薬学研究院

研究成果

フィルター
記事
2002

Sevoflurane and bradykinin-induced calcium mobilization in pulmonary arterial valvular endothelial cells in situ: Sevoflurane stimulates plasmalemmal calcium influx into endothelial cells

Kanna, T., Akata, T., Izumi, K., Nakashima, M., Yonemitsu, Y., Hashizume, M. & Takahashi, S., 11 1 2002, : : Journal of Cardiovascular Pharmacology. 40, 5, p. 714-724 11 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Transluminal gene transfer into brain capillary endothelial cells in vivo with HVJ-liposomes

Jiang, C., Matsuo, H., Koyabu, N., Ohtani, H., Fujimoto, H., Yonemitsu, Y., Kaneda, Y., Naito, M., Tsuruo, T. & Sawada, Y., 7 20 2002, : : Journal of Drug Targeting. 10, 4, p. 345-352 8 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Vascular endothelial growth factor is necessary in the development of arteriosclerosis by recruiting/activating monocytes in a rat model of long-term inhibition of nitric oxide synthesis

Zhao, Q., Egashira, K., Inoue, S., Usui, M., Kitamoto, S., Ni, W., Ishibashi, M., Hiasa, K. I., Ichiki, T., Shibuya, M. & Takeshita, A., 3 5 2002, : : Circulation. 105, 9, p. 1110-1115 6 p.

研究成果: ジャーナルへの寄稿記事

130 引用 (Scopus)
2001

Antiinflammatory and antiarteriosclerotic actions of HMG-CoA reductase inhibitors in a rat model of chronic inhibition of nitric oxide synthesis

Ni, W., Egashira, K., Kataoka, C., Kitamoto, S., Koyanagi, M., Inoue, S. & Takeshita, A., 8 31 2001, : : Circulation research. 89, 5, p. 415-421 7 p.

研究成果: ジャーナルへの寄稿記事

135 引用 (Scopus)

Cerivastatin, a hydroxymethylglutaryl coenzyme A reductase inhibitor, improves endothelial function in elderly diabetic patients within 3 days

Tsunekawa, T., Hayashi, T., Kano, H., Sumi, D., Matsui-Hirai, H., Thakur, N. K., Egashira, K. & Iguchi, A., 7 24 2001, : : Circulation. 104, 4, p. 376-379 4 p.

研究成果: ジャーナルへの寄稿記事

241 引用 (Scopus)

Clinicopathological and molecular evidence indicating the independence of bronchioloalveolar components from other subtypes of human peripheral lung adenocarcinoma

Koga, T., Hashimoto, S., Sugio, K., Yoshino, I., Mojtahedzadeh, S., Matsuo, Y., Yonemitsu, Y., Sugimachi, K. & Sueishi, K., 8 15 2001, : : Clinical Cancer Research. 7, 6, p. 1730-1738 9 p.

研究成果: ジャーナルへの寄稿記事

45 引用 (Scopus)

Downregulation of angiotensin II type 1 receptor by hydrophobic 3-hydroxy-3-methylglutaryl coenzyme a reductase inhibitors in vascular smooth muscle cells

Ichiki, T., Takeda, K., Tokunou, T., Iino, N., Egashira, K., Shimokawa, H., Hirano, K., Kanaide, H. & Takeshita, A., 1 1 2001, : : Arteriosclerosis, thrombosis, and vascular biology. 21, 12, p. 1896-1901 6 p.

研究成果: ジャーナルへの寄稿記事

123 引用 (Scopus)

Dual action of ZD6169, a novel K+ channel opener, on ATP-sensitive K+ channels in pig urethral myocytes

Teramoto, N., Yunoki, T., Takano, M., Yonemitsu, Y., Masaki, I., Sueishi, K., Brading, A. F. & Ito, Y., 1 1 2001, : : British Journal of Pharmacology. 133, 1, p. 154-164 11 p.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)

Genetic changes induced in human cells in Space Shuttle experiment (STS-95)

Ishizaki, K., Nishizawa, K., Kato, T., Kitao, H., Han, Z. B., Hirayama, J., Suzuki, F., Cannon, T. F., Kamigaichi, S., Tawarayama, Y., Masukawa, M., Shimazu, T. & Ikenaga, M., 9 12 2001, : : Aviation Space and Environmental Medicine. 72, 9, p. 794-798 5 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Greater susceptibility of failing cardiac myocytes to oxygen free radical-mediated injury

Tsutsui, H., Ide, T., Hayashidani, S., Suematsu, N., Utsumi, H., Nakamura, R., Egashira, K. & Takeshita, A., 1 1 2001, : : Cardiovascular research. 49, 1, p. 103-109 7 p.

研究成果: ジャーナルへの寄稿記事

46 引用 (Scopus)

Heterogeneous distribution of P53 immunoreactivity in human lung adenocarcinoma correlates with MDM2 protein expression, rather than with p53 gene mutation

Koga, T., Hashimoto, S., Sugio, K., Yoshino, I., Nakagawa, K., Yonemitsu, Y., Sugimachi, K. & Sueishi, K., 7 20 2001, : : International Journal of Cancer. 95, 4, p. 232-239 8 p.

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)

Immunohistochemical phenotypic alterations of rabbit autologous vein grafts implanted under arterial circulation with or without poor distal runoff-implications of vein graft remodeling

Ishida, M., Komori, K., Yonemitsu, Y., Taguchi, K., Onohara, T. & Sugimachi, K., 2 22 2001, : : Atherosclerosis. 154, 2, p. 345-354 10 p.

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)

Increased inactivation of nitric oxide is involved in coronary endothelial dysfunction in heart failure

Akimura, K., Egashira, K., Nakamura, R., Ide, T., Tsutsui, H., Shimokawa, H. & Takeshita, A., 6 11 2001, : : American Journal of Physiology - Heart and Circulatory Physiology. 280, 1 49-1, p. H68-H75

研究成果: ジャーナルへの寄稿記事

48 引用 (Scopus)

New anti-monocyte chemoattractant protein-1 gene therapy attenuates atherosclerosis in apolipoprotein E-knockout mice

Ni, W., Egashira, K., Kitamoto, S., Kataoka, C., Koyanagi, M., Inoue, S., Imaizumi, K., Akiyama, C., Nishida, K. I. & Takeshita, A., 4 24 2001, : : Circulation. 103, 16, p. 2096-2101 6 p.

研究成果: ジャーナルへの寄稿記事

207 引用 (Scopus)

Non-penetrating vascular clips anastomosis inhibited intimal thickening under poor runoff conditions in canine autogenous vein grafts

Komori, K., Shoji, T., Furuyama, T., Yonemitsu, Y., Mori, E., Yamaoka, T., Matsumoto, T. & Sugimachi, K., 1 1 2001, : : European Journal of Vascular and Endovascular Surgery. 21, 3, p. 241-247 7 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

Positive inotropic effects of calcium sensitizers on normal and failing cardiac myocytes

Tsutsui, H., Kinugawa, S., Ide, T., Hayashidani, S., Suematsu, N., Satoh, S., Nakamura, R., Egashira, K. & Takeshita, A., 1 10 2001, : : Journal of Cardiovascular Pharmacology. 37, 1, p. 16-24 9 p.

研究成果: ジャーナルへの寄稿記事

15 引用 (Scopus)

Preclinical and therapeutic utility of HVJ liposomes as a gene transfer vector for hepatocellular carcinoma using herpes simplex virus thymidine kinase

Hasegawa, H., Shimada, M., Yonemitsu, Y., Utsunomiya, T., Gion, T., Kaneda, Y. & Sugimachi, K., 6 7 2001, : : Cancer Gene Therapy. 8, 4, p. 252-258 7 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Recombinant Sendai virus-mediated gene transfer to vasculature: a new class of efficient gene transfer vector to the vascular system.

Masaki, I., Yonemitsu, Y., Komori, K., Ueno, H., Nakashima, Y., Nakagawa, K., Fukumura, M., Kato, A., Hasan, M. K., Nagai, Y., Sugimachi, K., Hasegawa, M. & Sueishi, K., 5 2001, : : The FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 15, 7, p. 1294-1296 3 p.

研究成果: ジャーナルへの寄稿記事

65 引用 (Scopus)

Regression by ACE inhibition of arteriosclerotic changes induced by chronic blockade of NO synthesis in rats

Katoh, M., Egashira, K., Kataoka, C., Usui, M., Koyanagi, M., Kitamoto, S., Ohmachi, Y., Takeshita, A. & Narita, H., 5 1 2001, : : American Journal of Physiology - Heart and Circulatory Physiology. 280, 5 49-5, p. H2306-H2312

研究成果: ジャーナルへの寄稿記事

19 引用 (Scopus)

Rho-kinase mediates angiotensin II-induced monocyte chemoattractant protein-1 expression in rat vascular smooth muscle cells

Funakoshi, Y., Ichiki, T., Shimokawa, H., Egashira, K., Takeda, K., Kaibuchi, K., Takeya, M., Yoshimura, T. & Takeshita, A., 1 1 2001, : : Hypertension. 38, 1, p. 100-104 5 p.

研究成果: ジャーナルへの寄稿記事

157 引用 (Scopus)

Role of nitric oxide in regulation of coronary blood flow in response to increased metabolic demand in dogs with pacing-induced heart failure

Tada, H., Egashira, K., Yamamoto, M., Usui, M., Arai, Y., Katsuda, Y., Shimokawa, H. & Takeshita, A., 9 26 2001, : : JAPANESE CIRCULATION JOURNAL. 65, 9, p. 827-833 7 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Successful and optimized in vivo gene transfer to rabbit carotid artery mediated by electronic pulse

Matsumoto, T., Komori, K., Shoji, T., Kuma, S., Kume, M., Yamaoka, T., Mori, E., Furuyama, T., Yonemitsu, Y. & Sugimachi, K., 9 3 2001, : : Gene Therapy. 8, 15, p. 1174-1179 6 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Thrombin induces interleukin-6 expression through the cAMP response element in vascular smooth muscle cells

Tokunou, T., Ichiki, T., Takeda, K., Funakoshi, Y., Iino, N., Shimokawa, H., Egashira, K. & Takeshita, A., 1 1 2001, : : Arteriosclerosis, thrombosis, and vascular biology. 21, 11, p. 1759-1763 5 p.

研究成果: ジャーナルへの寄稿記事

52 引用 (Scopus)

α1-adrenoceptor-Gq-RhoA signaling is upregulated to increase myofibrillar Ca2+ sensitivity in failing hearts

Suematsu, N., Satoh, S., Kinugawa, S., Tsutsui, H., Hayashidani, S., Nakamura, R., Egashira, K., Makino, N. & Takeshita, A., 8 29 2001, : : American Journal of Physiology - Heart and Circulatory Physiology. 281, 2 50-2, p. H637-H646

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)
2000

Angiogenesis and its regulation: Roles of vascular endothelial cell growth factor

Nakagawa, K., Chen, Y. X., Ishibashi, H., Yonemitsu, Y., Murata, T., Hata, Y., Nakashima, Y. & Sueishi, K., 5 15 2000, : : Seminars in Thrombosis and Hemostasis. 26, 1, p. 61-66 6 p.

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)
70 引用 (Scopus)

Anti-monocyte chemoattractant protein-1 gene therapy inhibits vascular remodeling in rats: Blockade of MCP-1 activity after intramuscular transfer of a mutant gene inhibits vascular remodeling induced by chronic blockade of NO synthesis

Egashira, K., Koyanagi, M., Kitamoto, S., Ni, W., Kataoka, C., Morishita, R., Kaneda, Y., Akiyama, C., Nishida, K. I., Sueishi, K. & Takeshita, A., 10 16 2000, : : FASEB Journal. 14, 13, p. 1974-1978 5 p.

研究成果: ジャーナルへの寄稿記事

78 引用 (Scopus)

A simultaneous resection of a concomitant abdominal aortic aneurysm and hepatocellular carcinoma: Two cases

Takeuchi, K., Komori, K., Ohta, S., Shimada, M., Yonemitsu, Y. & Sugimachi, K., 4 1 2000, : : International Surgery. 85, 2, p. 152-157 6 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

Chronic inhibition of nitric oxide synthesis in rats increases aortic superoxide anion production via the action of angiotensin II

Kitamoto, S., Egashira, K., Kataoka, C., Usui, M., Koyanagi, M., Takemoto, M. & Takeshita, A., 1 1 2000, : : Journal of hypertension. 18, 12, p. 1795-1800 6 p.

研究成果: ジャーナルへの寄稿記事

60 引用 (Scopus)

Conservative treatment for the removal of a central venous catheter with large thrombus: A case report

Sugimachi, K., Yonemitsu, Y., Komori, K. & Sugimachi, K., 1 1 2000, : : Nutrition in Clinical Practice. 15, 5, p. 223-226 4 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Direct evidence for increased hydroxyl radicals originating from superoxide in the failing myocardium

Ide, T., Tsutsui, H., Kinugawa, S., Suematsu, N., Hayashidani, S., Ichikawa, K., Utsumi, H., Machida, Y., Egashira, K. & Takeshita, A., 1 1 2000, : : Circulation research. 86, 2, p. 152-157 6 p.

研究成果: ジャーナルへの寄稿記事

326 引用 (Scopus)

Important role of local angiotensin II activity mediated via type I receptor in the pathogenesis of cardiovascular inflammatory changes induced by chronic blockade of nitric oxide synthesis in rats

Usui, M., Egashira, K., Tomita, H., Koyanagi, M., Katoh, M., Shimokawa, H., Takeya, M., Yoshimura, T., Matsushima, K. & Takeshita, A., 1 25 2000, : : Circulation. 101, 3, p. 305-310 6 p.

研究成果: ジャーナルへの寄稿記事

158 引用 (Scopus)

Increased activity of nuclear factor-κB participates in cardiovascular remodeling induced by chronic inhibition of nitric oxide synthesis in rats

Kitamoto, S., Egashira, K., Kataoka, C., Koyanagi, M., Katoh, M., Shimokawa, H., Morishita, R., Kaneda, Y., Sueishi, K. & Takeshita, A., 1 1 2000, : : Circulation. 102, 7, p. 806-812 7 p.

研究成果: ジャーナルへの寄稿記事

75 引用 (Scopus)

Increased expression of L-type calcium channels in vascular smooth muscle cells at spastic site in a porcine model of coronary artery spasm

Kuga, T., Shimokawa, H., Hirakawa, Y., Kadokami, Y., Arai, Y., Fukumoto, Y., Kuwata, K., Kozai, T., Egashira, K. & Takeshita, A., 5 22 2000, : : Journal of Cardiovascular Pharmacology. 35, 5, p. 822-828 7 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Inhibition of myosin phosphatase by upregulated Rho-kinase plays a key role for coronary artery spasm in a porcine model with interleukin-1β

Kandabashi, T., Shimokawa, H., Miyata, K., Kunihiro, I., Kawano, Y., Fukata, Y., Higo, T., Egashira, K., Takahashi, S., Kaibuchi, K. & Takeshita, A., 3 21 2000, : : Circulation. 101, 11, p. 1319-1323 5 p.

研究成果: ジャーナルへの寄稿記事

216 引用 (Scopus)

Local adenovirus-mediated transfer of C-type natriuretic peptide suppresses vascular remodeling in porcine coronary arteries in vivo

Morishige, K., Shimokawa, H., Yamawaki, T., Miyata, K., Eto, Y., Kandabashi, T., Yogo, K., Higo, T., Egashira, K., Ueno, H. & Takeshita, A., 3 15 2000, : : Journal of the American College of Cardiology. 35, 4, p. 1040-1047 8 p.

研究成果: ジャーナルへの寄稿記事

40 引用 (Scopus)

Pravastatin attenuates cardiovascular inflammatory and proliferative changes in a rat model of chronic inhibition of nitric oxide synthesis by its cholesterol-lowering independent actions

Egashira, K., Ni, W. N. I., Inoue, S., Kataoka, C., Kitamoto, S., Koyanagi, M. & Takeshita, A., 7 2000, : : Hypertension Research. 23, 4, p. 353-358 6 p.

研究成果: ジャーナルへの寄稿記事

34 引用 (Scopus)

Rho-kinase is involved in macrophage-mediated formation of coronary vascular lesions in pigs in vivo

Miyata, K., Shimokawa, H., Kandabashi, T., Higo, T., Morishige, K., Eto, Y., Egashira, K., Kaibuchi, K. & Takeshita, A., 1 1 2000, : : Arteriosclerosis, thrombosis, and vascular biology. 20, 11, p. 2351-2358 8 p.

研究成果: ジャーナルへの寄稿記事

168 引用 (Scopus)

Role of monocyte chemoattractant protein-1 in cardiovascular remodeling induced by chronic blockade of nitric oxide synthesis

Koyanagi, M., Egashira, K., Kitamoto, S., Ni, W., Shimokawa, H., Takeya, M., Yoshimura, T. & Takeshita, A., 10 31 2000, : : Circulation. 102, 18, p. 2243-2248 6 p.

研究成果: ジャーナルへの寄稿記事

102 引用 (Scopus)

Role of Transforming Growth Factor-β1 in Cardiovascular Inflammatory Changes Induced by Chronic Inhibition of Nitric Oxide Synthesis

Koyanagi, M., Egashira, K., Kubo-Inoue, M., Usui, M., Kitamoto, S., Tomita, H., Shimokawa, H. & Takeshita, A., 1 2000, : : Hypertension. 35, 1, 1 p.

研究成果: ジャーナルへの寄稿記事

58 引用 (Scopus)

Sarpogrelate, a selective 5-HT(2A) serotonergic receptor antagonist, inhibits serotonin-induced coronary artery spasm in a porcine model

Miyata, K., Shimokawa, H., Higo, T., Yamawaki, T., Katsumata, N., Kandabashi, T., Tanaka, E., Takamura, Y., Yogo, K., Egashira, K. & Takeshita, A., 2 10 2000, : : Journal of Cardiovascular Pharmacology. 35, 2, p. 294-301 8 p.

研究成果: ジャーナルへの寄稿記事

52 引用 (Scopus)

The effects of caffeine on ATP-sensitive K+ channels in smooth muscle cells from pig urethra

Teramoto, N., Yunoki, T., Tanaka, K., Takano, M., Masaki, I., Yonemitsu, Y., Sueishi, K. & Ito, Y., 1 1 2000, : : British Journal of Pharmacology. 131, 3, p. 505-513 9 p.

研究成果: ジャーナルへの寄稿記事

23 引用 (Scopus)
1999

Endocardial versus epicardial differences of sarcoplasmic reticulum Ca2+-ATPase gene expression in the canine failing myocardium

Igarashi-Saito, K., Tsutsui, H., Takahashi, M., Kinugawa, S., Egashira, K. & Takeshita, A., 8 1 1999, : : Basic Research in Cardiology. 94, 4, p. 267-273 7 p.

研究成果: ジャーナルへの寄稿記事

14 引用 (Scopus)

Endothelial vasodilator function is preserved at the spastic/inflammatory coronary lesions in pigs

Miyata, K., Shimokawa, H., Yamawaki, T., Kunihiro, I., Zhou, X., Higo, T., Tanaka, E., Katsumata, N., Egashira, K. & Takeshita, A., 9 28 1999, : : Circulation. 100, 13, p. 1432-1437 6 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Important role of endothelium-derived hyperpolarizing factor in shear stress-induced endothelium-dependent relaxations in the rat mesenteric artery

Takamura, Y., Shimokawa, H., Zhao, H., Igarashi, H., Egashira, K. & Takeshita, A., 9 1 1999, : : Journal of Cardiovascular Pharmacology. 34, 3, p. 381-387 7 p.

研究成果: ジャーナルへの寄稿記事

61 引用 (Scopus)

Mitochondrial electron transport complex I is a potential source of oxygen free radicals in the failing myocardium

Ide, T., Tsutsui, H., Kinugawa, S., Utsumi, H., Kang, D., Hattori, N., Uchida, K., Arimura, K. I., Egashira, K. & Takeshita, A., 8 20 1999, : : Circulation research. 85, 4, p. 357-363 7 p.

研究成果: ジャーナルへの寄稿記事

529 引用 (Scopus)

Pathogenic Role of Oxidative Stress in Vascular Angiotensin-Converting Enzyme Activation in Long-Term Blockade of Nitric Oxide Synthesis in Rats

Usui, M., Egashira, K., Kitamoto, S., Koyanagi, M., Katoh, M., Kataoka, C., Shimokawa, H. & Takeshita, A., 10 1999, : : Hypertension. 34, 4, p. 546-551 6 p.

研究成果: ジャーナルへの寄稿記事

96 引用 (Scopus)

Positive inotropic effect of insulin-like growth factor-1 on normal and failing cardiac myocytes

Kinugawa, S., Tsutsui, H., Ide, T., Nakamura, R., Arimura, K. I., Egashira, K. & Takeshita, A., 7 1999, : : Cardiovascular research. 43, 1, p. 157-164 8 p.

研究成果: ジャーナルへの寄稿記事

51 引用 (Scopus)

Rho-kinase-mediated pathway induces enhanced myosin light chain phosphorylations in a swine model of coronary artery spasm

Shimokawa, H., Seto, M., Katsumata, N., Amano, M., Kozai, T., Yamawaki, T., Kuwata, K., Kandabashi, T., Egashira, K., Ikegaki, I., Asano, T., Kaibuchi, K. & Takeshita, A., 9 1 1999, : : Cardiovascular research. 43, 4, p. 1029-1039 11 p.

研究成果: ジャーナルへの寄稿記事

263 引用 (Scopus)