細胞機能制御学部門

研究成果

フィルター
記事

Glomerular differentiation in p27 and p57 double-mutant metanephroi

Tomari, S., Nagahama, H., Shu, Y., Hoshi, S., Nakayama, K., Nakayama, K. I. & Nagata, M., 12 31 2002, : : Anatomy and Embryology. 206, 1-2, p. 31-36 6 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Genetic reevaluation of the Role of F-Box proteins in cyclin D1 degradation

Kanie, T., Onoyama, I., Matsumoto, A., Yamada, M., Nakatsumi, H., Tateishi, Y., Yamamura, S., Tsunematsu, R., Matsumoto, M. & Nakayama, K. I., 2 1 2012, : : Molecular and cellular biology. 32, 3, p. 590-605 16 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells

Terada, M., Kawamata, M., Kimura, R., Sekiya, S., Nagamatsu, G., Hayashi, K., Horisawa, K. & Suzuki, A., 11 1 2019, : : Genesis. 57, 11-12, e23334.

研究成果: ジャーナルへの寄稿記事

Generation of Mouse and Human Organoid-Forming Intestinal Progenitor Cells by Direct Lineage Reprogramming

Miura, S. & Suzuki, A., 10 5 2017, : : Cell stem cell. 21, 4, p. 456-471.e5

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Geminin is essential for the development of preimplantation mouse embryos

Hara, K., Nakayama, K. & Nakayama, K., 11 1 2006, : : Genes to Cells. 11, 11, p. 1281-1293 13 p.

研究成果: ジャーナルへの寄稿記事

49 引用 (Scopus)

GABAA receptor subunit alteration-dependent diazepam insensitivity in the cerebellum of phospholipase C-related inactive protein knockout mice

Mizokami, A., Tanaka, H., Ishibashi, H., Umebayashi, H., Fukami, K., Takenawa, T., Nakayama, K. I., Yokoyama, T., Nabekura, J., Kanematsu, T. & Hirata, M., 7 1 2010, : : Journal of Neurochemistry. 114, 1, p. 302-310 9 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

GABAA receptor phospho-dependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein

Terunuma, M., Jang, I. S., Ha, S. H., Kittler, J. T., Kanematsu, T., Jovanovic, J. N., Nakayama, K. I., Akaike, N., Ryu, S. H., Moss, S. J. & Hirata, M., 8 11 2004, : : Journal of Neuroscience. 24, 32, p. 7074-7084 11 p.

研究成果: ジャーナルへの寄稿記事

86 引用 (Scopus)

Functional regulation of FEZ1 by the U-box-type ubiquitin ligase E4B contributes to neuritogenesis

Okumura, F., Hatakeyama, S., Matsumoto, M., Kamura, T. & Nakayama, K. I., 12 17 2004, : : Journal of Biological Chemistry. 279, 51, p. 53533-53543 11 p.

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)

Functional analyses of the activation loop of phototropin2 in Arabidopsis

Inoue, S. I., Matsushita, T., Tomokiyo, Y., Matsumoto, M., Nakayama, K. I., Kinoshita, T. & Shimazaki, K. I., 5 1 2011, : : Plant physiology. 156, 1, p. 117-128 12 p.

研究成果: ジャーナルへの寄稿記事

52 引用 (Scopus)

Frequent detection of pituitary-derived PRPREs in human prion diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., 10 1 2019, : : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

研究成果: ジャーナルへの寄稿記事

Foxo3a Is Essential for Maintenance of the Hematopoietic Stem Cell Pool

Miyamoto, K., Araki, K. Y., Naka, K., Arai, F., Takubo, K., Yamazaki, S., Matsuoka, S., Miyamoto, T., Ito, K., Ohmura, M., Chen, C., Hosokawa, K., Nakauchi, H., Nakayama, K., Nakayama, K. I., Harada, M., Motoyama, N., Suda, T. & Hirao, A., 6 7 2007, : : Cell stem cell. 1, 1, p. 101-112 12 p.

研究成果: ジャーナルへの寄稿記事

568 引用 (Scopus)

Four mood stabilizers commonly induce FEZ1 expression in human astrocytes

Yu, Z., Ono, C., Kim, H. B., Komatsu, H., Tanabe, Y., Sakae, N., Nakayama, K., Matsuoka, H., Sora, I., Bunney, W. E. & Tomita, H., 8 1 2011, : : Bipolar Disorders. 13, 5-6, p. 486-499 14 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Formation of Mallory body-like inclusions and cell death induced by deregulated expression of keratin 18

Nakamichi, I., Hatakeyama, S. & Nakayama, K. I., 10 1 2002, : : Molecular biology of the cell. 13, 10, p. 3441-3451 11 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Flow cytometric isolation and clonal identification of self-renewing bipotent hepatic progenitor cells in adult mouse liver

Suzuki, A., Sekiya, S., Onishi, M., Oshima, N., Kiyonari, H., Nakauchi, H. & Taniguchi, H., 12 1 2008, : : Hepatology. 48, 6, p. 1964-1978 15 p.

研究成果: ジャーナルへの寄稿記事

123 引用 (Scopus)

Fbxw8 is essential for Cul1-Cul7 complex formation and for placental development

Tsunematsu, R., Nishiyama, M., Kotoshiba, S., Saiga, T., Kamura, T. & Nakayama, K. I., 8 1 2006, : : Molecular and cellular biology. 26, 16, p. 6157-6169 13 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Fbxw7β resides in the endoplasmic reticulum membrane and protects cells from oxidative stress

Matsumoto, A., Tateishi, Y., Onoyama, I., Okita, Y., Nakayama, K. & Nakayama, K., 4 1 2011, : : Cancer Science. 102, 4, p. 749-755 7 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Fbxw7 suppresses cancer metastasis by inhibiting niche formation

Yumimoto, K. & Nakayama, K. I., 8 3 2015, : : OncoImmunology. 4, 8

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Fbxw7 regulates lipid metabolism and cell fate decisions in the mouse liver

Onoyama, I., Suzuki, A., Matsumoto, A., Tomita, K., Katagiri, H., Oike, Y., Nakayama, K. & Nakayama, K. I., 1 4 2011, : : Journal of Clinical Investigation. 121, 1, p. 342-354 13 p.

研究成果: ジャーナルへの寄稿記事

76 引用 (Scopus)

FBXW7 is involved in the acquisition of the malignant phenotype in epithelial ovarian tumors

Kitade, S., Onoyama, I., Kobayashi, H., Yagi, H., Yoshida, S., Kato, M., Tsunematsu, R., Asanoma, K., Sonoda, K., Wake, N., Hata, K., Nakayama, K. I. & Kato, K., 10 1 2016, : : Cancer Science. 107, 10, p. 1399-1405 7 p.

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

Fbxw7-dependent degradation of notch is required for control of "Stemness" and neuronal-glial differentiation in neural stem cells

Matsumoto, A., Onoyama, I., Sunabori, T., Kageyama, R., Okano, H. & Nakayama, K. I., 4 15 2011, : : Journal of Biological Chemistry. 286, 15, p. 13754-13764 11 p.

研究成果: ジャーナルへの寄稿記事

63 引用 (Scopus)

Fbxw7 contributes to tumor suppression by targeting multiple proteins for ubiquitin-dependent degradation

Fujii, Y., Yada, M., Nishiyama, M., Kamura, T., Takahashi, H., Tsunematsu, R., Susaki, E., Nakagawa, T., Matsumoto, A. & Nakayama, K. I., 8 1 2006, : : Cancer Science. 97, 8, p. 729-736 8 p.

研究成果: ジャーナルへの寄稿記事

51 引用 (Scopus)

Fbxw7 acts as an E3 ubiquitin ligase that targets c-Myb for Nemo-like kinase (NLK)-induced degradation

Kanei-Ishii, C., Nomura, T., Takagi, T., Watanabe, N., Nakayama, K. I. & Ishii, S., 11 7 2008, : : Journal of Biological Chemistry. 283, 45, p. 30540-30548 9 p.

研究成果: ジャーナルへの寄稿記事

43 引用 (Scopus)

Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL

Matsuoka, S., Oike, Y., Onoyama, I., Iwama, A., Arai, F., Takubo, K., Mashimo, Y., Oguro, H., Nitta, E., Ito, K., Miyamoto, K., Yoshiwara, H., Hosokawa, K., Nakamura, Y., Gomei, Y., Iwasaki, H., Hayashi, Y., Matsuzaki, Y., Nakayama, K., Ikeda, Y. および4人, Hata, A., Chiba, S., Nakayama, K. I. & Suda, T., 4 15 2008, : : Genes and Development. 22, 8, p. 986-991 6 p.

研究成果: ジャーナルへの寄稿記事

125 引用 (Scopus)

Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene

Mao, J. H., Perez-Iosada, J., Wu, D., DelRosario, R., Tsunematsu, R., Nakayama, K. I., Brown, K., Bryson, S. & Balmain, A., 12 9 2004, : : Nature. 432, 7018, p. 775-779 5 p.

研究成果: ジャーナルへの寄稿記事

279 引用 (Scopus)

Fbxo45 forms a novel ubiquitin ligase complex and is required for neuronal development

Saiga, T., Fukuda, T., Matsumoto, M., Tada, H., Okano, H. J., Okano, H. & Nakayama, K. I., 7 1 2009, : : Molecular and cellular biology. 29, 13, p. 3529-3543 15 p.

研究成果: ジャーナルへの寄稿記事

66 引用 (Scopus)

Fbxo45, a novel ubiquitin ligase, regulates synaptic activity

Tada, H., Okano, H. J., Takagi, H., Shibata, S., Yao, I., Matsumoto, M., Saiga, T., Nakayama, K. I., Kashima, H., Takahashi, T., Setou, M. & Okano, H., 2 5 2010, : : Journal of Biological Chemistry. 285, 6, p. 3840-3849 10 p.

研究成果: ジャーナルへの寄稿記事

46 引用 (Scopus)

FBXO21 mediates the ubiquitylation and proteasomal degradation of EID1

Watanabe, K., Yumimoto, K. & Nakayama, K. I., 8 1 2015, : : Genes to Cells. 20, 8, p. 667-674 8 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

FBXL5 inactivation in mouse brain induces aberrant proliferation of neural stem progenitor cells

Yamauchi, T., Nishiyama, M., Moroishi, T., Kawamura, A. & Nakayama, K. I., 4 1 2017, : : Molecular and cellular biology. 37, 8, e00470-16.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

FBXL21 regulates oscillation of the circadian clock through ubiquitination and stabilization of cryptochromes

Hirano, A., Yumimoto, K., Tsunematsu, R., Matsumoto, M., Oyama, M., Kozuka-Hata, H., Nakagawa, T., Lanjakornsiripan, D., Nakayama, K. I. & Fukada, Y., 2 28 2013, : : Cell. 152, 5, p. 1106-1118 13 p.

研究成果: ジャーナルへの寄稿記事

128 引用 (Scopus)

FBXL12 regulates T-cell differentiation in a cell-autonomous manner

Nita, A., Nishiyama, M., Muto, Y. & Nakayama, K., 5 1 2016, : : Genes to Cells. 21, 5, p. 517-524 8 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

FBXL12-mediated degradation of ALDH3 is essential for trophoblast differentiation during placental development

Nishiyama, M., Nita, A., Yumimoto, K. & Nakayama, K. I., 11 2015, : : STEM CELLS. 33, 11, p. 3327-3340 14 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Fbw7 targets GATA3 through cyclin-dependent kinase 2-dependent proteolysis and contributes to regulation of T-cell development

Kitagawa, K., Shibat, K., Matsumoto, A., Matsumoto, M., Ohhata, T., Nakayama, K. I., Niida, H. & Kitagawa, M., 7 2014, : : Molecular and cellular biology. 34, 14, p. 2732-2744 13 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Fbw7 and p53 cooperatively suppress advanced and chromosomally unstable intestinal cancer

Grim, J. E., Knoblaugh, S. E., Guthrie, K. A., Hagar, A., Swanger, J., Hespelt, J., Delrow, J. J., Small, T., Grady, W. M., Nakayama, K. I. & Clurman, B. E., 6 1 2012, : : Molecular and cellular biology. 32, 11, p. 2160-2167 8 p.

研究成果: ジャーナルへの寄稿記事

51 引用 (Scopus)

F-box protein FBXW7 inhibits cancer metastasis in a non-cell-autonomous manner

Yumimoto, K., Akiyoshi, S., Ueo, H., Sagara, Y., Onoyama, I., Ueo, H., Ohno, S., Mori, M., Mimori, K. & Nakayama, K. I., 2 2 2015, : : Journal of Clinical Investigation. 125, 2, p. 621-635 15 p.

研究成果: ジャーナルへの寄稿記事

55 引用 (Scopus)

F-box and WD repeat domain-containing-7 (Fbxw7) protein targets endoplasmic reticulum-anchored osteogenic and chondrogenic transcriptional factors for degradation

Yumimoto, K., Matsumoto, M., Onoyama, I., Imaizumi, K. & Nakayama, K. I., 10 4 2013, : : Journal of Biological Chemistry. 288, 40, p. 28488-28502 15 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

Ex vivo maintenance of hematopoietic stem cells by quiescence induction through Fbxw7α overexpression

Iriuchishima, H., Takubo, K., Matsuoka, S., Onoyama, I., Nakayama, K. I., Nojima, Y. & Suda, T., 2 24 2011, : : Blood. 117, 8, p. 2373-2377 5 p.

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)
38 引用 (Scopus)

Expression of cdc2 and p27(KIP1) phosphorylation in mitotic cells of the human retinoblastoma

Kase, S., Yoshida, K., Ohgami, K., Shiratori, K., Suzuki, Y., Nakayama, K. I. & Ohno, S., 3 1 2006, : : International journal of molecular medicine. 17, 3, p. 465-468 4 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Ethanol metabolism in ALDH2 knockout mice - Blood acetate levels

Kiyoshi, A., Weihuan, W., Mostofa, J., Mitsuru, K., Toyoshi, I., Toshihiro, K., Kyoko, K., Keiichi, N., Iwao, I. & Hiroshi, K., 4 1 2009, : : Legal Medicine. 11, SUPPL. 1, p. S413-S415

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

Estrogens Down-regulate p27Kip1 in Breast Cancer Cells through Skp2 and through Nuclear Export Mediated by the ERK Pathway

Foster, J. S., Fernando, R. I., Ishida, N., Nakayama, K. I. & Wimalasena, J., 10 17 2003, : : Journal of Biological Chemistry. 278, 42, p. 41355-41366 12 p.

研究成果: ジャーナルへの寄稿記事

86 引用 (Scopus)

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

Xiang, Z., Ahmed, A. A., Möller, C., Nakayama, K. I., Hatakeyama, S. & Nilsson, G., 12 3 2001, : : Journal of Experimental Medicine. 194, 11, p. 1561-1569 9 p.

研究成果: ジャーナルへの寄稿記事

91 引用 (Scopus)

Essential role of FBXL5-mediated cellular iron homeostasis in maintenance of hematopoietic stem cells

Muto, Y., Nishiyama, M., Nita, A., Moroishi, T. & Nakayama, K. I., 7 17 2017, : : Nature communications. 8, 16114.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice

Seto, Y., Nakajima, H., Suto, A., Shimoda, K., Saito, Y., Nakayama, K. I. & Iwamoto, I., 1 15 2003, : : Journal of Immunology. 170, 2, p. 1077-1083 7 p.

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

Endosomal escape efficiency of fusogenic B18 and B55 peptides fused with anti-EGFR single chain Fv as estimated by nuclear translocation

Niikura, K., Horisawa, K. & Doi, N., 1 1 2016, : : Journal of biochemistry. 159, 1, p. 123-132 10 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

EGF signaling activates proliferation and blocks apoptosis of mouse and human intestinal stem/progenitor cells in long-term monolayer cell culture

Suzuki, A., Sekiya, S., Gunshima, E., Fujii, S. & Taniguchi, H., 10 1 2010, : : Laboratory Investigation. 90, 10, p. 1425-1436 12 p.

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

Effects of 5-week ethanol feeding on the liver of aldehyde dehydrogenase 2 knockout mice

Matsumoto, A., Kawamoto, T., Mutoh, F., Isse, T., Oyama, T., Kitagawa, K., Nakayama, K. I. & Ichiba, M., 10 1 2008, : : Pharmacogenetics and Genomics. 18, 10, p. 847-852 6 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

Early embryonic death in mice lacking the β-catenin-binding protein duplin

Nishiyama, M., Nakayama, K., Tsunematsu, R., Tsukiyama, T., Kikuchi, A. & Nakayama, K. I., 10 1 2004, : : Molecular and cellular biology. 24, 19, p. 8386-8394 9 p.

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)

Dynamic three-dimensional morphogenesis of intrahepatic bile ducts in mouse liver development

Takashima, Y., Terada, M., Kawabata, M. & Suzuki, A., 3 1 2015, : : Hepatology. 61, 3, p. 1003-1011 9 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis

Mukai, A., Mizuno, E., Kobayashi, K., Matsumoto, M., Nakayama, K. I., Kitamura, N. & Komada, M., 4 15 2008, : : Journal of Cell Science. 121, 8, p. 1325-1333 9 p.

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4: Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation

Tamamori-Adachi, M., Hayashida, K., Nobori, K., Omizu, C., Yamada, K., Sakamoto, N., Kamura, T., Fukuda, K., Ogawa, S., Nakayama, K. I. & Kitajima, S., 11 26 2004, : : Journal of Biological Chemistry. 279, 48, p. 50429-50436 8 p.

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)