研究成果 1976 2019

2018
5 引用 (Scopus)
CpG Islands
Human Activities
Methylation
Skin
Messenger RNA
1 引用 (Scopus)

Interleukin-27 controls basal pain threshold in physiological and pathological conditions

Sasaguri, T., Taguchi, T., Murata, Y., Kobayashi, K., Iizasa, S., Iizasa, E., Tsuda, M., Hirakawa, N., Hara, H., Yoshida, H. & Yasaka, T., 12 1 2018, : : Scientific reports. 8, 1, 11022.

研究成果: ジャーナルへの寄稿記事

Interleukin-27
Pain Threshold
Pain
Chronic Pain
Hypersensitivity
3 引用 (Scopus)

Internal-Edge-Substituted Coumarin-Fused [6]Helicenes: Asymmetric Synthesis, Structural Features, and Control of Self-Assembly

Usui, K., Yamamoto, K., Ueno, Y., Igawa, K., Hagihara, R., Masuda, T., Ojida, A., Karasawa, S., Tomooka, K., Hirai, G. & Suemune, H., 10 1 2018, : : Chemistry - A European Journal. 24, 55, p. 14617-14621 5 p.

研究成果: ジャーナルへの寄稿記事

Self assembly
X ray crystallography
Quantum yield
Electronic structure
Physical properties
2 引用 (Scopus)

Intramolecular H-bonds govern the recognition of a flexible peptide by an antibody

Miyanabe, K., Akiba, H., Kuroda, D., Nakakido, M., Kusano-Arai, O., Iwanari, H., Hamakubo, T., Caaveiro, J. M. M. & Tsumoto, K., 7 1 2018, : : Journal of biochemistry. 164, 1, p. 65-76 12 p.

研究成果: ジャーナルへの寄稿記事

Biological Phenomena
Molecular recognition
Peptides
Antibodies
Free energy
3 引用 (Scopus)

Introduction of a glycosylation site in the constant region decreases the aggregation of adalimumab Fab

Nakamura, H., Oda-Ueda, N., Ueda, T. & Ohkuri, T., 9 5 2018, : : Biochemical and Biophysical Research Communications. 503, 2, p. 752-756 5 p.

研究成果: ジャーナルへの寄稿記事

Glycosylation
Agglomeration
Density (optical)
Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase
Pichia

Lifestyle inspires future pharmacotherapy and drug discovery

Miyamoto, L. & Nishida, M., 1 1 2018, : : Yakugaku Zasshi. 138, 10, p. 1255-1256 2 p.

研究成果: ジャーナルへの寄稿編集

Drug Discovery
Life Style
Drug Therapy
7 引用 (Scopus)

Lipoteichoic acid anchor triggers Mincle to drive protective immunity against invasive group A Streptococcus infection

Imai, T., Matsumura, T., Mayer-Lambertz, S., Wells, C. A., Ishikawa, E., Butcher, S. K., Barnett, T. C., Walker, M. J., Imamura, A., Ishida, H., Ikebe, T., Miyamoto, T., Ato, M., Ohga, S., Lepenies, B., Van Sorge, N. M. & Yamasaki, S., 11 6 2018, : : Proceedings of the National Academy of Sciences of the United States of America. 115, 45, p. E10662-E10671

研究成果: ジャーナルへの寄稿記事

C-Type Lectins
Streptococcus
Immunity
Macrophages
Infection
5 引用 (Scopus)

Luminescent europium sensors for specific detection of 8-oxo-dGTP by time-gated fluorescence

Fuchi, Y., Fukuda, T. & Sasaki, S., 7 23 2018, : : Bioorganic and Medicinal Chemistry. 26, 12, p. 3254-3260 7 p.

研究成果: ジャーナルへの寄稿記事

Europium
Fluorescence
Sensors
Assays
Ions
8 引用 (Scopus)

Lycodine-type alkaloids and their glycosides from Lycopodiastrum casuarinoides

Wang, L. L., Hao, L. J., Zhou, Z. B., Zhu, X. L., Shi, Z. H., Miyamoto, T. & Pan, K., 10 1 2018, : : Phytochemistry. 154, p. 63-72 10 p.

研究成果: ジャーナルへの寄稿記事

Lycopodium alkaloids
Lycopodium
Glycosides
Alkaloids
glycosides
4 引用 (Scopus)

MDC1 methylation mediated by lysine methyltransferases EHMT1 and EHMT2 regulates active ATM accumulation flanking DNA damage sites

Watanabe, S., Iimori, M., Chan, D. V., Hara, E., Kitao, H. & Maehara, Y., 12 1 2018, : : Scientific reports. 8, 1, 10888.

研究成果: ジャーナルへの寄稿記事

Histone-Lysine N-Methyltransferase
Methyltransferases
Methylation
Lysine
DNA Damage
1 引用 (Scopus)

Mice deficient in aldo-keto reductase 1a (Akr1a) are resistant to thioacetamide-induced liver injury

Homma, T., Shirato, T., Akihara, R., Kobayashi, S., Lee, J., Yamada, K. I., Miyata, S., Takahashi, M. & Fujii, J., 9 15 2018, : : Toxicology Letters. 294, p. 37-43 7 p.

研究成果: ジャーナルへの寄稿記事

Thioacetamide
Liver
Wounds and Injuries
Metabolites
Cytochrome P-450 CYP2E1
50 引用 (Scopus)

Microglia in neuropathic pain: Cellular and molecular mechanisms and therapeutic potential

Inoue, K. & Tsuda, M., 2 16 2018, : : Nature Reviews Neuroscience. 19, 3, p. 138-152 15 p.

研究成果: ジャーナルへの寄稿評論記事

Microglia
Neuralgia
Chronic Pain
Nociceptive Pain
Peripheral Nerve Injuries
3 引用 (Scopus)

Microglia in the CNS and neuropathic pain

Makoto, T., 1 1 2018, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 77-91 15 p. (Advances in Experimental Medicine and Biology; 巻数 1099).

研究成果: 著書/レポートタイプへの貢献

Microglia
Neuralgia
Neurology
Brain
Nervous System Trauma
2 引用 (Scopus)

miR-3148 is a novel onco-microRNA that potentiates tumor growth in vivo

Akamine, T., Morodomi, Y., Harada, Y., Teraishi, K., Tagawa, T., Okamoto, T., Maehara, Y. & Yonemitsu, Y., 10 2018, : : Anticancer research. 38, 10, p. 5693-5701 9 p.

研究成果: ジャーナルへの寄稿記事

MicroRNAs
HCT116 Cells
Growth
Neoplasms
Extracellular Signal-Regulated MAP Kinases
2 引用 (Scopus)
Aminopyridines
Base Pairing
DNA
Nucleosides
Nucleotides
14 引用 (Scopus)

Modulation of Pain and Itch by Spinal Glia

Makoto, T., 2 1 2018, : : Neuroscience Bulletin. 34, 1, p. 178-185 8 p.

研究成果: ジャーナルへの寄稿評論記事

Neuroglia
Chronic Pain
Pain
Spinal Cord
Posterior Horn Cells

Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin

Tashima, T., Nagatoishi, S., Martinez Caaveiro, J. M., Nakakido, M., Sagara, H., Kusano-Arai, O., Iwanari, H., Mimuro, H., Hamakubo, T., Ohnuma, S. I. & Tsumoto, K., 12 1 2018, : : Communications Biology. 1, 1, 33.

研究成果: ジャーナルへの寄稿記事

公開
Collagen Type I
collagen
Collagen
Proteoglycans
Static Electricity

Natural antibody against neuroblastoma of TH-MYCN transgenic mice does not correlate with spontaneous regression

Kawakubo, N., Harada, Y., Ishii, M., Souzaki, R., Kinoshita, Y., Tajiri, T., Taguchi, T. & Yonemitsu, Y., 9 10 2018, : : Biochemical and Biophysical Research Communications. 503, 3, p. 1666-1673 8 p.

研究成果: ジャーナルへの寄稿記事

Neuroblastoma
Transgenic Mice
Antibodies
Tumors
Cytotoxicity
1 引用 (Scopus)

Neuropathic pain inhibitor, RAP-103, is a potent inhibitor of microglial CCL1/CCR8

Noda, M., Tomonaga, D., Kitazono, K., Yoshioka, Y., Liu, J., Rousseau, J. P., Kinkead, R., Ruff, M. R. & Pert, C. B., 10 1 2018, : : Neurochemistry International. 119, p. 184-189 6 p.

研究成果: ジャーナルへの寄稿記事

Neuralgia
Ligands
Hyperalgesia
Chemokine Receptors
Inhibitory Concentration 50

New strategies for exercise-mimetic medication

Oda, S., Numaga-Tomita, T. & Nishida, M., 1 1 2018, : : Yakugaku Zasshi. 138, 10, p. 1257-1262 6 p.

研究成果: ジャーナルへの寄稿記事

Exercise Therapy
Exercise
Reactive Oxygen Species
NADP
Vascular Smooth Muscle
Protein Phosphatase 2
Dextran Sulfate
Toll-Like Receptor 4
Protein Tyrosine Phosphatases
Colitis
2 引用 (Scopus)

Nucleosome positioning and gene regulation of the SGLT2 gene in the renal proximal tubular epithelial cells

Takesue, H., Hirota, T., Tachimura, M., Tokashiki, A. & Ieiri, I., 9 1 2018, : : Molecular Pharmacology. 94, 3, p. 953-962 10 p.

研究成果: ジャーナルへの寄稿記事

Sodium-Glucose Transport Proteins
Nucleosomes
Epithelial Cells
Kidney
Genes
1 引用 (Scopus)

Oleanane-type glycosides from the roots of Weigela florida “rumba” and evaluation of their antibody recognition

Champy-Tixier, A. S., Mitaine-Offer, A. C., Real Fernández, F., Miyamoto, T., Tanaka, C., Papini, A. M. & Lacaille-Dubois, M. A., 7 1 2018, : : Fitoterapia. 128, p. 198-203 6 p.

研究成果: ジャーナルへの寄稿記事

Glycosides
Acids
Antibodies
Triterpenes
Multiple Sclerosis
7 引用 (Scopus)

Optimized dosing schedule based on circadian dynamics of mouse breast cancer stem cells improves the antitumor effects of aldehyde dehydrogenase inhibitor

Naoya, M., Ogino, T., Hara, Y., Tanaka, T., Satoru, K. & Ohdo, S., 7 1 2018, : : Cancer Research. 78, 13, p. 3698-3708 11 p.

研究成果: ジャーナルへの寄稿記事

Aldehyde Dehydrogenase
Neoplastic Stem Cells
Appointments and Schedules
Breast Neoplasms
Triple Negative Breast Neoplasms
4 引用 (Scopus)

Optimizing the dosing schedule of L-asparaginase improves its anti-tumor activity in breast tumor-bearing mice

Shiromizu, S., Kusunose, N., Naoya, M., Satoru, K. & Ohdo, S., 4 1 2018, : : Journal of Pharmacological Sciences. 136, 4, p. 228-233 6 p.

研究成果: ジャーナルへの寄稿記事

Asparaginase
Appointments and Schedules
Breast Neoplasms
Asparagine
Neoplasms
8 引用 (Scopus)

Optogenetic activation of non-nociceptive aβ fibers induces neuropathic pain-like sensory and emotional behaviors after nerve injury in rats

Tashima, R., Koga, K., Sekine, M., Kanehisa, K., Kohro, Y., Tominaga, K., Matsushita, K., Tozaki-Saitoh, H., Fukazawa, Y., Inoue, K., Yawo, H., Furue, H. & Tsuda, M., 1 1 2018, : : eNeuro. 5, 1, e0450-17.2018.

研究成果: ジャーナルへの寄稿記事

Optogenetics
Peripheral Nerve Injuries
Neuralgia
Myelinated Nerve Fibers
Wounds and Injuries
2 引用 (Scopus)

Phytochemistry of weigela x “kosteriana variegata” (Caprifoliaceae)

Andriamisaina, N., Mitaine-Offer, A. C., Pruvot, B., Chluba, J., Miyamoto, T., Tanaka, C. & Lacaille-Dubois, M. A., 1 1 2018, : : Natural product communications. 13, 4, p. 403-406 4 p.

研究成果: ジャーナルへの寄稿記事

Caprifoliaceae
Weigela
plant biochemistry
Glycosides
glycosides

Population Pharmacodynamic Analysis of Uric Acid–Lowering Effects of Febuxostat Based on Electronic Medical Records in Two Hospitals

Muraki, S., Moriki, K., Shigematsu, S., Fukae, M., Kakara, M., Yamashita, D., Hirota, T., Takane, H., Shimada, M., Hirakawa, M. & Ieiri, I., 3 2018, : : Journal of Clinical Pharmacology. 58, 3, p. 304-313 10 p.

研究成果: ジャーナルへの寄稿記事

Electronic Health Records
Uric Acid
Population
Blood Urea Nitrogen
Urban Hospitals

Population Pharmacokinetics and Pharmacodynamics of Oral Propranolol in Pediatric Patients With Infantile Hemangioma

Takechi, T., Kumokawa, T., Kato, R., Higuchi, T., Kaneko, T. & Ieiri, I., 10 1 2018, : : Journal of Clinical Pharmacology. 58, 10, p. 1361-1370 10 p.

研究成果: ジャーナルへの寄稿記事

Hemangioma
Propranolol
Pharmacokinetics
Pediatrics
Population

Prolonged stimulation of β2-adrenergic receptor with β2-agonists impairs insulin actions in H9c2 cells

Parichatikanond, W., Nishimura, A., Nishida, M. & Mangmool, S., 11 1 2018, : : Journal of Pharmacological Sciences. 138, 3, p. 184-191 8 p.

研究成果: ジャーナルへの寄稿記事

Adrenergic Receptors
Insulin Resistance
Insulin
Glucose
Smooth Muscle Myocytes

Psychological assessment of acute schizophrenia patients who experienced seclusion either alone or in combination with restraint

Eguchi, R., Onozuka, D., Ikeda, K., Kuroda, K., Ieiri, I. & Hagihara, A., 5 1 2018, : : International Journal of Psychiatry in Medicine. 53, 3, p. 171-188 18 p.

研究成果: ジャーナルへの寄稿記事

Schizophrenia
Psychiatry
Psychology
Brief Psychiatric Rating Scale
Hostility
4 引用 (Scopus)

Reactive Cysteine Persulphides: Occurrence, Biosynthesis, Antioxidant Activity, Methodologies, and Bacterial Persulphide Signalling

Sawa, T., Ono, K., Tsutsuki, H., Zhang, T., Ida, T., Nishida, M. & Akaike, T., 1 1 2018, Nitric Oxide and Other Small Signalling Molecules. Poole, R. K. (版). Academic Press, p. 1-28 28 p. (Advances in Microbial Physiology; 巻数 72).

研究成果: 著書/レポートタイプへの貢献

Antioxidants
Sulfur
Cysteine
Homocysteine
Coenzyme A

Recent Developments in Electron Spin Science and Technology in Japan

Nakamura, T., Ikoma, T. & Yamada, K. I., 8 1 2018, : : Applied Magnetic Resonance. 49, 8, p. 755-756 2 p.

研究成果: ジャーナルへの寄稿編集

electron spin
Japan
2 引用 (Scopus)
CpG Islands
DNA Methylation
Liver
Proteins
Messenger RNA
1 引用 (Scopus)
oxaliplatin
Riluzole
Hyperalgesia
Spinal Ganglia
Oxalates
3 引用 (Scopus)
Intravenous Administration
Nanoparticles
Pharmacokinetics
Placebos
Research Personnel
5 引用 (Scopus)

Sensitive detection of fluorescence in western blotting by merging images

Kondo, Y., Higa, S., Iwasaki, T., Matsumoto, T., Maehara, K., Harada, A., Baba, Y., Fujita, M. & Ohkawa, Y., 1 2018, : : PloS one. 13, 1, e0191532.

研究成果: ジャーナルへの寄稿記事

Merging
Western blotting
Fluorescence
Western Blotting
fluorescence
2 引用 (Scopus)
Glycosides
Immunosorbents
Monoclonal antibodies
Assays
Enzymes
1 引用 (Scopus)

Sequential actions of immune effector cells induced by viral activation of dendritic cells to eliminate murine neuroblastoma

Kawakubo, N., Tanaka, S., Kinoshita, Y., Tajiri, T., Yonemitsu, Y. & Taguchi, T., 8 2018, : : Journal of Pediatric Surgery. 53, 8, p. 1615-1620 6 p.

研究成果: ジャーナルへの寄稿記事

Virus Activation
Neuroblastoma
Dendritic Cells
Radiation
Natural Killer Cells
3 引用 (Scopus)
Leukemia
Derivatives
Cephalotaxus
Immunosorbents
Acute Promyelocytic Leukemia

Stable and selective antiparallel type triplex DNA formation by targeting a GC base pair with the TFO containing one N2-phenyl-2-deoxyguanosine

Taniguchi, Y., Miyazaki, M., Matsueda, N., Wang, L., Okamura, H. & Sasaki, S., 1 1 2018, : : Chemical and Pharmaceutical Bulletin. 66, 6, p. 624-631 8 p.

研究成果: ジャーナルへの寄稿記事

Deoxyguanosine
Oligonucleotides
Base Pairing
DNA
Gene expression
8 引用 (Scopus)

Strategy for Catalytic Chemoselective Cross-Enolate Coupling Reaction via a Transient Homocoupling Dimer

Tanaka, T., Tanaka, T., Tsuji, T., Yazaki, R. & Ohshima, T., 6 15 2018, : : Organic Letters. 20, 12, p. 3541-3544 4 p.

研究成果: ジャーナルへの寄稿記事

cross coupling
Catalysis
Dimers
catalysis
Bearings (structural)

Structural and enzymatic properties of mammalian D-glutamate cyclase

Katane, M., Ariyoshi, M., Tateishi, S., Koiwai, S., Takaku, K., Nagai, K., Nakayama, K., Saitoh, Y., Miyamoto, T., Sekine, M., Mita, M., Hamase, K., Matoba, S. & Homma, H., 9 15 2018, : : Archives of Biochemistry and Biophysics. 654, p. 10-18 9 p.

研究成果: ジャーナルへの寄稿記事

Proline
Glutamic Acid
Heart Failure
D-glutamate cyclase
Oligomerization
2 引用 (Scopus)

Structure–function analyses of a stereotypic rheumatoid factor unravel the structural basis for germline-encoded antibody autoreactivity

Shiroishi, M., Ito, Y., Shimokawa, K., Lee, J. M., Kusakabe, T. & Ueda, T., 1 1 2018, : : Journal of Biological Chemistry. 293, 18, p. 7008-7016 9 p.

研究成果: ジャーナルへの寄稿記事

Rheumatoid Factor
Antibodies
Complementarity Determining Regions
Hematologic Diseases
Immunoglobulin G
2 引用 (Scopus)

Synthesis of azaheterocycles and related molecules by Tf2NH-catalyzed cycloadditions

Shindo, N. & Takasu, K., 1 1 2018, : : Heterocycles. 96, 2, p. 195-212 18 p.

研究成果: ジャーナルへの寄稿記事

Cycloaddition
Cycloaddition Reaction
Nitrogen
Nitrogen Compounds
Molecules

Synthesis of dendritic bisphosphonates as bone targeting ligands

Shimoda, K., Mitsuoka, T., Ueda, K., Suemune, H., Hirai, G. & Aso, M., 12 19 2018, : : Tetrahedron Letters. 59, 51, p. 4528-4531 4 p.

研究成果: ジャーナルへの寄稿記事

Diphosphonates
Bone
Ligands
Bone and Bones
Durapatite

Synthetic Method for 2′-Amino-LNA Bearing Any of the Four Nucleobases via a Transglycosylation Reaction

Sawamoto, H., Arai, Y., Yamakoshi, S., Obika, S. & Kawanishi, E., 4 6 2018, : : Organic Letters. 20, 7, p. 1928-1931 4 p.

研究成果: ジャーナルへの寄稿記事

Bearings (structural)
5-Methylcytosine
Thymine
Guanine
nucleic acids
6 引用 (Scopus)

Temporal kinetics of microgliosis in the spinal dorsal horn after peripheral nerve injury in rodents

Kohno, K., Kitano, J., Koro, Y., Saitoh, H., Inoue, K. & Makoto, T., 1 1 2018, : : Biological and Pharmaceutical Bulletin. 41, 7, p. 1096-1102 7 p.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Rodentia
Microglia
Neuralgia
S Phase
3 引用 (Scopus)

Terpenoid glycosides from the root's barks of Eriocoelum microspermum Radlk. ex Engl.

Pertuit, D., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C., Delaude, C. & Lacaille-Dubois, M. A., 8 1 2018, : : Phytochemistry. 152, p. 182-190 9 p.

研究成果: ジャーナルへの寄稿記事

Terpenes
Glycosides
terpenoids
glycosides
bark

The aryl hydrocarbon receptor is indispensable for dioxin-induced defects in sexually-dimorphic behaviors due to the reduction in fetal steroidogenesis of the pituitary-gonadal axis in rats

Hattori, Y., Takeda, T., Nakamura, A., Nishida, K., Shioji, Y., Fukumitsu, H., Yamada, H. & Ishii, Y., 8 1 2018, : : Biochemical Pharmacology. 154, p. 213-221 9 p.

研究成果: ジャーナルへの寄稿記事

Multifetal Pregnancy Reduction
Aryl Hydrocarbon Receptors
Dioxins
Rats
Defects