細胞機能制御学部門

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Down-regulation of p27Kip1 promotes cell proliferation of rat neonatal cardiomyocytes induced by nuclear expression of cyclin D1 and CDK4: Evidence for impaired Skp2-dependent degradation of p27 in terminal differentiation

Tamamori-Adachi, M., Hayashida, K., Nobori, K., Omizu, C., Yamada, K., Sakamoto, N., Kamura, T., Fukuda, K., Ogawa, S., Nakayama, K. I. & Kitajima, S., 11 26 2004, : : Journal of Biological Chemistry. 279, 48, p. 50429-50436 8 p.

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

Down-regulation of p27Kip1 expression is required for development and function of T cells

Tsukiyama, T., Ishida, N., Shirane, M., Minamishima, Y. A., Hatakeyama, S., Kitagawa, M., Nakayama, K. & Nakayama, K. I., 1 1 2001, : : Journal of Immunology. 166, 1, p. 304-312 9 p.

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

Shirane, M., Harumiya, Y., Ishida, N., Hirai, A., Miyamoto, C., Hatakeyama, S., Nakayama, K. I. & Kitagawa, M., 5 14 1999, : : Journal of Biological Chemistry. 274, 20, p. 13886-18893 5008 p.

研究成果: ジャーナルへの寄稿記事

211 引用 (Scopus)

Distribution of p27(KIP1), cylin D1, and proliferating cell nuclear antigen after retinal detachment

Yoshida, K., Kase, S., Nakayama, K., Nagahama, H., Harada, T., Ikeda, H., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Ohno, S. & Nakayama, K. I., 5 1 2004, : : Graefe's Archive for Clinical and Experimental Ophthalmology. 242, 5, p. 437-441 5 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

Distinct roles of c-Abl and Atm in oxidative stress response are mediated by protein kinase C δ

Li, B., Wang, X., Rasheed, N., Hu, Y., Boast, S., Ishii, T., Nakayama, K., Nakayama, K. I. & Golf, S. P., 8 1 2004, : : Genes and Development. 18, 15, p. 1824-1837 14 p.

研究成果: ジャーナルへの寄稿記事

89 引用 (Scopus)

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Muto, Y., Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y. & Nakayama, K. I., 4 1 2019, : : Journal of Experimental Medicine. 216, 4, p. 950-965 16 p.

研究成果: ジャーナルへの寄稿記事

公開
4 引用 (Scopus)

Disappearance of p27(KIP1) and increase in proliferation of the lens cells after extraction of most of the fiber cells of the lens

Kase, S., Yoshida, K., Ikeda, H., Harada, T., Harada, C., Imaki, J., Ohgami, K., Shiratori, K., Nakayama, K., Nakayama, K. & Ohno, S., 7 1 2005, : : Current Eye Research. 30, 6, p. 437-442 6 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Direct conversion of mouse fibroblasts to hepatocyte-like cells by defined factors

Sekiya, S. & Suzuki, A., 7 21 2011, : : Nature. 475, 7356, p. 390-395 6 p.

研究成果: ジャーナルへの寄稿記事

535 引用 (Scopus)
公開

Diminished alcohol preference in transgenic mice lacking aldehyde dehydrogenase activity

Isse, T., Oyama, T., Kitagawa, K., Matsuno, K., Matsumoto, A., Yoshida, A., Nakayama, K., Nakayama, K. & Kawamoto, T., 11 1 2002, : : Pharmacogenetics. 12, 8, p. 621-626 6 p.

研究成果: ジャーナルへの寄稿記事

54 引用 (Scopus)

Development of mice without Cip/Kip CDK inhibitors

Tateishi, Y., Matsumoto, A., Kanie, T., Hara, E., Nakayama, K. & Nakayama, K. I., 10 19 2012, : : Biochemical and Biophysical Research Communications. 427, 2, p. 285-292 8 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice

Matsumoto, A., Susaki, E., Onoyama, I., Nakayama, K., Hoshino, M. & Nakayama, K. I., 10 1 2011, : : Molecular and cellular biology. 31, 20, p. 4176-4192 17 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Deletion of Cdkn1b ameliorates hyperglycemia by maintaining compensatory hyperinsulinemia in diabetic mice

Uchida, T., Nakamura, T., Hashimoto, N., Matsuda, T., Kotani, K., Sakaue, H., Kido, Y., Hayashi, Y., Nakayama, K. I., White, M. F. & Kasuga, M., 2 1 2005, : : Nature medicine. 11, 2, p. 175-182 8 p.

研究成果: ジャーナルへの寄稿記事

159 引用 (Scopus)

Degradation of Tob1 mediated by SCFSkp2-dependent ubiquitination

Hiramatsu, Y., Kitagawa, K., Suzuki, T., Uchida, C., Hattori, T., Kikuchi, H., Oda, T., Hatakeyama, S., Nakayama, K. I., Yamamoto, T., Konno, H. & Kitagawa, M., 9 1 2006, : : Cancer Research. 66, 17, p. 8477-8483 7 p.

研究成果: ジャーナルへの寄稿記事

43 引用 (Scopus)

Degradation of the endoplasmic reticulum–anchored transcription factor MyRF by the ubiquitin ligase SCFFbxw7 in a manner dependent on the kinase GSK-3

Nakayama, S., Yumimoto, K., Kawamura, A. & Nakayama, K. I., 4 13 2018, : : Journal of Biological Chemistry. 293, 15, p. 5705-5714 10 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Degradation of p57Kip2 mediated by SCFSkp2-dependent ubiquitylation

Kamura, T., Hara, T., Kotoshiba, S., Yada, M., Ishida, N., Imaki, H., Hatakeyama, S., Nakayama, K. & Nakayama, K. I., 9 2 2003, : : Proceedings of the National Academy of Sciences of the United States of America. 100, 18, p. 10231-10236 6 p.

研究成果: ジャーナルへの寄稿記事

225 引用 (Scopus)

Degradation of p27Kip1 at the G0-G1 Transition Mediated by a Skp2-independent Ubiquitination Pathway

Hara, T., Kamura, T., Nakayama, K., Oshikawa, K., Hatakeyama, S. & Nakayama, K., 12 28 2001, : : Journal of Biological Chemistry. 276, 52, p. 48937-48943 7 p.

研究成果: ジャーナルへの寄稿記事

187 引用 (Scopus)

Deficient p27 phosphorylation at serine 10 increases macrophage foam cell formation and aggravates atherosclerosis through a proliferation-independent mechanism

Fuster, J. J., González-Navarro, H., Vinué, A., Molina-Sànchez, P., Andrés-Manzano, M. J., Nakayama, K. I., Nakayama, K., Díez-Juan, A., Bernad, A., Rodríguez, C., Martínez-González, J. & Andrés, V., 11 1 2011, : : Arteriosclerosis, thrombosis, and vascular biology. 31, 11, p. 2455-2463 9 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

Deficiency of Rap1-Binding Protein RAPL Causes Lymphoproliferative Disorders through Mislocalization of p27kip1

Katagiri, K., Ueda, Y., Tomiyama, T., Yasuda, K., Toda, Y., Ikehara, S., Nakayama, K. I. & Kinashi, T., 1 28 2011, : : Immunity. 34, 1, p. 24-38 15 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Decreased Brain pH as a Shared Endophenotype of Psychiatric Disorders

Hagihara, H., Catts, V. S., Katayama, Y., Shoji, H., Takagi, T., Huang, F. L., Nakao, A., Mori, Y., Huang, K. P., Ishii, S., Graef, I. A., Nakayama, K. I., Shannon Weickert, C. & Miyakawa, T., 2 1 2018, : : Neuropsychopharmacology. 43, 3, p. 459-468 10 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis

Chan, C. H., Lee, S. W., Li, C. F., Wang, J., Yang, W. L., Wu, C. Y., Wu, J., Nakayama, K. I., Kang, H. Y., Huang, H. Y., Hung, M. C., Pandolfi, P. P. & Lin, H. K., 5 1 2010, : : Nature Cell Biology. 12, 5, p. 457-467 11 p.

研究成果: ジャーナルへの寄稿記事

143 引用 (Scopus)

Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice

Morishita, H., Makishima, T., Kaneko, C., Lee, Y. S., Segil, N., Takahashi, K., Kuraoka, A., Nakagawa, T., Nabekura, J., Nakayama, K. & Nakayama, K. I., 1 1 2001, : : Biochemical and Biophysical Research Communications. 284, 1, p. 142-149 8 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27Kip1 at G1 phase

Kamura, T., Hara, T., Matsumoto, M., Ishida, N., Okumura, F., Hatakeyama, S., Yoshida, M., Nakayama, K. & Nakayama, K., 12 1 2004, : : Nature Cell Biology. 6, 12, p. 1229-1235 7 p.

研究成果: ジャーナルへの寄稿記事

320 引用 (Scopus)

Cyclin D2 translocates p27 out of the nucleus and promotes its degradation at the G0-G1 transition

Susaki, E., Nakayama, K. & Nakayama, K. I., 7 1 2007, : : Molecular and cellular biology. 27, 13, p. 4626-4640 15 p.

研究成果: ジャーナルへの寄稿記事

47 引用 (Scopus)

Cutting edge: Tyk2 is required for the induction and nuclear translocation of Daxx which regulates IFN-α-induced suppression of B lymphocyte formation

Shimoda, K., Kamesaki, K., Numata, A., Aoki, K., Matsuda, T., Oritani, K., Tamiya, S., Kato, K., Takase, K., Imamura, R., Yamamoto, T., Miyamoto, T., Nagafuji, K., Gondo, H., Nagafuchi, S., Nakayama, K. I. & Harada, M., 11 1 2002, : : Journal of Immunology. 169, 9, p. 4707-4711 5 p.

研究成果: ジャーナルへの寄稿記事

47 引用 (Scopus)

Corneal antifibrotic switch identified in genetic and pharmacological deficiency of vimentin

Bargagna-Mohan, P., Paranthan, R. R., Hamza, A., Zhan, C. G., Lee, D. M., Kim, K. B., Lau, D. L., Srinivasan, C., Nakayama, K., Nakayama, K., Herrmann, H. & Mohan, R., 1 6 2012, : : Journal of Biological Chemistry. 287, 2, p. 989-1006 18 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Copy number loss of FBXW7 is related to gene expression and poor prognosis in esophageal squamous cell carcinoma

Yokobori, T., Mimori, K., Iwatsuki, M., Ishii, H., Tanaka, F., Sato, T., Toh, H., Sudo, T., Iwaya, T., Tanaka, Y., Onoyama, I., Kuwano, H., Nakayama, K. I. & Mori, M., 7 1 2012, : : International journal of oncology. 41, 1, p. 253-259 7 p.

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)

Cooperative regulation of the cell division cycle by the protein kinases RAF and AKT

Mirza, A. M., Gysin, S., Malek, N., Nakayama, K. I., Roberts, J. M. & McMahon, M., 12 1 2004, : : Molecular and cellular biology. 24, 24, p. 10868-10881 14 p.

研究成果: ジャーナルへの寄稿記事

94 引用 (Scopus)

Control mechanism of JAK/STAT signal transduction pathway

Yamada, S., Shiono, S., Joo, A. & Yoshimura, A., 1 16 2003, : : FEBS Letters. 534, 1-3, p. 190-196 7 p.

研究成果: ジャーナルへの寄稿記事

143 引用 (Scopus)

Conditional inactivation of Fbxw7 impairs cell-cycle exit during T cell differentiation and results in lymphomatogenesis

Onoyama, I., Tsunematsu, R., Matsumoto, A., Kimura, T., De Alborán, I. M., Nakayama, K. & Nakayama, K. I., 11 26 2007, : : Journal of Experimental Medicine. 204, 12, p. 2875-2888 14 p.

研究成果: ジャーナルへの寄稿記事

141 引用 (Scopus)

Comprehensive identification of substrates for f-box proteins by differential proteomics analysis

Yumimoto, K., Matsumoto, M., Oyamada, K., Moroishi, T. & Nakayama, K. I., 6 1 2012, : : Journal of Proteome Research. 11, 6, p. 3175-3185 11 p.

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

Complex regulation of cell-cycle inhibitors by Fbxw7 in mouse embryonic fibroblasts

Masuda, K., Ishikawa, Y., Onoyama, I., Unno, M., De Alborán, I. M., Nakayama, K. I. & Nakayama, K., 3 1 2010, : : Oncogene. 29, 12, p. 1798-1809 12 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

Comparative analysis of human Src-family kinase substrate specificity in vitro

Takeda, H., Kawamura, Y., Miura, A., Mori, M., Wakamatsu, A., Yamamoto, J. I., Isogai, T., Matsumoto, M., Nakayama, K., Natsume, T., Nomura, N. & Goshima, N., 11 5 2010, : : Journal of Proteome Research. 9, 11, p. 5982-5993 12 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

Common pathway for the ubiquitination of IκBα, Iκbβ, and IκBε mediated by the F-box protein FWD1

Shirane, M., Hatakeyama, S., Hattori, K., Nakayama, K. & Nakayama, K., 10 1 1999, : : Journal of Biological Chemistry. 274, 40, p. 28169-28174 6 p.

研究成果: ジャーナルへの寄稿記事

61 引用 (Scopus)

Common and specific roles of the related CDK inhibitors p27 and p57 revealed by a knock-in mouse model

Susaki, E., Nakayama, K., Yamasaki, L. & Nakayama, K. I., 3 31 2009, : : Proceedings of the National Academy of Sciences of the United States of America. 106, 13, p. 5192-5197 6 p.

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

Combined mutation of Apc, Kras, and Tgfbr2 effectively drives metastasis of intestinal cancer

Sakai, E., Nakayama, M., Oshima, H., Kouyama, Y., Niida, A., Fujii, S., Ochiai, A., Nakayama, K. I., Mimori, K., Suzuki, Y., Hong, C. P., Ock, C. Y., Kim, S. J. & Oshima, M., 3 1 2018, : : Cancer Research. 78, 5, p. 1334-1346 13 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Clonal identification and characterization of self-renewing pluripotent stem cells in the developing liver

Suzuki, A., Zheng, Y. W., Kaneko, S., Onodera, M., Fukao, K., Nakauchi, H. & Taniguchi, H., 1 7 2002, : : Journal of Cell Biology. 156, 1, p. 173-184 12 p.

研究成果: ジャーナルへの寄稿記事

319 引用 (Scopus)
197 引用 (Scopus)

CIS1 interacts with the Y532 of the prolactin receptor and suppresses prolactin-dependent STAT5 activation

Endo, T., Sasaki, A., Minoguchi, M., Joo, A. & Yoshimura, A., 1 1 2003, : : Journal of biochemistry. 133, 1, p. 109-113 5 p.

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

Cholinergic alterations following alcohol exposure in the frontal cortex of Aldh2-deficient mice models

Jamal, M., Ameno, K., Miki, T., Wang, W., Kumihashi, M., Isse, T., Kawamoto, T., Kitagawa, K., Nakayama, K., Ijiri, I. & Kinoshita, H., 10 12 2009, : : Brain Research. 1295, p. 37-43 7 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

CHIP promotes proteasomal degradation of familial ALS-linked mutant SOD1 by ubiquitinating Hsp/Hsc70

Urushitani, M., Kurisu, J., Tateno, M., Hatakeyama, S., Nakayama, K., Kato, S. & Takahashi, R., 7 1 2004, : : Journal of Neurochemistry. 90, 1, p. 231-244 14 p.

研究成果: ジャーナルへの寄稿記事

135 引用 (Scopus)

CHIP is associated with Parkin, a gene responsible for familial Parkinson's Disease, and enhances its ubiquitin ligase activity

Imai, Y., Soda, M., Hatakeyama, S., Akagi, T., Hashikawa, T., Nakayama, K. I. & Takahashi, R., 1 1 2002, : : Molecular Cell. 10, 1, p. 55-67 13 p.

研究成果: ジャーナルへの寄稿記事

389 引用 (Scopus)

CHD8 suppresses p53-mediated apoptosis through histone H1 recruitment during early embryogenesis

Nishiyama, M., Oshikawa, K., Tsukada, Y. I., Nakagawa, T., Iemura, S. I., Natsume, T., Fan, Y., Kikuchi, A., Skoultchi, A. I. & Nakayama, K. I., 1 19 2009, : : Nature Cell Biology. 11, 2, p. 172-182 11 p.

研究成果: ジャーナルへの寄稿記事

97 引用 (Scopus)

CHD8 haploinsufficiency results in autistic-like phenotypes in mice

Katayama, Y., Nishiyama, M., Shoji, H., Ohkawa, Y., Kawamura, A., Sato, T., Suyama, M., Takumi, T., Miyakawa, T. & Nakayama, K. I., 1 1 2016, : : Nature. 537, 7622, p. 675-679 5 p.

研究成果: ジャーナルへの寄稿記事

86 引用 (Scopus)

Chd2 regulates chromatin for proper gene expression toward differentiation in mouse embryonic stem cells

Semba, Y., Harada, A., Maehara, K., Oki, S., Meno, C., Ueda, J., Yamagata, K., Suzuki, A., Onimaru, M., Nogami, J., Okada, S., Akashi, K. & Ohkawa, Y., 9 1 2017, : : Nucleic acids research. 45, 15, p. 8758-8772 15 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Characterization of the mouse gene for the U-box-type ubiquitin ligase UFD2a

Kaneko, C., Hatakeyama, S., Matsumoto, M., Yada, M., Nakayama, K. & Nakayama, K., 1 10 2003, : : Biochemical and Biophysical Research Communications. 300, 2, p. 297-304 8 p.

研究成果: ジャーナルへの寄稿記事

47 引用 (Scopus)

Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10

Maruyama, S. I., Hatakeyama, S., Nakayama, K., Ishida, N., Kawakami, K. & Nakayama, K. I., 9 15 2001, : : Genomics. 78, 3, p. 214-222 9 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Cell surface expression of CD147/EMMPRIN is regulated by cyclophilin 60

Pushkarsky, T., Yurchenko, V., Vanpouille, C., Brichacek, B., Vaisman, I., Hatakeyama, S., Nakayama, K. I., Sherry, B. & Bukrinsky, M. I., 7 29 2005, : : Journal of Biological Chemistry. 280, 30, p. 27866-27871 6 p.

研究成果: ジャーナルへの寄稿記事

61 引用 (Scopus)

Cell cycle regulation and differentiation in the human podocyte lineage

Nagata, M., Nakayama, K. I., Terada, Y., Hoshi, S. & Watanabe, T., 11 1998, : : American Journal of Pathology. 153, 5, p. 1511-1520 10 p.

研究成果: ジャーナルへの寄稿記事

120 引用 (Scopus)

Cell cycle-dependent regulation of the Skp2 promoter by GA-binding protein

Imaki, H., Nakayama, K., Delehouzee, S., Handa, H., Kitagawa, M., Kamura, T. & Nakayama, K. I., 8 1 2003, : : Cancer Research. 63, 15, p. 4607-4613 7 p.

研究成果: ジャーナルへの寄稿記事

70 引用 (Scopus)