応用幹細胞医科学部門

研究成果 1992 2019

2003
70 引用 (Scopus)

Distinct signaling requirements for Dμ selection, IgH allelic exclusion, Pre-B cell transition, and tumor suppression in B cell progenitors

Hayashi, K., Yamamoto, M., Nojima, T., Goitsuka, R. & Kitamura, D., 6 1 2003, : : Immunity. 18, 6, p. 825-836 12 p.

研究成果: ジャーナルへの寄稿記事

B-Lymphoid Precursor Cells
Pre-B Cell Receptors
Neoplasms
B-Lymphocytes
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
45 引用 (Scopus)

Interisland evolution of Trimeresurus flavoviridis venom phospholipase A2 isozymes

Chijiwa, T., Yamaguchi, Y., Ogawa, T., Deshimaru, M., Nobuhisa, I., Nakashima, K., Oda-Ueda, N., Fukumaki, Y., Hattori, S. & Ohno, M., 3 1 2003, : : Journal of Molecular Evolution. 56, 3, p. 286-293 8 p.

研究成果: ジャーナルへの寄稿記事

Trimeresurus flavoviridis
venom
phospholipase A2
Phospholipases A2
Venoms
95 引用 (Scopus)

Odorant response assays for a heterologously expressed olfactory receptor

Katada, S., Nakagawa, T., Kataoka, H. & Touhara, K., 6 13 2003, : : Biochemical and Biophysical Research Communications. 305, 4, p. 964-969 6 p.

研究成果: ジャーナルへの寄稿記事

Odorant Receptors
Assays
Complementary RNA
Luciferases
GTP-Binding Proteins
54 引用 (Scopus)

Regulation of Vav localization in membrane rafts by adaptor molecules Grb2 and BLNK

Johmura, S., Oh-hora, M., Inabe, K., Nishikawa, Y., Hayashi, K., Vigorito, E., Kitamura, D., Turner, M., Shingu, K., Hikida, M. & Kurosaki, T., 6 1 2003, : : Immunity. 18, 6, p. 777-787 11 p.

研究成果: ジャーナルへの寄稿記事

B-Lymphocytes
Membranes
2002
43 引用 (Scopus)

Cardiotrophin-like cytokine induces astrocyte differentiation of fetal neuroepithelial cells via activation of STAT3

Uemura, A., Takizawa, T., Ochiai, W., Yanagisawa, M., Nakashima, K. & Taga, T., 1 1 2002, : : Cytokine. 18, 1, p. 1-7 7 p.

研究成果: ジャーナルへの寄稿記事

Neuroepithelial Cells
Astrocytes
Chemical activation
Cells
Glial Fibrillary Acidic Protein
171 引用 (Scopus)

Epigenetic marks by DNA methylation specific to stem, germ and somatic cells in mice

Shiota, K., Kogo, Y., Ohgane, J., Imamura, T., Urano, A., Nishino, K., Tanaka, S. & Hattori, N., 9 1 2002, : : Genes to Cells. 7, 9, p. 961-969 9 p.

研究成果: ジャーナルへの寄稿記事

CpG Islands
DNA Methylation
Epigenomics
Germ Cells
Methylation
156 引用 (Scopus)

Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation

Seki, Y. I., Hayashi, K., Matsumoto, A., Seki, N., Tsukada, J., Ransom, J., Naka, T., Kishimoto, T., Yoshimura, A. & Kubo, M., 10 1 2002, : : Proceedings of the National Academy of Sciences of the United States of America. 99, 20, p. 13003-13008 6 p.

研究成果: ジャーナルへの寄稿記事

Suppressor of Cytokine Signaling Proteins
Interleukin-4 Receptors
Interleukin-4
Th1 Cells
Cytokines
2001
44 引用 (Scopus)

Astrocyte differentiation of fetal neuroepithelial cells involving cardiotrophin-1-induced activation of STAT3

Ochiai, W., Yanagisawa, M., Takizawa, T., Nakashima, K. & Taga, T., 6 7 2001, : : Cytokine. 14, 5, p. 264-271 8 p.

研究成果: ジャーナルへの寄稿記事

Neuroepithelial Cells
STAT3 Transcription Factor
Astrocytes
Chemical activation
Cells
89 引用 (Scopus)

CpG island of rat sphingosine kinase-1 gene: Tissue-dependent DNA methylation status and multiple alternative first exons

Imamura, T., Ohgane, J., Ito, S., Ogawa, T., Hattori, N., Tanaka, S. & Shiota, K., 7 15 2001, : : Genomics. 76, 1-3, p. 117-125 9 p.

研究成果: ジャーナルへの寄稿記事

CpG Islands
DNA Methylation
Exons
Genes
DNA Sequence Analysis
30 引用 (Scopus)

Directly linked soluble IL-6 receptor-IL-6 fusion protein induces astrocyte differentiation from neuroepithelial cells via activation of STAT3

Takizawa, T., Yanagisawa, M., Ochiai, W., Yasukawa, K., Ishiguro, T., Nakashima, K. & Taga, T., 3 7 2001, : : Cytokine. 13, 5, p. 272-279 8 p.

研究成果: ジャーナルへの寄稿記事

Neuroepithelial Cells
STAT3 Transcription Factor
Astrocytes
Interleukin-6
Chemical activation
7 引用 (Scopus)

Endomucin is expressed in embryonic dorsal aorta and is able to inhibit cell adhesion

Ueno, M., Igarashi, K., Kimura, N., Okita, K., Takizawa, M., Nobuhisa, I., Kojima, T., Kitamura, T., Samulowitz, U., Vestweber, D., Shimomura, T., Suda, T., Nakashima, K. & Taga, T., 9 21 2001, : : Biochemical and Biophysical Research Communications. 287, 2, p. 501-506 6 p.

研究成果: ジャーナルへの寄稿記事

Sialomucins
Cell adhesion
Cell Adhesion
Aorta
Endothelial cells
2000
44 引用 (Scopus)

Cell density-dependent regulation of hepatic development by a gp130-independent pathway

Kojima, N., Kinoshita, T., Kamiya, A., Nakamura, K., Nakashima, K., Taga, T. & Miyajima, A., 10 14 2000, : : Biochemical and Biophysical Research Communications. 277, 1, p. 152-158 7 p.

研究成果: ジャーナルへの寄稿記事

Oncostatin M
Cell Count
Oncostatin M Receptors
Liver
Hepatocytes
50 引用 (Scopus)

Regional evolution of venom-gland phospholipase A2 isoenzymes of Trimeresurus flavoviridis snakes in the southwestern islands of Japan

Chijiwa, T., Deshimaru, M., Nobuhisa, I., Nakai, M., Ogawa, T., Oda, N., Nakashima, K. I., Fukumaki, Y., Shimohigashi, Y., Hattori, S. & Ohno, M., 4 15 2000, : : Biochemical Journal. 347, 2, p. 491-499 9 p.

研究成果: ジャーナルへの寄稿記事

Trimeresurus
Snakes
Phospholipases A2
Venoms
Islands
120 引用 (Scopus)

The B cell-restricted adaptor BASH is required for normal development and antigen receptor-mediated activation of B cells

Hayashi, K., Nittono, R., Okamoto, N., Tsuji, S., Hara, Y., Goitsuka, R. & Kitamura, D., 3 14 2000, : : Proceedings of the National Academy of Sciences of the United States of America. 97, 6, p. 2755-2760 6 p.

研究成果: ジャーナルへの寄稿記事

Antigen Receptors
B-Lymphocytes
Ligation
Bone Marrow
T-Lymphocytes
73 引用 (Scopus)

Three-dimensional modeling of and ligand docking to vitamin D receptor ligand binding domain

Yamamoto, K., Masuno, H., Choi, M., Nakashima, K., Taga, T., Ooizumi, H., Umesono, K., Sicinska, W., VanHooke, J., DeLuca, H. F. & Yamada, S., 2 15 2000, : : Proceedings of the National Academy of Sciences of the United States of America. 97, 4, p. 1467-1472 6 p.

研究成果: ジャーナルへの寄稿記事

Calcitriol Receptors
Ligands
Hydroxyl Radical
Calcitriol
Hydrogen
1996
145 引用 (Scopus)

Accelerated evolution of crotalinae snake venom gland serine proteases

Deshimaru, M., Ogawa, T., Nakashima, K., Nobuhisa, I., Chijiwa, T., Shimohigashi, Y., Fukumaki, Y., Niwa, M., Yamashina, I., Hattori, S. & Ohno, M., 11 11 1996, : : FEBS Letters. 397, 1, p. 83-88 6 p.

研究成果: ジャーナルへの寄稿記事

Trimeresurus
Snake Venoms
Serine Proteases
Genes
Venoms
53 引用 (Scopus)

Accelerated evolution of snake venom phospholipase A2 isozymes for acquisition of diverse physiological functions

Ogawa, T., Nakashima, K., Nobuhisa, I., Deshimaru, M., Shimohigashi, Y., Fukumaki, Y., Sakaki, Y., Hattori, S. & Ohno, M., 11 1 1996, : : Toxicon. 34, 11-12, p. 1229-1236 8 p.

研究成果: ジャーナルへの寄稿記事

Snake Venoms
Phospholipases A2
Isoenzymes
Genes
Open Reading Frames
54 引用 (Scopus)

Accelerated evolution of Trimeresurus okinavensis venom gland phospholipase A2 isozyme-encoding genes

Nobuhisa, I., Nakashima, K. I., Deshimaru, M., Ogawa, T., Shimohigashi, Y., Fukumaki, Y., Sakaki, Y., Hattori, S., Kihara, H. & Ohno, M., 6 26 1996, : : Gene. 172, 2, p. 267-272 6 p.

研究成果: ジャーナルへの寄稿記事

Phospholipases A2
Isoenzymes
Venoms
Genes
Open Reading Frames
2 引用 (Scopus)

Roles of lysine-69 in dimerization and activity of trimeresurus flavoviridis venom aspartate-49-phospholipase A 2

Nakamura, S., Nakai, M., Nakashima, K., Ogawa, T., Shimohigashi, Y., Ohno, M., Kihara, H., Yamane, T. & Ashida, T., 1 1 1996, : : Journal of Molecular Recognition. 9, 1, p. 23-30 8 p.

研究成果: ジャーナルへの寄稿記事

Trimeresurus
Phospholipases A
Dimerization
Aspartic Acid
Lysine
1995
176 引用 (Scopus)

Accelerated evolution in the protein-coding regions is universal in crotalinae snake venom gland phospholipase A2 isozyme genes

Nakashima, K., Nobuhisa, I., Deshimaru, M., Nakai, M., Ogawa, T., Shimohigashi, Y., Fukumaki, Y., Hattori, M., Sakaki, Y., Hattori, S. & Ohno, M., 6 6 1995, : : Proceedings of the National Academy of Sciences of the United States of America. 92, 12, p. 5605-5609 5 p.

研究成果: ジャーナルへの寄稿記事

Snake Venoms
Phospholipases A2
Open Reading Frames
Isoenzymes
Trimeresurus
42 引用 (Scopus)

Lysine-49-phospholipases A2 from Trimeresurus flavoviridis venom are membrane-acting enzymes

Shimohigashi, Y., Tani, A., Matsumoto, H., Nakashima, K., Yamuguchi, Y., Oda, N., Takano, Y., Kamiya, H. O., Kishino, J., Arita, H. & Ohno, M., 10 1 1995, : : Journal of biochemistry. 118, 5, p. 1037-1044 8 p.

研究成果: ジャーナルへの寄稿記事

Phospholipases A2
Venoms
Lysine
Phospholipids
Membranes
56 引用 (Scopus)

Molecular evolution of group II phospholipases A2

Ogawa, T., Kitajima, M., Nakashima, K., Sakaki, Y. & Ohno, M., 1 1 1995, : : Journal of Molecular Evolution. 41, 6, p. 867-877 11 p.

研究成果: ジャーナルへの寄稿記事

Group II Phospholipases A2
phospholipase A2
Molecular Evolution
Complementary DNA
Open Reading Frames
27 引用 (Scopus)

Structures of genes encoding TATA box-binding proteins from trimeresurus gramineus and t. flavoviridis snakes

Nakashima, K. I., Nobuhisa, I., Deshimaru, M., Ogawa, T., Shimohigashi, Y., Fukumaki, Y., Hattori, M., Sakaki, Y., Hattori, S. & Ohno, M., 1 23 1995, : : Gene. 152, 2, p. 209-213 5 p.

研究成果: ジャーナルへの寄稿記事

Trimeresurus
TATA-Box Binding Protein
Snakes
Genes
Complementary DNA
9 引用 (Scopus)

Trimeresurus flavoviridis venom gland phospholipase A2 isozymes genes have evolved via accelerated substitutions

Ogawa, T., Nakashima, K. ., Oda, N., Shimohigashi, Y., Ohno, M., Hattori, S., Hattori, M., Sakaki, Y. & Kihara, H., 1 1 1995, : : Journal of Molecular Recognition. 8, 1-2, p. 40-46 7 p.

研究成果: ジャーナルへの寄稿記事

Phospholipases A2
Isoenzymes
Exons
Introns
Genes
1994
2 引用 (Scopus)

Darwinian evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes

Nakashima, K., Ogawa, T., Oda, N., Shimohigashi, Y., Hattorit, M., Sakakit, Y., Kihara, H. & Ohno, M., 1 1 1994, : : Pure and Applied Chemistry. 66, 4, p. 715-720 6 p.

研究成果: ジャーナルへの寄稿記事

Phospholipases A2
Venoms
Nucleotides
Isoenzymes
Substitution reactions
3 引用 (Scopus)

Polymorphisms of Trimeresurus flavoviridis Venom Gland Phospholipase A2Isozyme Genes

Nakashima, K., Nobuhisa, I., Ogawa, T., Ohno, M., Hattori, M., Sakaki, Y. & Kihara, H., 1 1 1994, : : Bioscience, biotechnology, and biochemistry. 58, 8, p. 1510-1511 2 p.

研究成果: ジャーナルへの寄稿記事

Phospholipases
Phospholipases A2
Venoms
Polymorphism
Genes
1993
155 引用 (Scopus)

Accelerated evolution of Trimeresurus flavoviridis venom gland phospholipase A2 isozymes

Nakashima, K. I., Ogawa, T., Oda, N., Hattori, M., Sakaki, Y., Kihara, H. & Ohno, M., 7 1 1993, : : Proceedings of the National Academy of Sciences of the United States of America. 90, 13, p. 5964-5968 5 p.

研究成果: ジャーナルへの寄稿記事

Phospholipases A2
Introns
Isoenzymes
Open Reading Frames
Exons
11 引用 (Scopus)

Chymotrypsin inhibitory conformation of dipeptides constructed by side chain–side chain hydrophobic interactions

Sakamoto, H., Shimohigashi, Y., Maeda, I., Nose, T., Nakashima, K., Nakamura, I., Ogawa, T., Ohno, M. & Kawano, K., 1 1 1993, : : Journal of Molecular Recognition. 6, 2, p. 95-100 6 p.

研究成果: ジャーナルへの寄稿記事

Dipeptides
Chymotrypsin
Hydrophobic and Hydrophilic Interactions
Esters
Benzene
1992
2 引用 (Scopus)

Refolding of trimeresurus flavoviridis phospholipases A2

Tsuno, S., Ogawa, T., Nakashima, K., Oda, N., Lee, S., Shimohigashi, Y., Aoyagi, H. & Ohno, M., 10 1 1992, : : Bulletin of the Chemical Society of Japan. 65, 10, p. 2655-2659 5 p.

研究成果: ジャーナルへの寄稿記事

Phospholipases A2
Disulfides
Isoenzymes
Protein Disulfide-Isomerases
Isomerases
96 引用 (Scopus)

Unusually high conservation of untranslated sequences in cDNAs for Trimeresurus flavoviridis phospholipase A2 isozymes

Ogawa, T., Oda, N., Nakashima, K. I., Sasaki, H., Hattori, M., Sakaki, Y., Kihara, H. & Ohno, M., 1 1 1992, : : Proceedings of the National Academy of Sciences of the United States of America. 89, 18, p. 8557-8561 5 p.

研究成果: ジャーナルへの寄稿記事

Trimeresurus
Phospholipases A2
Isoenzymes
Complementary DNA
Group II Phospholipases A2