応用幹細胞医科学部門

研究成果 1992 2020

2018
3 引用 (Scopus)

The role of telomere binding molecules for normal and abnormal hematopoiesis

Hosokawa, K. & Arai, F., 6 1 2018, : : International journal of hematology. 107, 6, p. 646-655 10 p.

研究成果: ジャーナルへの寄稿評論記事

Telomere
Hematopoiesis
Hematopoietic Stem Cells
Hematopoietic System
DNA Damage
2019

CCR6+ group 3 innate lymphoid cells accumulate in inflamed joints in rheumatoid arthritis and produce Th17 cytokines

Takaki-Kuwahara, A., Arinobu, Y., Miyawaki, K., Yamada, H., Tsuzuki, H., Irino, K., Ayano, M., Kimoto, Y., Mitoma, H., Akahoshi, M., Tsukamoto, H., Horiuchi, T., Niiro, H. & Akashi, K., 8 30 2019, : : Arthritis Research and Therapy. 21, 1, 198.

研究成果: ジャーナルへの寄稿記事

公開
Rheumatoid Arthritis
Joints
Lymphocytes
Cytokines
Synovial Fluid
Phase II Clinical Trials
Clinical Trials, Phase I
Systemic Scleroderma
Hematopoietic Stem Cell Transplantation
Japan
10 引用 (Scopus)

Cell-based screen identifies a new potent and highly selective CK2 inhibitor for modulation of circadian rhythms and cancer cell growth

Oshima, T., Niwa, Y., Kuwata, K., Srivastava, A., Hyoda, T., Tsuchiya, Y., Kumagai, M., Tsuyuguchi, M., Tamaru, T., Sugiyama, A., Ono, N., Zolboot, N., Aikawa, Y., Oishi, S., Nonami, A., Arai, F., Hagihara, S., Yamaguchi, J., Tama, F., Kunisaki, Y. および6人, Yagita, K., Ikeda, M., Kinoshita, T., Kay, S. A., Itami, K. & Hirota, T., 1 23 2019, : : Science Advances. 5, 1, eaau9060.

研究成果: ジャーナルへの寄稿記事

公開
Circadian Rhythm
Circadian Clocks
Phosphotransferases
Growth
Neoplasms
公開
Metagenome
Bacterial Genomes
Base Composition
Libraries
Metagenomics

Early-life exposure to low levels of permethrin exerts impairments in learning and memory with the effects on neuronal and glial population in adult male mice

Saito, H., Hara, K., Tominaga, T., Nakashima, K. & Tanemura, K., 12 1 2019, : : Journal of Applied Toxicology. 39, 12, p. 1651-1662 12 p.

研究成果: ジャーナルへの寄稿記事

Permethrin
Neuroglia
Learning
Data storage equipment
Population

Environmental Optimization Enables Maintenance of Quiescent Hematopoietic Stem Cells Ex Vivo

Kobayashi, H., Morikawa, T., Okinaga, A., Hamano, F., Hashidate-Yoshida, T., Watanuki, S., Hishikawa, D., Shindou, H., Arai, F., Kabe, Y., Suematsu, M., Shimizu, T. & Takubo, K., 7 2 2019, : : Cell Reports. 28, 1, p. 145-158.e9

研究成果: ジャーナルへの寄稿記事

公開
Hematopoietic Stem Cells
Stem cells
Maintenance
Fatty Acids
Cell culture
1 引用 (Scopus)
Mesentery
Epithelial-Mesenchymal Transition
Gonads
Morphogenesis
Ovary
1 引用 (Scopus)

Evaluation of SNP calling methods for closely related bacterial isolates and a novel high-accuracy pipeline: BactSNP

Yoshimura, D., Kajitani, R., Gotoh, Y., Katahira, K., Okuno, M., Ogura, Y., Hayashi, T. & Itoh, T., 5 1 2019, : : Microbial Genomics. 5, 5

研究成果: ジャーナルへの寄稿記事

公開
Single Nucleotide Polymorphism
Genome
Benchmarking
Disease Outbreaks
Bacteria

Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells

Terada, M., Kawamata, M., Kimura, R., Sekiya, S., Nagamatsu, G., Hayashi, K., Horisawa, K. & Suzuki, A., 11 1 2019, : : Genesis. 57, 11-12, e23334.

研究成果: ジャーナルへの寄稿記事

Pluripotent Stem Cells
Germ Cells
Embryonic Stem Cells
Genetic Promoter Regions
Transgenic Mice

Genome sequencing verifies relapsed infection of helicobacter cinaedi

Sawada, O., Gotoh, Y., Taniguchi, T., Furukawa, S., Yoshimura, D., Sasaki, S., Shida, H., Kusunoki, Y., Yamamura, T., Furuya, K., Itoh, T., Horita, T., Hayashi, T. & Misawa, N., 1 1 2019, : : Open Forum Infectious Diseases. 6, 5

研究成果: ジャーナルへの寄稿記事

公開
Helicobacter Infections
Genome
Infection
Single Nucleotide Polymorphism
Clone Cells

Genomic Features of Rickettsia heilongjiangensis Revealed by Intraspecies Comparison and Detailed Comparison With Rickettsia japonica

Kasama, K., Fujita, H., Yamamoto, S., Ooka, T., Gotoh, Y., Ogura, Y., Ando, S. & Hayashi, T., 12 6 2019, : : Frontiers in Microbiology. 10, 2787.

研究成果: ジャーナルへの寄稿記事

公開
Rickettsia
Ticks
Single Nucleotide Polymorphism
China
Fever
Neural Stem Cells
Astrocytes
Epigenomics
Central Nervous System
Multipotent Stem Cells
1 引用 (Scopus)

Hypoxia induces the dormant state in oocytes through expression of Foxo3

Shimamoto, S., Nishimura, Y., Nagamatsu, G., Hamada, N., Kita, H., Hikabe, O., Hamazaki, N. & Hayashi, K., 6 18 2019, : : Proceedings of the National Academy of Sciences of the United States of America. 116, 25, p. 12321-12326 6 p.

研究成果: ジャーナルへの寄稿記事

Oocytes
Reproductive Medicine
Oogenesis
Transcriptome
Mammals

In vitro reconstitution of germ cell development

Hayashi, K., 9 1 2019, : : Biology of Reproduction. 101, 3, p. 567-578 12 p.

研究成果: ジャーナルへの寄稿評論記事

Gametogenesis
Germ Cells
Developmental Biology
Haploidy
Meiosis

Lack of whey acidic protein (WAP) four-disulfide core domain protease inhibitor 2 (WFDC2) causes neonatal death from respiratory failure in mice

Nakajima, K., Ono, M., Radovic, U. S., Dizdarevic, S., Tomizawa, S. I., Kuroha, K., Nagamatsu, G., Hoshi, I., Matsunaga, R., Shirakawa, T., Kurosawa, T., Miyazaki, Y., Seki, A., Suzuki, Y., Koseki, H., Nakamura, M., Suda, T. & Ohbo, K., 1 1 2019, : : DMM Disease Models and Mechanisms. 12, 11, dmm.040139.

研究成果: ジャーナルへの寄稿記事

公開
Protease Inhibitors
Respiratory Insufficiency
Disulfides
Cause of Death
Lung
1 引用 (Scopus)

Large-scale genome analysis of bovine commensal Escherichia coli reveals that bovine-adapted E. Coli lineages are serving as evolutionary sources of the emergence of human intestinal pathogenic strains

Arimizu, Y., Kirino, Y., Sato, M. P., Uno, K., Sato, T., Gotoh, Y., Auvray, F., Brugere, H., Oswald, E., Mainil, J. G., Anklam, K. S., Döpfer, D., Yoshino, S., Ooka, T., Tanizawa, Y., Nakamura, Y., Iguchi, A., Morita-Ishihara, T., Ohnishi, M., Akashi, K. および2人, Hayashi, T. & Ogura, Y., 1 1 2019, : : Genome Research. 29, 9, p. 1495-1505 11 p.

研究成果: ジャーナルへの寄稿記事

公開
Enteropathogenic Escherichia coli
Genome
Escherichia coli
Virulence
Enterocytes
7 引用 (Scopus)

Mechanical stress accompanied with nuclear rotation is involved in the dormant state of mouse oocytes

Nagamatsu, G., Shimamoto, S., Hamazaki, N., Nishimura, Y. & Hayashi, K., 1 1 2019, : : Science Advances. 5, 6, eaav9960.

研究成果: ジャーナルへの寄稿記事

公開
gametocytes
mice
ovaries
boxes
activation
2 引用 (Scopus)

Multi-step genomic dissection of a suspected intra-hospital helicobacter cinaedi outbreak

Gotoh, Y., Taniguchi, T., Yoshimura, D., Katsura, K., Saeki, Y., Hirabara, Y., Fukuda, M., Takajo, I., Tomida, J., Kawamura, Y., Ogura, Y., Itoh, T., Misawa, N., Okayama, A. & Hayashi, T., 1 2019, : : Microbial Genomics. 5, 1, 000236.

研究成果: ジャーナルへの寄稿記事

Helicobacter
Disease Outbreaks
Dissection
Genome
Bacteremia

Nox4 Promotes Neural Stem/Precursor Cell Proliferation and Neurogenesis in the Hippocampus and Restores Memory Function Following Trimethyltin-Induced Injury

Yoshikawa, Y., Ago, T., Kuroda, J., Wakisaka, Y., Tachibana, M., Komori, M., Shibahara, T., Nakashima, H., Nakashima, K. & Kitazono, T., 2 1 2019, : : Neuroscience. 398, p. 193-205 13 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Neurogenesis
Hippocampus
Cell Proliferation
Wounds and Injuries

Np95/Uhrf1 regulates tumor suppressor gene expression of neural stem/precursor cells, contributing to neurogenesis in the adult mouse brain

Murao, N., Matsubara, S., Matsuda, T., Noguchi, H., Mutoh, T., Mutoh, M., Koseki, H., Namihira, M. & Nakashima, K., 6 2019, : : Neuroscience Research. 143, p. 31-43 13 p.

研究成果: ジャーナルへの寄稿記事

Neural Stem Cells
Neurogenesis
Tumor Suppressor Genes
Gene Expression
Brain

O-antigen biosynthesis gene clusters of Escherichia albertii: Their diversity and similarity to Escherichia coli gene clusters and the development of an o-genotyping method

Ooka, T., Seto, K., Ogura, Y., Nakamura, K., Iguchi, A., Gotoh, Y., Honda, M., Etoh, Y., Ikeda, T., Sugitani, W., Konno, T., Kawano, K., Imuta, N., Yoshiie, K., Hara-Kudo, Y., Murakami, K., Hayashi, T. & Nishi, J., 1 1 2019, : : Microbial Genomics. 5, 11, 000314.

研究成果: ジャーナルへの寄稿記事

公開
Escherichia
O Antigens
Multigene Family
Escherichia coli
Genotype
12 引用 (Scopus)

Pioneer Factor NeuroD1 Rearranges Transcriptional and Epigenetic Profiles to Execute Microglia-Neuron Conversion

Matsuda, T., Irie, T., Katsurabayashi, S., Hayashi, Y., Nagai, T., Hamazaki, N., Adefuin, A. M. D., Miura, F., Ito, T., Kimura, H., Shirahige, K., Takeda, T., Iwasaki, K., Imamura, T. & Nakashima, K., 2 6 2019, : : Neuron. 101, 3, p. 472-485.e7

研究成果: ジャーナルへの寄稿記事

Microglia
Epigenomics
Neurons
Transcription Factors
Genes
2 引用 (Scopus)

Regnase-1-mediated post-transcriptional regulation is essential for hematopoietic stem and progenitor cell homeostasis

Kidoya, H., Muramatsu, F., Shimamura, T., Jia, W., Satoh, T., Hayashi, Y., Naito, H., Kunisaki, Y., Arai, F., Seki, M., Suzuki, Y., Osawa, T., Akira, S. & Takakura, N., 12 1 2019, : : Nature communications. 10, 1, 1072.

研究成果: ジャーナルへの寄稿記事

公開
homeostasis
stem cells
Hematopoietic Stem Cells
Homeostasis
hematopoiesis

Stem Cell-Derived Human Gametes: The Public Engagement Imperative

Adashi, E. Y., Cohen, I. G., Hanna, J. H., Surani, A. M. & Hayashi, K., 3 2019, : : Trends in Molecular Medicine. 25, 3, p. 165-167 3 p.

研究成果: ジャーナルへの寄稿小調査

Germ Cells
Stem Cells
Technology
3 引用 (Scopus)

Suppressor of fused controls perinatal expansion and quiescence of future dentate adult neural stem cells

Noguchi, H., Castillo, J. G., Nakashima, K. & Pleasure, S. J., 4 11 2019, : : eLife. 8, e42918.

研究成果: ジャーナルへの寄稿記事

公開
Adult Stem Cells
Neural Stem Cells
Stem cells
Hedgehogs
Dentate Gyrus
1 引用 (Scopus)

The earth is small for “leviathans”: Long distance dispersal of giant viruses across aquatic environments

Li, Y., Endo, H., Gotoh, Y., Watai, H., Ogawa, N., Blanc-Mathieu, R., Yoshida, T. & Ogata, H., 1 1 2019, : : Microbes and Environments. 34, 3, p. 334-339 6 p.

研究成果: ジャーナルへの寄稿記事

公開
Otus
aquatic environment
virus
viruses
hot springs
1 引用 (Scopus)

Therapeutic time window of anti-high mobility group box-1 antibody administration in mouse model of spinal cord injury

Nakajo, M., Uezono, N., Nakashima, H., Wake, H., Komiya, S., Nishibori, M. & Nakashima, K., 4 2019, : : Neuroscience Research. 141, p. 63-70 8 p.

研究成果: ジャーナルへの寄稿記事

Spinal Cord Injuries
Antibodies
Injections
Monoclonal Antibodies
Therapeutics
2020

Enhanced processivity of Dnmt1 by monoubiquitinated histone H3

Mishima, Y., Brueckner, L., Takahashi, S., Kawakami, T., Otani, J., Shinohara, A., Takeshita, K., Garvilles, R. G., Watanabe, M., Sakai, N., Takeshima, H., Nachtegael, C., Nishiyama, A., Nakanishi, M., Arita, K., Nakashima, K., Hojo, H. & Suetake, I., 1 1 2020, : : Genes to Cells. 25, 1, p. 22-32 11 p.

研究成果: ジャーナルへの寄稿記事

Histones
Ubiquitination
Methyltransferases
DNA Methylation
DNA