研究成果 1976 2020

2019

Structural and In Vitro Functional Analyses of Novel Plant-Produced Anti-Human PD1 Antibody

Rattanapisit, K., Phakham, T., Buranapraditkun, S., Siriwattananon, K., Boonkrai, C., Pisitkun, T., Hirankarn, N., Strasser, R., Abe, Y. & Phoolcharoen, W., 12 1 2019, : : Scientific reports. 9, 1, 15205.

研究成果: ジャーナルへの寄稿記事

公開
Antibodies
Immunotherapy
Monoclonal Antibodies
Plant Structures
Costs and Cost Analysis

Structural and thermodynamic basis for the recognition of the substrate-binding cleft on hen egg lysozyme by a single-domain antibody

Akiba, H., Tamura, H., Kiyoshi, M., Yanaka, S., Sugase, K., Caaveiro, J. M. M. & Tsumoto, K., 12 1 2019, : : Scientific reports. 9, 1, 15481.

研究成果: ジャーナルへの寄稿記事

公開
Single-Domain Antibodies
Surface Antigens
Thermodynamics
Antibodies
Epitopes

Study of the inducible cross-linking reaction to mRNA and the effect on the translation

Kikuta, K., Taniguchi, Y. & Sasaki, S., 1 1 2019, : : Chemical and Pharmaceutical Bulletin. 67, 8, p. 877-883 7 p.

研究成果: ジャーナルへの寄稿記事

公開
Cross Reactions
Derivatives
Messenger RNA
Oligoribonucleotides
Uracil
Acridines
Chemiluminescence
Choline
Hydrogen peroxide
Hydrogen Peroxide
1 引用 (Scopus)

Synthesis of 12- O-Mono- and Diglycosyl-oxystearates, a New Class of Agonists for the C-type Lectin Receptor Mincle

Van Huy, L., Tanaka, C., Imai, T., Yamasaki, S. & Miyamoto, T., 10 1 2019, : : ACS Medicinal Chemistry Letters. 10, 1, p. 44-49 6 p.

研究成果: ジャーナルへの寄稿記事

C-Type Lectins
Macrophages
NFATC Transcription Factors
Structure-Activity Relationship
Green Fluorescent Proteins
Oligonucleotides
Pseudouridine
Derivatives
Uracil
Oligodeoxyribonucleotides

Synthesis of All Stereoisomers of Monomeric Spectomycin A1/A2 and Evaluation of Their Protein SUMOylation-Inhibitory Activity

Nomura, Y., Thuaud, F., Sekine, D., Ito, A., Maeda, S., Koshino, H., Hashizume, D., Muranaka, A., Cruchter, T., Uchiyama, M., Ichikawa, S., Matsuda, A., Yoshida, M., Hirai, G. & Sodeoka, M., 6 21 2019, : : Chemistry - A European Journal. 25, 35, p. 8387-8392 6 p.

研究成果: ジャーナルへの寄稿記事

Stereoisomerism
Isomers
Stereochemistry
Proteins
Optical rotation
1 引用 (Scopus)

Synthesis of All Stereoisomers of RK460 and Evaluation of Their Activity and Selectivity as Abscisic Acid Receptor Antagonists

Mikame, Y., Yoshida, K., Hashizume, D., Hirai, G., Nagasawa, K., Osada, H. & Sodeoka, M., 3 7 2019, : : Chemistry - A European Journal. 25, 14, p. 3496-3500 5 p.

研究成果: ジャーナルへの寄稿記事

Abscisic Acid
Stereochemistry
Stereoisomerism
Agrochemicals
Lead compounds
3 引用 (Scopus)

Synthesis of CH 2 -Linked α(1,6)-Disaccharide Analogues by α-Selective Radical Coupling C-Glycosylation

Kiya, N., Hidaka, Y., Usui, K. & Hirai, G., 3 15 2019, : : Organic Letters. 21, 6, p. 1588-1592 5 p.

研究成果: ジャーナルへの寄稿記事

Glycosylation
Glycoconjugates
Disaccharides
carbohydrates
linkages

Synthesis of the deuterated thymidine-d9 and deuterated oligonucleotides

Taniguchi, Y., Cao, X. & Sasaki, S., 9 19 2019, : : Tetrahedron Letters. 60, 38, 151037.

研究成果: ジャーナルへの寄稿記事

Oligonucleotides
Thymidine
Glycosylation
Sugars
DNA

Synthesis of γ-N-modified 8-oxo-2’-deoxyguanosine triphosphate and its characterization

Thavoncharoensub, N., Maruyama, K., Heh, C. H., Hoong Leong, K., Shi, H., Shigematsu, Y., Sasaki, S. & Taniguchi, Y., 8 3 2019, : : Nucleosides, Nucleotides and Nucleic Acids. 38, 8, p. 578-589 12 p.

研究成果: ジャーナルへの寄稿記事

DNA-Directed DNA Polymerase
Nucleotides
DNA Replication
Reactive Oxygen Species
Repair
Thioguanine
Polyamines
Ligands
Repair
DNA

The association of tobacco use with prescription of muscle relaxants, benzodiazepines, and opioid analgesics for non-cancer pain

Takaki, H., Ieiri, I., Shibuta, H., Onozuka, D. & Hagihara, A., 1 9 2019, : : American Journal on Addictions.

研究成果: ジャーナルへの寄稿記事

Tobacco Use
Benzodiazepines
Opioid Analgesics
Prescriptions
Pain
1 引用 (Scopus)

The augmented expression of the cytidine deaminase gene by 5-azacytidine predicts therapeutic efficacy in myelodysplastic syndromes

Murakami, Y., Kimura, Y., Kawahara, A., Mitsuyasu, S., Miyake, H., Tohyama, K., Endo, Y., Yoshida, N., Imamura, Y., Watari, K., Ono, M., Okamura, T. & Kuwano, M., 3 19 2019, : : Oncotarget. 10, 23, p. 2270-2281 12 p.

研究成果: ジャーナルへの寄稿記事

Cytidine Deaminase
Azacitidine
Myelodysplastic Syndromes
Genes
Therapeutics

The evolution of surgical treatment for gastrointestinal cancers

Maehara, Y., Soejima, Y., Yoshizumi, T., Kawahara, N., Oki, E., Saeki, H., Akahoshi, T., Ikegami, T., Yamashita, Y. I., Furuyama, T., Sugimachi, K., Harada, N., Tagawa, T., Harimoto, N., Itoh, S., Sonoda, H., Ando, K., Nakashima, Y., Nagao, Y., Yamashita, N. および17人, Kasagi, Y., Yukaya, T., Kurihara, T., Tsutsumi, R., Takamori, S., Sasaki, S., Ikeda, T., Yonemitsu, Y., Fukuhara, T., Kitao, H., Iimori, M., Kataoka, Y., Wakasa, T., Suzuki, M., Teraishi, K., Yoshida, Y. & Mori, M., 11 1 2019, : : International Journal of Clinical Oncology. 24, 11, p. 1333-1349 17 p.

研究成果: ジャーナルへの寄稿記事

Gastrointestinal Neoplasms
Neoplasms
Chromosomal Instability
Stomach
Therapeutics

The isolation of new pore-forming toxins from the sea anemone actinia fragacea provides insights into the mechanisms of actinoporin evolution

Morante, K., Bellomio, A., Viguera, A. R., González-Mañas, J. M., Tsumoto, K. & Caaveiro, J. M. M., 7 10 2019, : : Toxins. 11, 7, toxins11070401.

研究成果: ジャーナルへの寄稿記事

公開
Actinium
Sea Anemones
Proteins
Species Specificity
Protein Stability

The roles of inhibitory smads in cancer progression

Hironaka, T., Ohba, Y., Kurose, H. & Nakaya, M., 1 1 2019, : : Folia Pharmacologica Japonica. 154, 1, 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

Neoplasms

Thionoesters as 1,2-Dipolarophiles for [4+2] Cycloaddition with Cyclobutanones

Matsumoto, Y., Tsuji, T., Nakatake, D., Yazaki, R. & Ohshima, T., 7 1 2019, : : Asian Journal of Organic Chemistry. 8, 7, p. 1071-1074 4 p.

研究成果: ジャーナルへの寄稿記事

Cycloaddition
Carbon Monoxide
Biological Products
Ketones
Carbon

Three-Dimensional High-Performance Liquid Chromatographic Determination of Asn, Ser, Ala, and Pro Enantiomers in the Plasma of Patients with Chronic Kidney Disease

Furusho, A., Koga, R., Akita, T., Mita, M., Kimura, T. & Hamase, K., 9 17 2019, : : Analytical chemistry. 91, 18, p. 11569-11575 7 p.

研究成果: ジャーナルへの寄稿記事

Enantiomers
Plasmas
Amino Acids
Liquids
Plasma (human)
3 引用 (Scopus)

Transcription factor MafB contributes to the activation of spinal microglia underlying neuropathic pain development

Tozaki-Saitoh, H., Masuda, J., Kawada, R., Kojima, C., Yoneda, S., Masuda, T., Inoue, K. & Tsuda, M., 4 2019, : : GLIA. 67, 4, p. 729-740 12 p.

研究成果: ジャーナルへの寄稿記事

MafB Transcription Factor
Peripheral Nerve Injuries
Microglia
Neuralgia
Hypersensitivity

Triterpenoid saponins from the root bark of haplocoelum congolanum

Pertuit, D., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Tran, D. K., Delaude, C. & Lacaille-Dubois, M. A., 5 2019, : : Natural product communications. 14, 5

研究成果: ジャーナルへの寄稿記事

公開
triterpenoid saponins
Saponins
bark
Acids
acids

Triterpenoid saponins from the stem bark of pentaclethra eetveldeana

Pertuit, D., Kapundu, M., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Delaude, C. & Lacaille-Dubois, M. A., 1 1 2019, : : Natural product communications. 14, 7

研究成果: ジャーナルへの寄稿記事

公開
Pentaclethra
triterpenoid saponins
Saponins
Mass Spectrometry
bark

TRPC3-Nox2 axis mediates nutritional deficiency-induced cardiomyocyte atrophy

Sudi, S. B., Tanaka, T., Oda, S., Nishiyama, K., Nishimura, A., Sunggip, C., Mangmool, S., Numaga-Tomita, T. & Nishida, M., 12 1 2019, : : Scientific reports. 9, 1, 9785.

研究成果: ジャーナルへの寄稿記事

公開
Cardiac Myocytes
Malnutrition
Atrophy
Adenosine Triphosphate
Reactive Oxygen Species
1 引用 (Scopus)

TRPC6 regulates phenotypic switching of vascular smooth muscle cells through plasma membrane potential-dependent coupling with PTEN

Numaga-Tomita, T., Shimauchi, T., Oda, S., Tanaka, T., Nishiyama, K., Nishimura, A., Birnbaumer, L., Mori, Y. & Nishida, M., 9 1 2019, : : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 33, 9, p. 9785-9796 12 p.

研究成果: ジャーナルへの寄稿記事

Cell membranes
Vascular Smooth Muscle
Membrane Potentials
Smooth Muscle Myocytes
Muscle
2 引用 (Scopus)

TRPC channels in exercise-mimetic therapy

Numaga-Tomita, T., Oda, S., Nishiyama, K., Tanaka, T., Nishimura, A. & Nishida, M., 3 7 2019, : : Pflugers Archiv European Journal of Physiology. 471, 3, p. 507-517 11 p.

研究成果: ジャーナルへの寄稿評論記事

Exercise Therapy
Muscle
Mechanical Stress
Proteins
Oxidative stress

Two new polyhydroxylated steroids from Egyptian soft coral Heteroxenia fuscescens (Fam.; Xeniidae)

Abdelkarem, F. M., Desoky, E. E. K., Nafady, A. M., Allam, A. E., Mahdy, A., Ashour, A., Mohamed, G. A., Miyamoto, T. & Shimizu, K., 1 1 2019, : : Natural Product Research.

研究成果: ジャーナルへの寄稿記事

Anthozoa
Fluorouracil
Inhibitory Concentration 50
steroids
inhibitory concentration 50

Δ 9 -Tetrahydrocannabinol elicited 22-kHz ultrasonic vocalization changes after air puff stimulus through CB 1 receptor in adult rats

Myose, T., Shirakawa, A., Irie, K., Yamashita, Y., Nakano, T., Takase, Y., Matsuo, K., Satho, T., Tuchihashi, R., Kinjo, J., Tanaka, H., Morimoto, S., Funada, M., Sano, K. & Mishima, K., 5 14 2019, : : Neuroscience Letters. 701, p. 132-135 4 p.

研究成果: ジャーナルへの寄稿記事

Dronabinol
Ultrasonics
Air
rimonabant
Cannabinoid Receptors
2018
6 引用 (Scopus)

3-Mono-Substituted BINOL Phosphoric Acids as Effective Organocatalysts in Direct Enantioselective Friedel–Crafts-Type Alkylation of N-Unprotected α-Ketiminoester

Yonesaki, R., Kondo, Y., Akkad, W., Sawa, M., Morisaki, K., Morimoto, H. & Ohshima, T., 10 12 2018, : : Chemistry - A European Journal. 24, 57, p. 15211-15214 4 p.

研究成果: ジャーナルへの寄稿記事

Phosphoric Acids
Enantioselectivity
Alkylation
Phosphoric acid
Catalysts

Abnormalities of the serotonergic system in diacylglycerol kinase δ-deficient mouse brain

Lu, Q., Komenoi, S., Usuki, T., Takahashi, D. & Sakane, F., 3 18 2018, : : Biochemical and Biophysical Research Communications. 497, 4, p. 1031-1037 7 p.

研究成果: ジャーナルへの寄稿記事

Diacylglycerol Kinase
Brain
Obsessive-Compulsive Disorder
Knockout Mice
Serotonin
Sorbitol
Neuralgia
Sciatic Nerve
Medical problems
Diabetic Neuropathies
2 引用 (Scopus)

Alleviation of fatty liver in a rat model by enhancing N 1 -methylnicotinamide bioavailability through aldehyde oxidase inhibition

Takeuchi, K., Yokouchi, C., Goto, H., Umehara, K., Yamada, H. & Ishii, Y., 12 9 2018, : : Biochemical and Biophysical Research Communications. 507, 1-4, p. 203-210 8 p.

研究成果: ジャーナルへの寄稿記事

公開
Aldehyde Oxidase
Fatty Liver
Liver
Biological Availability
Rats
3 引用 (Scopus)

A minimal threshold of FANCJ helicase activity is required for its response to replication stress or double-strand break repair

Bharti, S. K., Sommers, J. A., Awate, S., Bellani, M. A., Khan, I., Bradley, L., King, G. A., Seol, Y., Vidhyasagar, V., Wu, Y., Abe, T., Kobayashi, K., Shin-Ya, K., Kitao, H., Wold, M. S., Branzei, D., Neuman, K. C. & Brosh, R. M., 7 6 2018, : : Nucleic acids research. 46, 12, p. 6238-6256 19 p.

研究成果: ジャーナルへの寄稿記事

Fanconi Anemia
DNA
Aphidicolin
Bleomycin
G-Quadruplexes
2 引用 (Scopus)

A Monoclonal Antibody-Based Enzyme-Linked Immunosorbent Assay for Determination of Homoharringtonine

Pongkitwitoon, B., Sakamoto, S., Nagamitsu, R., Putalun, W., Tanaka, H. & Morimoto, S., 2 28 2018, : : Planta medica. 84, 14, p. 1038-1044 7 p.

研究成果: ジャーナルへの寄稿記事

Immunosorbents
Assays
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies
Enzymes
26 引用 (Scopus)
Cyclopropanes
Cycloaddition
Catalysis
Iron
tetrahydrothiophene
1 引用 (Scopus)

Angiotensin-II regulates dosing time-dependent intratumoral accumulation of macromolecular drug formulations via 24-h blood pressure rhythm in tumor-bearing mice

Matsunaga, T., Matsunaga, N., Kusunose, N., Ikeda, E., Okazaki, H., Kakimoto, K., Hamamura, K., Koyanagi, S. & Ohdo, S., 3 25 2018, : : Biochemical and Biophysical Research Communications. 498, 1, p. 86-91 6 p.

研究成果: ジャーナルへの寄稿記事

Bearings (structural)
Drug Compounding
Blood pressure
Angiotensin II
Tumors
5 引用 (Scopus)

A novel engineered interchain disulfide bond in the constant region enhances the thermostability of adalimumab Fab

Nakamura, H., Oda-Ueda, N., Ueda, T. & Ohkuri, T., 1 1 2018, : : Biochemical and Biophysical Research Communications. 495, 1, p. 7-11 5 p.

研究成果: ジャーナルへの寄稿記事

Disulfides
Pichia
Adalimumab
Computer Simulation
Yeast
1 引用 (Scopus)

Antioxidant nitroxides protect hepatic cells from oxidative stress-induced cell death

Shinto, S., Matsuoka, Y., Yamato, M. & Yamada, K. I., 3 2018, : : Journal of Clinical Biochemistry and Nutrition. 62, 2, p. 132-138 7 p.

研究成果: ジャーナルへの寄稿記事

Oxidative stress
Cell death
Hepatocytes
Oxidative Stress
Cell Death
1 引用 (Scopus)

A recombinant fab antibody against kwakhurin as a tool for sensitive indirect competitive ELISA

Chanpokapaiboon, K., Khoonrit, P., Yusakul, G., Juengwatanatrakul, T., Putalun, W., Tanaka, H., Sakamoto, S. & Morimoto, S., 1 1 2018, : : Current Pharmaceutical Biotechnology. 19, 14, p. 1170-1176 7 p.

研究成果: ジャーナルへの寄稿記事

Enzyme-Linked Immunosorbent Assay
Antibodies
Monoclonal Antibodies
Pueraria
kwakhurin

Assessing the effects of prescription adjustment and medication non-adherence associated with medication efficacy classifications from leftover drugs through the setsuyaku-bag campaign

Kobayashi, D., Koyanagi, K., Kubota, T., Sakamoto, Y., Kihara, T., Miisho, T., Kasaki, T., Kunitake, M., Takeshita, F., Ando, E., Baba, T., Seo, T., Tanaka, T. & Shimazoe, T., 1 1 2018, : : Yakugaku Zasshi. 138, 10, p. 1313-1322 10 p.

研究成果: ジャーナルへの寄稿記事

Social Adjustment
Medication Adherence
Prescriptions
Pharmaceutical Preparations
Health Expenditures
7 引用 (Scopus)

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column

Kiyoshi, M., Caaveiro, J. M. M., Tada, M., Tamura, H., Tanaka, T., Terao, Y., Morante, K., Harazono, A., Hashii, N., Shibata, H., Kuroda, D., Nagatoishi, S., Oe, S., Ide, T., Tsumoto, K. & Ishii-Watabe, A., 12 1 2018, : : Scientific Reports. 8, 1, 3955.

研究成果: ジャーナルへの寄稿記事

Polysaccharides
Antibodies
Column chromatography
Cytotoxicity
Immunoglobulin G
6 引用 (Scopus)

Astrocytes in the spinal dorsal horn and chronic itch

Makoto, T., 1 1 2018, : : Neuroscience Research. 126, p. 9-14 6 p.

研究成果: ジャーナルへの寄稿評論記事

Atopic Dermatitis
Astrocytes
Peripheral Nervous System
Central Nervous System
Skin
3 引用 (Scopus)

Astrocytic Ca2+ responses in the spinal dorsal horn by noxious stimuli to the skin

Yoshihara, K., Matsuda, T., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 5 1 2018, : : Journal of Pharmacological Sciences. 137, 1, p. 101-104 4 p.

研究成果: ジャーナルへの寄稿記事

Astrocytes
Skin
Automatic Data Processing
Photons
Formaldehyde
1 引用 (Scopus)

Bioconjugation with Thiols by Benzylic Substitution

Watanabe, K. & Ohshima, T., 3 15 2018, : : Chemistry - A European Journal. 24, 16, p. 3959-3964 6 p.

研究成果: ジャーナルへの寄稿記事

Muramidase
Sulfhydryl Compounds
Substitution reactions
Enzymes
Kinetics
1 引用 (Scopus)

Biophysical analysis of the protein-small molecule interactions to develop small molecule drug discovery

Nagatoishi, S., Caaveiro, J. M. M. & Tsumoto, K., 1 1 2018, : : Yakugaku Zasshi. 138, 8, p. 1033-1041 9 p.

研究成果: ジャーナルへの寄稿評論記事

Drug Discovery
Small Molecule Libraries
Thermodynamics
Proteins
Research Personnel
1 引用 (Scopus)

BubR1 insufficiency impairs angiogenesis in aging and in experimental critical limb ischemic mice

Okadome, J., Matsumoto, T., Yoshiya, K., Matsuda, D., Tamada, K., Onimaru, M., Nakano, K., Egashira, K., Yonemitsu, Y. & Maehara, Y., 8 2018, : : Journal of Vascular Surgery. 68, 2, p. 576-586.e1

研究成果: ジャーナルへの寄稿記事

Extremities
Ambulatory Surgical Procedures
Muscles
Ischemia
Vascular Endothelial Growth Factor A
2 引用 (Scopus)

Capecitabine reverses tumor escape from anti-VEGF through the eliminating CD11bhigh/Gr1high myeloid cells

Iwai, T., Harada, Y., Saeki, H., Oki, E., Maehara, Y. & Yonemitsu, Y., 4 1 2018, : : Oncotarget. 9, 25, p. 17620-17630 11 p.

研究成果: ジャーナルへの寄稿記事

Tumor Escape
Myeloid Cells
Vascular Endothelial Growth Factor A
Neoplasms
Granulocyte Colony-Stimulating Factor
10 引用 (Scopus)

Catalytic Enantioselective Decarboxylative Mannich-Type Reaction of N-Unprotected Isatin-Derived Ketimines

Sawa, M., Miyazaki, S., Yonesaki, R., Morimoto, H. & Ohshima, T., 9 7 2018, : : Organic Letters. 20, 17, p. 5393-5397 5 p.

研究成果: ジャーナルへの寄稿記事

Isatin
synthesis
AG-041R
ketimine
1 引用 (Scopus)

Changes in HER2 expression and amplification status following preoperative chemotherapy for gastric cancer

Shu, S., Iimori, M., Nakanishi, R., Jogo, T., Saeki, H., Oki, E. & Maehara, Y., 11 1 2018, : : In Vivo. 32, 6, p. 1491-1498 8 p.

研究成果: ジャーナルへの寄稿記事

Chemotherapy
Stomach Neoplasms
Amplification
Drug Therapy
Epidermal Growth Factor Receptor
1 引用 (Scopus)

Characterization of changes in HbA1c in patients with and without secondary failure after metformin treatments by a population pharmacodynamic analysis using mixture models

Tamaki, Y., Maema, K., Kakara, M., Fukae, M., Kinoshita, R., Kashihara, Y., Muraki, S., Hirota, T. & Ieiri, I., 12 1 2018, : : Drug metabolism and pharmacokinetics. 33, 6, p. 264-269 6 p.

研究成果: ジャーナルへの寄稿記事

Metformin
Population
Therapeutics
Electronic Health Records
Glycosylated Hemoglobin A
Oligonucleotides
Nucleic Acids
Genes
DNA sequences
Nucleosides