. 222-236 15 p.

研究成果: ジャーナルへの寄稿記事

33 引用 (Scopus)

Limitin, an interferon-like cytokine, transduces inhibitory signals on B-cell growth through activation of Tyk2, but not Stat1, followed by induction and nuclear translocation of Daxx

Aoki, K., Shimoda, K., Oritani, K., Matsuda, T., Kamezaki, K., Muromoto, R., Numata, A., Tamiya, S., Haro, T., Ishikawa, F., Takase, K., Yamamoto, T., Yumioka, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nagafuchi, S., Nakayama, K. I. & Harada, M., 12 2003, : : Experimental Hematology. 31, 12, p. 1317-1322 6 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Large-scale proteomic analysis of tyrosine-phosphorylation induced by T-cell receptor or B-cell receptor activation reveals new signaling pathways

Matsumoto, M., Oyamada, K., Takahashi, H., Sato, T., Hatakeyama, S. & Nakayama, K., 7 1 2009, : : Proteomics. 9, 13, p. 3549-3563 15 p.

研究成果: ジャーナルへの寄稿記事

43 引用 (Scopus)

Large-scale analysis of the human ubiquitin-related proteome

Matsumoto, M., Hatakeyama, S., Oyamada, K., Oda, Y., Nishimura, T. & Nakayama, K. I., 11 1 2005, : : Proteomics. 5, 16, p. 4145-4151 7 p.

研究成果: ジャーナルへの寄稿記事

147 引用 (Scopus)

Kupffer cells induce Notch-mediated hepatocyte conversion in a common mouse model of intrahepatic cholangiocarcinoma

Terada, M., Horisawa, K., Miura, S., Takashima, Y., Ohkawa, Y., Sekiya, S., Matsuda-Ito, K. & Suzuki, A., 10 4 2016, : : Scientific reports. 6, 34691.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

KDM7 is a dual demethylase for histone H3 Lys 9 and Lys 27 and functions in brain development

Tsukada, Y. I., Ishitani, T. & Nakayama, K. I., 3 1 2010, : : Genes and Development. 24, 5, p. 432-437 6 p.

研究成果: ジャーナルへの寄稿記事

90 引用 (Scopus)

Isolation of Mouse Pancreatic Ductal Progenitor Cells Expressing CD133 and c-Met by Flow Cytometric Cell Sorting

Oshima, Y., Suzuki, A., Kawashimo, K., Ishikawa, M., Ohkohchi, N. & Taniguchi, H., 2 2007, : : Gastroenterology. 132, 2, p. 720-732 13 p.

研究成果: ジャーナルへの寄稿記事

110 引用 (Scopus)

Isolation and characterization of a novel F-box protein Pof10 in fission yeast

Ikebe, C., Nakayama, K. I., Ikebe, C., Kominami, K. I., Nakayama, K. I., Kominami, K. I., Nakayama, K. I. & Toda, T., 1 1 2002, : : Biochemical and Biophysical Research Communications. 290, 5, p. 1399-1407 9 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Involvement of phospholipase C-related inactive protein in the mouse reproductive system through the regulation of gonadotropin levels

Matsuda, M., Tsutsumi, K., Kanematsu, T., Fukami, K., Terada, Y., Takenawa, T., Nakayama, K. I. & Hirata, M., 12 1 2009, : : Biology of Reproduction. 81, 4, p. 681-689 9 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Involvement of p27KIP1 in the proliferation of the developing corneal endothelium

Yoshida, K., Kase, S., Nakayama, K., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ilieva, I. B., Ohno, S., Nishi, S. & Nakayama, K. I., 7 1 2004, : : Investigative Ophthalmology and Visual Science. 45, 7, p. 2163-2167 5 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

Involvement of p27(KIP1) in proliferation of the retinal pigment epithelium and ciliary body

Yoshida, K., Nakayama, K., Kase, S., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ohno, S., Nishi, S. & Nakayama, K. I., 5 1 2004, : : Anatomy and Embryology. 208, 2, p. 145-150 6 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

Involvement of a novel Q-SNARE, D12, in quality control of the endomembrane system

Okumura, A. J., Hatsuzawa, K., Tamura, T., Nagaya, H., Saeki, K., Okumura, F., Nagao, K., Nishikawa, M., Yoshimura, A. & Wada, I., 2 17 2006, : : Journal of Biological Chemistry. 281, 7, p. 4495-4506 12 p.

研究成果: ジャーナルへの寄稿記事

公開
21 引用 (Scopus)

In vitro histone demethylase assay

Tsukada, Y. I. & Nakayama, K. I., 10 1 2010, : : Cold Spring Harbor Protocols. 5, 10

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

Intrahepatic cholangiocarcinoma can arise from Notch-mediated conversion of hepatocytes

Sekiya, S. & Suzuki, A., 11 1 2012, : : Journal of Clinical Investigation. 122, 11, p. 3914-3918 5 p.

研究成果: ジャーナルへの寄稿記事

187 引用 (Scopus)

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Guarnerio, J., Zhang, Y., Cheloni, G., Panella, R., Mae Katon, J., Simpson, M., Matsumoto, A., Papa, A., Loretelli, C., Petri, A., Kauppinen, S., Garbutt, C., Petur Nielsen, G., Deshpande, V., Castillo-Martin, M., Cordon-Cardo, C., Dimitrios, S., Clohessy, J. G., Batish, M. & Pandolfi, P. P., 8 1 2019, : : Cell Research. 29, 8, p. 628-640 13 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Intracellular signal transduction of interferon on the suppression of haematopoietic progenitor cell growth

Kato, K., Kamezaki, K., Shimoda, K., Numata, A., Haro, T., Aoki, K., Ishikawa, F., Takase, K., Ariyama, H., Matsuda, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nakayama, K. I. & Harada, M., 11 1 2003, : : British Journal of Haematology. 123, 3, p. 528-535 8 p.

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

Interaction of U-box-type ubiquitin-protein ligases (E3s) with molecular chaperones

Hatakeyama, S., Matsumoto, M., Yada, M. & Nakayama, K., 6 1 2004, : : Genes to Cells. 9, 6, p. 533-548 16 p.

研究成果: ジャーナルへの寄稿記事

70 引用 (Scopus)

Interaction of presenilins with FKBP38 promotes apoptosis by reducing mitochondrial Bcl-2

Wang, H. Q., Nakaya, Y., Du, Z., Yamane, T., Shirane, M., Kudo, T., Takeda, M., Takebayashi, K., Noda, Y., Nakayama, K. & Nishimura, M., 7 1 2005, : : Human Molecular Genetics. 14, 13, p. 1889-1902 14 p.

研究成果: ジャーナルへの寄稿記事

73 引用 (Scopus)

Inhibiting Skp2 E3 ligase suppresses bleomycin-induced pulmonary fibrosis

Mikamo, M., Kitagawa, K., Sakai, S., Uchida, C., Ohhata, T., Nishimoto, K., Niida, H., Suzuki, S., Nakayama, K. I., Inui, N., Suda, T. & Kitagawa, M., 2 6 2018, : : International journal of molecular sciences. 19, 2, 474.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cδ

Miyamoto, A., Nakayama, K., Imaki, H., Hirose, S., Jiang, Y., Abe, M., Tsukiyama, T., Nagahama, H., Ohno, S., Hatakeyama, S. & Nakayama, K. I., 4 25 2002, : : Nature. 416, 6883, p. 865-869 5 p.

研究成果: ジャーナルへの寄稿記事

331 引用 (Scopus)

Increased formation of hepatic N2 -ethylidene-2′-deoxyguanosine DNA adducts in aldehyde dehydrogenase 2-knockout mice treated with ethanol

Matsuda, T., Matsumoto, A., Uchida, M., Kanaly, R. A., Misaki, K., Shibutani, S., Kawamoto, T., Kitagawa, K., Nakayama, K. I., Tomokuni, K. & Ichiba, M., 11 1 2007, : : Carcinogenesis. 28, 11, p. 2363-2366 4 p.

研究成果: ジャーナルへの寄稿記事

53 引用 (Scopus)

Increased efficiency in the generation of induced pluripotent stem cells by Fbxw7 ablation

Okita, Y., Matsumoto, A., Yumimoto, K., Isoshita, R. & Nakayama, K. I., 9 1 2012, : : Genes to Cells. 17, 9, p. 768-777 10 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Increased E4 activity in mice leads to ubiquitin-containing aggregates and degeneration of hypothalamic neurons resulting in obesity

Susaki, E., Kaneko-Oshikawa, C., Miyata, K., Tabata, M., Yamada, T., Oike, Y., Katagiri, H. & Nakayama, K. I., 5 14 2010, : : Journal of Biological Chemistry. 285, 20, p. 15538-15547 10 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

Laukoter, S., Beattie, R., Pauler, F. M., Amberg, N., Nakayama, K. I. & Hippenmeyer, S., 12 1 2020, : : Nature communications. 11, 1, 195.

研究成果: ジャーナルへの寄稿記事

公開

Impaired ovarian development and reduced fertility in female mice deficient in Skp2

Fotovati, A., Abu-Ali, S., Nakayama, K. & Nakayama, K. I., 6 1 2011, : : Journal of Anatomy. 218, 6, p. 668-677 10 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Impaired germ cell development due to compromised cell cycle progression in Skp2-deficient mice

Fotovati, A., Nakayama, K. & Nakayama, K. I., 4 7 2006, : : Cell Division. 1, 4.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Impaired degradation of inhibitory subunit of NF-κB (IκB) and β-catenin as a result of targeted disruption of the β-TrCP1 gene

Nakayama, K., Hatakeyama, S., Maruyama, S. I., Kikuchi, A., Onoé, K., Good, R. A. & Nakayama, K. I., 7 22 2003, : : Proceedings of the National Academy of Sciences of the United States of America. 100, 15, p. 8752-8757 6 p.

研究成果: ジャーナルへの寄稿記事

82 引用 (Scopus)

Impaired chemotaxis and cell adhesion due to decrease in several cell-surface receptors in cathepsin E-deficient macrophages

Tsukuba, T., Yanagawa, M., Okamoto, K., Okamoto, Y., Yasuda, Y., Nakayama, K. I., Kadowaki, T. & Yamamoto, K., 5 1 2009, : : Journal of biochemistry. 145, 5, p. 565-573 9 p.

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

Identification of novel E2F1 target genes regulated in cell cycle-dependent and independent manners

Iwanaga, R., Komori, H., Ishida, S., Okamura, N., Nakayama, K., Nakayama, K. & Ohtani, K., 3 16 2006, : : Oncogene. 25, 12, p. 1786-1798 13 p.

研究成果: ジャーナルへの寄稿記事

46 引用 (Scopus)

Identification of low-abundance proteins in serum via the isolation of HSP72 complexes

Tanaka, M., Shiota, M., Nakao, T., Uemura, R., Nishi, S., Ohkawa, Y., Matsumoto, M., Yamaguchi, M., Osada-Oka, M., Inagaki, A., Takahashi, K., Nakayama, K. I., Gi, M., Izumi, Y., Miura, K. & Iwao, H., 3 16 2016, : : Journal of Proteomics. 136, p. 214-221 8 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Identification of CHD7 S as a novel splicing variant of CHD7 with functions similar and antagonistic to those of the full-length CHD7 L

Kita, Y., Nishiyama, M. & Nakayama, K., 7 1 2012, : : Genes to Cells. 17, 7, p. 536-547 12 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Identification and characterization of a neuron-specific isoform of protrudin

Ohnishi, T., Shirane, M., Hashimoto, Y., Saita, S. & Nakayama, K. I., 2 1 2014, : : Genes to Cells. 19, 2, p. 97-111 15 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Hypersensitivity to pentylenetetrazol-induced convulsion in mice lacking the PLC-related inactive protein-1

Yamaguchi, T., Kubota, T., Kanematsu, T., Nakayama, K., Hirata, M. & Yamamoto, T., 10 29 2004, : : Brain Research. 1025, 1-2, p. 237-240 4 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Hyperinsulinemia in PRIP-1 gene deleted mice

Doira, N., Kanematsu, T., Matsuda, M., Takeuchi, H., Nakano, H. O., Ito, Y., Nakayama, K., Nakayama, K. I. & Hirata, M., 1 1 2001, : : Biomedical Research. 22, 3, p. 157-165 9 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Human synovial sarcoma proto-oncogene Syt is essential for early embryonic development through the regulation of cell migration

Kimura, T., Sakai, M., Tabu, K., Wang, L., Tsunematsu, R., Tsuda, M., Sawa, H., Nagashima, K., Nishihara, H., Hatakeyama, S., Nakayama, K., Ladanyi, M., Tanaka, S. & Nakayama, K. I., 6 1 2009, : : Laboratory Investigation. 89, 6, p. 645-656 12 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress

Hayakawa, H., Fujikane, A., Ito, R., Matsumoto, M., Nakayama, K. & Sekiguchi, M., 12 10 2010, : : Biochemical and Biophysical Research Communications. 403, 2, p. 220-224 5 p.

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

HSP27 favors ubiquitination and proteasomal degradation of p27 Kip1 and helps S-phase re-entry in stressed cells

Parcellier, A., Brunet, M., Schmitt, E., Col, E., Didelot, C., Hammann, A., Nakayama, K., Nakayama, K., Khochbin, S., Solary, E. & Garrido, C., 6 2006, : : FASEB Journal. 20, 8

研究成果: ジャーナルへの寄稿記事

91 引用 (Scopus)

Histone H1 recruitment by CHD8 is essential for suppression of the Wnt-β-catenin signaling pathway

Nishiyama, M., Skoultchi, A. I. & Nakayama, K. I., 1 1 2012, : : Molecular and cellular biology. 32, 2, p. 501-512 12 p.

研究成果: ジャーナルへの寄稿記事

63 引用 (Scopus)

Hippo Signaling Suppresses Cell Ploidy and Tumorigenesis through Skp2

Zhang, S., Chen, Q., Liu, Q., Li, Y., Sun, X., Hong, L., Ji, S., Liu, C., Geng, J., Zhang, W., Lu, Z., Yin, Z. Y., Zeng, Y., Lin, K. H., Wu, Q., Li, Q., Nakayama, K., Nakayama, K. I., Deng, X., Johnson, R. L. および4人, Zhu, L., Gao, D., Chen, L. & Zhou, D., 5 8 2017, : : Cancer Cell. 31, 5, p. 669-684.e7

研究成果: ジャーナルへの寄稿記事

49 引用 (Scopus)

HERC2 targets the iron regulator FBXL5 for degradation and modulates iron metabolism

Moroishi, T., Yamauchi, T., Nishiyama, M. & Nakayama, K. I., 6 6 2014, : : Journal of Biological Chemistry. 289, 23, p. 16430-16441 12 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)
65 引用 (Scopus)

Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores

Kurosawa, Y., Dorn, A., Kitsuji-Shirane, M., Shimada, H., Satoh, T., Matile, H., Hofheinz, W., Masciadri, R., Kansy, M. & Ridley, R. G., 1 1 2000, : : Antimicrobial Agents and Chemotherapy. 44, 10, p. 2638-2644 7 p.

研究成果: ジャーナルへの寄稿記事

72 引用 (Scopus)

GRWD1 regulates ribosomal protein L23 levels via the ubiquitin-proteasome system

Watanabe, S., Fujiyama, H., Takafuji, T., Kayama, K., Matsumoto, M., Nakayama, K. I., Yoshida, K., Sugimoto, N. & Fujita, M., 8 1 2018, : : Journal of cell science. 131, 15

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

GRWD1 negatively regulates p53 via the RPL11–MDM2 pathway and promotes tumorigenesis

Kayama, K., Watanabe, S., Takafuji, T., Tsuji, T., Hironaka, K., Matsumoto, M., Nakayama, K. I., Enari, M., Kohno, T., Shiraishi, K., Kiyono, T., Yoshida, K., Sugimoto, N. & Fujita, M., 1 1 2017, : : EMBO Reports. 18, 1, p. 123-137 15 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)
23 引用 (Scopus)