薬学研究院

研究成果

記事

Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure

Akimura, K., Egashira, K., Nakamura, R., Ide, T., Tsutsui, H., Shimokawa, H. & Takeshita, A., 6 11 2001, : : American Journal of Physiology - Heart and Circulatory Physiology. 280, 1 49-1, p. H68-H75

研究成果: ジャーナルへの寄稿記事

48 引用 (Scopus)

Induction of cell fusion/apoptosis in anaplastic thyroid carcinoma in orthotopic mouse model by urokinase-specific oncolytic Sendai virus

Miyagawa, Y., Araki, K., Yamashita, T., Tanaka, S., Tanaka, Y., Tomifuji, M., Ueda, Y., Yonemitsu, Y., Shimada, H. & Shiotani, A., 1 1 2019, : : Head and Neck. 41, 9, p. 2873-2882 10 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Induction of efficient antitumor immunity using dendritic cells activated by recombinant Sendai virus and its modulation by exogenous IFN-β gene

Shibata, S., Okano, S., Yonemitsu, Y., Onimaru, M., Sata, S., Nagata-Takeshita, H., Inoue, M., Zhu, T., Hasegawa, M., Moroi, Y., Furue, M. & Sueishi, K., 9 15 2006, : : Journal of Immunology. 177, 6, p. 3564-3576 13 p.

研究成果: ジャーナルへの寄稿記事

57 引用 (Scopus)

Infiltration of thymidine phosphorylase-positive macrophages is closely associated with tumor angiogenesis and survival in intestinal type gastric cancer

Kawahara, A., Hattori, S., Akiba, J., Nakashima, K., Taira, T., Watari, K., Hosoi, F., Uba, M., Basaki, Y., Koufuji, K., Shirouzu, K., Akiyama, S. I., Kuwano, M., Kage, M. & Ono, M., 8 2010, : : Oncology reports. 24, 2, p. 405-415 11 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth-muscle phenotypes in pigs

Fukumoto, Y., Shimokawa, H., Ito, A., Kadokami, T., Yonemitsu, Y., Aikawa, M., Owada, M. K., Egashira, K., Sueishi, K., Nagai, R., Yazaki, Y. & Takeshita, A., 2 1 1997, : : Journal of Cardiovascular Pharmacology. 29, 2, p. 222-231 10 p.

研究成果: ジャーナルへの寄稿記事

65 引用 (Scopus)

Inflammatory stimuli from macrophages and cancer cells synergistically promote tumor growth and angiogenesis

Kimura, Y. N., Watari, K., Fotovati, A., Hosoi, F., Yasumoto, K., Izumi, H., Kohno, K., Umezawa, K., Iguchi, H., Shirouzu, K., Takamori, S., Kuwano, M. & Ono, M., 12 1 2007, : : Cancer Science. 98, 12, p. 2009-2018 10 p.

研究成果: ジャーナルへの寄稿記事

94 引用 (Scopus)

Inhibition of bone and muscle metastases of lung cancer cells by a decrease in the number of monocytes/macrophages

Hiraoka, K., Zenmyo, M., Watari, K., Iguchi, H., Fotovati, A., Kimura, Y. N., Hosoi, F., Shoda, T., Nagata, K., Osada, H., Ono, M. & Kuwano, M., 8 25 2008, : : Cancer Science. 99, 8, p. 1595-1602 8 p.

研究成果: ジャーナルへの寄稿記事

85 引用 (Scopus)

Inhibition of intrinsic interferon-γ function prevents neointima formation after balloon injury

Kusaba, K., Kai, H., Koga, M., Takayama, N., Ikeda, A., Yasukawa, H., Seki, Y., Egashira, K. & Imaizumi, T., 4 1 2007, : : Hypertension. 49, 4, p. 909-915 7 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β

Kandabashi, T., Shimokawa, H., Miyata, K., Kunihiro, I., Kawano, Y., Fukata, Y., Higo, T., Egashira, K., Takahashi, S., Kaibuchi, K. & Takeshita, A., 3 21 2000, : : Circulation. 101, 11, p. 1319-1323 5 p.

研究成果: ジャーナルへの寄稿記事

216 引用 (Scopus)

Inhibition of neointimal hyperplasia after balloon injury by cis-element 'decoy' of early growth response gene-1 in hypercholesterolemic rabbits

Ohtani, K., Egashira, K., Usui, M., Ishibashi, M., Hiasa, K. I., Zhao, Q., Aoki, M., Kaneda, Y., Morishita, R. & Takeshita, A., 1 1 2004, : : Gene Therapy. 11, 2, p. 126-132 7 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Inhibition of NO synthesis induces inflammatory changes and monocyte chemoattractant protein-1 expression in rat hearts and vessels

Tomita, H., Egashira, K., Kubo-Inoue, M., Usui, M., Koyanagi, M., Shimokawa, H., Takeya, M., Yoshimura, T. & Takeshita, A., 1 1 1998, : : Arteriosclerosis, thrombosis, and vascular biology. 18, 9, p. 1456-1464 9 p.

研究成果: ジャーナルへの寄稿記事

110 引用 (Scopus)

Inhibition of nuclear translocation of apoptosis-inducing factor is an essential mechanism of the neuroprotective activity of pigment epithelium-derived factor in a rat model of retinal degeneration

Murakami, Y., Ikeda, Y., Yonemitsu, Y., Onimaru, M., Nakagawa, K., Kohno, R. I., Miyazaki, M., Hisatomi, T., Nakamura, M., Yabe, T., Hasegawa, M., Ishibashi, T. & Sueishi, K., 11 2008, : : American Journal of Pathology. 173, 5, p. 1326-1338 13 p.

研究成果: ジャーナルへの寄稿記事

77 引用 (Scopus)

Inhibition of progression and stabilization of plaques by postnatal interferon-γ function blocking in ApoE-knockout mice

Koga, M., Kai, H., Yasukawa, H., Yamamoto, T., Kawai, Y., Kato, S., Kusaba, K., Kai, M., Egashira, K., Kataoka, Y. & Imaizumi, T., 8 1 2007, : : Circulation research. 101, 4, p. 348-356 9 p.

研究成果: ジャーナルへの寄稿記事

71 引用 (Scopus)

Initial Clinical Cases of the Use of a NF-κB Decoy at the Site of Coronary Stenting for the Prevention of Restenosis

Suzuki, J. I., Ito, H., Gotoh, R., Morishita, R., Egashira, K. & Isobe, M., 3 1 2004, : : Circulation Journal. 68, 3, p. 270-271 2 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)
46 引用 (Scopus)

Intracoronary Artery Gene Transfer Using the REMEDY Catheter: Case Studies in Pigs and Humans

Gotoh, R., Suzuki, J. I., Ito, H., Egashira, K., Morishita, R. & Isobe, M., 5 19 2004, : : Japanese Journal of Interventional Cardiology. 19, 2, p. 144-149 6 p.

研究成果: ジャーナルへの寄稿記事

33 引用 (Scopus)

Intramural delivery of a specific tyrosine kinase inhibitor with biodegradable stent suppresses the restenotic changes of the coronary artery in pigs in vivo

Yamawaki, T., Shimokawa, H., Kozai, T., Miyata, K., Higo, T., Tanaka, E., Egashira, K., Shiraishi, T., Tamai, H., Igaki, K. & Takeshita, A., 9 1 1998, : : Journal of the American College of Cardiology. 32, 3, p. 780-786 7 p.

研究成果: ジャーナルへの寄稿記事

121 引用 (Scopus)

Intramuscular gene transfer of FGF-2 attenuates endothelial dysfunction and inhibits intimal hyperplasia of vein grafts in poor-runoff limbs of rabbit

Shoji, T., Yonemitsu, Y., Komori, K., Tanii, M., Itoh, H., Sata, S., Shimokawa, H., Hasegawa, M., Sueishi, K. & Maehara, Y., 7 1 2003, : : American Journal of Physiology - Heart and Circulatory Physiology. 285, 1 54-1, p. H173-H182

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

In vivo delivery of glial cell-derived neurotrophic factor across the blood-brain barrier by gene transfer into brain capillary endothelial cells

Jiang, C., Koyabu, N., Yonemitsu, Y., Shimazoe, T., Watanabe, S., Naito, M., Tsuruo, T., Ohtani, H. & Sawada, Y., 8 10 2003, : : Human Gene Therapy. 14, 12, p. 1181-1191 11 p.

研究成果: ジャーナルへの寄稿記事

36 引用 (Scopus)

In vivo reduction of the nuclear factor-κB activity using synthetic cis-element decoy oligonucleotides suppresses intimal hyperplasia in the injured carotid arteries in rabbits

Takeuchi, K., Itoh, H., Yonemitsu, Y., Matsumoto, T., Kume, M., Komori, K. & Maehara, Y., 7 1 2007, : : Surgery today. 37, 7, p. 575-583 9 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)
32 引用 (Scopus)

Local adenovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo

Morishige, K., Shimokawa, H., Yamawaki, T., Miyata, K., Eto, Y., Kandabashi, T., Yogo, K., Higo, T., Egashira, K., Ueno, H. & Takeshita, A., 3 15 2000, : : Journal of the American College of Cardiology. 35, 4, p. 1040-1047 8 p.

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

Local delivery of anti-monocyte chemoattractant protein-1 by gene-eluting stents attenuates in-stent stenosis in rabbits and monkeys

Egashira, K., Nakano, K., Ohtani, K., Funakoshi, K., Zhao, G., Ihara, Y., Koga, J. I., Kimura, S., Tominaga, R. & Sunagawa, K., 12 1 2007, : : Arteriosclerosis, thrombosis, and vascular biology. 27, 12, p. 2563-2568 6 p.

研究成果: ジャーナルへの寄稿記事

54 引用 (Scopus)

Local delivery of imatinib mesylate (STI571)-incorporated nanoparticle ex vivo suppresses vein graft neointima formation.

Kimura, S., Egashira, K., Nakano, K., Iwata, E., Miyagawa, M., Tsujimoto, H., Hara, K., Kawashima, Y., Tominaga, R. & Sunagawa, K., 9 30 2008, : : Circulation. 118, 14 Suppl, p. S65-70

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

Long-term follow up of initial clinical cases with NF-κB decoy oligodeoxynucleotide transfection at the site of coronary stenting

Egashira, K., Suzuki, J. I., Ito, H., Aoki, M., Isobe, M. & Morishita, R., 7 1 2008, : : Journal of Gene Medicine. 10, 7, p. 805-809 5 p.

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

Long-term inhibition of nitric oxide synthesis increases arterial thrombogenecity in rat carotid artery

Kubo-Inoue, M., Egashira, K., Usui, M., Takemoto, M., Ohtani, K., Katoh, M., Shimokawa, H. & Takeshita, A., 6 29 2002, : : American Journal of Physiology - Heart and Circulatory Physiology. 282, 4 51-4, p. H1478-H1484

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

Long-Term Prognosis of Vasospastic Angina without Significant Atherosclerotic Coronary Artery Disease

Egashira, K., Kikuchi, Y., Sagara, T., Sugihara, M. & Nakamura, M., 1 1 1987, : : japanese heart journal. 28, 6, p. 841-849 9 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

Lung adenocarcinoma may be a more susceptive subtype to a dendritic cell-based cancer vaccine than other subtypes of non-small cell lung cancers: a multicenter retrospective analysis

Takahashi, H., Shimodaira, S., Ogasawara, M., Ota, S., Kobayashi, M., Abe, H., Morita, Y., Nagai, K., Tsujitani, S., Okamoto, M., Suzuki, Y., Nakanishi, Y., Yonemitsu, Y. & for the DC Vaccine Study Group at the Japanese Society of Immunotherapy, T. DC. V. S. G. A. T. J. S. O. I., 9 1 2016, : : Cancer Immunology, Immunotherapy. 65, 9, p. 1099-1111 13 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Lung adenocarcinoma with bronchioloalveolar carcinoma component is frequently associated with foci of high-grade atypical adenomatous hyperplasia

Koga, T., Hashimoto, S., Sugio, K., Yonemitsu, Y., Nakashima, Y., Yoshino, I., Matsuo, Y., Mojtahedzadeh, S., Sugimachi, K. & Sueishi, K., 3 25 2002, : : American Journal of Clinical Pathology. 117, 3, p. 464-470 7 p.

研究成果: ジャーナルへの寄稿記事

54 引用 (Scopus)

Macrophage infiltration predicts a poor prognosis for human ewing sarcoma

Fujiwara, T., Fukushi, J. I., Yamamoto, S., Matsumoto, Y., Setsu, N., Oda, Y., Yamada, H., Okada, S., Watari, K., Ono, M., Kuwano, M., Kamura, S., Iida, K., Okada, Y., Koga, M. & Iwamoto, Y., 9 1 2011, : : American Journal of Pathology. 179, 3, p. 1157-1170 14 p.

研究成果: ジャーナルへの寄稿記事

76 引用 (Scopus)

MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity

Kanda, H., Tateya, S., Tamori, Y., Kotani, K., Hiasa, K. I., Kitazawa, R., Kitazawa, S., Miyachi, H., Maeda, S., Egashira, K. & Kasuga, M., 6 1 2006, : : Journal of Clinical Investigation. 116, 6, p. 1494-1505 12 p.

研究成果: ジャーナルへの寄稿記事

1550 引用 (Scopus)

MCP-1 expressed by osteoclasts stimulates osteoclastogenesis in an autocrine/paracrine manner

Miyamoto, K., Ninomiya, K., Sonoda, K. H., Miyauchi, Y., Hoshi, H., Iwasaki, R., Miyamoto, H., Yoshida, S., Sato, Y., Morioka, H., Chiba, K., Egashira, K., Suda, T., Toyama, Y. & Miyamoto, T., 6 5 2009, : : Biochemical and Biophysical Research Communications. 383, 3, p. 373-377 5 p.

研究成果: ジャーナルへの寄稿記事

55 引用 (Scopus)

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites

Watanabe, S., Iimori, M., Chan, D. V., Hara, E., Kitao, H. & Maehara, Y., 12 1 2018, : : Scientific reports. 8, 1, 10888.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Mechanism of ergonovine-induced hyperconstriction of the large epicardial coronary artery in conscious dogs a month after arterial injury

Egashira, K., Tomoike, H., Hayashi, Y., Yamada, A., Nakamura, M. & Takeshita, A., 8 1992, : : Circulation research. 71, 2, p. 435-442 8 p.

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

Mesenchymal stem cells stably transduced with a dominant-negative inhibitor of CCL2 greatly attenuate bleomycin-induced lung damage

Saito, S., Nakayama, T., Hashimoto, N., Miyata, Y., Egashira, K., Nakao, N., Nishiwaki, S., Hasegawa, M., Hasegawa, Y. & Naoe, T., 9 1 2011, : : American Journal of Pathology. 179, 3, p. 1088-1094 7 p.

研究成果: ジャーナルへの寄稿記事

31 引用 (Scopus)

miR-3148 is a novel onco-microRNA that potentiates tumor growth in vivo

Akamine, T., Morodomi, Y., Harada, Y., Teraishi, K., Tagawa, T., Okamoto, T., Maehara, Y. & Yonemitsu, Y., 10 2018, : : Anticancer research. 38, 10, p. 5693-5701 9 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium

Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., Uchida, K., Arimura, K. I., Egashira, K. & Takeshita, A., 8 20 1999, : : Circulation research. 85, 4, p. 357-363 7 p.

研究成果: ジャーナルへの寄稿記事

529 引用 (Scopus)

Mitotic slippage and the subsequent cell fates after inhibition of Aurora B during tubulin-binding agent-induced mitotic arrest

Tsuda, Y., Iimori, M., Nakashima, Y., Nakanishi, R., Ando, K., Ohgaki, K., Kitao, H., Saeki, H., Oki, E. & Maehara, Y., 12 1 2017, : : Scientific reports. 7, 1, 16762.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Molecular Mechanism and Role of Endothelial Monocyte Chemoattractant Protein-1 Induction by Vascular Endothelial Growth Factor

Yamada, M., Kim, S., Egashira, K., Takeya, M., Ikeda, T., Mimura, O. & Iwao, H., 11 1 2003, : : Arteriosclerosis, thrombosis, and vascular biology. 23, 11, p. 1996-2001 6 p.

研究成果: ジャーナルへの寄稿記事

81 引用 (Scopus)
137 引用 (Scopus)

Monitoring trifluridine incorporation in the peripheral blood mononuclear cells of colorectal cancer patients under trifluridine/tipiracil medication

Nakanishi, R., Kitao, H., Kiniwa, M., Morodomi, Y., Iimori, M., Kurashige, J., Sugiyama, M., Nakashima, Y., Saeki, H., Oki, E. & Maehara, Y., 12 1 2017, : : Scientific reports. 7, 1, 16969.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Monocyte chemoattractant protein-1 increases microglial infiltration and aggressiveness of gliomas

Platten, M., Kretz, A., Naumann, U., Aulwurm, S., Egashira, K., Isenmann, S. & Weller, M., 9 1 2003, : : Annals of Neurology. 54, 3, p. 388-392 5 p.

研究成果: ジャーナルへの寄稿記事

143 引用 (Scopus)

Monocyte Chemoattractant Protein-1 is an Essential Inflammatory Mediator in Angiotensin II-Induced Progression of Established Atherosclerosis in Hypercholesterolemic Mice

Ni, W., Kitamoto, S., Ishibashi, M., Usui, M., Inoue, S., Hiasa, K. I., Zhao, Q., Nishida, K. I., Takeshita, A. & Egashira, K., 3 1 2004, : : Arteriosclerosis, thrombosis, and vascular biology. 24, 3, p. 534-539 6 p.

研究成果: ジャーナルへの寄稿記事

91 引用 (Scopus)

Monocyte chemottractant protein-1 activates a regional Th1 immunoresponse in nephritis of MRL/lpr mice

Shimizu, S., Nakashima, H., Karube, K. N., Ohshima, K. & Egashira, K., 3 1 2005, : : Clinical and experimental rheumatology. 23, 2, p. 239-242 4 p.

研究成果: ジャーナルへの寄稿記事

22 引用 (Scopus)

Mutant MCP-1 protein delivery from layer-by-layer coatings onorthopedic implants to modulate inflammatory response

Keeney, M., Waters, H., Barcay, K., Jiang, X., Yao, Z., Pajarinen, J., Egashira, K., Goodman, S. B. & Yang, F., 12 1 2013, : : Biomaterials. 34, 38, p. 10287-10295 9 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

Mutant MCP-1 therapy inhibits tumor angiogenesis and growth of malignant melanoma in mice

Koga, M., Kai, H., Egami, K., Murohara, T., Ikeda, A., Yasuoka, S., Egashira, K., Matsuishi, T., Kai, M., Kataoka, Y., Kuwano, M. & Imaizumi, T., 1 11 2008, : : Biochemical and Biophysical Research Communications. 365, 2, p. 279-284 6 p.

研究成果: ジャーナルへの寄稿記事

66 引用 (Scopus)

MutT Homolog-1 Attenuates Oxidative DNA Damage and Delays Photoreceptor Cell Death in Inherited Retinal Degeneration

Murakami, Y., Ikeda, Y., Yoshida, N., Notomi, S., Hisatomi, T., Oka, S., De Luca, G., Yonemitsu, Y., Bignami, M., Nakabeppu, Y. & Ishibashi, T., 10 1 2012, : : American Journal of Pathology. 181, 4, p. 1378-1386 9 p.

研究成果: ジャーナルへの寄稿記事

18 引用 (Scopus)

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J-I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., 6 1 2019, : : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

研究成果: ジャーナルへの寄稿記事

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J. I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., 6 1 2019, : : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

研究成果: ジャーナルへの寄稿記事

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2 引用 (Scopus)