応用幹細胞医科学部門

研究成果 1992 2019

2019

CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines

Takaki-Kuwahara, A., Arinobu, Y., Miyawaki, K., Yamada, H., Tsuzuki, H., Irino, K., Ayano, M., Kimoto, Y., Mitoma, H., Akahoshi, M., Tsukamoto, H., Horiuchi, T., Niiro, H. & Akashi, K., 8 30 2019, : : Arthritis Research and Therapy. 21, 1, 198.

研究成果: ジャーナルへの寄稿記事

公開
Rheumatoid Arthritis
Joints
Lymphocytes
Cytokines
Synovial Fluid
Phase II Clinical Trials
Clinical Trials, Phase I
Systemic Scleroderma
Hematopoietic Stem Cell Transplantation
Japan
8 引用 (Scopus)

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. および6人, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., 1 23 2019, : : Science Advances. 5, 1, eaau9060.

研究成果: ジャーナルへの寄稿記事

公開
Circadian Rhythm
Circadian Clocks
Phosphotransferases
Growth
Neoplasms

Comparison of the sequencing bias of currently available library preparation kits for Illumina sequencing of bacterial genomes and metagenomes

Sato, M. P., Ogura, Y., Nakamura, K., Nishida, R., Gotoh, Y., Hayashi, M., Hisatsune, J., Sugai, M., Takehiko, I. & Hayashi, T., 10 1 2019, : : DNA research : an international journal for rapid publication of reports on genes and genomes. 26, 5, p. 391-398 8 p.

研究成果: ジャーナルへの寄稿記事

公開
Metagenome
Bacterial Genomes
Base Composition
Libraries
Metagenomics

Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice

Saito, H., Hara, K., Tominaga, T., Nakashima, K. & Tanemura, K., 12 1 2019, : : Journal of Applied Toxicology. 39, 12, p. 1651-1662 12 p.

研究成果: ジャーナルへの寄稿記事

Permethrin
Neuroglia
Learning
Data storage equipment
Population

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., 7 2 2019, : : Cell Reports. 28, 1, p. 145-158.e9

研究成果: ジャーナルへの寄稿記事

公開
Hematopoietic Stem Cells
Stem cells
Maintenance
Fatty Acids
Cell culture
1 引用 (Scopus)
Mesentery
Epithelial-Mesenchymal Transition
Gonads
Morphogenesis
Ovary
1 引用 (Scopus)

Evaluation of SNP calling methods for closely related bacterial isolates and a novel high-accuracy pipeline: BactSNP

Yoshimura, D., Kajitani, R., Gotoh, Y., Katahira, K., Okuno, M., Ogura, Y., Hayashi, T. & Itoh, T., 5 1 2019, : : Microbial Genomics. 5, 5

研究成果: ジャーナルへの寄稿記事

公開
Single Nucleotide Polymorphism
Genome
Benchmarking
Disease Outbreaks
Bacteria

Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells

Terada, M., Kawamata, M., Kimura, R., Sekiya, S., Nagamatsu, G., Hayashi, K., Horisawa, K. & Suzuki, A., 1 1 2019, (受理済み/印刷中) : : Genesis. e23334.

研究成果: ジャーナルへの寄稿記事

Pluripotent Stem Cells
Germ Cells
Embryonic Stem Cells
Genetic Promoter Regions
Transgenic Mice

Genome sequencing verifies relapsed infection of helicobacter cinaedi

Sawada, O., Gotoh, Y., Taniguchi, T., Furukawa, S., Yoshimura, D., Sasaki, S., Shida, H., Kusunoki, Y., Yamamura, T., Furuya, K., Itoh, T., Horita, T., Hayashi, T. & Misawa, N., 1 1 2019, : : Open Forum Infectious Diseases. 6, 5

研究成果: ジャーナルへの寄稿記事

公開
Helicobacter Infections
Genome
Infection
Single Nucleotide Polymorphism
Clone Cells
Neural Stem Cells
Astrocytes
Epigenomics
Central Nervous System
Multipotent Stem Cells
1 引用 (Scopus)

Hypoxia induces the dormant state in oocytes through expression of Foxo3

Shimamoto, S., Nishimura, Y., Nagamatsu, G., Hamada, N., Kita, H., Hikabe, O., Hamazaki, N. & Hayashi, K., 6 18 2019, : : Proceedings of the National Academy of Sciences of the United States of America. 116, 25, p. 12321-12326 6 p.

研究成果: ジャーナルへの寄稿記事

Oocytes
Reproductive Medicine
Oogenesis
Transcriptome
Mammals

Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice

Nakajima, K., Ono, M., Radović, U., Dizdarević, S., Tomizawa, S. I., Kuroha, K., Nagamatsu, G., Hoshi, I., Matsunaga, R., Shirakawa, T., Kurosawa, T., Miyazaki, Y., Seki, M., Suzuki, Y., Koseki, H., Nakamura, M., Suda, T. & Ohbo, K., 11 12 2019, : : Disease models & mechanisms. 12, 11

研究成果: ジャーナルへの寄稿記事

公開
Protease Inhibitors
Respiratory Insufficiency
Disulfides
Cause of Death
Lung

Large-scale genome analysis of bovine commensal Escherichia coli reveals that bovine-adapted E. Coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains

Arimizu, Y., Kirino, Y., Sato, M. P., Uno, K., Sato, T., Gotoh, Y., Auvray, F., Brugere, H., Oswald, E., Mainil, J. G., Anklam, K. S., Döpfer, D., Yoshino, S., Ooka, T., Tanizawa, Y., Nakamura, Y., Iguchi, A., Morita-Ishihara, T., Ohnishi, M., Akashi, K. および2人, Hayashi, T. & Ogura, Y., 1 1 2019, : : Genome Research. 29, 9, p. 1495-1505 11 p.

研究成果: ジャーナルへの寄稿記事

公開
Enteropathogenic Escherichia coli
Genome
Escherichia coli
Virulence
Enterocytes
2 引用 (Scopus)

Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes

Nagamatsu, G., Shimamoto, S., Hamazaki, N., Nishimura, Y. & Hayashi, K., 1 1 2019, : : Science Advances. 5, 6, eaav9960.

研究成果: ジャーナルへの寄稿記事

公開
gametocytes
mice
ovaries
boxes
activation
2 引用 (Scopus)

Multi-step genomic dissection of a suspected intra-hospital helicobacter cinaedi outbreak

Gotoh, Y., Taniguchi, T., Yoshimura, D., Katsura, K., Saeki, Y., Hirabara, Y., Fukuda, M., Takajo, I., Tomida, J., Kawamura, Y., Ogura, Y., Itoh, T., Misawa, N., Okayama, A. & Hayashi, T., 1 1 2019, : : Microbial Genomics. 5, 1, 000236.

研究成果: ジャーナルへの寄稿記事

Helicobacter
Disease Outbreaks
Dissection
Genome
Bacteremia

Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury

Yoshikawa, Y., Ago, T., Kuroda, J., Wakisaka, Y., Tachibana, M., Komori, M., Shibahara, T., Nakashima, H., Nakashima, K. & Kitazono, T., 2 1 2019, : : Neuroscience. 398, p. 193-205 13 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Neurogenesis
Hippocampus
Cell Proliferation
Wounds and Injuries

Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain

Murao, N., Matsubara, S., Matsuda, T., Noguchi, H., Mutoh, T., Mutoh, M., Koseki, H., Namihira, M. & Nakashima, K., 6 1 2019, : : Neuroscience Research. 143, p. 31-43 13 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Neurogenesis
Tumor Suppressor Genes
Gene Expression
Brain
8 引用 (Scopus)

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

Matsuda, T., Irie, T., Katsurabayashi, S., Hayashi, Y., Nagai, T., Hamazaki, N., Adefuin, A. M. D., Miura, F., Ito, T., Kimura, H., Shirahige, K., Takeda, T., Iwasaki, K., Imamura, T. & Nakashima, K., 2 6 2019, : : Neuron. 101, 3, p. 472-485.e7

研究成果: ジャーナルへの寄稿記事

Microglia
Epigenomics
Neurons
Transcription Factors
Genes
2 引用 (Scopus)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Kidoya, H., Muramatsu, F., Shimamura, T., Jia, W., Satoh, T., Hayashi, Y., Naito, H., Kunisaki, Y., Arai, F., Seki, M., Suzuki, Y., Osawa, T., Akira, S. & Takakura, N., 12 1 2019, : : Nature communications. 10, 1, 1072.

研究成果: ジャーナルへの寄稿記事

公開
homeostasis
stem cells
Hematopoietic Stem Cells
Homeostasis
hematopoiesis

Stem Cell-Derived Human Gametes: The Public Engagement Imperative

Adashi, E. Y., Cohen, I. G., Hanna, J. H., Surani, A. M. & Hayashi, K., 3 1 2019, : : Trends in Molecular Medicine. 25, 3, p. 165-167 3 p.

研究成果: ジャーナルへの寄稿小調査

Germ Cells
Stem Cells
Technology
3 引用 (Scopus)

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

Noguchi, H., Castillo, J. G., Nakashima, K. & Pleasure, S. J., 4 11 2019, : : eLife. 8, e42918.

研究成果: ジャーナルへの寄稿記事

公開
Adult Stem Cells
Neural Stem Cells
Stem cells
Hedgehogs
Dentate Gyrus
1 引用 (Scopus)

Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury

Nakajo, M., Uezono, N., Nakashima, H., Wake, H., Komiya, S., Nishibori, M. & Nakashima, K., 4 1 2019, : : Neuroscience Research. 141, p. 63-70 8 p.

研究成果: ジャーナルへの寄稿記事

Spinal Cord Injuries
Antibodies
Injections
Monoclonal Antibodies
Therapeutics
2018
2 引用 (Scopus)

Canonical TGF-β signaling negatively regulates neuronal morphogenesis through TGIF/Smad complex-mediated CRMP2 suppression

Nakashima, H., Tsujimura, K., Irie, K., Ishizu, M., Pan, M., Kameda, T. & Nakashima, K., 5 16 2018, : : Journal of Neuroscience. 38, 20, p. 4791-4810 20 p.

研究成果: ジャーナルへの寄稿記事

Transforming Growth Factors
Morphogenesis
Neurons
Cytokines
Induced Pluripotent Stem Cells

Current advance of in vitro gametogenesis

Hayashi, K., 1 1 2018, : : Seikagaku. 90, 4, p. 533-538 6 p.

研究成果: ジャーナルへの寄稿評論記事

Gametogenesis
In Vitro Techniques
5 引用 (Scopus)
Neurogenesis
Valproic Acid
Anticonvulsants
Seizures
Neural Stem Cells
5 引用 (Scopus)
glycohemoglobin
rheumatoid arthritis
tumor necrosis factors
Glycosylated Hemoglobin A
observational studies
11 引用 (Scopus)

Embryos and embryonic stem cells from the white rhinoceros

Hildebrandt, T. B., Hermes, R., Colleoni, S., Diecke, S., Holtze, S., Renfree, M. B., Stejskal, J., Hayashi, K., Drukker, M., Loi, P., Göritz, F., Lazzari, G. & Galli, C., 12 1 2018, : : Nature communications. 9, 1, 2589.

研究成果: ジャーナルへの寄稿記事

gametocytes
Mammals
stem cells
embryos
Blastocyst

Epigenetic Regulation of Human Neural Stem Cell Differentiation

Honda, M., Nakashima, K. & Katada, S., 1 1 2018, Results and Problems in Cell Differentiation. Springer Verlag, p. 125-136 12 p. (Results and Problems in Cell Differentiation; 巻数 66).

研究成果: 著書/レポートタイプへの貢献

Neural Stem Cells
Epigenomics
Cell Differentiation
Histone Code
Induced Pluripotent Stem Cells
6 引用 (Scopus)

Epigenetic regulation of neural stem cell differentiation towards spinal cord regeneration

Kameda, T., Imamura, T. & Nakashima, K., 1 1 2018, : : Cell and tissue research. 371, 1, p. 189-199 11 p.

研究成果: ジャーナルへの寄稿評論記事

Spinal Cord Regeneration
Neural Stem Cells
Epigenomics
Cell Differentiation
Spinal Cord Injuries
15 引用 (Scopus)

Genome-wide CRISPR-Cas9 Screen Identifies Leukemia-Specific Dependence on a Pre-mRNA Metabolic Pathway Regulated by DCPS

yamauchi, T., Masuda, T., Canver, M. C., Seiler, M., Semba, Y., Shboul, M., Al-Raqad, M., Maeda, M., Schoonenberg, V. A. C., Cole, M. A., Macias-Trevino, C., Ishikawa, Y., Yao, Q., Nakano, M., Arai, F., Orkin, S. H., Reversade, B., Buonamici, S., Pinello, L., Akashi, K. および2人, Bauer, D. E. & Maeda, T., 3 12 2018, : : Cancer Cell. 33, 3, p. 386-400.e5

研究成果: ジャーナルへの寄稿記事

Clustered Regularly Interspaced Short Palindromic Repeats
RNA Precursors
Metabolic Networks and Pathways
Leukemia
Genome

Genomic characterization of β-glucuronidase–positive escherichia coli O157:H7 producing Stx2a

Ogura, Y., Seto, K., Morimoto, Y., Nakamura, K., Sato, M. P., Gotoh, Y., Itoh, T., Toyoda, A., Ohnishi, M. & Hayashi, T., 12 2018, : : Emerging Infectious Diseases. 24, 12, p. 2219-2227 9 p.

研究成果: ジャーナルへの寄稿記事

Escherichia coli O157
Virulence
Clone Cells
Shiga-Toxigenic Escherichia coli
Diarrhea

Guest editorial: Regulatory signaling in normal and abnormal hematopoiesis

Arai, F., 6 1 2018, : : International journal of hematology. 107, 6, p. 624-626 3 p.

研究成果: ジャーナルへの寄稿編集

Hematopoiesis
Hematopoietic Stem Cells
Stem Cells
Stem Cell Niche
Maintenance
5 引用 (Scopus)

HMGB2 expression is associated with transition from a quiescent to an activated state of adult neural stem cells

Kimura, A., Matsuda, T., sakai, A., Murao, N. & Nakashima, K., 1 1 2018, : : Developmental Dynamics. 247, 1, p. 229-238 10 p.

研究成果: ジャーナルへの寄稿記事

HMGB2 Protein
Adult Stem Cells
Neural Stem Cells
Hippocampus
High Mobility Group Proteins
22 引用 (Scopus)

Leukaemia hijacks a neural mechanism to invade the central nervous system

Yao, H., Price, T. T., Cantelli, G., Ngo, B., Warner, M. J., Olivere, L., Ridge, S. M., Jablonski, E. M., Therrien, J., Tannheimer, S., McCall, C. M., Chenn, A. & Sipkins, D. A., 8 2 2018, : : Nature. 560, 7716, p. 55-60 6 p.

研究成果: ジャーナルへの寄稿記事

Precursor Cell Lymphoblastic Leukemia-Lymphoma
Leukemia
Central Nervous System
Integrins
Neoplasm Metastasis
11 引用 (Scopus)

Neural stem cell therapy aiming at better functional recovery after spinal cord injury

Zhu, Y., Uezono, N., Yasui, T. & Nakashima, K., 1 1 2018, : : Developmental Dynamics. 247, 1, p. 75-84 10 p.

研究成果: ジャーナルへの寄稿評論記事

Neural Stem Cells
Cell- and Tissue-Based Therapy
Spinal Cord Injuries
Stem Cell Transplantation
Stem Cell Research
16 引用 (Scopus)

New aspects of glioblastoma multiforme revealed by similarities between neural and glioblastoma stem cells

Kawamura, Y., Takouda, J., Yoshimoto, K. & Nakashima, K., 12 15 2018, : : Cell Biology and Toxicology. 34, 6, p. 425-440 16 p.

研究成果: ジャーナルへの寄稿評論記事

Neural Stem Cells
Glioblastoma
Stem cells
Stem Cells
Epigenomics

Nuclear factor I/A coordinates the timing of oligodendrocyte differentiation/maturation via olig1 promoter methylation

Semi, K., Sanosaka, T., Namihira, M. & Nakashima, K., 4 1 2018, : : HAYATI Journal of Biosciences. 25, 2, p. 70-78 9 p.

研究成果: ジャーナルへの寄稿記事

NFI Transcription Factors
Methylation
Oligodendroglia
methylation
Transcription Factors
7 引用 (Scopus)

Prior Treatment with Anti-High Mobility Group Box-1 Antibody Boosts Human Neural Stem Cell Transplantation-Mediated Functional Recovery After Spinal Cord Injury

Uezono, N., Zhu, Y., Fujimoto, Y., Yasui, T., Matsuda, T., Nakajo, M., Abematsu, M., Setoguchi, T., Mori, S., Takahashi, H. K., Komiya, S., Nishibori, M. & Nakashima, K., 5 2018, : : STEM CELLS. 36, 5, p. 737-750 14 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Stem Cell Transplantation
Spinal Cord Injuries
Induced Pluripotent Stem Cells
Neurons

Rett syndrome and stem cell research

Tsujimura, K. & Nakashima, K., 6 27 2018, Stem Cell Genetics for Biomedical Research: Past, Present, and Future. Springer International Publishing, p. 27-41 15 p.

研究成果: 著書/レポートタイプへの貢献

Rett Syndrome
Stem Cell Research
Stem cells
Methyl-CpG-Binding Protein 2
Technology
3 引用 (Scopus)

Small RNA repertoires and their intraspecies variation in Aggregatibacter actinomycetemcomitans

Oogai, Y., Gotoh, Y., Ogura, Y., Kawada-Matsuo, M., Hayashi, T. & Komatsuzawa, H., 4 1 2018, : : DNA Research. 25, 2, p. 207-215 9 p.

研究成果: ジャーナルへの寄稿記事

Aggregatibacter actinomycetemcomitans
RNA
Intergenic DNA
Genes
Virulence
4 引用 (Scopus)

Spred1 Safeguards Hematopoietic Homeostasis against Diet-Induced Systemic Stress

Tadokoro, Y., Hoshii, T., Yamazaki, S., Eto, K., Ema, H., Kobayashi, M., Ueno, M., Ohta, K., Arai, Y., Hara, E., Harada, K., Oshima, M., Oshima, H., Arai, F., Yoshimura, A., Nakauchi, H. & Hirao, A., 5 3 2018, : : Cell stem cell. 22, 5, p. 713-725.e8

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cells
Homeostasis
Diet
High Fat Diet
Dysbiosis

The role of hedgehog-BMP4 signaling in the patterning of coelomic mesoderm and the onset of gonadogenesis

Yoshino, T., 6 12 2018, Cell Biology of the Ovary: Stem Cells, Development, Cancer, and Clinical Aspects. Springer Singapore, p. 21-33 13 p.

研究成果: 著書/レポートタイプへの貢献

Hedgehogs
Mesoderm
Embryonic Structures
Gonads
Hedgehog Proteins
3 引用 (Scopus)

The role of telomere binding molecules for normal and abnormal hematopoiesis

Hosokawa, K. & Arai, F., 6 1 2018, : : International journal of hematology. 107, 6, p. 646-655 10 p.

研究成果: ジャーナルへの寄稿評論記事

Telomere
Hematopoiesis
Hematopoietic Stem Cells
Hematopoietic System
DNA Damage
2017
13 引用 (Scopus)

Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice

Miyauchi, H., Ohta, H., Nagaoka, S., Nakaki, F., Sasaki, K., Hayashi, K., Yabuta, Y., Nakamura, T., Yamamoto, T. & Saitou, M., 11 2 2017, : : EMBO Journal. 36, 21, p. 3100-3119 20 p.

研究成果: ジャーナルへの寄稿記事

Bone Morphogenetic Proteins
Tretinoin
Germ Cells
Cells
Stem cells
2 引用 (Scopus)

Detection of bidirectional promoter-derived lncRNAs from small-scale samples using pre-amplification-free directional RNA-seq method

Hamazaki, N., Nakashima, K., Hayashi, K. & Imamura, T., 1 1 2017, Methods in Molecular Biology. Humana Press Inc., p. 83-103 21 p. (Methods in Molecular Biology; 巻数 1605).

研究成果: 著書/レポートタイプへの貢献

Long Noncoding RNA
Untranslated RNA
Interleukin-27
RNA
Transcriptional Activation
95 引用 (Scopus)

Differential cytokine contributions of perivascular haematopoietic stem cell niches

Asada, N., Kunisaki, Y., Pierce, H., Wang, Z., Fernandez, N. F., Birbrair, A., Ma'ayan, A. & Frenette, P. S., 3 1 2017, : : Nature Cell Biology. 19, 3, p. 214-223 10 p.

研究成果: ジャーナルへの寄稿記事

Stem Cell Niche
Hematopoietic Stem Cells
Cytokines
Leptin Receptors
Neuroglia
10 引用 (Scopus)

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells

Sanosaka, T., Imamura, T., Hamazaki, N., Chai, M. C., Igarashi, K., Ideta-Otsuka, M., Miura, F., Ito, T., Fujii, N., Ikeo, K. & Nakashima, K., 9 19 2017, : : Cell Reports. 20, 12, p. 2992-3003 12 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Stem cells
Epigenomics
Mental Competency
Neurons
8 引用 (Scopus)
Neural Stem Cells
stem cells
brain
emerging
Brain
4 引用 (Scopus)
Untranslated RNA
Transcriptional Activation
Mammals
Genes
Gene Expression Profiling