薬学研究院

研究成果 1983 2020

1983

A rare anomaly of the abdominal aorta and its branches. A case report with angiography and embryological consideration

Kajiwara, T., Kishikawa, T., Tamura, S., Hasuo, K., Sakino, I., Matsuura, K. & Egashira, K., 11 25 1983, : : Nippon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica. 43, 11, p. 1255-1259 5 p.

研究成果: ジャーナルへの寄稿記事

1985
2 引用 (Scopus)

Acute myocardial infarction following asymptomatic ST elevation despite diltiazem therapy

Egashira, K., Araki, H., Koiwaya, Y., Takeshita, A. & Nakamura, M., 2 1985, : : American heart journal. 109, 2, p. 379-380 2 p.

研究成果: ジャーナルへの寄稿記事

Coronary Vasospasm
Diltiazem
Angina Pectoris
Myocardial Infarction
Therapeutics
1986
73 引用 (Scopus)

Histamine-induced coronary spasm in regions of intimal thickening in miniature pigs: Roles of serum cholesterol and spontaneous or induced intimal thickening

Egashira, K., Tomoike, H., Yamamoto, Y., Yamada, A., Hayashi, Y. & Nakamura, M., 1 1 1986, : : Circulation. 74, 4, p. 826-837 12 p.

研究成果: ジャーナルへの寄稿記事

Tunica Intima
Spasm
Histamine
Swine
Cholesterol
1987
56 引用 (Scopus)
Muscle Spasticity
Vascular Smooth Muscle
Histamine
Endothelium
Swine
32 引用 (Scopus)
Leukotriene D4
Leukotriene C4
Constriction
Coronary Vessels
Electrocardiography
15 引用 (Scopus)

Long-Term Prognosis of Vasospastic Angina without Significant Atherosclerotic Coronary Artery Disease

Egashira, K., Kikuchi, Y., Sagara, T., Sugihara, M. & Nakamura, M., 1 1 1987, : : japanese heart journal. 28, 6, p. 841-849 9 p.

研究成果: ジャーナルへの寄稿記事

Coronary Artery Disease
Calcium
Sudden Death
Myocardial Infarction
Atrioventricular Block
28 引用 (Scopus)

Pathogenesis of coronary artery spasm in miniature swine with regional intimal thickening after balloon denudation

Yamamoto, Y., Tomoike, H., Egashira, K., Kobayashi, T., Kawasaki, T. & Nakamura, M., 1 1 1987, : : Circulation research. 60, 1, p. 113-121 9 p.

研究成果: ジャーナルへの寄稿記事

Tunica Intima
Miniature Swine
Spasm
Histamine
Coronary Vessels
1 引用 (Scopus)

Prompt relief of vasospastic angina by calcium antagonists

Egashira, K., Araki, H., Tomoike, H., Takeshita, A. & Nakamura, M., 9 30 1987, : : International Journal of Clinical Pharmacology Therapy and Toxicology. 25, 4, p. 175-177 3 p.

研究成果: ジャーナルへの寄稿記事

Variant Angina Pectoris
Diltiazem
Nitroglycerin
Calcium Channel Blockers
Electrocardiography
5 引用 (Scopus)

Prostanoids, Coronary Circulation and Coronary Artery Spasm in Open Chest Dogs and Miniature Pigs

Egashira, K., Shimokawa, H., Tomoike, H. & Nakamura, M., 1 1 1987, : : JAPANESE CIRCULATION JOURNAL. 51, 4, p. 459-461 3 p.

研究成果: ジャーナルへの寄稿記事

Coronary Circulation
Spasm
Prostaglandins
Coronary Vessels
Swine
1988

A case of indocyanine green excretion defect worsened during acute hepatitis following sudden deafness

Sakamoto, S., Egashira, K., Koga, S. & Ibayashi, H., 1 1 1988, : : Kanzo. 26, 12, p. 1686-1689 4 p.

研究成果: ジャーナルへの寄稿記事

Sudden Hearing Loss
Indocyanine Green
Hepatitis
Sulfobromophthalein
Otolaryngology
1989
10 引用 (Scopus)

Silent myocardial ischemia in patients with variant angina

Egashira, K., Araki, H., Takeshita, A. & Nakamura, M., 1 1 1989, : : JAPANESE CIRCULATION JOURNAL. 53, 11, p. 1452-1457 6 p.

研究成果: ジャーナルへの寄稿記事

Myocardial Ischemia
Cardiac Arrhythmias
Atrioventricular Block
Ventricular Tachycardia
Coronary Care Units
1990
4 引用 (Scopus)

Cocaine-Induced Coronary-Artery Constriction

Ambre, J. J., Wilkerson, R. D., Fraker, T. D., Temesy-Armos, P. N., Egashira, K., Morgan, J. P., Cregler, L. L., Folev, A. E., Lange, R. A., Cigarroa, R. G. & Hillis, L. D., 4 26 1990, : : New England Journal of Medicine. 322, 17, p. 1235-1237 3 p.

研究成果: ジャーナルへの寄稿レター

Cocaine
Constriction
Coronary Vessels
Intravenous Injections
1991
31 引用 (Scopus)
Miniature Swine
Cocaine
Coronary Vessels
Cholesterol
Wounds and Injuries
43 引用 (Scopus)

Effects of cocaine on excitation-contraction coupling of aortic smooth muscle from the ferret

Egashira, K., Morgan, K. G. & Morgan, J. P., 4 1991, : : Journal of Clinical Investigation. 87, 4, p. 1322-1328 7 p.

研究成果: ジャーナルへの寄稿記事

Excitation Contraction Coupling
Ferrets
Cocaine
Smooth Muscle
Muscles

Effects of nicorandil on coronary circulation and coronary flow reserve in patients with chronic effort angina

Yamada, A., Egashira, K., Inou, T., Maruoka, Y., Meno, H., Hirooka, Y. & Takeshita, A., 1 1 1991, : : Therapeutic Research. 12, 6, p. 196-201 6 p.

研究成果: ジャーナルへの寄稿記事

Nicorandil
Coronary Circulation
12 引用 (Scopus)

Effects of synthetic human atrial natriuretic peptide on the human coronary circulation in subjects with normal coronary arteries

Egashira, K., Inou, T., Imaizumi, T., Tomoike, H. & Takeshita, A., 1 1 1991, : : JAPANESE CIRCULATION JOURNAL. 55, 11, p. 1050-1056 7 p.

研究成果: ジャーナルへの寄稿記事

Coronary Circulation
Atrial Natriuretic Factor
Coronary Vessels
Myocardial Ischemia
Dilatation
1992
22 引用 (Scopus)

Mechanism of ergonovine-induced hyperconstriction of the large epicardial coronary artery in conscious dogs a month after arterial injury

Egashira, K., Tomoike, H., Hayashi, Y., Yamada, A., Nakamura, M. & Takeshita, A., 8 1992, : : Circulation research. 71, 2, p. 435-442 8 p.

研究成果: ジャーナルへの寄稿記事

Ergonovine
Coronary Vessels
Dogs
Wounds and Injuries
Constriction
82 引用 (Scopus)

Preserved endothelium-dependent vasodilation at the vasospastic site in patients with variant angina

Egashira, K., Inou, T., Yamada, A., Hirooka, Y. & Takeshita, A., 1 1 1992, : : Journal of Clinical Investigation. 89, 3, p. 1047-1052 6 p.

研究成果: ジャーナルへの寄稿記事

Vasodilation
Endothelium
Acetylcholine
Substance P
Coronary Vasospasm
3 引用 (Scopus)

Recombinant tissue-type plasminogen activator ameliorates ischemic derangements induced by thrombotic occlusion in closed chest anesthetized dogs

Egashira, K., Kawai, K., Nagano, M., Sakuma, A., Nakamura, M. & Tomoike, H., 1 1 1992, : : Journal of the American College of Cardiology. 20, 1, p. 218-225 8 p.

研究成果: ジャーナルへの寄稿記事

Tissue Plasminogen Activator
Reperfusion
Thorax
Dogs
Coronary Occlusion

Vascular endothelial function in coronary artery spasm

Egashira, K., Kuga, T. & Tomoike, H., 11 1992, : : Kokyu to junkan. Respiration & circulation. 40, 11, p. 1065-1074 10 p.

研究成果: ジャーナルへの寄稿記事

Coronary Vasospasm
Vascular Endothelium
Spasm
Substance P
Blood Vessels
1993
33 引用 (Scopus)

Beneficial effects of atrial natriuretic peptide on exercise-induced myocardial ischemia in patients with stable effort angina pectoris

Lai, C. P., Egashira, K., Tashiro, H., Narabayashi, H., Koyanagi, S., Imaizumi, T. & Takeshita, A., 1 1993, : : Circulation. 87, 1, p. 144-151 8 p.

研究成果: ジャーナルへの寄稿記事

Stable Angina
Atrial Natriuretic Factor
Myocardial Ischemia
Exercise
Blood Pressure
40 引用 (Scopus)

Correlation of basal coronary artery tone with constrictive response to ergonovine in patients with variant angina

Kuga, T., Egashira, K., Inou, T. & Takeshita, A., 7 1993, : : Journal of the American College of Cardiology. 22, 1, p. 144-150 7 p.

研究成果: ジャーナルへの寄稿記事

Ergonovine
Coronary Vessels
Spasm
Muscle Spasticity
Nitroglycerin
20 引用 (Scopus)

Differentiation between aberrant ventricular conduction and ventricular ectopy in atrial fibrillation using RR interval scattergram

Suyama, A. C., Sunagawa, K., Sugimachi, M., Anan, T., Egashira, K. & Takeshita, A., 11 1993, : : Circulation. 88, 5, p. 2307-2314 8 p.

研究成果: ジャーナルへの寄稿記事

Atrial Fibrillation
Atrioventricular Node
Bundle-Branch Block
Electrocardiography
322 引用 (Scopus)

Effects of age on endothelium-dependent vasodilation of resistance coronary artery by acetylcholine in humans

Egashira, K., Inou, T., Hirooka, Y., Kai, H., Sugimachi, M., Suzuki, S., Kuga, T., Urabe, Y. & Takeshita, A., 1 1 1993, : : Circulation. 88, 1, p. 77-81 5 p.

研究成果: ジャーナルへの寄稿記事

Vasodilation
Acetylcholine
Endothelium
Coronary Vessels
Papaverine
10 引用 (Scopus)

Effects of a new calcium antagonist, CD-832, on experimental coronary artery spasm in miniature pigs

Takahashi, T., Fukai, T., Hata, H., Kasuya, H., Kuga, T., Egashira, K. & Takeshita, A., 4 1 1993, : : Cardiovascular Drugs and Therapy. 7, 2, p. 265-271 7 p.

研究成果: ジャーナルへの寄稿記事

Spasm
Coronary Vessels
Swine
Calcium
Histamine
1 引用 (Scopus)

Endothelial Dysfunction in Microvascular Angina

Rossen, J. D., Agmon, Y., Gorlin, R., Abbott, E. C., Egashira, K. & Takeshita, A., 12 2 1993, : : New England Journal of Medicine. 329, 23, p. 1739-1740 2 p.

研究成果: ジャーナルへの寄稿レター

Microvascular Angina
Papaverine
Lactic Acid
Coronary Vessels
Spasm
61 引用 (Scopus)

Glibenclamide, a putative ATP-sensitive K+ channel blocker, inhibits coronary autoregulation in anesthetized dogs

Narishige, T., Egashira, K., Akatsuka, Y., Katsuda, Y., Numaguchi, K., Sakata, M. & Takeshita, A., 10 1993, : : Circulation research. 73, 4, p. 771-776 6 p.

研究成果: ジャーナルへの寄稿記事

Glyburide
Homeostasis
Perfusion
Adenosine Triphosphate
Dogs
313 引用 (Scopus)

Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions

Egashira, K., Inou, T., Hirooka, Y., Yamada, A., Maruoka, Y., Kai, H., Sugimachi, M., Suzuki, S. & Takeshita, A., 1 1 1993, : : Journal of Clinical Investigation. 91, 1, p. 29-37 9 p.

研究成果: ジャーナルへの寄稿記事

Acetylcholine
Coronary Vessels
Arteries
Papaverine
Endothelium
38 引用 (Scopus)

Serotonin-induced coronary spasm in a swine model: A minor role of defective endothelium-derived relaxing factor

Fukai, T., Egashira, K., Hata, H., Numaguchi, K., Ohara, Y., Takahashi, T., Tomoike, H. & Takeshita, A., 1 1 1993, : : Circulation. 88, 4 I, p. 1922-1930 9 p.

研究成果: ジャーナルへの寄稿記事

Endothelium-Dependent Relaxing Factors
Spasm
Serotonin
Swine
Vascular Smooth Muscle

The role of endothelial function in the pathogenesis of coronary spasm in humans

Kensuke, E., Tetsuzi, I., Akira, Y., Yoshitaka, H. & Akira, T., 1 1 1993, : : JAPANESE CIRCULATION JOURNAL. 56, p. 1319-1323 5 p.

研究成果: ジャーナルへの寄稿記事

Variant Angina Pectoris
Coronary Vasospasm
Vascular Endothelium
Spasm
Substance P
1994
58 引用 (Scopus)

ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dog

Akatsuka, Y., Egashira, K., Katsuda, Y., Narishige, T., Ueno, H., Shimokawa, H. & Takeshita, A., 1 1 1994, : : Cardiovascular research. 28, 6, p. 906-911 6 p.

研究成果: ジャーナルへの寄稿記事

Adenosine A2 Receptors
KATP Channels
Vasodilation
Adenosine-5'-(N-ethylcarboxamide)
Dogs
2 引用 (Scopus)
Cholesterol
Therapy
2 引用 (Scopus)

Effects of intracoronary infusion of atrial natriuretic peptide on pacing- induced myocardial ischemia in patients with effort angina pectoris

Kai, H., Egashira, K., Hirooka, Y., Sugimachi, M., Suzuki, S., Kuga, T., Mohri, K., Urabe, Y., Inou, T. & Takeshita, A., 12 1 1994, : : Coronary Artery Disease. 5, 12, p. 987-994 8 p.

研究成果: ジャーナルへの寄稿記事

Angina Pectoris
Atrial Natriuretic Factor
Myocardial Ischemia
Coronary Vessels
Arteries
5 引用 (Scopus)

Effects of N-nitro-L-arginine on coronary artery tone and reactive hyperemia after brief coronary occlusion in conscious dogs

Muramatsu, K. H., Numaguchi, K. T., Egashira, K., Takahashi, T., Kasuya, H. & Takeshita, A., 1 1 1994, : : Coronary Artery Disease. 5, 10, p. 815-820 6 p.

研究成果: ジャーナルへの寄稿記事

Coronary Occlusion
Hyperemia
Arginine
Coronary Vessels
Dilatation
609 引用 (Scopus)

Reduction in serum cholesterol with pravastatin improves endothelium- dependent coronary vasomotion in patients with hypercholesterolemia

Egashira, K., Hirooka, Y., Kai, H., Sugimachi, M., Suzuki, S., Inou, T. & Takeshita, A., 1 1 1994, : : Circulation. 89, 6, p. 2519-2524 6 p.

研究成果: ジャーナルへの寄稿記事

Pravastatin
Hypercholesterolemia
Endothelium
Cholesterol
Acetylcholine
45 引用 (Scopus)

Role of protein kinase C-mediated pathway in the pathogenesis of coronary artery spasm in a swine model

Ito, A., Shimokawa, H., Nakaike, R., Fukai, T., Sakata, M., Takayanagi, T., Egashira, K. & Takeshita, A., 11 1994, : : Circulation. 90, 5, p. 2425-2431 7 p.

研究成果: ジャーナルへの寄稿記事

Spasm
Protein Kinase C
Coronary Vessels
Swine
Muscle Spasticity
1995
70 引用 (Scopus)

Bradykinin-induced vasodilation is impaired at the atherosclerotic site but is preserved at the spastic site of human coronary arteries in vivo

Kuga, T., Egashira, K., Mohri, M., Tsutsui, H., Harasawa, Y., Urabe, Y., Ando, S., Shimokawa, H. & Takeshita, A., 7 15 1995, : : Circulation. 92, 2, p. 183-189 7 p.

研究成果: ジャーナルへの寄稿記事

Muscle Spasticity
Bradykinin
Vasodilation
Coronary Vessels
Acetylcholine
77 引用 (Scopus)

Chronic inhibition of endothelium-derived nitric oxide synthesis causes coronary microvascular structural changes and hyperreactivity to serotonin in pigs

Ito, A., Egashira, K., Kadokami, T., Fukumoto, Y., Takayanagi, T., Nakaike, R., Kuga, T., Sueishi, K., Shimokawa, H. & Takeshita, A., 11 1 1995, : : Circulation. 92, 9, p. 2636-2644 9 p.

研究成果: ジャーナルへの寄稿記事

NG-Nitroarginine Methyl Ester
Serotonin
Nitric Oxide
Swine
Therapeutics
197 引用 (Scopus)

Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats

Numaguchi, K., Egashira, K., Takemoto, M., Kadokami, T., Shimokawa, H., Sueishi, K. & Takeshita, A., 12 1995, : : Hypertension. 26, 6 I, p. 957-962 6 p.

研究成果: ジャーナルへの寄稿記事

Nitric Oxide
Fibrosis
Hydralazine
Arginine
Cardiomegaly
26 引用 (Scopus)

Effects of L-arginine analogues on vasomotion of isolated porcine coronary arteries

Nakaike, R., Shimokawa, H., Yasutake, H., Sumimoto, H., Ito, A., Numaguchi, K., Egashira, K., Takeshige, K. & Takeshita, A., 1 1 1995, : : American Journal of Physiology - Heart and Circulatory Physiology. 268, 5 37-5, p. H1966-H1972

研究成果: ジャーナルへの寄稿記事

Arginine
Coronary Vessels
Swine
Endothelium
Nitric Oxide
8 引用 (Scopus)

Endothelium-derived nitric oxide does not modulate metabolic coronary vasodilation induced by tachycardia in dogs

Katsuda, Y., Egashira, K., Akatsuka, Y., Narishige, T., Shimokawa, H. & Takeshita, A., 9 1995, : : Journal of Cardiovascular Pharmacology. 26, 3, p. 437-444 8 p.

研究成果: ジャーナルへの寄稿記事

Tachycardia
Vasodilation
Nitric Oxide
NG-Nitroarginine Methyl Ester
Dogs
2 引用 (Scopus)

Immediate Relief of Spontaneous Coronary Artery Spasm by Intracoronary Infusion of an Endothelium-dependent Vasodilator, Substance P

Numagughi, K., Egashira, K., Inou, T. & Takeshita, A., 1 1 1995, : : japanese heart journal. 36, 1, p. 111-114 4 p.

研究成果: ジャーナルへの寄稿記事

Endothelium-Dependent Relaxing Factors
Spasm
Substance P
Coronary Vessels
Coronary Vasospasm
187 引用 (Scopus)

Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension: Different responses to acetylcholine and substance P

Egashira, K., Suzuki, S., Hirooka, Y., Kai, H., Sugimachi, M., Imaizumi, T. & Takeshita, A., 1 1 1995, : : Hypertension. 25, 2, p. 201-206 6 p.

研究成果: ジャーナルへの寄稿記事

Substance P
Vasodilation
Acetylcholine
Endothelium
Coronary Vessels
7 引用 (Scopus)

Portal Vein Thrombosis Due To Antithrombin III Deficiency: A Case Report

Yonemitsu, Y., Yanaga, K., Matsumata, T. & Sugimachi, K., 11 1995, : : Angiology. 46, 11, p. 1043-1047 5 p.

研究成果: ジャーナルへの寄稿記事

Antithrombin III Deficiency
Portal Vein
Thrombosis
Common Bile Duct
39 引用 (Scopus)

Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1β in pigs in vivo

Ito, A., Shimokawa, H., Kadokami, T., Fukumoto, Y., Owada, M. K., Shiraishi, T., Nakaike, R., Takayanagi, T., Egashira, K. & Takeshita, A., 9 1995, : : Journal of Clinical Investigation. 96, 3, p. 1288-1294 7 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-1
Protein-Tyrosine Kinases
Swine
Autacoids
Tunica Intima
1996
7 引用 (Scopus)

Abnormalities of cardiac sympathetic neuronal and left ventricular function in chronic mitral regurgitation: Assessment by iodine-123 metaiodobenzylguanidine scintigraphy

Tsutsui, H., Ando -i., S., Kubota, T., Kuroiwa-Matsumoto, M., Egashira, K., Sasaki, M., Kuwabara, Y., Koyanagi, S., Yasui, H. & Takeshita, A., 2 29 1996, : : American Journal of Cardiac Imaging. 10, 1, p. 14-22 9 p.

研究成果: ジャーナルへの寄稿記事

3-Iodobenzylguanidine
Mitral Valve Insufficiency
Left Ventricular Function
Radionuclide Imaging
Iodine
26 引用 (Scopus)

Altered serotonin receptor subtypes mediate coronary microvascular hyperreactivity in pigs with chronic inhibition of nitric oxide synthesis

Kadokami, T., Egashira, K., Kuwata, K., Fukumoto, Y., Kozai, T., Yasutake, H., Kuga, T., Shimokawa, H., Sueishi, K. & Takeshita, A., 1 1 1996, : : Circulation. 94, 2, p. 182-189 8 p.

研究成果: ジャーナルへの寄稿記事

Serotonin Receptors
Serotonin
Nitric Oxide
Swine
Ketanserin
7 引用 (Scopus)

ATP-sensitive K+ channel opener pinacidil augments β1-adrenoceptor- induced coronary vasodilation in dogs

Katsuda, Y., Egashira, K., Ueno, H., Arai, Y., Akatsuka, Y., Kuga, T., Shimokawa, H. & Takeshita, A., 6 1 1996, : : American Journal of Physiology - Heart and Circulatory Physiology. 270, 6 39-6, p. H2210-H2215

研究成果: ジャーナルへの寄稿記事

Pinacidil
Vasodilation
Adrenergic Receptors
Adenosine Triphosphate
Dogs
47 引用 (Scopus)

Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina

Egashira, K., Katsuda, Y., Mohri, M., Kuga, T., Tagawa, T., Shimokawa, H. & Takeshita, A., 5 1996, : : Journal of the American College of Cardiology. 27, 6, p. 1444-1449 6 p.

研究成果: ジャーナルへの寄稿記事

Muscle Spasticity
Spasm
omega-N-Methylarginine
Nitric Oxide
Coronary Vessels
90 引用 (Scopus)
Sendai virus
Liposomes
Smooth Muscle Myocytes
Transfection
Blood Vessels