応用幹細胞医科学部門

研究成果 1992 2019

コメント/討論

Bidirectional communication between the innate immune and nervous systems for homeostatic neurogenesis in the adult hippocampus

Matsuda, T. & Nakashima, K., 1 1 2015, : : Neurogenesis. 2, 1, p. e1081714-1-e1081714-5 e1081714.

研究成果: ジャーナルへの寄稿コメント/討論

Neurogenesis
Nervous System
Immune System
Hippocampus
Communication
1 引用 (Scopus)

Erratum: Correction: PCGF6-PRC1 suppresses premature differentiation of mouse embryonic stem cells by regulating germ cell-related genes (eLife (2017) 6 PII: e27970)

Endoh, M., Endo, T. A., Shinga, J., Hayashi, K., Farcas, A., Ma, K. W., Ito, S., Sharif, J., Endoh, T., Onaga, N., Nakayama, M., Ishikura, T., Masui, O., Kessler, B. M., Suda, T., Ohara, O., Okuda, A., Klose, R. J. & Koseki, H., 4 25 2017, : : eLife. 6

研究成果: ジャーナルへの寄稿コメント/討論

公開
4 引用 (Scopus)

Prenatal deletion of DNA methyltransferase 1 in neural stem cells impairs neurogenesis and causes anxiety-like behavior in adulthood

Noguchi, H., Kimura, A., Murao, N., Namihira, M. & Nakashima, K., 1 1 2016, : : Neurogenesis. 3, 1, e1232679.

研究成果: ジャーナルへの寄稿コメント/討論

Neural Stem Cells
Neurogenesis
Methyltransferases
Anxiety
Epigenomics

Redefining reproduction

Hayashi, K. & Perry, A., 1 1 2017, : : Biochemist. 39, 1, p. 34-37 4 p.

研究成果: ジャーナルへの寄稿コメント/討論

Reproduction
レター
2 引用 (Scopus)

Synergistic induction of astrocytic differentiation by factors secreted from meninges in the mouse developing brain

Kawamura, Y., Katada, S., Noguchi, H., Yamamoto, H., Sanosaka, T., Iihara, K. & Nakashima, K., 11 2017, : : FEBS Letters. 591, 22, p. 3709-3720 12 p.

研究成果: ジャーナルへの寄稿レター

Meninges
Neural Stem Cells
Brain
Astrocytes
Bone Morphogenetic Protein 4
記事
176 引用 (Scopus)

Accelerated evolution in the protein-coding regions is universal in crotalinae snake venom gland phospholipase A2 isozyme genes

Nakashima, K., Nobuhisa, I., Deshimaru, M., Nakai, M., Ogawa, T., Shimohigashi, Y., Fukumaki, Y., Hattori, M., Sakaki, Y., Hattori, S. & Ohno, M., 6 6 1995, : : Proceedings of the National Academy of Sciences of the United States of America. 92, 12, p. 5605-5609 5 p.

研究成果: ジャーナルへの寄稿記事

Snake Venoms
Phospholipases A2
Open Reading Frames
Isoenzymes
Trimeresurus
145 引用 (Scopus)

Accelerated evolution of crotalinae snake venom gland serine proteases

Deshimaru, M., Ogawa, T., Nakashima, K., Nobuhisa, I., Chijiwa, T., Shimohigashi, Y., Fukumaki, Y., Niwa, M., Yamashina, I., Hattori, S. & Ohno, M., 11 11 1996, : : FEBS Letters. 397, 1, p. 83-88 6 p.

研究成果: ジャーナルへの寄稿記事

Trimeresurus
Snake Venoms
Serine Proteases
Genes
Venoms
53 引用 (Scopus)

Accelerated evolution of snake venom phospholipase A2 isozymes for acquisition of diverse physiological functions

Ogawa, T., Nakashima, K., Nobuhisa, I., Deshimaru, M., Shimohigashi, Y., Fukumaki, Y., Sakaki, Y., Hattori, S. & Ohno, M., 11 1 1996, : : Toxicon. 34, 11-12, p. 1229-1236 8 p.

研究成果: ジャーナルへの寄稿記事

Snake Venoms
Phospholipases A2
Isoenzymes
Genes
Open Reading Frames
155 引用 (Scopus)

Accelerated evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes

Nakashima, K. I., Ogawa, T., Oda, N., Hattori, M., Sakaki, Y., Kihara, H. & Ohno, M., 7 1 1993, : : Proceedings of the National Academy of Sciences of the United States of America. 90, 13, p. 5964-5968 5 p.

研究成果: ジャーナルへの寄稿記事

Phospholipases A2
Introns
Isoenzymes
Open Reading Frames
Exons
54 引用 (Scopus)

Accelerated evolution of Trimeresurus okinavensis venom gland phospholipase A2 isozyme-encoding genes

Nobuhisa, I., Nakashima, K. I., Deshimaru, M., Ogawa, T., Shimohigashi, Y., Fukumaki, Y., Sakaki, Y., Hattori, S., Kihara, H. & Ohno, M., 6 26 1996, : : Gene. 172, 2, p. 267-272 6 p.

研究成果: ジャーナルへの寄稿記事

Phospholipases A2
Isoenzymes
Venoms
Genes
Open Reading Frames
4 引用 (Scopus)

Akhirin regulates the proliferation and differentiation of neural stem cells in intact and injured mouse spinal cord

Abdulhaleem M, F. A., Song, X., Kawano, R., Uezono, N., Ito, A., Ahmed, G., Hossain, M., Nakashima, K., Tanaka, H. & Ohta, K., 5 1 2015, : : Developmental Neurobiology. 75, 5, p. 494-504 11 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Spinal Cord
Cell Adhesion Molecules
Gene Silencing
Bromodeoxyuridine
44 引用 (Scopus)

Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3

Ochiai, W., Yanagisawa, M., Takizawa, T., Nakashima, K. & Taga, T., 6 7 2001, : : Cytokine. 14, 5, p. 264-271 8 p.

研究成果: ジャーナルへの寄稿記事

Neuroepithelial Cells
STAT3 Transcription Factor
Astrocytes
Chemical activation
Cells
49 引用 (Scopus)

Astrocyte-specific genes are generally demethylated in neural precursor cells prior to astrocytic differentiation

Hatada, I., Namihira, M., Morita, S., Kimura, M., Horii, T. & Nakashima, K., 9 11 2008, : : PloS one. 3, 9, e3189.

研究成果: ジャーナルへの寄稿記事

astrocytes
Astrocytes
Genes
genes
cells
56 引用 (Scopus)

Bidirectional promoters are the major source of gene activation-associated non-coding RNAs in mammals

Uesaka, M., Nishimura, O., Go, Y., Nakashima, K., Agata, K. & Imamura, T., 1 17 2014, : : BMC Genomics. 15, 1, 35.

研究成果: ジャーナルへの寄稿記事

Untranslated RNA
Transcriptional Activation
Mammals
Long Noncoding RNA
Messenger RNA
7 引用 (Scopus)
Untranslated RNA
PC12 Cells
Cell Cycle
Nerve Growth Factor
Acetylation
50 引用 (Scopus)

BMP-induced REST regulates the establishment and maintenance of astrocytic identity

Kohyama, J., Sanosaka, T., Tokunaga, A., Takatsuka, E., Tsujimura, K., Okano, H. & Nakashima, K., 4 5 2010, : : Journal of Cell Biology. 189, 1, p. 159-170 12 p.

研究成果: ジャーナルへの寄稿記事

Bone Morphogenetic Proteins
Astrocytes
Maintenance
Stem Cells
Oligodendroglia
15 引用 (Scopus)

Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice

Miyauchi, H., Ohta, H., Nagaoka, S., Nakaki, F., Sasaki, K., Hayashi, K., Yabuta, Y., Nakamura, T., Yamamoto, T. & Saitou, M., 11 2 2017, : : EMBO Journal. 36, 21, p. 3100-3119 20 p.

研究成果: ジャーナルへの寄稿記事

Bone Morphogenetic Proteins
Tretinoin
Germ Cells
Cells
Stem cells
3 引用 (Scopus)

Canonical TGF-β signaling negatively regulates neuronal morphogenesis through TGIF/Smad complex-mediated CRMP2 suppression

Nakashima, H., Tsujimura, K., Irie, K., Ishizu, M., Pan, M., Kameda, T. & Nakashima, K., 5 16 2018, : : Journal of Neuroscience. 38, 20, p. 4791-4810 20 p.

研究成果: ジャーナルへの寄稿記事

Transforming Growth Factors
Morphogenesis
Neurons
Cytokines
Induced Pluripotent Stem Cells
43 引用 (Scopus)

Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3

Uemura, A., Takizawa, T., Ochiai, W., Yanagisawa, M., Nakashima, K. & Taga, T., 1 1 2002, : : Cytokine. 18, 1, p. 1-7 7 p.

研究成果: ジャーナルへの寄稿記事

Neuroepithelial Cells
Astrocytes
Chemical activation
Cells
Glial Fibrillary Acidic Protein

CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines

Takaki-Kuwahara, A., Arinobu, Y., Miyawaki, K., Yamada, H., Tsuzuki, H., Irino, K., Ayano, M., Kimoto, Y., Mitoma, H., Akahoshi, M., Tsukamoto, H., Horiuchi, T., Niiro, H. & Akashi, K., 8 30 2019, : : Arthritis Research and Therapy. 21, 1, 198.

研究成果: ジャーナルへの寄稿記事

公開
Rheumatoid Arthritis
Joints
Lymphocytes
Cytokines
Synovial Fluid
Phase II Clinical Trials
Clinical Trials, Phase I
Systemic Scleroderma
Hematopoietic Stem Cell Transplantation
Japan
9 引用 (Scopus)

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. および6人, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., 1 23 2019, : : Science Advances. 5, 1, eaau9060.

研究成果: ジャーナルへの寄稿記事

公開
Circadian Rhythm
Circadian Clocks
Phosphotransferases
Growth
Neoplasms
44 引用 (Scopus)

Cell density-dependent regulation of hepatic development by a gp130-independent pathway

Kojima, N., Kinoshita, T., Kamiya, A., Nakamura, K., Nakashima, K., Taga, T. & Miyajima, A., 10 14 2000, : : Biochemical and Biophysical Research Communications. 277, 1, p. 152-158 7 p.

研究成果: ジャーナルへの寄稿記事

Oncostatin M
Cell Count
Oncostatin M Receptors
Liver
Hepatocytes
11 引用 (Scopus)

Chymotrypsin inhibitory conformation of dipeptides constructed by side chain–side chain hydrophobic interactions

Sakamoto, H., Shimohigashi, Y., Maeda, I., Nose, T., Nakashima, K., Nakamura, I., Ogawa, T., Ohno, M. & Kawano, K., 1 1 1993, : : Journal of Molecular Recognition. 6, 2, p. 95-100 6 p.

研究成果: ジャーナルへの寄稿記事

Dipeptides
Chymotrypsin
Hydrophobic and Hydrophilic Interactions
Esters
Benzene
公開
Metagenome
Bacterial Genomes
Base Composition
Libraries
Metagenomics
51 引用 (Scopus)

Complete in vitro generation of fertile oocytes from mouse primordial germ cells

Morohaku, K., Tanimoto, R., Sasaki, K., Kawahara-Miki, R., Kono, T., Hayashi, K., Hirao, Y. & Obata, Y., 8 9 2016, : : Proceedings of the National Academy of Sciences of the United States of America. 113, 32, p. 9021-9026 6 p.

研究成果: ジャーナルへの寄稿記事

Oogenesis
Germ Cells
Oocytes
Gonads
Gametogenesis
89 引用 (Scopus)

CpG island of rat sphingosine kinase-1 gene: Tissue-dependent DNA methylation status and multiple alternative first exons

Imamura, T., Ohgane, J., Ito, S., Ogawa, T., Hattori, N., Tanaka, S. & Shiota, K., 7 15 2001, : : Genomics. 76, 1-3, p. 117-125 9 p.

研究成果: ジャーナルへの寄稿記事

CpG Islands
DNA Methylation
Exons
Genes
DNA Sequence Analysis
2 引用 (Scopus)

Darwinian evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes

Nakashima, K., Ogawa, T., Oda, N., Shimohigashi, Y., Hattorit, M., Sakakit, Y., Kihara, H. & Ohno, M., 1 1 1994, : : Pure and Applied Chemistry. 66, 4, p. 715-720 6 p.

研究成果: ジャーナルへの寄稿記事

Phospholipases A2
Venoms
Nucleotides
Isoenzymes
Substitution reactions
23 引用 (Scopus)

Defining the genome features of Escherichia albertii, an emerging enteropathogen closely related to Escherichia coli

Ooka, T., Ogura, Y., Katsura, K., Seto, K., Kobayashi, H., Kawano, K., Tokuoka, E., Furukawa, M., Harada, S., Yoshino, S., Seto, J., Ikeda, T., Yamaguchi, K., Murase, K., Gotoh, Y., Imuta, N., Nishi, J., Gomes, T. A., Beutin, L. & Hayashi, T., 1 1 2015, : : Genome Biology and Evolution. 7, 12, p. 3170-3179 10 p.

研究成果: ジャーナルへの寄稿記事

Escherichia albertii
enteropathogens
Escherichia
genomics
genome
99 引用 (Scopus)

Differential cytokine contributions of perivascular haematopoietic stem cell niches

Asada, N., Kunisaki, Y., Pierce, H., Wang, Z., Fernandez, N. F., Birbrair, A., Ma'ayan, A. & Frenette, P. S., 3 1 2017, : : Nature Cell Biology. 19, 3, p. 214-223 10 p.

研究成果: ジャーナルへの寄稿記事

Stem Cell Niche
Hematopoietic Stem Cells
Cytokines
Leptin Receptors
Neuroglia
43 引用 (Scopus)

Differentiation of multipotent neural stem cells derived from Rett syndrome patients is biased toward the astrocytic lineage

Andoh-Noda, T., Akamatsu, W., Miyake, K., Matsumoto, T., Yamaguchi, R., Sanosaka, T., Okada, Y., Kobayashi, T., Ohyama, M., Nakashima, K., Kurosawa, H., Kubota, T. & Okano, H., 5 27 2015, : : Molecular Brain. 8, 1, 31.

研究成果: ジャーナルへの寄稿記事

Multipotent Stem Cells
Rett Syndrome
Neural Stem Cells
Induced Pluripotent Stem Cells
Methyl-CpG-Binding Protein 2
30 引用 (Scopus)

Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3

Takizawa, T., Yanagisawa, M., Ochiai, W., Yasukawa, K., Ishiguro, T., Nakashima, K. & Taga, T., 3 7 2001, : : Cytokine. 13, 5, p. 272-279 8 p.

研究成果: ジャーナルへの寄稿記事

Neuroepithelial Cells
STAT3 Transcription Factor
Astrocytes
Interleukin-6
Chemical activation
70 引用 (Scopus)

Distinct signaling requirements for Dμ selection, IgH allelic exclusion, Pre-B cell transition, and tumor suppression in B cell progenitors

Hayashi, K., Yamamoto, M., Nojima, T., Goitsuka, R. & Kitamura, D., 6 1 2003, : : Immunity. 18, 6, p. 825-836 12 p.

研究成果: ジャーナルへの寄稿記事

B-Lymphoid Precursor Cells
Pre-B Cell Receptors
Neoplasms
B-Lymphocytes
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
2 引用 (Scopus)

Distinct vascular niches determine hematopoietic stem cell fate

Kunisaki, Y., 6 1 2015, : : [Rinshō ketsueki] The Japanese journal of clinical hematology. 56, 6, p. 606-613 8 p.

研究成果: ジャーナルへの寄稿記事

Hematopoietic Stem Cells
Blood Vessels
Arterioles
Stem Cell Niche
Nestin
11 引用 (Scopus)

DNA Methylome Analysis Identifies Transcription Factor-Based Epigenomic Signatures of Multilineage Competence in Neural Stem/Progenitor Cells

Sanosaka, T., Imamura, T., Hamazaki, N., Chai, M. C., Igarashi, K., Ideta-Otsuka, M., Miura, F., Ito, T., Fujii, N., Ikeo, K. & Nakashima, K., 9 19 2017, : : Cell Reports. 20, 12, p. 2992-3003 12 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Stem cells
Epigenomics
Mental Competency
Neurons
12 引用 (Scopus)

DNA methyltransferase 1 is indispensable for development of the hippocampal dentate gyrus

Noguchi, H., Murao, N., Kimura, A., Matsuda, T., Namihira, M. & Nakashima, K., 6 1 2016, : : Journal of Neuroscience. 36, 22, p. 6050-6068 19 p.

研究成果: ジャーナルへの寄稿記事

Parahippocampal Gyrus
Dentate Gyrus
Methyltransferases
Neural Stem Cells
DNA

Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice

Saito, H., Hara, K., Tominaga, T., Nakashima, K. & Tanemura, K., 12 1 2019, : : Journal of Applied Toxicology. 39, 12, p. 1651-1662 12 p.

研究成果: ジャーナルへの寄稿記事

Permethrin
Neuroglia
Learning
Data storage equipment
Population
5 引用 (Scopus)
Neurogenesis
Valproic Acid
Anticonvulsants
Seizures
Neural Stem Cells
5 引用 (Scopus)
glycohemoglobin
rheumatoid arthritis
tumor necrosis factors
Glycosylated Hemoglobin A
observational studies
11 引用 (Scopus)

Embryos and embryonic stem cells from the white rhinoceros

Hildebrandt, T. B., Hermes, R., Colleoni, S., Diecke, S., Holtze, S., Renfree, M. B., Stejskal, J., Hayashi, K., Drukker, M., Loi, P., Göritz, F., Lazzari, G. & Galli, C., 12 1 2018, : : Nature communications. 9, 1, 2589.

研究成果: ジャーナルへの寄稿記事

gametocytes
Mammals
stem cells
embryos
Blastocyst
13 引用 (Scopus)

Emergence of a multidrug-resistant Shiga toxin-producing enterotoxigenic Escherichia coli lineage in diseased swine in Japan

Kusumoto, M., Hikoda, Y., Fujii, Y., Murata, M., Miyoshi, H., Ogura, Y., Gotoh, Y., Iwata, T., Hayashi, T. & Akiba, M., 4 2016, : : Journal of Clinical Microbiology. 54, 4, p. 1074-1081 8 p.

研究成果: ジャーナルへの寄稿記事

Swine Diseases
Shiga-Toxigenic Escherichia coli
Enterotoxigenic Escherichia coli
Japan
Pulsed Field Gel Electrophoresis
7 引用 (Scopus)

Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion

Ueno, M., Igarashi, K., Kimura, N., Okita, K., Takizawa, M., Nobuhisa, I., Kojima, T., Kitamura, T., Samulowitz, U., Vestweber, D., Shimomura, T., Suda, T., Nakashima, K. & Taga, T., 9 21 2001, : : Biochemical and Biophysical Research Communications. 287, 2, p. 501-506 6 p.

研究成果: ジャーナルへの寄稿記事

Sialomucins
Cell adhesion
Cell Adhesion
Aorta
Endothelial cells

Enhanced processivity of Dnmt1 by monoubiquitinated histone H3

Mishima, Y., Brueckner, L., Takahashi, S., Kawakami, T., Otani, J., Shinohara, A., Takeshita, K., Garvilles, R. G., Watanabe, M., Sakai, N., Takeshima, H., Nachtegael, C., Nishiyama, A., Nakanishi, M., Arita, K., Nakashima, K., Hojo, H. & Suetake, I., 1 1 2019, (受理済み/印刷中) : : Genes to Cells.

研究成果: ジャーナルへの寄稿記事

Histones
Ubiquitination
Methyltransferases
DNA Methylation
DNA
8 引用 (Scopus)

Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit Wv Mutations

Yurino, A., Takenaka, K., Yamauchi, T., Nunomura, T., Uehara, Y., Jinnouchi, F., Miyawaki, K., Kikushige, Y., Kato, K., Miyamoto, T., Iwasaki, H., Kunisaki, Y. & Akashi, K., 9 13 2016, : : Stem Cell Reports. 7, 3, p. 425-438 14 p.

研究成果: ジャーナルへの寄稿記事

Thrombopoiesis
Erythropoiesis
Bone
Cells
Clodronic Acid

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., 7 2 2019, : : Cell Reports. 28, 1, p. 145-158.e9

研究成果: ジャーナルへの寄稿記事

公開
Hematopoietic Stem Cells
Stem cells
Maintenance
Fatty Acids
Cell culture
93 引用 (Scopus)

Epiblast stem cell-based system reveals reprogramming synergy of germline factors

Gillich, A., Bao, S., Grabole, N., Hayashi, K., Trotter, M. W. B., Pasque, V., Magnúsdóttir, E. & Surani, M. A., 4 6 2012, : : Cell stem cell. 10, 4, p. 425-439 15 p.

研究成果: ジャーナルへの寄稿記事

Germ Layers
Germ Cells
Stem Cells
Epigenomics
Mental Competency
171 引用 (Scopus)

Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice

Shiota, K., Kogo, Y., Ohgane, J., Imamura, T., Urano, A., Nishino, K., Tanaka, S. & Hattori, N., 9 1 2002, : : Genes to Cells. 7, 9, p. 961-969 9 p.

研究成果: ジャーナルへの寄稿記事

CpG Islands
DNA Methylation
Epigenomics
Germ Cells
Methylation
76 引用 (Scopus)

Epigenetic regulation of Kiss1 gene expression mediating estrogen-positive feedback action in the mouse brain

Tomikawa, J., Uenoyama, Y., Ozawa, M., Fukanuma, T., Takase, K., Goto, T., Abe, H., Ieda, N., Minabe, S., Deura, C., Inoue, N., Sanbo, M., Tomita, K., Hirabayashi, M., Tanaka, S., Imamura, T., Okamura, H., Maeda, K. I. & Tsukamura, H., 5 15 2012, : : Proceedings of the National Academy of Sciences of the United States of America. 109, 20, p. E1294-E1301

研究成果: ジャーナルへの寄稿記事

Anterior Hypothalamus
Gene Expression Regulation
Epigenomics
Estrogens
Brain
38 引用 (Scopus)

Epigenetic regulation of neural stem cell fate during corticogenesis

MuhChyi, C., Juliandi, B., Matsuda, T. & Nakashima, K., 10 1 2013, : : International Journal of Developmental Neuroscience. 31, 6, p. 424-433 10 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Epigenomics
Cerebral Cortex
Multipotent Stem Cells
Intrinsic Factor