研究成果 1976 2020

2019
1 引用 (Scopus)

Induction of cell fusion/apoptosis in anaplastic thyroid carcinoma in orthotopic mouse model by urokinase-specific oncolytic Sendai virus

Miyagawa, Y., Araki, K., Yamashita, T., Tanaka, S., Tanaka, Y., Tomifuji, M., Ueda, Y., Yonemitsu, Y., Shimada, H. & Shiotani, A., 1 1 2019, : : Head and Neck. 41, 9, p. 2873-2882 10 p.

研究成果: ジャーナルへの寄稿記事

Oncolytic Viruses
Sendai virus
Cell Fusion
Urokinase-Type Plasminogen Activator
Apoptosis
2 引用 (Scopus)

Inhibiting the MCM8-9 complex selectively sensitizes cancer cells to cisplatin and olaparib

Morii, I., Iwabuchi, Y., Mori, S., Suekuni, M., Natsume, T., Yoshida, K., Sugimoto, N., Kanemaki, M. T. & Fujita, M., 3 2019, : : Cancer Science. 110, 3, p. 1044-1053 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Cisplatin
Platinum Compounds
Neoplasms
Papillomaviridae
DNA Helicases
1 引用 (Scopus)
Bacterial DNA
Single-Stranded DNA
DNA Replication
Dimers
Escherichia coli

Investigation of the endoplasmic reticulum localization of UDP-glucuronosyltransferase 2B7 with systematic deletion mutants

Miyauchi, Y., Kimura, S., Kimura, A., Kurohara, K., Hirota, Y., Fujimoto, K., Mackenzie, P. I., Tanaka, Y. & Ishii, Y., 5 1 2019, : : Molecular Pharmacology. 95, 5, p. 551-562 12 p.

研究成果: ジャーナルへの寄稿記事

Glucuronosyltransferase
Endoplasmic Reticulum
lysyllysine
Calnexin
Microscopy
2 引用 (Scopus)

In Vivo Imaging of the Intra-and Extracellular Redox Status in Rat Stomach with Indomethacin-Induced Gastric Ulcers Using Overhauser-Enhanced Magnetic Resonance Imaging

Yasukawa, K., Shigemi, R., Kanbe, T., Mutsumoto, Y., Oda, F., Ichikawa, K., Yamada, K-I., Tun, X. & Utsumi, H., 1 1 2019, : : Antioxidants and Redox Signaling. 30, 9, p. 1147-1161 15 p.

研究成果: ジャーナルへの寄稿記事

Stomach Ulcer
Indomethacin
Oxidation-Reduction
Rats
Stomach
2 引用 (Scopus)

Isolation and identification of new anthraquinones from Rhamnus alaternus L and evaluation of their free radical scavenging activity

Ben Ammar, R., Miyamoto, T., Chekir-Ghedira, L., Ghedira, K. & Lacaille-Dubois, M. A., 1 17 2019, : : Natural Product Research. 33, 2, p. 280-286 7 p.

研究成果: ジャーナルへの寄稿記事

Rhamnus
Anthraquinones
anthraquinones
Scavenging
Free Radicals

Kinetics and localisation of haemin-induced lipoprotein oxidation

Morales, N. P., Chunephisal, P., Janprasit, J., Ishida, Y., Luechapudiporn, R. & Yamada, K. I., 10 3 2019, : : Free Radical Research. 53, 9-10, p. 968-978 11 p.

研究成果: ジャーナルへの寄稿記事

Hemin
Lipoproteins
Oxidation
Kinetics
Paramagnetic resonance
1 引用 (Scopus)

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Tsuda, M., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., 5 15 2019, : : Science Advances. 5, 5, eaav5086.

研究成果: ジャーナルへの寄稿記事

公開
spinal cord injuries
macrophages
healing
interferon
lesions

Magnetic particles-based enzyme immunoassay for rapid determination of secoiridoid glycoside, amarogentin

Sakamoto, S., Wada, S., Morita, Y., Yamaguchi, T., Tanaka, H. & Morimoto, S., 3 1 2019, : : Talanta. 194, p. 731-736 6 p.

研究成果: ジャーナルへの寄稿記事

Iridoid Glycosides
Enzymes
Food additives
amarogentin
Immunosorbents
1 引用 (Scopus)

Marine natural products from Indonesian waters

Hanif, N., Murni, A., Tanaka, C. & Tanaka, J., 6 19 2019, : : Marine Drugs. 17, 6, 364.

研究成果: ジャーナルへの寄稿評論記事

公開
Biological Products
Biodiversity
Water
Organic Chemistry
Aquatic Organisms

Mechanistic insight into catalytic aerobic chemoselective α-oxidation of acylpyrazoles

Taninokuchi, S., Yazaki, R. & Ohshima, T., 1 1 2019, : : Heterocycles. 99, 2, p. 906-918 13 p.

研究成果: ジャーナルへの寄稿記事

公開
Catalysis
Lewis Acids
Oxidation
Hydroxy Acids
Isotopes

Melanogenesis Inhibitors from the Endophytic Fungus Aspergillus amstelodami

Elsbaey, M., Sallam, A., El-Metwally, M., Nagata, M., Tanaka, C., Shimizu, K. & Miyamoto, T., 1 1 2019, : : Chemistry and Biodiversity. 16, 8, e1900237.

研究成果: ジャーナルへの寄稿記事

Arbutin
Melanin
Anti-Allergic Agents
Electrospray ionization
Aspergillus
1 引用 (Scopus)

Metabolic plasticity of astrocytes and aging of the brain

Morita, M., Ikeshima-Kataoka, H., Kreft, M., Vardjan, N., Zorec, R. & Noda, M., 2 2 2019, : : International journal of molecular sciences. 20, 4, 941.

研究成果: ジャーナルへの寄稿評論記事

公開
plastic properties
Astrocytes
brain
Plasticity
Brain

Microcurrent stimulation activates the circadian machinery in mice

Matsunaga, N., Yoshida, Y., Kitajou, N., Shiraishi, A., Kusunose, N., Koyanagi, S. & Ohdo, S., 5 28 2019, : : Biochemical and Biophysical Research Communications. 513, 2, p. 293-299 7 p.

研究成果: ジャーナルへの寄稿記事

Machinery
Clocks
Genes
Cyclic AMP Response Element-Binding Protein
Phosphors

Microdosing clinical study to clarify pharmacokinetic and pharmacogenetic characteristics of atorvastatin in Japanese hypercholesterolemic patients

Lee, N., Maeda, K., Fukizawa, S., Ieiri, I., Tomaru, A., Akao, H., Takeda, K., Iwadare, M., Niwa, O., Masauji, T., Yamane, N., Kajinami, K., Kusuhara, H. & Sugiyama, Y., 12 2019, : : Drug metabolism and pharmacokinetics. 34, 6, p. 387-395 9 p.

研究成果: ジャーナルへの寄稿記事

Pharmacogenetics
Pharmacokinetics
Area Under Curve
Therapeutics
Hydroxymethylglutaryl-CoA Reductase Inhibitors

Microglia-mediated regulation of neuropathic pain: Molecular and cellular mechanisms

Tsuda, M., 1 1 2019, : : Biological and Pharmaceutical Bulletin. 42, 12, p. 1959-1968 10 p.

研究成果: ジャーナルへの寄稿評論記事

公開
Microglia
Neuralgia
Nervous System
Drug Delivery Systems
Chronic Pain
1 引用 (Scopus)

Microglia-neuron interactions in the models of neuropathic pain

Saitoh, H. & Makoto, T., 11 1 2019, : : Biochemical Pharmacology. 169, 113614.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuralgia
Neurons
Chronic Pain
Chemical activation
1 引用 (Scopus)

Mitochondrial dynamics in exercise physiology

Tanaka, T., Nishimura, A., Nishiyama, K., Goto, T., Numaga-Tomita, T. & Nishida, M., 1 1 2019, : : Pflugers Archiv European Journal of Physiology.

研究成果: ジャーナルへの寄稿評論記事

Mitochondrial Dynamics
Physiology
Organelle Biogenesis
Post Translational Protein Processing
Homeostasis
Colforsin
Immunoglobulin G
Antigens
Enzyme-Linked Immunosorbent Assay
Bombyx

Mutation of the gene encoding the circadian clock component PERIOD2 in oncogenic cells confers chemoresistance by up-regulating the Aldh3a1 gene

Katamune, C., Koyanagi, S., Hashikawa, K. I., Kusunose, N., Akamine, T., Matsunaga, N. & Ohdo, S., 1 1 2019, : : Journal of Biological Chemistry. 294, 2, p. 547-558 12 p.

研究成果: ジャーナルへの寄稿記事

Aldehyde Dehydrogenase
Circadian Clocks
Gene encoding
Clocks
oxaliplatin
1 引用 (Scopus)

Myristic acid specifically stabilizes diacylglycerol kinase δ protein in C2C12 skeletal muscle cells

Iwata, K., Sakai, H., Takahashi, D. & Sakane, F., 7 1 2019, : : Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids. 1864, 7, p. 1031-1038 8 p.

研究成果: ジャーナルへの寄稿記事

Diacylglycerol Kinase
Myristic Acid
Muscle Cells
Skeletal Muscle
Proteins

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J-I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., 6 1 2019, : : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

研究成果: ジャーナルへの寄稿記事

Myocardial Reperfusion Injury
Toll-Like Receptor 4
Reperfusion Injury
Nanoparticles
Myocardial Ischemia
2 引用 (Scopus)

Nanoparticle incorporating Toll-like receptor 4 inhibitor attenuates myocardial ischaemia-reperfusion injury by inhibiting monocyte-mediated inflammation in mice

Fujiwara, M., Matoba, T., Koga, J. I., Okahara, A., Funamoto, D., Nakano, K., Tsutsui, H. & Egashira, K., 6 1 2019, : : Cardiovascular research. 115, 7, p. 1244-1255 12 p.

研究成果: ジャーナルへの寄稿記事

公開
Myocardial Reperfusion Injury
Toll-Like Receptor 4
Reperfusion Injury
Nanoparticles
Myocardial Ischemia

New applications of high-resolution analytical methods to study trace organic compounds in extraterrestrial materials

Naraoka, H., Hashiguchi, M., Sato, Y. & Hamase, K., 9 2019, : : Life. 9, 3, 62.

研究成果: ジャーナルへの寄稿評論記事

公開
Meteoroids
organic compounds
Organic compounds
analytical methods
organic compound

New approach for investigating neuropathic allodynia by optogenetics

Makoto, T., 5 1 2019, : : Pain. 160, p. S53-S58

研究成果: ジャーナルへの寄稿記事

Optogenetics
Mechanoreceptors
Hyperalgesia
Myelinated Nerve Fibers
Neuralgia
1 引用 (Scopus)
oxaliplatin
Hyperalgesia
Pharmacology
Small Molecule Libraries
Peripheral Nervous System Diseases

New secondary metabolites from the mangrove endophytic fungus Aspergillus versicolor

Elsbaey, M., Tanaka, C. & Miyamoto, T., 8 1 2019, : : Phytochemistry Letters. 32, p. 70-76 7 p.

研究成果: ジャーナルへの寄稿記事

Aspergillus versicolor
Hydroxy Acids
Aspergillus
Metabolites
Fungi
1 引用 (Scopus)

Non-invasive mapping of glutathione levels in mouse brains by in vivo electron paramagnetic resonance (EPR) imaging: Applied to a kindling mouse model

Emoto, M. C., Sato-Akaba, H., Matsuoka, Y., Yamada, K-I. & Fujii, H. G., 1 18 2019, : : Neuroscience Letters. 690, p. 6-10 5 p.

研究成果: ジャーナルへの寄稿記事

Electron Spin Resonance Spectroscopy
Glutathione
Brain
Brain Mapping
Pentylenetetrazole

Nuciferols A and B: Novel sesquineolignans from Cocos nucifera

Elsbaey, M., Jie, B., Tanaka, C., Kato, H., Tsukamoto, S., Usui, K., Hirai, G. & Miyamoto, T., 8 15 2019, : : Tetrahedron Letters. 60, 33, 150948.

研究成果: ジャーナルへの寄稿記事

Cocos
Scavenging
Neuroprotective Agents
Cell death
Skeleton
3 引用 (Scopus)

Oncogenic Y-box binding protein-1 as an effective therapeutic target in drug-resistant cancer

Kuwano, M., Shibata, T., Watari, K. & Ono, M., 5 2019, : : Cancer Science. 110, 5, p. 1536-1543 8 p.

研究成果: ジャーナルへの寄稿評論記事

公開
Y-Box-Binding Protein 1
Drug Resistance
Pharmaceutical Preparations
Neoplasms
Therapeutics
1 引用 (Scopus)

Optimized reaction pair of the Cyshis tag and Ni(II)-Nta probe for highly selective chemical labeling of membrane proteins

Zenmyo, N., Tokumaru, H., Uchinomiya, S., Fuchida, H., Tabata, S., Hamachi, I., Shigemoto, R. & Ojida, A., 1 1 2019, : : Bulletin of the Chemical Society of Japan. 92, 5, p. 995-1000 6 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Membrane Proteins
Proteins
Cells
Molecular Probes

Pancreatic carcinoma metastasis to a lung carcinoma lesion and pulmonary fibrotic regions, overtaking the stromal microenvironment: A case report

Nakaya, T., Sogabe, M., Yamamoto, S. I., Tsuji, K., Nakaya, M., Niki, T., Endo, S. & Tanaka, A., 6 1 2019, : : Medicine (United States). 98, 24, e15888.

研究成果: ジャーナルへの寄稿記事

公開
Neoplasm Metastasis
Carcinoma
Lung
Pancreatic Neoplasms
Lung Neoplasms

Pentacylic triterpenes from Lavandula coronopifolia: structure related inhibitory activity on α-glucosidase

Elsbaey, M., Mwakalukwa, R., Shimizu, K. & Miyamoto, T., 1 1 2019, (受理済み/印刷中) : : Natural Product Research.

研究成果: ジャーナルへの寄稿記事

Lavandula
Glucosidases
Triterpenes
glucosidases
triterpenoids
1 引用 (Scopus)

Pharmacokinetics, Pharmacodynamics, and Safety of E6011, a Novel Humanized Antifractalkine (CX3CL1) Monoclonal Antibody: A Randomized, Double-Blind, Placebo-Controlled Single-Ascending-Dose Study

Tabuchi, H., Katsurabara, T., Mori, M., Aoyama, M., Obara, T., Yasuda, N., Kawano, T., Imai, T., Ieiri, I. & Kumagai, Y., 5 1 2019, : : Journal of Clinical Pharmacology. 59, 5, p. 688-701 14 p.

研究成果: ジャーナルへの寄稿記事

Pharmacokinetics
Monoclonal Antibodies
Placebos
Safety
Serum

Phytostilbenoid production in white mulberry (Morus alba L.) cell culture using bioreactors and simple deglycosylation by endogenous enzymatic hydrolysis

Komaikul, J., Kitisripanya, T., Inyai, C., Likhitwitayawuid, K., Sritularak, B., Tanaka, H. & Putalun, W., 4 15 2019, : : In Vitro Cellular and Developmental Biology - Plant. 55, 2, p. 199-208 10 p.

研究成果: ジャーナルへの寄稿記事

Morus
Morus alba
Bioreactors
enzymatic hydrolysis
bioreactors

Population Pharmacokinetic Analysis of Phenytoin After Intravenous Administration of Fosphenytoin in Adult and Elderly Epileptic Patients

Higuchi, K., Yamashita, D., Kashihara, Y., Kakara, M., Hirota, T., Hirakawa, M. & Ieiri, I., 10 1 2019, : : Therapeutic drug monitoring. 41, 5, p. 674-680 7 p.

研究成果: ジャーナルへの寄稿記事

Phenytoin
Intravenous Administration
Pharmacokinetics
Population
Body Weight

Preincubation format for a sensitive immunochromatographic assay for monocrotaline, a toxic pyrrolizidine alkaloid

Yusakul, G., Sakamoto, S., Chanpokapaiboon, K., Tanaka, H. & Morimoto, S., 11 1 2019, : : Phytochemical Analysis. 30, 6, p. 653-660 8 p.

研究成果: ジャーナルへの寄稿記事

monocrotaline
Immunochromatography
Monocrotaline
Pyrrolizidine Alkaloids
immunoaffinity chromatography

Preparation of a highly specific single chain variable fragment antibody targeting miroestrol and its application in quality control of Pueraria candollei by enzyme-linked immunosorbent assay

Pongkitwitoon, B., Boonsnongcheep, P., Kitisripanya, T., Yusakul, G., Sakamoto, S., Tanaka, H., Morimoto, S. & Putalun, W., 11 1 2019, : : Phytochemical Analysis. 30, 6, p. 600-608 9 p.

研究成果: ジャーナルへの寄稿記事

Pueraria
Single-Chain Antibodies
Immunosorbents
Quality Control
quality control

Promoting patient care through communication training in a pre-clerkship pharmacy education course in Japan

Epp, D. A., Kubota, T., Yoshida, M., Kishimoto, J., Kobayashi, D. & Shimazoe, T., 1 1 2019, : : American Journal of Pharmaceutical Education. 83, 5, p. 814-823 10 p., 6745.

研究成果: ジャーナルへの寄稿記事

Pharmacy Education
patient care
Patient Care
Japan
Communication

Radiation-induced redox alteration in the mouse brain

Nakamura, M., Yamasaki, T., Ueno, M., Shibata, S., Ozawa, Y., Kamada, T., Nakanishi, I., Yamada, K. I., Aoki, I. & Matsumoto, K. I., 11 1 2019, : : Free Radical Biology and Medicine. 143, p. 412-421 10 p.

研究成果: ジャーナルへの寄稿記事

Oxidation-Reduction
Brain
Carbon
Ion beams
Irradiation

Recent strategic advances for the activation of benzylic C–H bonds for the formation of C–C bonds

Yazaki, R. & Ohshima, T., 11 7 2019, : : Tetrahedron Letters. 60, 45, 151225.

研究成果: ジャーナルへの寄稿評論記事

Hydrocarbons
Anions
Chemical activation
Feedstocks

Regulation of replication initiation: Lessons from Caulobacter crescentus

Ozaki, S., 1 1 2019, : : Genes and Genetic Systems. 94, 5, p. 183-196 14 p.

研究成果: ジャーナルへの寄稿記事

公開
Caulobacter crescentus
Cell Cycle
Chromosomes
Replication Origin
DNA Replication
Thermococcus
Replication Protein A
DNA-Directed DNA Polymerase
Single-Stranded DNA
DNA

Role of P2X3 receptors in scratching behavior in mouse models

Shiratori-Hayashi, M., Hasegawa, A., Toyonaga, H., Andoh, T., Nakahara, T., Kido-Nakahara, M., Furue, M., Kuraishi, Y., Inoue, K., Dong, X. & Tsuda, M., 3 2019, : : Journal of Allergy and Clinical Immunology. 143, 3, p. 1252-1254.e8

研究成果: ジャーナルへの寄稿記事

Purinergic P2X3 Receptors
9 引用 (Scopus)

Selective and reversible modification of kinase cysteines with chlorofluoroacetamides

Shindo, N., Fuchida, H., Sato, M., Watari, K., Shibata, T., Kuwata, K., Miura, C., Okamoto, K., Hatsuyama, Y., Tokunaga, K., Sakamoto, S., Morimoto, S., Abe, Y., Shiroishi, M., Caaveiro, J. M. M., Ueda, T., Tamura, T., Matsunaga, N., Nakao, T., Koyanagi, S. および5人, Ohdo, S., Yamaguchi, Y., Hamachi, I., Ono, M. & Ojida, A., 1 14 2019, : : Nature Chemical Biology.

研究成果: ジャーナルへの寄稿記事

Quinazolines
Epidermal Growth Factor Receptor
Cysteine
Phosphotransferases
Hydrolysis

Serum d-serine accumulation after proximal renal tubular damage involves neutral amino acid transporter Asc-1

Suzuki, M., Gonda, Y., Yamada, M., Vandebroek, A. A., Mita, M., Hamase, K., Yasui, M. & Sasabe, J., 12 1 2019, : : Scientific reports. 9, 1, 16705.

研究成果: ジャーナルへの寄稿記事

公開
Neutral Amino Acid Transport Systems
Serine
Kidney
Serum
Cisplatin
1 引用 (Scopus)

Species differences in metabolism of a new antiepileptic drug candidate, DSP-0565 [2-(2′-fluoro[1,1′-biphenyl]-2-yl)acetamide]

Yahata, M., Ishii, Y., Nakagawa, T., Watanabe, T. & Bando, K., 5 1 2019, : : Biopharmaceutics and Drug Disposition. 40, 5-6, p. 165-175 11 p.

研究成果: ジャーナルへの寄稿記事

Anticonvulsants
Metabolic Networks and Pathways
Hydrolysis
Dogs
Hepatocytes

Specific basic patch-dependent multimerization of Saccharomyces cerevisiae ORC on single-stranded DNA promotes ATP hydrolysis

Kawakami, H., Muraoka, R., Ohashi, E., Kawabata, K., Kanamoto, S., Chichibu, T., Tsurimoto, T. & Katayama, T., 9 1 2019, : : Genes to Cells. 24, 9, p. 608-618 11 p.

研究成果: ジャーナルへの寄稿記事

Origin Recognition Complex
Single-Stranded DNA
Saccharomyces cerevisiae
Hydrolysis
Adenosine Triphosphate

Stereospecific Overman Rearrangement of Substituted Cyclic Vinyl Bromides: Access to Fully Substituted α-Amino Ketones

Velasco-Rubio, Á., Alexy, E. J., Yoritate, M., Wright, A. C. & Stoltz, B. M., 11 15 2019, : : Organic Letters. 21, 22, p. 8962-8965 4 p.

研究成果: ジャーナルへの寄稿記事

Enantioselectivity
Ketones
ketones
Amines
bromides
1 引用 (Scopus)

Steroidal glycosides from Ornithogalum dubium Houtt

Andriamisaina, N., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Paululat, T., Lirussi, F. & Lacaille-Dubois, M. A., 4 1 2019, : : Phytochemistry. 160, p. 78-84 7 p.

研究成果: ジャーナルへの寄稿記事

Ornithogalum
Cytotoxicity
glycosides
Cells
cytotoxicity