研究成果 1976 2019

2019
1 引用 (Scopus)

2-Oxo-histidine-containing dipeptides are functional oxidation products

Ihara, H., Kakihana, Y., Yamakage, A., Kai, K., Shibata, T., Nishida, M., Yamada, K-I. & Uchida, K., 1 1 2019, : : Journal of Biological Chemistry. 294, 4, p. 1279-1289 11 p.

研究成果: ジャーナルへの寄稿記事

Carnosine
Dipeptides
Histidine
Oxidation
Antioxidants

A Convenient Preparation Method for Benzophenone Imine Catalyzed by Tetrabutylammonium Fluoride

Kondo, Y., Morisaki, K., Hirazawa, Y., Morimoto, H. & Ohshima, T., 8 16 2019, : : Organic Process Research and Development. 23, 8, p. 1718-1724 7 p.

研究成果: ジャーナルへの寄稿記事

Imines
imines
fluorides
preparation
synthesis

A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats

Shimizu, Y., Yanobu-Takanashi, R., Nakano, K., Hamase, K., Shimizu, T. & Okamura, T., 2 13 2019, : : Mammalian Genome. 30, 1-2, p. 23-33 11 p.

研究成果: ジャーナルへの寄稿記事

Cystine
Kidney
Glucose
Cystinosis
Genes

Alginate immobilization of Morus alba L. cell suspension cultures improved the accumulation and secretion of stilbenoids

Inyai, C., Boonsnongcheep, P., Komaikul, J., Sritularak, B., Tanaka, H. & Putalun, W., 1 30 2019, : : Bioprocess and Biosystems Engineering. 42, 1, p. 131-141 11 p.

研究成果: ジャーナルへの寄稿記事

Morus
Alginate
Resveratrol
Immobilized Cells
Immobilization

A method to induce hen egg lysozyme-specific humoral immune tolerance in mice by pre-exposition with the protein's oligomers

Ohkuri, T., Yuge, N., Sato, K. & Ueda, T., 12 1 2019, : : Biochemistry and Biophysics Reports. 20, 100679.

研究成果: ジャーナルへの寄稿記事

公開
Immune Tolerance
Oligomers
Antibodies
Anti-Idiotypic Antibodies
Proteins
1 引用 (Scopus)

Ammonium Salt-Accelerated Hydrazinolysis of Unactivated Amides: Mechanistic Investigation and Application to a Microwave Flow Process

Noshita, M., Shimizu, Y., Morimoto, H., Akai, S., Hamashima, Y., Ohneda, N., Odajima, H. & Ohshima, T., 4 19 2019, : : Organic Process Research and Development. 23, 4, p. 588-594 7 p.

研究成果: ジャーナルへの寄稿記事

hydrazine
Ammonium Compounds
Amides
amides
Salts

A new approach to prevent the chemotherapy-induced peripheral neuropathy

kawashiri, T., 1 1 2019, : : Folia Pharmacologica Japonica. 153, 4, 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

Peripheral Nervous System Diseases
Drug Therapy
1 引用 (Scopus)

An indirect competitive enzyme-linked immunosorbent assay toward the standardization of Pueraria candollei based on its unique isoflavonoid, kwakhurin

Yusakul, G., Togita, R., Minami, K., Chanpokapaiboon, K., Juengwatanatrakul, T., Putalun, W., Tanaka, H., Sakamoto, S. & Morimoto, S., 3 1 2019, : : Fitoterapia. 133, p. 23-28 6 p.

研究成果: ジャーナルへの寄稿記事

Pueraria
Enzyme-Linked Immunosorbent Assay
Estrogen Replacement Therapy
Bovine Serum Albumin
Limit of Detection

Anti-allergic activity of polyphenolic compounds isolated from olive mill wastes

Mwakalukwa, R., Ashour, A., Amen, Y., Niwa, Y., Tamrakar, S., Miyamoto, T. & Shimizu, K., 7 1 2019, : : Journal of Functional Foods. 58, p. 207-217 11 p.

研究成果: ジャーナルへの寄稿記事

Anti-Allergic Agents
Olea
Inhibitory Concentration 50
polyphenols
Calcium Channels

Chronopharmacological strategies focused on chrono-drug discovery

Ohdo, S., Satoru, K. & Naoya, M., 10 1 2019, : : Pharmacology and Therapeutics. 202, p. 72-90 19 p.

研究成果: ジャーナルへの寄稿評論記事

Drug Discovery
Periodicity
Chronic Renal Insufficiency
Pharmaceutical Preparations
Neoplastic Stem Cells
1 引用 (Scopus)

Circulating messenger for neuroprotection induced by molecular hydrogen

Noda, M., Uemura, Y., Yoshii, Y., Horita, T., Takemi, S., Sakata, I. & Sakai, T., 1 1 2019, : : Canadian Journal of Physiology and Pharmacology. 97, 10, p. 909-915 7 p.

研究成果: ジャーナルへの寄稿評論記事

Ghrelin
Hydrogen
Drinking Water
Oxidative Stress
Ghrelin Receptor
4 引用 (Scopus)

Clinical Pharmacokinetics of Anaplastic Lymphoma Kinase Inhibitors in Non-Small-Cell Lung Cancer

Hirota, T., Muraki, S. & Ieiri, I., 4 4 2019, : : Clinical Pharmacokinetics. 58, 4, p. 403-420 18 p.

研究成果: ジャーナルへの寄稿評論記事

Non-Small Cell Lung Carcinoma
Pharmacokinetics
Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP3A
2 引用 (Scopus)

Crystal structure and calcium-induced conformational changes of diacylglycerol kinase α EF-hand domains

Takahashi, D., Suzuki, K., Sakamoto, T., Iwamoto, T., Murata, T. & Sakane, F., 4 1 2019, : : Protein Science. 28, 4, p. 694-706 13 p.

研究成果: ジャーナルへの寄稿記事

Diacylglycerol Kinase
EF Hand Motifs
Crystal structure
Calcium
Phosphatidic Acids

Cytotoxicity of trifluridine correlates with the thymidine kinase 1 expression level

Kataoka, Y., Iimori, M., Niimi, S., Tsukihara, H., Wakasa, T., Saeki, H., Oki, E., Maehara, Y. & Kitao, H., 5 28 2019, : : Scientific reports. 9, 1, 1 p.

研究成果: ジャーナルへの寄稿記事

公開
Trifluridine
thymidine kinase 1
Colorectal Neoplasms
DNA
Clustered Regularly Interspaced Short Palindromic Repeats

Depolysulfidation of Drp1 induced by low-dose methylmercury exposure increases cardiac vulnerability to hemodynamic overload

Nishimura, A., Shimoda, K., Tanaka, T., Toyama, T., Nishiyama, K., Shinkai, Y., Numaga-Tomita, T., Yamazaki, D., Kanda, Y., Akaike, T., Kumagai, Y. & Nishida, M., 1 1 2019, : : Science Signaling. 12, 587, eaaw1920.

研究成果: ジャーナルへの寄稿記事

Filamins
Hemodynamics
Cardiac Myocytes
Oxidation-Reduction
Rats

Development of a simple and rapid method for the detection of isomiroestrol in Pueraria candollei by an immunochromatographic strip test

Chaingam, J., Kitisripanya, T., Krittanai, S., Sakamoto, S., Tanaka, H. & Putalun, W., 6 14 2019, : : Journal of Natural Medicines. 73, 3, p. 577-583 7 p.

研究成果: ジャーナルへの寄稿記事

Pueraria
Standardization
Benzopyrans
Gold Colloid
Immunosorbents

Development of novel functional molecules targeting DNA and RNA

Sasaki, S., 1 1 2019, : : Chemical and Pharmaceutical Bulletin. 67, 6, p. 505-518 14 p.

研究成果: ジャーナルへの寄稿評論記事

公開
Nucleosides
Oligonucleotides
Artificial Receptors
RNA
Molecules
2 引用 (Scopus)

Development of Turn-On Probes for Acids Triggered by Aromaticity Enhancement Using Tricyclic Amidine Derivatives

Matsumoto, S., Fuchi, Y., Usui, K., Hirai, G. & Karasawa, S., 6 7 2019, : : Journal of Organic Chemistry. 84, 11, p. 6612-6622 11 p.

研究成果: ジャーナルへの寄稿記事

Amidines
Fluorescence
Protonation
Quantum yield
Derivatives
3 引用 (Scopus)

Diacylglycerol kinase α-selective inhibitors induce apoptosis and reduce viability of melanoma and several other cancer cell lines

Yamaki, A., Akiyama, R., Murakami, C., Takao, S., Murakami, Y., Mizuno, S., Takahashi, D., Kado, S., Taketomi, A., Shirai, Y., Goto, K. & Sakane, F., 6 1 2019, : : Journal of Cellular Biochemistry. 120, 6, p. 10043-10056 14 p.

研究成果: ジャーナルへの寄稿記事

Diacylglycerol Kinase
Melanoma
Phosphotransferases
Phosphatidic Acids
Cells
1 引用 (Scopus)
公開
oxaliplatin
Peripheral Nervous System Diseases
Rodentia
Hyperalgesia
Neoplasms

Donepezil ameliorates oxaliplatin-induced peripheral neuropathy via a neuroprotective effect

kawashiri, T., Shimizu, S., Shigematsu, N., Kobayashi, D. & Shimazoe, T., 7 1 2019, : : Journal of Pharmacological Sciences. 140, 3, p. 291-294 4 p.

研究成果: ジャーナルへの寄稿記事

公開
oxaliplatin
Neuroprotective Agents
Peripheral Nervous System Diseases
Cultured Cells
Nerve Degeneration

Dosing Time-Dependent Changes in the Anti-tumor Effect of xCT Inhibitor Erastin in Human Breast Cancer Xenograft Mice

Shiromizu, S., Yamauchi, T., Kusunose, N., Matsunaga, N., Koyanagi, S. & Ohdo, S., 1 1 2019, : : Biological and Pharmaceutical Bulletin. 42, 11, p. 1921-1925 5 p.

研究成果: ジャーナルへの寄稿記事

公開
Heterografts
Breast Neoplasms
Neoplasms
Cysteine
Cystine
1 引用 (Scopus)

D -Serine reflects kidney function and diseases

Hesaka, A., Sakai, S., Hamase, K., Ikeda, T., Matsui, R., Mita, M., Horio, M., Isaka, Y. & Kimura, T., 12 1 2019, : : Scientific reports. 9, 1, 5104.

研究成果: ジャーナルへの寄稿記事

公開
Kidney Diseases
Serine
Chronic Renal Insufficiency
Kidney
Amino Acids

Effect of Digital Labels on Electronic Medical Records for Reducing the Use of Benzodiazepine Receptor Agonists

Shin, K., Kobayashi, D., Kawashiri, T., Ikari, K., Mitsuyasu, H., Murakami, T., Tsutsumi, K., Kanazawa, Y., Kamimura, H. & Shimazoe, T., 1 1 2019, : : Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan. 139, 11, p. 1449-1456 8 p.

研究成果: ジャーナルへの寄稿記事

公開
Electronic Health Records
GABA-A Receptors
Prescriptions
Pharmacists
Delirium
4 引用 (Scopus)

Effect of OATP1B1 genotypes on plasma concentrations of endogenous OATP1B1 substrates and drugs, and their association in healthy volunteers

Mori, D., Kashihara, Y., Yoshikado, T., Kimura, M., Hirota, T., Matsuki, S., Maeda, K., Irie, S., Ieiri, I., Sugiyama, Y. & Kusuhara, H., 2 1 2019, : : Drug metabolism and pharmacokinetics. 34, 1, p. 78-86 9 p.

研究成果: ジャーナルへの寄稿記事

Sulfates
Healthy Volunteers
Genotype
fluvastatin
Pharmaceutical Preparations

Effects of magnesium oxide on pharmacokinetics of L-dopa/carbidopa and assessment of pharmacodynamic changes by a model-based simulation

Kashihara, Y., Terao, Y., Yoda, K., Hirota, T., Kubota, T., Kimura, M., Matsuki, S., Hirakawa, M., Irie, S. & Ieiri, I., 3 6 2019, : : European Journal of Clinical Pharmacology. 75, 3, p. 351-361 11 p.

研究成果: ジャーナルへの寄稿記事

Magnesium Oxide
Carbidopa
Levodopa
Pharmacokinetics
Meta-Analysis
公開
DNA-Directed DNA Polymerase
DNA Polymerase I
Adenosine
Nucleotides
Derivatives
3 引用 (Scopus)

Efficacy of DPP-4 inhibitors, GLP-1 analogues, and SGLT2 inhibitors as add-ons to metformin monotherapy in T2DM patients: a model-based meta-analysis

Inoue, H., Tamaki, Y., Kashihara, Y., Muraki, S., Kakara, M., Hirota, T. & Ieiri, I., 2 1 2019, : : British journal of clinical pharmacology. 85, 2, p. 393-402 10 p.

研究成果: ジャーナルへの寄稿記事

Glucagon-Like Peptide 1
Metformin
Hypoglycemic Agents
Type 2 Diabetes Mellitus
Meta-Analysis

Elevation of endocannabinoids in the brain by synthetic cannabinoid JWH-018: mechanism and effect on learning and memory

Li, R. S., Fukumori, R., Takeda, T., Song, Y., Morimoto, S., Kikura-Hanajiri, R., Yamaguchi, T., Watanabe, K., Aritake, K., Tanaka, Y., Yamada, H., Yamamoto, T. & Ishii, Y., 7 3 2019, : : Scientific reports. 9, 1, 1 p.

研究成果: ジャーナルへの寄稿記事

公開
Endocannabinoids
Cannabinoids
Learning
Brain-Derived Neurotrophic Factor
Brain

Elucidation of N1-methyladenosine as a potential surrogate biomarker for drug interaction studies involving renal organic cation transporters

Miyake, T., Mizuno, T., Takehara, I., Mochizuki, T., Kimura, M., Matsuki, S., Irie, S., Watanabe, N., Kato, Y., Ieiri, I., Maeda, K., Ando, O. & Kusuhara, H., 1 1 2019, : : Drug Metabolism and Disposition. 47, 11, p. 1270-1280 11 p.

研究成果: ジャーナルへの寄稿記事

Drug Interactions
Cations
Biomarkers
Kidney
Pharmaceutical Preparations

Enhancement of saccharothriolide production and discovery of a new metabolite, saccharothriolide C 2 , by combined-culture of Saccharothrix sp. and Tsukamurella pulmonis

Jiang, Y., Lu, S., Hirai, G., Kato, T., Onaka, H. & Kakeya, H., 4 11 2019, : : Tetrahedron Letters. 60, 15, p. 1072-1074 3 p.

研究成果: ジャーナルへの寄稿記事

Mycolic Acids
Metabolites
Bacteria
公開
Escherichia coli Proteins
Cell Division
Proteins
AT Rich Sequence
DNA Polymerase III

Estradiol regulation of P-glycoprotein expression in mouse kidney and human tubular epithelial cells, implication for renal clearance of drugs

Kanado, Y., Tsurudome, Y., Omata, Y., Yasukochi, S., Kusunose, N., Akamine, T., Matsunaga, N., Koyanagi, S. & Ohdo, S., 11 12 2019, : : Biochemical and Biophysical Research Communications. 519, 3, p. 613-619 7 p.

研究成果: ジャーナルへの寄稿記事

P-Glycoprotein
Estradiol
Digoxin
Epithelial Cells
Kidney

Evaluation of pharmacist-led interview before doctor examination for psychiatry outpatients

Shin, K., Kobayashi, D., kawashiri, T., Ushijima, Y., Umeda, Y., Kanazawa, Y., Kamimura, H. & Shimazoe, T., 1 1 2019, : : Yakugaku Zasshi. 139, 2, p. 317-325 9 p.

研究成果: ジャーナルへの寄稿コメント/討論

Pharmacists
Psychiatry
Outpatients
Interviews
Hospital Psychiatric Department

Evaluation of the immunomodulatory effects of fucoidan derived from cladosiphon okamuranus tokida in mice

Tomori, M., Nagamine, T., Miyamoto, T. & Iha, M., 9 24 2019, : : Marine Drugs. 17, 10, 547.

研究成果: ジャーナルへの寄稿記事

公開
Humoral Immunity
Cellular Immunity
Macrophages
Cell Proliferation
Phaeophyta
1 引用 (Scopus)

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Saitoh, H., Makoto, T., Inoue, K. & Ueda, T., 1 1 2019, (受理済み/印刷中) : : Purinergic Signalling.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head

Evidence for detection of rat P2X4 receptor expressed on cells by generating monoclonal antibodies recognizing the native structure

Igawa, T., Kishikawa, S., Abe, Y., Yamashita, T., Nagai, S., Shiroishi, M., Shinozaki, C., Tanaka, H., Tozaki-Saitoh, H., Tsuda, M., Inoue, K. & Ueda, T., 1 25 2019, : : Purinergic Signalling.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Monoclonal Antibodies
Antibodies
Purinergic P2X Receptors
Head

Expression, Purification, and Characterization of Human Diacylglycerol Kinase ζ

Saito, T., Takahashi, D. & Sakane, F., 3 19 2019, : : ACS Omega. 4, 3, p. 5540-5546 7 p.

研究成果: ジャーナルへの寄稿記事

公開
Diacylglycerol Kinase
Purification
Enzymes
Dichroism
Agglomeration

Hederagenin glycosides from the fruits of Blighia unijugata

Petit, B., Mitaine-Offer, A. C., Delaude, C., Miyamoto, T., Tanaka, C. & Lacaille-Dubois, M. A., 6 1 2019, : : Phytochemistry. 162, p. 260-269 10 p.

研究成果: ジャーナルへの寄稿記事

Blighia
Glycosides
Fruits
glycosides
Fruit

Hyperactivation of proprioceptors induces microglia-mediated long-lasting pain in a rat model of chronic fatigue syndrome

Yasui, M., Menjyo, Y., Tokizane, K., Shiozawa, A., Tsuda, M., Inoue, K. & Kiyama, H., 3 30 2019, : : Journal of neuroinflammation. 16, 1, 67.

研究成果: ジャーナルへの寄稿記事

公開
Chronic Fatigue Syndrome
Microglia
Pain
Neurons
Spinal Cord
1 引用 (Scopus)

Ibudilast attenuates doxorubicin-induced cytotoxicity by suppressing formation of TRPC3 channel and NADPH oxidase 2 protein complexes

Nishiyama, K., Numaga-Tomita, T., Fujimoto, Y., Tanaka, T., Toyama, C., Nishimura, A., Yamashita, T., Naoya, M., Satoru, K., Azuma, Y. T., Ibuki, Y., Uchida, K., Ohdo, S. & Nishida, M., 9 1 2019, : : British Journal of Pharmacology. 176, 18, p. 3723-3738 16 p.

研究成果: ジャーナルへの寄稿記事

NADPH Oxidase
Doxorubicin
Tobacco Smoke Pollution
Proteins
Pharmaceutical Preparations

Identification of candidate molecular targets of the novel antineoplastic antimitotic NP-10

Yokoyama, T., Yukuhiro, M., Iwasaki, Y., Tanaka, C., Sankoda, K., Fujiwara, R., Shibuta, A., Higashi, T., Motoyama, K., Arima, H., Yoshida, K., Sugimoto, N., Morimoto, H., Kosako, H., Ohshima, T. & Fujita, M., 12 1 2019, : : Scientific reports. 9, 1, 16825.

研究成果: ジャーナルへの寄稿記事

公開
Antimitotic Agents
Antineoplastic Agents
polyoxyethylene(10)nonylphenyl ether
Karyopherins
HCT116 Cells
4 引用 (Scopus)

Identification of drug transporters contributing to oxaliplatin-induced peripheral neuropathy

Fujita, S., Hirota, T., Sakiyama, R., Baba, M. & Ieiri, I., 2 2019, : : Journal of Neurochemistry. 148, 3, p. 373-385 13 p.

研究成果: ジャーナルへの寄稿記事

oxaliplatin
Peripheral Nervous System Diseases
Spinal Ganglia
Platinum
Pharmaceutical Preparations

Identification of lipophilic ligands of Siglec5 and -14 that modulate innate immune responses

Suematsu, R., Miyamoto, T., Saijo, S., Yamasaki, S., Tada, Y., Yoshida, H. & Miyake, Y., 1 1 2019, : : Journal of Biological Chemistry. 294, 45, p. 16776-16788 13 p.

研究成果: ジャーナルへの寄稿記事

公開
Sialic Acid Binding Immunoglobulin-like Lectins
Innate Immunity
Ligands
Lipids
N-Acetylneuraminic Acid

Improvement of stilbenoid production by 2-hydroxypropyl-β-cyclodextrin in white mulberry (Morus alba L.) callus cultures

Komaikul, J., Kitisripanya, T., Likhitwitayawuid, K., Sritularak, B., Tanaka, H. & Putalun, W., 10 2 2019, : : Natural Product Research. 33, 19, p. 2762-2769 8 p.

研究成果: ジャーナルへの寄稿記事

stilbenoids
Morus
Morus alba
cyclodextrins
Bony Callus
1 引用 (Scopus)

Induction of cell fusion/apoptosis in anaplastic thyroid carcinoma in orthotopic mouse model by urokinase-specific oncolytic Sendai virus

Miyagawa, Y., Araki, K., Yamashita, T., Tanaka, S., Tanaka, Y., Tomifuji, M., Ueda, Y., Yonemitsu, Y., Shimada, H. & Shiotani, A., 1 1 2019, : : Head and Neck. 41, 9, p. 2873-2882 10 p.

研究成果: ジャーナルへの寄稿記事

Oncolytic Viruses
Sendai virus
Cell Fusion
Urokinase-Type Plasminogen Activator
Apoptosis
2 引用 (Scopus)

Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib

Morii, I., Iwabuchi, Y., Mori, S., Suekuni, M., Natsume, T., Yoshida, K., Sugimoto, N., Kanemaki, M. T. & Fujita, M., 3 2019, : : Cancer Science. 110, 3, p. 1044-1053 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Cisplatin
Platinum Compounds
Neoplasms
Papillomaviridae
DNA Helicases
1 引用 (Scopus)
Bacterial DNA
Single-Stranded DNA
DNA Replication
Dimers
Escherichia coli

Investigation of the endoplasmic reticulum localization of UDP-glucuronosyltransferase 2B7 with systematic deletion mutants

Miyauchi, Y., Kimura, S., Kimura, A., Kurohara, K., Hirota, Y., Fujimoto, K., Mackenzie, P. I., Tanaka, Y. & Ishii, Y., 5 1 2019, : : Molecular Pharmacology. 95, 5, p. 551-562 12 p.

研究成果: ジャーナルへの寄稿記事

Glucuronosyltransferase
Endoplasmic Reticulum
lysyllysine
Calnexin
Microscopy
2 引用 (Scopus)

In Vivo Imaging of the Intra-and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging

Yasukawa, K., Shigemi, R., Kanbe, T., Mutsumoto, Y., Oda, F., Ichikawa, K., Yamada, K-I., Tun, X. & Utsumi, H., 1 1 2019, : : Antioxidants and Redox Signaling. 30, 9, p. 1147-1161 15 p.

研究成果: ジャーナルへの寄稿記事

Stomach Ulcer
Indomethacin
Oxidation-Reduction
Rats
Stomach