薬学研究院

研究成果

2004

Anti-monocyte chemoattractant protein-1 gene therapy attenuates nephritis in MRL/lpr mice

Shimizu, S., Nakashima, H., Masutani, K., Inoue, Y., Miyake, K., Akahoshi, M., Tanaka, Y., Egashira, K., Hirakata, H., Otsuka, T. & Harada, M., 9 1 2004, : : Rheumatology. 43, 9, p. 1121-1128 8 p.

研究成果: ジャーナルへの寄稿記事

76 引用 (Scopus)

Anti-monocyte chemoattractant protein-1 gene therapy attenuates pulmonary fibrosis in mice

Inoshima, I., Kuwano, K., Hamada, N., Hagimoto, N., Yoshimi, M., Maeyama, T., Takeshita, A., Kitamoto, S., Egashira, K. & Hara, N., 5 1 2004, : : American Journal of Physiology - Lung Cellular and Molecular Physiology. 286, 5 30-5, p. L1038-L1044

研究成果: ジャーナルへの寄稿記事

99 引用 (Scopus)

Anti-monocyte chemoattractant protein-1 gene therapy prevents dimethylnitrosamine-induced hepatic fibrosis in rats.

Tsuruta, S., Nakamuta, M., Enjoji, M., Kotoh, K., Hiasa, K., Egashira, K. & Nawata, H., 11 2004, : : International journal of molecular medicine. 14, 5, p. 837-842 6 p.

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

Anti-monocyte chemoattractant protein-1 gene therapy protects against focal brain ischemia in hypertensive rats

Kumai, Y., Ooboshi, H., Takada, J., Kamouchi, M., Kitazono, T., Egashira, K., Ibayashi, S. & Iida, M., 12 2004, : : Journal of Cerebral Blood Flow and Metabolism. 24, 12, p. 1359-1368 10 p.

研究成果: ジャーナルへの寄稿記事

51 引用 (Scopus)

Antimonocyte chemoattractant protein-1 gene therapy reduces experimental in-stent restenosis in hypercholesterolemic rabbits and monkeys

Ohtani, K., Usui, M., Nakano, K., Kohjimoto, Y., Kitajima, S., Hirouchi, Y., Li, X. H., Kitamoto, S., Takeshita, A. & Egashira, K., 8 1 2004, : : Gene Therapy. 11, 16, p. 1273-1282 10 p.

研究成果: ジャーナルへの寄稿記事

45 引用 (Scopus)

Blockade of vascular endothelial growth factor suppresses experimental restenosis after intraluminal injury by inhibiting recruitment of monocyte lineage cells

Ohtani, K., Egashira, K., Hiasa, K. I., Zhao, Q., Kitamoto, S., Ishibashi, M., Usui, M., Inoue, S., Yonemitsu, Y., Sueishi, K., Sata, M., Shibuya, M. & Sunagawa, K., 10 19 2004, : : Circulation. 110, 16, p. 2444-2452 9 p.

研究成果: ジャーナルへの寄稿記事

111 引用 (Scopus)

Bone marrow-derived monocyte chemoattractant protein-1 receptor CCR2 is critical in angiotensin II-induced acceleration of atherosclerosis and aneurysm formation in hypercholesterolemic mice.

Ishibashi, M., Egashira, K., Zhao, Q., Hiasa, K. I., Ohtani, K., Ihara, Y., Charo, I. F., Kura, S., Tsuzuki, T., Takeshita, A. & Sunagawa, K., 11 2004, : : Arteriosclerosis, thrombosis, and vascular biology. 24, 11, p. e174-178

研究成果: ジャーナルへの寄稿記事

118 引用 (Scopus)

Bone marrow mononuclear cell therapy limits myocardial infarct size through vascular endothelial growth factor

Hiasa, K. I., Egashira, K., Kitamoto, S., Ishibashi, M., Inoue, S., Ni, W., Zhao, Q., Nagata, S., Katoh, M., Sata, M. & Takeshita, A., 5 1 2004, : : Basic Research in Cardiology. 99, 3, p. 165-172 8 p.

研究成果: ジャーナルへの寄稿記事

53 引用 (Scopus)

cAMP-response element-binding protein mediates tumor necrosis factor-α-induced vascular smooth muscle cell migration

Ono, H., Ichiki, T., Fukuyama, K., Iino, N., Masuda, S., Egashira, K. & Takeshita, A., 9 1 2004, : : Arteriosclerosis, thrombosis, and vascular biology. 24, 9, p. 1634-1639 6 p.

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

Cholesterol-lowering independent regression and stabilization of atherosclerotic lesions by pravastatin and by antimonocyte chemoattractant protein-1 therapy in nonhuman primates

Kitamoto, S., Nakano, K., Hirouchi, Y., Kohjimoto, Y., Kitajima, S., Usui, M., Inoue, S. & Egashira, K., 8 1 2004, : : Arteriosclerosis, thrombosis, and vascular biology. 24, 8, p. 1522-1528 7 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Critical role of monocyte chemoattractant protein-1 receptor CCR2 on monocytes in hypertension-induced vascular inflammation and remodeling

Ishibashi, M., Hiasa, K. I., Zhao, Q., Inoue, S., Ohtani, K., Kitamoto, S., Tsuchihashi, M., Sugaya, T., Charo, I. F., Kura, S., Tsuzuki, T., Ishibashi, T., Takeshita, A. & Egashira, K., 5 14 2004, : : Circulation research. 94, 9, p. 1203-1210 8 p.

研究成果: ジャーナルへの寄稿記事

151 引用 (Scopus)

Development of new gene therapy strategies: a grand design for frontier medicine

Yonemitsu, Y. & Sueishi, K., 1 1 2004, : : Fukuoka igaku zasshi = Hukuoka acta medica. 95, 10, p. 258-264 7 p.

研究成果: ジャーナルへの寄稿評論記事

Endothelial dysfunction and coronary atherosclerosis

Kitamoto, S. & Egashira, K., 3 1 2004, : : Current Drug Targets - Cardiovascular and Haematological Disorders. 4, 1, p. 13-22 10 p.

研究成果: ジャーナルへの寄稿評論記事

12 引用 (Scopus)

Essential role of PDGFRα-p70S6K signaling in mesenchymal cells during therapeutic and tumor angiogenesis in vivo role of PDGFRα during angiogenesis

Tsutsumi, N., Yonemitsu, Y., Shikada, Y., Onimaru, M., Tanii, M., Okano, S., Kaneko, K., Hasegawa, M., Hashizume, M., Maehara, Y. & Sueishi, K., 5 14 2004, : : Circulation research. 94, 9, p. 1186-1194 9 p.

研究成果: ジャーナルへの寄稿記事

66 引用 (Scopus)

Essential role of vascular endothelial growth factor and Flt-1 signals in neointimal formation after periadventitial injury

Zhao, Q., Egashira, K., Hiasa, K. I., Ishibashi, M., Inoue, S., Ohtani, K., Tan, C., Shibuya, M., Takeshita, A. & Sunagawa, K., 12 1 2004, : : Arteriosclerosis, thrombosis, and vascular biology. 24, 12, p. 2284-2289 6 p.

研究成果: ジャーナルへの寄稿記事

69 引用 (Scopus)

Essential role of vascular endothelial growth factor in angiotensin II-induced vascular inflammation and remodeling

Zhao, Q., Ishibashi, M., Hiasa, K. I., Tan, C., Takeshita, A. & Egashira, K., 9 1 2004, : : Hypertension. 44, 3, p. 264-270 7 p.

研究成果: ジャーナルへの寄稿記事

135 引用 (Scopus)

Gene therapy: its history, current status, and future perspectives

Yonemitsu, Y. & Sueishi, K., 1 1 2004, : : Fukuoka igaku zasshi = Hukuoka acta medica. 95, 4, p. 81-88 8 p.

研究成果: ジャーナルへの寄稿評論記事

Gene Therapy via Blockade of Monocyte Chemoattractant Protein-1 for Renal Fibrosis

Wada, T., Furuichi, K., Sakai, N., Iwata, Y., Kitagawa, K., Ishida, Y., Kondo, T., Hashimoto, H., Ishiwata, Y., Mukaida, N., Tomosugi, N., Matsushima, K., Egashira, K. & Yokoyama, H., 4 1 2004, : : Journal of the American Society of Nephrology. 15, 4, p. 940-948 9 p.

研究成果: ジャーナルへの寄稿記事

144 引用 (Scopus)

Growth pattern correlates with the distribution of basement membrane and prognosis in lung adenocarcinoma

Matsuo, Y., Hashimoto, S., Koga, T., Yonemitsu, Y., Yoshino, I., Sugimachi, K., Honda, H., Masuda, K. & Sueishi, K., 8 2004, : : Pathology Research and Practice. 200, 7-8, p. 517-529 13 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Hypertensive Myocardial Fibrosis and Diastolic Dysfunction: Another Model of Inflammation?

Kuwahara, F., Kai, H., Tokuda, K., Takeya, M., Takeshita, A., Egashira, K. & Imaizumi, T., 4 1 2004, : : Hypertension. 43, 4, p. 739-745 7 p.

研究成果: ジャーナルへの寄稿記事

204 引用 (Scopus)

Inhibition of neointimal hyperplasia after balloon injury by cis-element 'decoy' of early growth response gene-1 in hypercholesterolemic rabbits

Ohtani, K., Egashira, K., Usui, M., Ishibashi, M., Hiasa, K. I., Zhao, Q., Aoki, M., Kaneda, Y., Morishita, R. & Takeshita, A., 1 1 2004, : : Gene Therapy. 11, 2, p. 126-132 7 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Initial Clinical Cases of the Use of a NF-κB Decoy at the Site of Coronary Stenting for the Prevention of Restenosis

Suzuki, J. I., Ito, H., Gotoh, R., Morishita, R., Egashira, K. & Isobe, M., 3 1 2004, : : Circulation Journal. 68, 3, p. 270-271 2 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Intracoronary Artery Gene Transfer Using the REMEDY Catheter: Case Studies in Pigs and Humans

Gotoh, R., Suzuki, J. I., Ito, H., Egashira, K., Morishita, R. & Isobe, M., 5 19 2004, : : Japanese Journal of Interventional Cardiology. 19, 2, p. 144-149 6 p.

研究成果: ジャーナルへの寄稿記事

Monocyte Chemoattractant Protein-1 is an Essential Inflammatory Mediator in Angiotensin II-Induced Progression of Established Atherosclerosis in Hypercholesterolemic Mice

Ni, W., Kitamoto, S., Ishibashi, M., Usui, M., Inoue, S., Hiasa, K. I., Zhao, Q., Nishida, K. I., Takeshita, A. & Egashira, K., 3 1 2004, : : Arteriosclerosis, thrombosis, and vascular biology. 24, 3, p. 534-539 6 p.

研究成果: ジャーナルへの寄稿記事

91 引用 (Scopus)

NO and atherosclerosis

Ohtani, K. & Egashira, K., 9 2004, : : Nippon rinsho. Japanese journal of clinical medicine. 62 Suppl 9, p. 544-547 4 p.

研究成果: ジャーナルへの寄稿評論記事

Novel anti-inflammatory actions of amlodipine in a rat model of arteriosclerosis induced by long-term inhibition of nitric oxide synthesis

Kataoka, C., Egashira, K., Ishibashi, M., Inoue, S., Ni, W., Ken-Ichi, H., Kitamoto, S., Usui, M. & Takeshita, A., 2 1 2004, : : American Journal of Physiology - Heart and Circulatory Physiology. 286, 2 55-2

研究成果: ジャーナルへの寄稿記事

56 引用 (Scopus)

SOC1 inhibits HPV-E7-mediated transformation by inducing degradation of E7 protein

Kamio, M., Yoshida, T., Ogata, H., Douchi, T., Nagata, Y., Inoue, M., Hasegawa, M., Yonemitsu, Y. & Yoshimura, A., 4 15 2004, : : Oncogene. 23, 17, p. 3107-3115 9 p.

研究成果: ジャーナルへの寄稿記事

53 引用 (Scopus)

The relative contributions of each subset of ocular infiltrated cells in experimental choroidal neovascularisation

Tsutsumi-Miyahara, C., Sonoda, K. H., Egashira, K., Ishibashi, M., Qiao, H., Oshima, T., Murata, T., Miyazaki, M., Charo, I. F., Hamano, S. & Ishibashi, T., 9 1 2004, : : British Journal of Ophthalmology. 88, 9, p. 1217-1222 6 p.

研究成果: ジャーナルへの寄稿記事

63 引用 (Scopus)

The Sprouty-related protein, Spred, inhibits cell motility, metastasis, and Rho-mediated actin reorganization

Miyoshi, K., Wakioka, T., Nishinakamura, H., Kamio, M., Yang, L., Inoue, M., Hasegawa, M., Yonemitsu, Y., Komiya, S. & Yoshimura, A., 7 22 2004, : : Oncogene. 23, 33, p. 5567-5576 10 p.

研究成果: ジャーナルへの寄稿記事

68 引用 (Scopus)

Vascular endothelial growth factor - Basic science and its clinical implications

Celec, P. & Yonemitsu, Y., 10 1 2004, : : Pathophysiology. 11, 2, p. 69-75 7 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)
2005

A FancD2-monoubiquitin fusion reveals hidden functions of Fanconi anemia core complex in DNA repair

Matsushita, N., Kitao, H., Ishiai, M., Nagashima, N., Hirano, S., Okawa, K., Ohta, T., Yu, D. S., McHugh, P. J., Hickson, I. D., Venkitaraman, A. R., Kurumizaka, H. & Takata, M., 9 16 2005, : : Molecular Cell. 19, 6, p. 841-847 7 p.

研究成果: ジャーナルへの寄稿記事

108 引用 (Scopus)

Angiogenesis and lymphangiogenesis and expression of lymphangiogenic factors in the atherosclerotic intima of human coronary arteries

Nakano, T., Nakashima, Y., Yonemitsu, Y., Sumiyoshi, S., Chen, Y. X., Akishima, Y., Ishii, T., Iida, M. & Sueishi, K., 4 2005, : : Human Pathology. 36, 4, p. 330-340 11 p.

研究成果: ジャーナルへの寄稿記事

71 引用 (Scopus)

Angiogenic growth factors in rheumatoid arthritis

Yamashita, A. & Yonemitsu, Y., 1 1 2005, : : Nippon rinsho. Japanese journal of clinical medicine. 63 Suppl 1, p. 189-194 6 p.

研究成果: ジャーナルへの寄稿評論記事

Antibody-induced arthritis

Yamashita, A. & Yonemitsu, Y., 1 2005, : : Nippon rinsho. Japanese journal of clinical medicine. 63 Suppl 1, p. 46-50 5 p.

研究成果: ジャーナルへの寄稿評論記事

Anti-monocyte chemoattractant protein 1 gene therapy attenuates experimental chronic pancreatitis induced by dibutyltin dichloride in rats

Zhao, H. F., Ito, T., Gibo, J., Kawabe, K., Oono, T., Kaku, T., Arita, Y., Zhao, Q. W., Usui, M., Egashira, K. & Nawata, H., 12 1 2005, : : Gut. 54, 12, p. 1759-1767 9 p.

研究成果: ジャーナルへの寄稿記事

46 引用 (Scopus)

Anti-vascular endothelial growth factor gene therapy attenuates lung injury and fibrosis in mice

Hamada, N., Kuwano, K., Yamada, M., Hagimoto, N., Hiasa, K., Egashira, K., Nakashima, N., Maeyama, T., Yoshimi, M. & Nakanishi, Y., 7 15 2005, : : Journal of Immunology. 175, 2, p. 1224-1231 8 p.

研究成果: ジャーナルへの寄稿記事

124 引用 (Scopus)

Critical role for monocyte chemoattractant protein-1 and macrophage inflammatory protein-1α in induction of experimental autoimmune myocarditis and effective anti-monocyte chemoattractant protein-1 gene therapy

Göser, S., Öttl, R., Brodner, A., Dengler, T. J., Torzewski, J., Egashira, K., Rose, N. R., Katus, H. A. & Kaya, Z., 11 1 2005, : : Circulation. 112, 22, p. 3400-3407 8 p.

研究成果: ジャーナルへの寄稿記事

107 引用 (Scopus)

Cytoplasmic expression and extracellular deposition of an antiangiogenic factor, pigment epithelium-derived factor, in human atherosclerotic plaques

Baba, H., Yonemitsu, Y., Nakano, T., Onimaru, M., Miyazaki, M., Ikeda, Y., Sumiyoshi, S., Ueda, Y., Hasegawa, M., Yoshino, I., Maehara, Y. & Sueishi, K., 9 1 2005, : : Arteriosclerosis, thrombosis, and vascular biology. 25, 9, p. 1938-1944 7 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Endogenous NO blockade enhances tissue factor expression via increased Ca2+ influx through MCP-1 in endothelial cells by monocyte adhesion

Sakamoto, T., Ishibashi, T., Sakamoto, N., Sugimoto, K., Egashira, K., Ohkawara, H., Nagata, K., Yokoyama, K., Kamioka, M., Ichiki, T., Sugimoto, N., Kurabayashi, M., Suzuki, K., Takuwa, Y. & Maruyama, Y., 9 1 2005, : : Arteriosclerosis, thrombosis, and vascular biology. 25, 9, p. 2005-2011 7 p.

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)

Ex vivo electroporation as a potent new strategy for nonviral gene transfer into autologous vein grafts

Yamaoka, T., Yonemitsu, Y., Komori, K., Baba, H., Matsumoto, T., Onohara, T. & Maehara, Y., 11 1 2005, : : American Journal of Physiology - Heart and Circulatory Physiology. 289, 5 58-5, p. H1865-H1872

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Gene therapy for retinal disease

Kohno, R., Yonemitsu, Y. & Ikeda, Y., 12 2005, : : Nippon rinsho. Japanese journal of clinical medicine. 63 Suppl 12, p. 679-687 9 p.

研究成果: ジャーナルへの寄稿評論記事

Monocyte chemottractant protein-1 activates a regional Th1 immunoresponse in nephritis of MRL/lpr mice

Shimizu, S., Nakashima, H., Karube, K. N., Ohshima, K. & Egashira, K., 3 1 2005, : : Clinical and experimental rheumatology. 23, 2, p. 239-242 4 p.

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

Platelet-derived growth factor-AA is an essential and autocrine regulator of vascular endothelial growth factor expression in non-small cell lung carcinomas

Shikada, Y., Yonemitsu, Y., Koga, T., Onimaru, M., Nakano, T., Okano, S., Sata, S., Nakagawa, K., Yoshino, I., Maehara, Y. & Sueishi, K., 8 15 2005, : : Cancer Research. 65, 16, p. 7241-7248 8 p.

研究成果: ジャーナルへの寄稿記事

70 引用 (Scopus)

The effects of flavoxate hydrochloride on voltage-dependent L-type Ca 2+ currents in human urinary bladder

Tomoda, T., Aishima, M., Takano, N., Nakano, T., Seki, N., Yonemitsu, Y., Sueishi, K., Naito, S., Ito, Y. & Teramoto, N., 12 1 2005, : : British Journal of Pharmacology. 146, 1, p. 25-32 8 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

The gene transfer of soluble VEGF type I receptor (Flt-1) attenuates peritoneal fibrosis formation in mice but not soluble TGF-β type II receptor gene transfer

Motomura, Y., Kanbayashi, H., Khan, W. I., Deng, Y., Blennerhassett, P. A., Margetts, P. J., Gauldie, J., Egashira, K. & Collins, S. M., 1 1 2005, : : American Journal of Physiology - Gastrointestinal and Liver Physiology. 288, 1 51-1, p. G143-G150

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

The use of transformed Escherichia coli for experimental angiogenesis induced by regulated in situ production of vascular endothelial growth factor - An alternative gene therapy

Celec, P., Gardlík, R., Pálffy, R., Hodosy, J., Stuchlík, S., Drahovská, H., Stuchlíková, M., Minárik, G., Lukács, J., Jurkovičová, I., Hulín, I., Turňa, J., Jakubovský, J., Kopáni, M., Danišovič, Ľ., Jandzík, D., Kúdela, M. & Yonemitsu, Y., 1 7 2005, : : Medical Hypotheses. 64, 3, p. 505-511 7 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Tumor necrosis factor and vascular endothelial growth factor induce endothelial integrin repertories, regulating endovascular differentiation and apoptosis in a human extravillous trophoblast cell line

Fukushima, K., Miyamoto, S., Tsukimori, K., Kobayashi, H., Seki, H., Takeda, S., Kensuke, E., Ohtani, K., Shibuya, M. & Nakano, H., 7 1 2005, : : Biology of Reproduction. 73, 1, p. 172-179 8 p.

研究成果: ジャーナルへの寄稿記事

46 引用 (Scopus)
2006

Actions of ZD0947, a novel ATP-sensitive K + channel opener, on membrane currents in human detrusor myocytes

Aishima, M., Tomoda, T., Yunoki, T., Nakano, T., Seki, N., Yonemitsu, Y., Sueishi, K., Naito, S., Ito, Y. & Teramoto, N., 11 21 2006, : : British Journal of Pharmacology. 149, 5, p. 542-550 9 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

A free radical scavenger but not FGF-2-mediated angiogenic therapy rescues myonephropathic metabolic syndrome in severe hindlimb ischemia

Kaneko, K., Yonemitsu, Y., Fujii, T., Onimaru, M., Jin, C. H., Inoue, M., Hasegawa, M., Onohara, T., Maehara, Y. & Sueishi, K., 4 1 2006, : : American Journal of Physiology - Heart and Circulatory Physiology. 290, 4, p. H1484-H1492

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

AII and inflammation

Ihara, Y. & Egashira, K., 7 2006, : : Nippon rinsho. Japanese journal of clinical medicine. 64 Suppl 5, p. 79-83 5 p.

研究成果: ジャーナルへの寄稿評論記事