薬学研究院

研究成果

HVJ (Sendai virus)-cationic liposomes: A novel and potentially effective liposome-mediated technique for gene transfer to the airway epithelium

Yonemitsu, Y., Kaneda, Y., Muraishi, A., Yoshizumi, T., Sugimachi, K. & Sueishi, K., 1 1 1997, : : Gene Therapy. 4, 7, p. 631-638 8 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

HVJ (Sendai virus) liposome-mediated gene transfer: Current status and future perspectives

Yonemitsu, Y., Alton, E. W. F. W., Komori, K., Yoshizumi, T., Sugimachi, K. & Kaneda, Y., 6 1 1998, : : International journal of oncology. 12, 6, p. 1277-1285 9 p.

研究成果: ジャーナルへの寄稿評論記事

16 引用 (Scopus)

Hypertensive Myocardial Fibrosis and Diastolic Dysfunction: Another Model of Inflammation?

Kuwahara, F., Kai, H., Tokuda, K., Takeya, M., Takeshita, A., Egashira, K. & Imaizumi, T., 4 1 2004, : : Hypertension. 43, 4, p. 739-745 7 p.

研究成果: ジャーナルへの寄稿記事

204 引用 (Scopus)
54 引用 (Scopus)

Imatinib mesylate-incorporated nanoparticle-eluting stent attenuates in-stent neointimal formation in porcine coronary arteries

Masuda, S., Nakano, K., Funakoshi, K., Zhao, G., Meng, W., Kimura, S., Matoba, T., Miyagawa, M., Iwata, E., Sunagawa, K. & Egashira, K., 12 22 2011, : : Journal of atherosclerosis and thrombosis. 18, 12, p. 1043-1053 11 p.

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

Immediate Relief of Spontaneous Coronary Artery Spasm by Intracoronary Infusion of an Endothelium-dependent Vasodilator, Substance P

Numagughi, K., Egashira, K., Inou, T. & Takeshita, A., 1 1 1995, : : japanese heart journal. 36, 1, p. 111-114 4 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

Immunohistochemical phenotypic alterations of rabbit autologous vein grafts implanted under arterial circulation with or without poor distal runoff-implications of vein graft remodeling

Ishida, M., Komori, K., Yonemitsu, Y., Taguchi, K., Onohara, T. & Sugimachi, K., 2 22 2001, : : Atherosclerosis. 154, 2, p. 345-354 10 p.

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)

Impact of deletion of envelope-related genes of recombinant Sendai viruses on immune responses following pulmonary gene transfer of neonatal mice

Tanaka, S., Yonemitsu, Y., Yoshida, K., Okano, S., Kondo, H., Inoue, M., Hasegawa, M., Masumoto, K., Suita, S., Taguchi, T. & Sueishi, K., 7 1 2007, : : Gene Therapy. 14, 13, p. 1017-1028 12 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Impact of dendritic cell vaccines pulsed with Wilms' tumour-1 peptide antigen on the survival of patients with advanced non-small cell lung cancers

Takahashi, H., Okamoto, M., Shimodaira, S., Tsujitani, S. I., Nagaya, M., Ishidao, T., Kishimoto, J. & Yonemitsu, Y., 3 1 2013, : : European Journal of Cancer. 49, 4, p. 852-859 8 p.

研究成果: ジャーナルへの寄稿記事

37 引用 (Scopus)

Impact of monocyte chemoattractant protein-1 deficiency on cerebral aneurysm formation

Aoki, T., Kataoka, H., Ishibashi, R., Nozaki, K., Egashira, K. & Hashimoto, N., 3 1 2009, : : Stroke. 40, 3, p. 942-951 10 p.

研究成果: ジャーナルへの寄稿記事

123 引用 (Scopus)

Impaired coronary blood flow response to acetylcholine in patients with coronary risk factors and proximal atherosclerotic lesions

Egashira, K., Inou, T., Hirooka, Y., Yamada, A., Maruoka, Y., Kai, H., Sugimachi, M., Suzuki, S. & Takeshita, A., 1 1 1993, : : Journal of Clinical Investigation. 91, 1, p. 29-37 9 p.

研究成果: ジャーナルへの寄稿記事

314 引用 (Scopus)

Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice

Watari, K., Shibata, T., Nabeshima, H., Shinoda, A., Fukunaga, Y., Kawahara, A., Karasuyama, K., Fukushi, J. I., Iwamoto, Y., Kuwano, M. & Ono, M., 1 18 2016, : : Scientific reports. 6, 19470.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension: Different responses to acetylcholine and substance P

Egashira, K., Suzuki, S., Hirooka, Y., Kai, H., Sugimachi, M., Imaizumi, T. & Takeshita, A., 1 1 1995, : : Hypertension. 25, 2, p. 201-206 6 p.

研究成果: ジャーナルへの寄稿記事

187 引用 (Scopus)

Importance of endothelium-derived hyperpolarizing factor in human arteries

Urakami-Harasawa, L., Shimokawa, H., Nakashima, M., Egashira, K. & Takeshita, A., 12 1 1997, : : Journal of Clinical Investigation. 100, 11, p. 2793-2799 7 p.

研究成果: ジャーナルへの寄稿記事

252 引用 (Scopus)

Importance of monocyte chemoattractant protein-1 pathway in neointimal hyperplasia after periarterial injury in mice and monkeys

Egashira, K., Zhao, Q., Kataoka, C., Ohtani, K., Usui, M., Charo, I. F., Nishida, K. I., Inoue, S., Katoh, M., Ichiki, T. & Takeshita, A., 6 14 2002, : : Circulation research. 90, 11, p. 1167-1172 6 p.

研究成果: ジャーナルへの寄稿記事

148 引用 (Scopus)

Important role of endothelium-derived hyperpolarizing factor in shear stress-induced endothelium-dependent relaxations in the rat mesenteric artery

Takamura, Y., Shimokawa, H., Zhao, H., Igarashi, H., Egashira, K. & Takeshita, A., 9 1 1999, : : Journal of Cardiovascular Pharmacology. 34, 3, p. 381-387 7 p.

研究成果: ジャーナルへの寄稿記事

61 引用 (Scopus)

Important role of local angiotensin II activity mediated via type I receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats

Usui, M., Egashira, K., Tomita, H., Koyanagi, M., Katoh, M., Shimokawa, H., Takeya, M., Yoshimura, T., Matsushima, K. & Takeshita, A., 1 25 2000, : : Circulation. 101, 3, p. 305-310 6 p.

研究成果: ジャーナルへの寄稿記事

158 引用 (Scopus)

Important role of Rho-kinase in the pathogenesis of cardiovascular inflammation and remodeling induced by long-term blockade of nitric oxide synthesis in rats

Kataoka, C., Egashira, K., Inoue, S., Takemoto, M., Ni, W., Koyanagi, M., Kitamoto, S., Usui, M., Kaibuchi, K., Shimokawa, H. & Takeshita, A., 3 4 2002, : : Hypertension. 39, 2 I, p. 245-250 6 p.

研究成果: ジャーナルへの寄稿記事

164 引用 (Scopus)

Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats

Takemoto, M., Egashira, K., Usui, M., Numaguchi, K., Tomita, H., Tsutsui, H., Shimokawa, H., Sueishi, K. & Takeshita, A., 1 15 1997, : : Journal of Clinical Investigation. 99, 2, p. 278-287 10 p.

研究成果: ジャーナルへの寄稿記事

307 引用 (Scopus)

Improved quality of life in patients with no-option critical limb ischemia undergoing gene therapy with DVC1-0101

Matsumoto, T., Tanaka, M., Yoshiya, K., Yoshiga, R., Matsubara, Y., Horiuchi-Yoshida, K., Yonemitsu, Y. & Maehara, Y., 7 15 2016, : : Scientific reports. 6, 30035.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Increased activity of nuclear factor-κB participates in cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis in rats

Kitamoto, S., Egashira, K., Kataoka, C., Koyanagi, M., Katoh, M., Shimokawa, H., Morishita, R., Kaneda, Y., Sueishi, K. & Takeshita, A., 1 1 2000, : : Circulation. 102, 7, p. 806-812 7 p.

研究成果: ジャーナルへの寄稿記事

75 引用 (Scopus)

Increased expression of L-type calcium channels in vascular smooth muscle cells at spastic site in a porcine model of coronary artery spasm

Kuga, T., Shimokawa, H., Hirakawa, Y., Kadokami, Y., Arai, Y., Fukumoto, Y., Kuwata, K., Kozai, T., Egashira, K. & Takeshita, A., 5 22 2000, : : Journal of Cardiovascular Pharmacology. 35, 5, p. 822-828 7 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure

Akimura, K., Egashira, K., Nakamura, R., Ide, T., Tsutsui, H., Shimokawa, H. & Takeshita, A., 6 11 2001, : : American Journal of Physiology - Heart and Circulatory Physiology. 280, 1 49-1, p. H68-H75

研究成果: ジャーナルへの寄稿記事

48 引用 (Scopus)

Induction of cell fusion/apoptosis in anaplastic thyroid carcinoma in orthotopic mouse model by urokinase-specific oncolytic Sendai virus

Miyagawa, Y., Araki, K., Yamashita, T., Tanaka, S., Tanaka, Y., Tomifuji, M., Ueda, Y., Yonemitsu, Y., Shimada, H. & Shiotani, A., 1 1 2019, : : Head and Neck. 41, 9, p. 2873-2882 10 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Induction of efficient antitumor immunity using dendritic cells activated by recombinant Sendai virus and its modulation by exogenous IFN-β gene

Shibata, S., Okano, S., Yonemitsu, Y., Onimaru, M., Sata, S., Nagata-Takeshita, H., Inoue, M., Zhu, T., Hasegawa, M., Moroi, Y., Furue, M. & Sueishi, K., 9 15 2006, : : Journal of Immunology. 177, 6, p. 3564-3576 13 p.

研究成果: ジャーナルへの寄稿記事

57 引用 (Scopus)

Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer

Kawahara, A., Hattori, S., Akiba, J., Nakashima, K., Taira, T., Watari, K., Hosoi, F., Uba, M., Basaki, Y., Koufuji, K., Shirouzu, K., Akiyama, S. I., Kuwano, M., Kage, M. & Ono, M., 8 2010, : : Oncology reports. 24, 2, p. 405-415 11 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth-muscle phenotypes in pigs

Fukumoto, Y., Shimokawa, H., Ito, A., Kadokami, T., Yonemitsu, Y., Aikawa, M., Owada, M. K., Egashira, K., Sueishi, K., Nagai, R., Yazaki, Y. & Takeshita, A., 2 1 1997, : : Journal of Cardiovascular Pharmacology. 29, 2, p. 222-231 10 p.

研究成果: ジャーナルへの寄稿記事

65 引用 (Scopus)

Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis

Kimura, Y. N., Watari, K., Fotovati, A., Hosoi, F., Yasumoto, K., Izumi, H., Kohno, K., Umezawa, K., Iguchi, H., Shirouzu, K., Takamori, S., Kuwano, M. & Ono, M., 12 1 2007, : : Cancer Science. 98, 12, p. 2009-2018 10 p.

研究成果: ジャーナルへの寄稿記事

94 引用 (Scopus)

Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

Hiraoka, K., Zenmyo, M., Watari, K., Iguchi, H., Fotovati, A., Kimura, Y. N., Hosoi, F., Shoda, T., Nagata, K., Osada, H., Ono, M. & Kuwano, M., 8 25 2008, : : Cancer Science. 99, 8, p. 1595-1602 8 p.

研究成果: ジャーナルへの寄稿記事

85 引用 (Scopus)

Inhibition of intrinsic interferon-γ function prevents neointima formation after balloon injury

Kusaba, K., Kai, H., Koga, M., Takayama, N., Ikeda, A., Yasukawa, H., Seki, Y., Egashira, K. & Imaizumi, T., 4 1 2007, : : Hypertension. 49, 4, p. 909-915 7 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β

Kandabashi, T., Shimokawa, H., Miyata, K., Kunihiro, I., Kawano, Y., Fukata, Y., Higo, T., Egashira, K., Takahashi, S., Kaibuchi, K. & Takeshita, A., 3 21 2000, : : Circulation. 101, 11, p. 1319-1323 5 p.

研究成果: ジャーナルへの寄稿記事

216 引用 (Scopus)

Inhibition of neointimal hyperplasia after balloon injury by cis-element 'decoy' of early growth response gene-1 in hypercholesterolemic rabbits

Ohtani, K., Egashira, K., Usui, M., Ishibashi, M., Hiasa, K. I., Zhao, Q., Aoki, M., Kaneda, Y., Morishita, R. & Takeshita, A., 1 1 2004, : : Gene Therapy. 11, 2, p. 126-132 7 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Inhibition of NO synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vessels

Tomita, H., Egashira, K., Kubo-Inoue, M., Usui, M., Koyanagi, M., Shimokawa, H., Takeya, M., Yoshimura, T. & Takeshita, A., 1 1 1998, : : Arteriosclerosis, thrombosis, and vascular biology. 18, 9, p. 1456-1464 9 p.

研究成果: ジャーナルへの寄稿記事

110 引用 (Scopus)

Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration

Murakami, Y., Ikeda, Y., Yonemitsu, Y., Onimaru, M., Nakagawa, K., Kohno, R. I., Miyazaki, M., Hisatomi, T., Nakamura, M., Yabe, T., Hasegawa, M., Ishibashi, T. & Sueishi, K., 11 2008, : : American Journal of Pathology. 173, 5, p. 1326-1338 13 p.

研究成果: ジャーナルへの寄稿記事

77 引用 (Scopus)

Inhibition of progression and stabilization of plaques by postnatal interferon-γ function blocking in ApoE-knockout mice

Koga, M., Kai, H., Yasukawa, H., Yamamoto, T., Kawai, Y., Kato, S., Kusaba, K., Kai, M., Egashira, K., Kataoka, Y. & Imaizumi, T., 8 1 2007, : : Circulation research. 101, 4, p. 348-356 9 p.

研究成果: ジャーナルへの寄稿記事

71 引用 (Scopus)

Initial Clinical Cases of the Use of a NF-κB Decoy at the Site of Coronary Stenting for the Prevention of Restenosis

Suzuki, J. I., Ito, H., Gotoh, R., Morishita, R., Egashira, K. & Isobe, M., 3 1 2004, : : Circulation Journal. 68, 3, p. 270-271 2 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)
46 引用 (Scopus)

Intracoronary Artery Gene Transfer Using the REMEDY Catheter: Case Studies in Pigs and Humans

Gotoh, R., Suzuki, J. I., Ito, H., Egashira, K., Morishita, R. & Isobe, M., 5 19 2004, : : Japanese Journal of Interventional Cardiology. 19, 2, p. 144-149 6 p.

研究成果: ジャーナルへの寄稿記事

33 引用 (Scopus)

Intramural delivery of a specific tyrosine kinase inhibitor with biodegradable stent suppresses the restenotic changes of the coronary artery in pigs in vivo

Yamawaki, T., Shimokawa, H., Kozai, T., Miyata, K., Higo, T., Tanaka, E., Egashira, K., Shiraishi, T., Tamai, H., Igaki, K. & Takeshita, A., 9 1 1998, : : Journal of the American College of Cardiology. 32, 3, p. 780-786 7 p.

研究成果: ジャーナルへの寄稿記事

121 引用 (Scopus)

Intramuscular gene transfer of FGF-2 attenuates endothelial dysfunction and inhibits intimal hyperplasia of vein grafts in poor-runoff limbs of rabbit

Shoji, T., Yonemitsu, Y., Komori, K., Tanii, M., Itoh, H., Sata, S., Shimokawa, H., Hasegawa, M., Sueishi, K. & Maehara, Y., 7 1 2003, : : American Journal of Physiology - Heart and Circulatory Physiology. 285, 1 54-1, p. H173-H182

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

In vivo delivery of glial cell-derived neurotrophic factor across the blood-brain barrier by gene transfer into brain capillary endothelial cells

Jiang, C., Koyabu, N., Yonemitsu, Y., Shimazoe, T., Watanabe, S., Naito, M., Tsuruo, T., Ohtani, H. & Sawada, Y., 8 10 2003, : : Human Gene Therapy. 14, 12, p. 1181-1191 11 p.

研究成果: ジャーナルへの寄稿記事

36 引用 (Scopus)

In vivo reduction of the nuclear factor-κB activity using synthetic cis-element decoy oligonucleotides suppresses intimal hyperplasia in the injured carotid arteries in rabbits

Takeuchi, K., Itoh, H., Yonemitsu, Y., Matsumoto, T., Kume, M., Komori, K. & Maehara, Y., 7 1 2007, : : Surgery today. 37, 7, p. 575-583 9 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)
32 引用 (Scopus)

Local adenovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo

Morishige, K., Shimokawa, H., Yamawaki, T., Miyata, K., Eto, Y., Kandabashi, T., Yogo, K., Higo, T., Egashira, K., Ueno, H. & Takeshita, A., 3 15 2000, : : Journal of the American College of Cardiology. 35, 4, p. 1040-1047 8 p.

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

Local delivery of anti-monocyte chemoattractant protein-1 by gene-eluting stents attenuates in-stent stenosis in rabbits and monkeys

Egashira, K., Nakano, K., Ohtani, K., Funakoshi, K., Zhao, G., Ihara, Y., Koga, J. I., Kimura, S., Tominaga, R. & Sunagawa, K., 12 1 2007, : : Arteriosclerosis, thrombosis, and vascular biology. 27, 12, p. 2563-2568 6 p.

研究成果: ジャーナルへの寄稿記事

54 引用 (Scopus)

Local delivery of imatinib mesylate (STI571)-incorporated nanoparticle ex vivo suppresses vein graft neointima formation.

Kimura, S., Egashira, K., Nakano, K., Iwata, E., Miyagawa, M., Tsujimoto, H., Hara, K., Kawashima, Y., Tominaga, R. & Sunagawa, K., 9 30 2008, : : Circulation. 118, 14 Suppl, p. S65-70

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

Long-term follow up of initial clinical cases with NF-κB decoy oligodeoxynucleotide transfection at the site of coronary stenting

Egashira, K., Suzuki, J. I., Ito, H., Aoki, M., Isobe, M. & Morishita, R., 7 1 2008, : : Journal of Gene Medicine. 10, 7, p. 805-809 5 p.

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery

Kubo-Inoue, M., Egashira, K., Usui, M., Takemoto, M., Ohtani, K., Katoh, M., Shimokawa, H. & Takeshita, A., 6 29 2002, : : American Journal of Physiology - Heart and Circulatory Physiology. 282, 4 51-4, p. H1478-H1484

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

Long-Term Prognosis of Vasospastic Angina without Significant Atherosclerotic Coronary Artery Disease

Egashira, K., Kikuchi, Y., Sagara, T., Sugihara, M. & Nakamura, M., 1 1 1987, : : japanese heart journal. 28, 6, p. 841-849 9 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)