薬学研究院

研究成果

1998

Transfer of wild-type p53 gene effectively inhibits vascular smooth muscle cell proliferation in vitro and in vivo

Yonemitsu, Y., Kaneda, Y., Tanaka, S., Nakashima, Y., Komori, K., Sugimachi, K. & Sueishi, K., 2 9 1998, : : Circulation research. 82, 2, p. 147-156 10 p.

研究成果: ジャーナルへの寄稿記事

118 引用 (Scopus)
1997

Acceleration of impairment of endothelium-dependent responses under poor runoff conditions in canine autogenous vein grafts

Komori, K., Yamamura, S., Ishida, M., Matsumoto, T., Kuma, S., Eguchi, D., Yonemitsu, Y., Onohara, T. & Sugimachi, K., 1 1 1997, : : European Journal of Vascular and Endovascular Surgery. 14, 6, p. 475-481 7 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)
52 引用 (Scopus)

Basal release of nitric oxide is decreased in the coronary circulation in patients with heart failure

Mohri, M., Egashira, K., Tagawa, T., Kuga, T., Tagawa, H., Harasawa, Y., Shimokawa, H. & Takeshita, A., 7 1997, : : Hypertension. 30, 1, p. 50-56 7 p.

研究成果: ジャーナルへの寄稿記事

71 引用 (Scopus)

Bradykinin-induced vasodilation of human coronary arteries in vivo: Role of nitric oxide and angiotensin-converting enzyme

Kuga, T., Mohri, M., Egashira, K., Hirakawa, Y., Tagawa, T., Shimokawa, H. & Takeshita, A., 7 1 1997, : : Journal of the American College of Cardiology. 30, 1, p. 108-112 5 p.

研究成果: ジャーナルへの寄稿記事

72 引用 (Scopus)

Central role of vascular smooth muscle hyperreactivity in coronary hyperconstriction after balloon injury in miniature pigs

Kuga, T., Kadokami, T., Kuwata, K., Hata, H., Ohara, Y., Egashira, K., Shimokawa, H. & Takeshita, A., 6 25 1997, : : Coronary Artery Disease. 8, 2, p. 69-75 7 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Chronic angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade: Effects on cardiovascular remodeling in rats induced by the long-term blockade of nitric oxide synthesis

Takemoto, M., Egashira, K., Tomita, H., Usui, M., Okamoto, H., Kitabatake, A., Shimokawa, H., Sueishi, K. & Takeshita, A., 1 1 1997, : : Hypertension. 30, 6, p. 1621-1627 7 p.

研究成果: ジャーナルへの寄稿記事

152 引用 (Scopus)

Correlations between recruitable coronary collateral flow velocities, distal occlusion pressure, and electrocardiographic changes in patients undergoing angioplasty

Mohri, M., Egashira, K., Kuga, T., Shimokawa, H. & Takeshita, A., 12 1 1997, : : JAPANESE CIRCULATION JOURNAL. 61, 12, p. 971-978 8 p.

研究成果: ジャーナルへの寄稿記事

6 引用 (Scopus)

Enhancement of nitric oxide production after arterial reconstruction in patients with arteriosclerosis obliterans

Komori, K., Matsumoto, T., Ishida, M., Kuma, S., Yonemitsu, Y., Eguchi, D. & Sugimachi, K., 1 1 1997, : : Journal of Vascular Surgery. 26, 4, p. 657-662 6 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

HVJ (Sendai virus)-cationic liposomes: A novel and potentially effective liposome-mediated technique for gene transfer to the airway epithelium

Yonemitsu, Y., Kaneda, Y., Muraishi, A., Yoshizumi, T., Sugimachi, K. & Sueishi, K., 1 1 1997, : : Gene Therapy. 4, 7, p. 631-638 8 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Importance of endothelium-derived hyperpolarizing factor in human arteries

Urakami-Harasawa, L., Shimokawa, H., Nakashima, M., Egashira, K. & Takeshita, A., 12 1 1997, : : Journal of Clinical Investigation. 100, 11, p. 2793-2799 7 p.

研究成果: ジャーナルへの寄稿記事

252 引用 (Scopus)

Important role of tissue angiotensin-converting enzyme activity in the pathogenesis of coronary vascular and myocardial structural changes induced by long-term blockade of nitric oxide synthesis in rats

Takemoto, M., Egashira, K., Usui, M., Numaguchi, K., Tomita, H., Tsutsui, H., Shimokawa, H., Sueishi, K. & Takeshita, A., 1 15 1997, : : Journal of Clinical Investigation. 99, 2, p. 278-287 10 p.

研究成果: ジャーナルへの寄稿記事

307 引用 (Scopus)

Inflammatory cytokines cause coronary arteriosclerosis-like changes and alterations in the smooth-muscle phenotypes in pigs

Fukumoto, Y., Shimokawa, H., Ito, A., Kadokami, T., Yonemitsu, Y., Aikawa, M., Owada, M. K., Egashira, K., Sueishi, K., Nagai, R., Yazaki, Y. & Takeshita, A., 2 1 1997, : : Journal of Cardiovascular Pharmacology. 29, 2, p. 222-231 10 p.

研究成果: ジャーナルへの寄稿記事

65 引用 (Scopus)

Nitric oxide activity at the site of coronary spasm: Deficient or preserved? [6] (multiple letters)

Egashira, K., Takeshita, A., Kugiyama, K. & Yasue, H., 8 19 1997, : : Circulation. 96, 3, p. 1048-1050 3 p.

研究成果: ジャーナルへの寄稿レター

7 引用 (Scopus)

Preserved endothelial function and morphology in canine arterial grafts under conditions of poor distal runoff

Wei, C. G., Komori, K., Mawatari, K., Yonemitsu, Y. & Sugimachi, K., 8 1997, : : Journal of Surgical Research. 71, 2, p. 117-122 6 p.

研究成果: ジャーナルへの寄稿記事

3 引用 (Scopus)

Role of myocyte nitric oxide in β-adrenergic hyporesponsiveness in heart failure

Yamamoto, S., Tsutsui, H., Tagawa, H., Saito, K., Takahashi, M., Tada, H., Yamamoto, M., Katoh, M., Egashira, K. & Takeshita, A., 1 1 1997, : : Circulation. 95, 5, p. 1111-1114 4 p.

研究成果: ジャーナルへの寄稿記事

71 引用 (Scopus)

Role of nitric oxide in substance P-induced vasodilation differs between the coronary and forearm circulation in humans

Tagawa, T., Mohri, M., Tagawa, H., Egashira, K., Shimokawa, H., Kuga, T., Hirooka, Y. & Takeshita, A., 4 1 1997, : : Journal of Cardiovascular Pharmacology. 29, 4, p. 546-553 8 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

The immediate early gene of human cytomegalovirus stimulates vascular smooth muscle cell proliferation in vitro and in vivo

Yonemitsu, Y., Kaneda, Y., Komori, K., Hirai, K., Sugimachi, K. & Sueishi, K., 2 13 1997, : : Biochemical and Biophysical Research Communications. 231, 2, p. 447-451 5 p.

研究成果: ジャーナルへの寄稿記事

30 引用 (Scopus)

Tyrosine kinase inhibitor markedly suppresses the development of coronary lesions induced by long-term treatment with platelet-derived growth factor in pigs in vivo

Kozai, T., Shimokawa, H., Fukumoto, Y., Kobayashi, S., Owada, M. K., Kadokami, T., Ito, A., Kuwata, K., Egashira, K., Shiraishi, T., Kanaide, H. & Takeshita, A., 4 1 1997, : : Journal of Cardiovascular Pharmacology. 29, 4, p. 536-545 10 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Vasculoprotective role of inducible nitric oxide synthase at inflammatory coronary lesions induced by chronic treatment with interleukin- 1β in pigs in vivo

Fukumoto, Y., Shimokawa, H., Kozai, T., Kadokami, T., Kuwata, K., Yonemitsu, Y., Kuga, T., Egashira, K., Sueishi, K. & Takeshita, A., 11 4 1997, : : Circulation. 96, 9, p. 3104-3111 8 p.

研究成果: ジャーナルへの寄稿記事

30 引用 (Scopus)

Wild-type p53 gene transfer: A novel therapeutic strategy for neointimal hyperplasia after arterial injury

Yonemitsu, Y., Kaneda, Y., Hata, Y., Nakashima, Y. & Sueishi, K., 1 1 1997, : : Annals of the New York Academy of Sciences. 811, p. 395-400 6 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)
1996

Abnormalities of cardiac sympathetic neuronal and left ventricular function in chronic mitral regurgitation: Assessment by iodine-123 metaiodobenzylguanidine scintigraphy

Tsutsui, H., Ando -i., S., Kubota, T., Kuroiwa-Matsumoto, M., Egashira, K., Sasaki, M., Kuwabara, Y., Koyanagi, S., Yasui, H. & Takeshita, A., 2 29 1996, : : American Journal of Cardiac Imaging. 10, 1, p. 14-22 9 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Altered serotonin receptor subtypes mediate coronary microvascular hyperreactivity in pigs with chronic inhibition of nitric oxide synthesis

Kadokami, T., Egashira, K., Kuwata, K., Fukumoto, Y., Kozai, T., Yasutake, H., Kuga, T., Shimokawa, H., Sueishi, K. & Takeshita, A., 1 1 1996, : : Circulation. 94, 2, p. 182-189 8 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

ATP-sensitive K+ channel opener pinacidil augments β1-adrenoceptor- induced coronary vasodilation in dogs

Katsuda, Y., Egashira, K., Ueno, H., Arai, Y., Akatsuka, Y., Kuga, T., Shimokawa, H. & Takeshita, A., 6 1 1996, : : American Journal of Physiology - Heart and Circulatory Physiology. 270, 6 39-6, p. H2210-H2215

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Basal release of endothelium-derived nitric oxide at site of spasm in patients with variant angina

Egashira, K., Katsuda, Y., Mohri, M., Kuga, T., Tagawa, T., Shimokawa, H. & Takeshita, A., 5 1996, : : Journal of the American College of Cardiology. 27, 6, p. 1444-1449 6 p.

研究成果: ジャーナルへの寄稿記事

47 引用 (Scopus)
90 引用 (Scopus)

Chronic treatment with interleukin-1β induces coronary intimal lesions and vasospastic responses in pigs in vivo: The role of platelet-derived growth factor

Shimokawa, H., Ito, A., Fukumoto, Y., Kadokami, T., Nakaike, R., Sakata, M., Takayanagi, T., Egashira, K. & Takeshita, A., 2 1 1996, : : Journal of Clinical Investigation. 97, 3, p. 769-776 8 p.

研究成果: ジャーナルへの寄稿記事

216 引用 (Scopus)

Coronary artery spasm does not depend on the intracellular calcium store but is substantially mediated by the protein kinase C-mediated pathway in a swine model with interleukin-1β in vivo

Kadokami, T., Shimokawa, H., Fukumoto, Y., Ito, A., Takayanagi, T., Egashira, K. & Takeshita, A., 1 1 1996, : : Circulation. 94, 2, p. 190-196 7 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Coronary vascular ATP-sensitive potassium channels are activated to a greater extent in spontaneously hypertensive rats than in Wistar-Kyoto rats

Numaguchi, K., Egashira, K., Sakata, M., Shimokawa, H. & Takeshita, A., 5 3 1996, : : Journal of hypertension. 14, 2, p. 183-189 7 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Effects of L-arginine supplementation on endothelium-dependent coronary vasodilation in patients with angina pectoris and normal coronary arteriograms

Egashira, K., Hirooka, Y., Kuga, T., Mohri, M. & Takeshita, A., 1 1 1996, : : Circulation. 94, 2, p. 130-134 5 p.

研究成果: ジャーナルへの寄稿記事

136 引用 (Scopus)
46 引用 (Scopus)

PKC inhibitors prevent endothelial dysfunction after myocardial ischemia-reperfusion in rats

Numaguchi, K., Shimokawa, H., Nakaike, R., Egashira, K. & Takeshita, A., 12 1 1996, : : American Journal of Physiology - Heart and Circulatory Physiology. 270, 5 39-5, p. H1634-H1639

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

The role of fibroblast growth factor-2 in the vascular effects ofinterleukin-1β in porcine coronary arteries in vivo

Ito, A., Shimokawa, H., Fukumoto, Y., Kadokami, T., Nakaike, R., Takayanagi, T., Egashira, K., Sueishi, K. & Takeshita, A., 9 1 1996, : : Cardiovascular research. 32, 3, p. 570-579 10 p.

研究成果: ジャーナルへの寄稿記事

17 引用 (Scopus)

Tyrosine kinase inhibitor suppresses the (re)stenotic changes of the coronary artery after balloon injury in pigs

Fukumoto, Y., Shimokawa, H., Kozai, T., Kadokami, T., Kuwata, K., Owada, M. K., Shiraishi, T., Kuga, T., Egashira, K. & Takeshita, A., 12 1 1996, : : Cardiovascular research. 32, 6, p. 1131-1140 10 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Vasospastic angina in patients with systemic triglyceride storage disease with Jordans' anomaly and cardiomyopathy

Ando, S. I., Usui, M., Matsumoto, T., Egashira, K., Takeshita, A., Terasaki, F., Deguchi, H. & Kawamura, K., 4 11 1996, : : JAPANESE CIRCULATION JOURNAL. 60, 2, p. 124-129 6 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)
1995

Bradykinin-induced vasodilation is impaired at the atherosclerotic site but is preserved at the spastic site of human coronary arteries in vivo

Kuga, T., Egashira, K., Mohri, M., Tsutsui, H., Harasawa, Y., Urabe, Y., Ando, S., Shimokawa, H. & Takeshita, A., 7 15 1995, : : Circulation. 92, 2, p. 183-189 7 p.

研究成果: ジャーナルへの寄稿記事

70 引用 (Scopus)

Chronic inhibition of endothelium-derived nitric oxide synthesis causes coronary microvascular structural changes and hyperreactivity to serotonin in pigs

Ito, A., Egashira, K., Kadokami, T., Fukumoto, Y., Takayanagi, T., Nakaike, R., Kuga, T., Sueishi, K., Shimokawa, H. & Takeshita, A., 11 1 1995, : : Circulation. 92, 9, p. 2636-2644 9 p.

研究成果: ジャーナルへの寄稿記事

77 引用 (Scopus)

Chronic inhibition of nitric oxide synthesis causes coronary microvascular remodeling in rats

Numaguchi, K., Egashira, K., Takemoto, M., Kadokami, T., Shimokawa, H., Sueishi, K. & Takeshita, A., 12 1995, : : Hypertension. 26, 6 I, p. 957-962 6 p.

研究成果: ジャーナルへの寄稿記事

197 引用 (Scopus)

Detection of angina-provoking coronary stenosis by resting iodine 123 metaiodobenzylguanidine scintigraphy in patients with unstable angina pectoris

Tsutsui, H., Ando, S. I., Fukai, T., Kuroiwa, M., Egashira, K., Sasaki, M., Kuwabara, Y., Koyanagi, S. & Takeshita, A., 4 1995, : : American heart journal. 129, 4, p. 708-715 8 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Effects of L-arginine analogues on vasomotion of isolated porcine coronary arteries

Nakaike, R., Shimokawa, H., Yasutake, H., Sumimoto, H., Ito, A., Numaguchi, K., Egashira, K., Takeshige, K. & Takeshita, A., 1 1 1995, : : American Journal of Physiology - Heart and Circulatory Physiology. 268, 5 37-5, p. H1966-H1972

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Endothelin-1 is not involved in serotonin-induced coronary spasm in a swine model

Fukai, T., Egashira, K., Numaguchi, K., Hata, H., Takahashi, T., Kasuya, H., Sakata, M., Shimokawa, H. & Takeshita, A., 1 1 1995, : : Cardiovascular research. 30, 2, p. 193-199 7 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

Endothelium-derived nitric oxide does not modulate metabolic coronary vasodilation induced by tachycardia in dogs

Katsuda, Y., Egashira, K., Akatsuka, Y., Narishige, T., Shimokawa, H. & Takeshita, A., 9 1995, : : Journal of Cardiovascular Pharmacology. 26, 3, p. 437-444 8 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Immediate Relief of Spontaneous Coronary Artery Spasm by Intracoronary Infusion of an Endothelium-dependent Vasodilator, Substance P

Numagughi, K., Egashira, K., Inou, T. & Takeshita, A., 1 1 1995, : : japanese heart journal. 36, 1, p. 111-114 4 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

Impaired endothelium-dependent vasodilation of large epicardial and resistance coronary arteries in patients with essential hypertension: Different responses to acetylcholine and substance P

Egashira, K., Suzuki, S., Hirooka, Y., Kai, H., Sugimachi, M., Imaizumi, T. & Takeshita, A., 1 1 1995, : : Hypertension. 25, 2, p. 201-206 6 p.

研究成果: ジャーナルへの寄稿記事

187 引用 (Scopus)

Portal Vein Thrombosis Due To Antithrombin III Deficiency: A Case Report

Yonemitsu, Y., Yanaga, K., Matsumata, T. & Sugimachi, K., 11 1995, : : Angiology. 46, 11, p. 1043-1047 5 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

Tyrosine kinase inhibitor suppresses coronary arteriosclerotic changes and vasospastic responses induced by chronic treatment with interleukin-1β in pigs in vivo

Ito, A., Shimokawa, H., Kadokami, T., Fukumoto, Y., Owada, M. K., Shiraishi, T., Nakaike, R., Takayanagi, T., Egashira, K. & Takeshita, A., 9 1995, : : Journal of Clinical Investigation. 96, 3, p. 1288-1294 7 p.

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)
1994

ATP sensitive potassium channels are involved in adenosine A2 receptor mediated coronary vasodilatation in the dog

Akatsuka, Y., Egashira, K., Katsuda, Y., Narishige, T., Ueno, H., Shimokawa, H. & Takeshita, A., 6 1994, : : Cardiovascular research. 28, 6, p. 906-911 6 p.

研究成果: ジャーナルへの寄稿記事

59 引用 (Scopus)
2 引用 (Scopus)

Effect of l-arginine on acetylcholine-induced endothelium-dependent vasodilation differs between the coronary and forearm vasculatures in humans

Hirooka, Y., Egashira, K., Imaizumi, T., Tagawa, T., Kai, H., Sugimachi, M. & Takeshita, A., 10 1994, : : Journal of the American College of Cardiology. 24, 4, p. 948-955 8 p.

研究成果: ジャーナルへの寄稿記事

84 引用 (Scopus)

Effects of intracoronary infusion of atrial natriuretic peptide on pacing- induced myocardial ischemia in patients with effort angina pectoris

Kai, H., Egashira, K., Hirooka, Y., Sugimachi, M., Suzuki, S., Kuga, T., Mohri, K., Urabe, Y., Inou, T. & Takeshita, A., 12 1 1994, : : Coronary Artery Disease. 5, 12, p. 987-994 8 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)