研究成果 1976 2019

2017
10 引用 (Scopus)

Uncovering the arrhythmogenic potential of TRPM4 activation in atrial-derived HL-1 cells using novel recording and numerical approaches

Hu, Y., Duan, Y., Takeuchi, A., Hai-Kurahara, L., Ichikawa, J., Hiraishi, K., Numata, T., Ohara, H., Iribe, G., Nakaya, M., Mori, M. X., Matsuoka, S., Ma, G. & Inoue, R., 8 1 2017, : : Cardiovascular research. 113, 10, p. 1243-1255 13 p.

研究成果: ジャーナルへの寄稿記事

Action Potentials
Ionomycin
Transient Receptor Potential Channels
Patch-Clamp Techniques
Cardiac Myocytes
5 引用 (Scopus)

Uniqueness of Entamoeba sulfur metabolism: sulfolipid metabolism that plays pleiotropic roles in the parasitic life cycle

Mi-ichi, F., Miyamoto, T. & Yoshida, H., 11 1 2017, : : Molecular Microbiology. 106, 3, p. 479-491 13 p.

研究成果: ジャーナルへの寄稿記事

Entamoeba
Life Cycle Stages
Sulfur
Sulfatases
Sulfotransferases
11 引用 (Scopus)

Vancomycin induces reactive oxygen species-dependent apoptosis via mitochondrial cardiolipin peroxidation in renal tubular epithelial cells

Sakamoto, Y., Yano, T., Hanada, Y., Takeshita, A., Inagaki, F., Masuda, S., Matsunaga, N., Koyanagi, S. & Ohdo, S., 1 1 2017, : : European Journal of Pharmacology. 800, p. 48-56 9 p.

研究成果: ジャーナルへの寄稿記事

Cardiolipins
Vancomycin
Reactive Oxygen Species
Epithelial Cells
Apoptosis
3 引用 (Scopus)

Water-Proton Relaxivities of Radical Nanoparticles Self-Assembled via Hydration or Dehydration Processes

Morishita, K., Okamoto, Y., Murayama, S., Usui, K., Ohashi, E., Hirai, G., Aoki, I. & Karasawa, S., 8 8 2017, : : Langmuir. 33, 31, p. 7810-7817 8 p.

研究成果: ジャーナルへの寄稿記事

Dehydration
dehydration
Hydration
hydration
Protons

X-ray crystal structure of Escherichia coli HspQ, a protein involved in the retardation of replication initiation

Abe, Y., Shioi, S., Kita, S., Nakata, H., Maenaka, K., Kohda, D., Katayama, T. & Ueda, T., 11 2017, : : FEBS Letters. 591, 22, p. 3805-3816 12 p.

研究成果: ジャーナルへの寄稿レター

Crystal structure
X-Rays
X rays
Heat-Shock Proteins
Proteins

リゾチームの触媒機構:無脊椎動物型とニワトリ型の比較から

阿部義人, 2017, : : 生物物理. 57, 3, p. 140-143 4 p.

研究成果: ジャーナルへの寄稿記事

Muramidase
Acetylglucosamine
Oligomers
Invertebrates
Hydrolysis
4 引用 (Scopus)

α-Lipoic acid potentially targets AMP-activated protein kinase and energy production in the fetal brain to ameliorate dioxin-produced attenuation in fetal steroidogenesis

Takeda, T., Matsuo, Y., Nishida, K., Fujiki, A., Hattori, Y., Koga, T., Ishii, Y. & Yamada, H., 1 1 2017, : : Journal of Toxicological Sciences. 42, 1, p. 13-23 11 p.

研究成果: ジャーナルへの寄稿記事

Thioctic Acid
AMP-Activated Protein Kinases
Dioxins
Citric Acid Cycle
Brain
12 引用 (Scopus)

β-Adrenergic receptor and insulin resistance in the heart

Mangmool, S., Denkaew, T., Parichatikanond, W. & Kurose, H., 1 2017, : : Biomolecules and Therapeutics. 25, 1, p. 44-56 13 p.

研究成果: ジャーナルへの寄稿記事

Adrenergic Receptors
Insulin Resistance
Insulin
Heart Failure
Sympathetic Nervous System

螺旋空間を利用した新規不斉リン配位子の開発と不斉触媒反応への応用

Usui, K., 11 1 2017, : : Yakugaku Zasshi. 137, 11, p. 1381-1390 10 p.

研究成果: ジャーナルへの寄稿記事

phosphine
Ligands
Indoles
Synthetic Chemistry Techniques
Acetates
2016
7 引用 (Scopus)

3- and 4-(α-diazobenzyl)pyridine-: N -oxides as photoresponsive magnetic couplers for 2p-4f heterospin systems: Formation of carbene-TbIII and carbene-DyIII single-molecule magnets

Murashima, K., Karasawa, S., Yoza, K., Inagaki, Y. & Koga, N., 4 28 2016, : : Dalton Transactions. 45, 16, p. 7067-7077 11 p.

研究成果: ジャーナルへの寄稿記事

Magnets
Irradiation
Molecules
Magnetic relaxation
Magnetic couplings
6 引用 (Scopus)

Ablation of aldehyde reductase aggravates carbon tetrachloride-induced acute hepatic injury involving oxidative stress and endoplasmic reticulum stress

Akihara, R., Homma, T., Lee, J., Yamada, K-I., Miyata, S. & Fujii, J., 9 16 2016, : : Biochemical and Biophysical Research Communications. 478, 2, p. 765-771 7 p.

研究成果: ジャーナルへの寄稿記事

Aldehyde Reductase
Endoplasmic Reticulum Stress
Oxidative stress
Carbon Tetrachloride
Ablation
3 引用 (Scopus)

Adhesive Dimerization of Human P-Cadherin Catalyzed by a Chaperone-like Mechanism

Kudo, S., Caaveiro, J. M. M. & Tsumoto, K., 9 6 2016, : : Structure. 24, 9, p. 1523-1536 14 p.

研究成果: ジャーナルへの寄稿記事

Dimerization
Cadherins
Adhesives
Motion Pictures
Thermodynamics
16 引用 (Scopus)

A highly stable but highly reactive zinc catalyst for transesterification supported by a bis(imidazole) ligand

Nakatake, D., Yokote, Y., Matsushima, Y., Yazaki, R. & Ohshima, T., 3 21 2016, : : Green Chemistry. 18, 6, p. 1524-1530 7 p.

研究成果: ジャーナルへの寄稿記事

Transesterification
ligand
Zinc
zinc
catalyst
11 引用 (Scopus)

Alterations of hepatic metabolism in chronic kidney disease via D-box-binding protein aggravate the renal dysfunction

Hamamura, K., Matsunaga, N., Ikeda, E., Kondo, H., Ikeyama, H., Tokushige, K., Itcho, K., Furuichi, Y., Yoshida, Y., Matsuda, M., Yasuda, K., Doi, A., Yokota, Y., Amamoto, T., Aramaki, H., Irino, Y., Koyanagi, S. & Ohdo, S., 3 4 2016, : : Journal of Biological Chemistry. 291, 10, p. 4913-4927 15 p.

研究成果: ジャーナルへの寄稿記事

Vitamin A
Chronic Renal Insufficiency
Metabolism
Carrier Proteins
Kidney
8 引用 (Scopus)
Deoxycytidine
DNA
Genes
Derivatives
Oligonucleotides
1 引用 (Scopus)

An Enzyme-linked Immunosorbent Assay for Genistein 7-O-[α-rhamnopyranosyl-(1→6)]-β-glucopyranoside Determination in Derris scandens using a Polyclonal Antibody

Jutathis, K., Kitisripanya, T., Udomsin, O., Inyai, C., Sritularak, B., Tanaka, H. & Putalun, W., 11 1 2016, : : Phytochemical Analysis. 27, 6, p. 336-342 7 p.

研究成果: ジャーナルへの寄稿記事

Derris
Immunosorbents
Genistein
genistein
polyclonal antibodies

A new approach of indirect enzyme-linked immunosorbent assay for determination of D-glutamic acid through in situ conjugation

Sakamoto, S., Nagamitsu, R., Matsuura, Y., Tsuneura, Y., Kurose, H., Tanaka, H. & Morimoto, S., 5 3 2016, : : Journal of Immunoassay and Immunochemistry. 37, 3, p. 296-306 11 p.

研究成果: ジャーナルへの寄稿記事

Immunosorbents
Glutamic Acid
Anti-Idiotypic Antibodies
Assays
Haptens
12 引用 (Scopus)

A novel class of plant type III polyketide synthase involved in orsellinic acid biosynthesis from Rhododendron dauricum

Taura, F., Iijima, M., Yamanaka, E., Takahashi, H., Kenmoku, H., Saeki, H., Morimoto, S., Asakawa, Y., Kurosaki, F. & Morita, H., 9 27 2016, : : Frontiers in Plant Science. 7, September2016, 1452.

研究成果: ジャーナルへの寄稿記事

polyketide synthases
Rhododendron
biosynthesis
acids
Cannabis sativa
20 引用 (Scopus)

A novel DPP-4 inhibitor teneligliptin scavenges hydroxyl radicals: In vitro study evaluated by electron spin resonance spectroscopy and in vivo study using DPP-4 deficient rats

Kimura, S., Inoguchi, T., Yamasaki, T., Yamato, M., Ide, M., Sonoda, N., Yamada, K. & Takayanagi, R., 3 1 2016, : : Metabolism: Clinical and Experimental. 65, 3, p. 138-145 8 p.

研究成果: ジャーナルへの寄稿記事

Dipeptidyl-Peptidase IV Inhibitors
Electron Spin Resonance Spectroscopy
Hydroxyl Radical
Dipeptidyl Peptidase 4
Experimental Diabetes Mellitus
33 引用 (Scopus)

A novel P2X4 receptor-selective antagonist produces anti-allodynic effect in a mouse model of herpetic pain

Matsumura, Y., Yamashita, T., Sasaki, A., Nakata, E., Kohno, K., Masuda, T., Tozaki-Saitoh, H., Imai, T., Kuraishi, Y., Tsuda, M. & Inoue, K., 8 31 2016, : : Scientific reports. 6, 32461.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Chronic Pain
Acute Pain
Pain
Down-Regulation
7 引用 (Scopus)

Anti-miroestrol polyclonal antibodies: A comparison of immunogen preparations used to obtain desired antibody properties

Kitisripanya, T., Jutathis, K., Inyai, C., Komaikul, J., Udomsin, O., Yusakul, G., Tanaka, H. & Putalun, W., 4 1 2016, : : Journal of Natural Medicines. 70, 2, p. 296-299 4 p.

研究成果: ジャーナルへの寄稿記事

Antibodies
Immunoassay
Pueraria
Quality Control
Quality control
1 引用 (Scopus)

Application of Monoclonal Antibodies Against Ginsenosides in the Field of Ginseng Studies

Tung, N. H., Chao, Z., Tanaka, H. & Shoyama, Y., 1 1 2016, Studies in Natural Products Chemistry. Elsevier B.V., p. 265-278 14 p. (Studies in Natural Products Chemistry; 巻数 49).

研究成果: 著書/レポートタイプへの貢献

Ginsenosides
Panax
Monoclonal Antibodies
Materia Medica
Thin layer chromatography
5 引用 (Scopus)

A profluorescent nitroxide probe for ascorbic acid detection and its application to quantitative analysis of diabetic rat plasma

Matsuoka, Y., Ohkubo, K., Yamasaki, T., Yamato, M., Ohtabu, H., Shirouzu, T., Fukuzumi, S. & Yamada, K. I., 1 1 2016, : : RSC Advances. 6, 65, p. 60907-60915 9 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic acid
Ascorbic Acid
Rats
Plasmas
Chemical analysis
14 引用 (Scopus)

Ascorbic acid prevents acetaminophen-induced hepatotoxicity in mice by ameliorating glutathione recovery and autophagy

Kurahashi, T., Lee, J., Nabeshima, A., Homma, T., Kang, E. S., Saito, Y., Yamada, S., Nakayama, T., Yamada, K. I., Miyata, S. & Fujii, J., 8 15 2016, : : Archives of Biochemistry and Biophysics. 604, p. 36-46 11 p.

研究成果: ジャーナルへの寄稿記事

Autophagy
Acetaminophen
Ascorbic Acid
Glutathione
Recovery
14 引用 (Scopus)

Atomic structure of an archaeal GAN suggests its dual roles as an exonuclease in DNA repair and a CMG component in DNA replication

Oyama, T., Ishino, S., Shirai, T., Yamagami, T., Nagata, M., Ogino, H., Kusunoki, M. & Ishino, Y., 11 2 2016, : : Nucleic acids research. 44, 19, p. 9505-9517 13 p.

研究成果: ジャーナルへの寄稿記事

DNA Replication
Chromosomes
Maintenance
Archaeal DNA
Thermococcus
Kampo Medicine
Body Composition
Electric Impedance
Edema
Muscles
18 引用 (Scopus)

Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury

Tashima, R., Mikuriya, S., Tomiyama, D., Shiratori-Hayashi, M., Yamashita, T., Kohro, Y., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., 3 23 2016, : : Scientific reports. 6, 23701.

研究成果: ジャーナルへの寄稿記事

Peripheral Nerve Injuries
Microglia
Bone Marrow Cells
Population
Spinal Cord
3 引用 (Scopus)

Brain contrasting ability of blood-brain-barrier–permeable nitroxyl contrast agents for magnetic resonance redox imaging

Matsumoto, K. I., Yamasaki, T., Nakamura, M., Ishikawa, J., Ueno, M., Nakanishi, I., Sekita, A., Ozawa, Y., Kamada, T., Aoki, I. & Yamada, K-I., 9 1 2016, : : Magnetic Resonance in Medicine. 76, 3, p. 935-945 11 p.

研究成果: ジャーナルへの寄稿記事

Contrast Media
Oxidation-Reduction
Magnetic Resonance Imaging
Brain
Pharmacokinetics
6 引用 (Scopus)

BubR1 Insufficiency Results in Decreased Macrophage Proliferation and Attenuated Atherogenesis in Apolipoprotein E-Deficient Mice

Tanaka, S., Matsumoto, T., Matsubara, Y., Harada, Y., Kyuragi, R., Koga, J. I., Egashira, K., Nakashima, Y., Yonemitsu, Y. & Maehara, Y., 9 2016, : : Journal of the American Heart Association. 5, 9, e004081.

研究成果: ジャーナルへの寄稿記事

Apolipoproteins E
Atherosclerosis
Macrophages
Bone Marrow Cells
Bone Marrow
8 引用 (Scopus)

Cell Surface-Anchored Fluorescent Probe Capable of Real-Time Imaging of Single Mast Cell Degranulation Based on Histamine-Induced Coordination Displacement

Oshikawa, Y., Furuta, K., Tanaka, S. & Ojida, A., 2 2 2016, : : Analytical chemistry. 88, 3, p. 1526-1529 4 p.

研究成果: ジャーナルへの寄稿記事

Fluorescent Dyes
Histamine
Imaging techniques
Fluorescence
Coloring Agents

Chamical biology for pharmaceutical sciences-novel approaches for exploring cellular functions with non-drug chemicals

Ojida, A. & Nakagawa, H., 1 1 2016, : : Yakugaku Zasshi. 136, 1, 1 p.

研究成果: ジャーナルへの寄稿編集

Molecular Probes
Cell Physiological Phenomena
Pharmaceutical Chemistry
Biological Science Disciplines
Drug Discovery

Chapter 5: Pharmacogenomics of Drug Transporters: Clinical Implications

Ieiri, I., 1 1 2016, Privileged Scaffolds in Medicinal Chemistry: Design, Synthesis, Evaluation. 55 版 Royal Society of Chemistry, p. 114-142 29 p. (RSC Drug Discovery Series; 巻数 2016-January, 番号 55).

研究成果: 著書/レポートタイプへの貢献

Pharmacogenetics
P-Glycoprotein
Pharmaceutical Preparations
Pharmacokinetics
Genes
13 引用 (Scopus)

Characterization and regulation of expression of an antifungal peptide from hemolymph of an insect, Manduca sexta

Al Souhail, Q., Hiromasa, Y., Rahnamaeian, M., Giraldo, M. C., Takahashi, D., Valent, B., Vilcinskas, A. & Kanost, M. R., 8 1 2016, : : Developmental and Comparative Immunology. 61, p. 258-268 11 p.

研究成果: ジャーナルへの寄稿記事

Manduca
Hemolymph
Insects
Fat Body
Peptides
10 引用 (Scopus)
Unsaturated compounds
Click Chemistry
Amino Alcohols
Azides
Catalysis
4 引用 (Scopus)
Transesterification
alkoxides
acrylates
Zinc
monomers
48 引用 (Scopus)

Chiral amino acid metabolomics for novel biomarker screening in the prognosis of chronic kidney disease

Kimura, T., Hamase, K., Miyoshi, Y., Yamamoto, R., Yasuda, K., Mita, M., Rakugi, H., Hayashi, T. & Isaka, Y., 5 18 2016, : : Scientific reports. 6, 26137.

研究成果: ジャーナルへの寄稿記事

Metabolomics
Chronic Renal Insufficiency
Biomarkers
Amino Acids
Kidney Diseases
7 引用 (Scopus)

Chromosomal location of the DnaA-reactivating sequence DARS2 is important to regulate timely initiation of DNA replication in Escherichia coli

Inoue, Y., Tanaka, H., Kasho, K., Fujimitsu, K., Oshima, T. & Katayama, T., 9 1 2016, : : Genes to Cells. 21, 9, p. 1015-1023 9 p.

研究成果: ジャーナルへの寄稿記事

DNA Replication
Adenosine Triphosphate
Escherichia coli
Adenosine Diphosphate
Chromosomes
12 引用 (Scopus)

Circadian clock in a mouse colon tumor regulates intracellular iron levels to promote tumor progression

Okazaki, F., Matsunaga, N., Okazaki, H., Azuma, H., Hamamura, K., Tsuruta, A., Tsurudome, Y., Ogino, T., Hara, Y., Suzuki, T., Hyodo, K., Ishihara, H., Kikuchi, H., To, H., Aramaki, H., Koyanagi, S. & Ohdo, S., 3 25 2016, : : Journal of Biological Chemistry. 291, 13, p. 7017-7028 12 p.

研究成果: ジャーナルへの寄稿記事

Circadian Clocks
Tumors
Clocks
Colon
Iron
10 引用 (Scopus)

Circulating intestine-derived exosomal miR-328 in plasma, a possible biomarker for estimating BCRP function in the human intestines

Gotanda, K., Hirota, T., Saito, J., Fukae, M., Egashira, Y., Izumi, N., Deguchi, M., Kimura, M., Matsuki, S., Irie, S. & Ieiri, I., 8 30 2016, : : Scientific reports. 6, 32299.

研究成果: ジャーナルへの寄稿記事

Intestines
Biomarkers
Breast Neoplasms
Proteins
Area Under Curve
22 引用 (Scopus)

Clarification of the mechanism of clopidogrel-mediated drug-drug interaction in a clinical cassette small-dose study and its prediction based on in vitro information

Kim, S. J., Yoshikado, T., Ieiri, I., Maeda, K., Kimura, M., Irie, S., Kusuhara, H. & Sugiyama, Y., 10 2016, : : Drug Metabolism and Disposition. 44, 10, p. 1622-1632 11 p.

研究成果: ジャーナルへの寄稿記事

clopidogrel
repaglinide
pioglitazone
Drug Interactions
Pharmaceutical Preparations
Human Body
Pharmacokinetics
Pharmaceutical Preparations
Renal Elimination
16 引用 (Scopus)

Colloidal gold-based indirect competitive immunochromatographic assay for rapid detection of bioactive isoflavone glycosides daidzin and genistin in soy products

Sakamoto, S., Yusakul, G., Pongkitwitoon, B., Tanaka, H. & Morimoto, S., 8 11 2016, : : Food Chemistry. 194, p. 191-195 5 p.

研究成果: ジャーナルへの寄稿記事

Immunochromatography
daidzin
genistin
immunoaffinity chromatography
Gold Colloid
9 引用 (Scopus)

Comparative characterization of the leaf tissue of physalis alkekengi and physalis peruviana using RNA-seq and metabolite profiling

Fukushima, A., Nakamura, M., Suzuki, H., Yamazaki, M., Knoch, E., Mori, T., Umemoto, N., Morita, M., Hirai, G., Sodeoka, M. & Saito, K., 12 20 2016, : : Frontiers in Plant Science. 7, DECEMBER2016, 1883.

研究成果: ジャーナルへの寄稿記事

Physalis alkekengi
Physalis peruviana
Physalis
unigenes
RNA
19 引用 (Scopus)

C-type Lectin Mincle Recognizes Glucosyl-diacylglycerol of Streptococcus pneumoniae and Plays a Protective Role in Pneumococcal Pneumonia

Behler-Janbeck, F., Takano, T., Maus, R., Stolper, J., Jonigk, D., Tort Tarrés, M., Fuehner, T., Prasse, A., Welte, T., Timmer, M. S. M., Stocker, B. L., Nakanishi, Y., Miyamoto, T., Yamasaki, S. & Maus, U. A., 12 6 2016, : : PLoS pathogens. 12, 12, e1006038.

研究成果: ジャーナルへの寄稿記事

Pneumococcal Pneumonia
C-Type Lectins
Streptococcus pneumoniae
Alveolar Macrophages
Immunity
21 引用 (Scopus)

C-Type Lectin Receptor DCAR Recognizes Mycobacterial Phosphatidyl-Inositol Mannosides to Promote a Th1 Response during Infection

Toyonaga, K., Torigoe, S., Motomura, Y., Kamichi, T., Hayashi, J. M., Morita, Y. S., Noguchi, N., Chuma, Y., Kiyohara, H., Matsuo, K., Tanaka, H., Nakagawa, Y., Sakuma, T., Ohmuraya, M., Yamamoto, T., Umemura, M., Matsuzaki, G., Yoshikai, Y., Yano, I., Miyamoto, T. および1人, Yamasaki, S., 12 20 2016, : : Immunity. 45, 6, p. 1245-1257 13 p.

研究成果: ジャーナルへの寄稿記事

C-Type Lectins
Mycobacterium
Infection
Chemokine CCL2
Monocytes

Cycloartane-Type Saponins from Astragalus tmoleus var. tmoleus

Avunduk, S., Mitaine-Offer, A. C., Miyamoto, T., Tanaka, C. & Lacaille-Dubois, M. A., 1 1 2016, : : Natural Product Communications. 11, 1, p. 37-38 2 p.

研究成果: ジャーナルへの寄稿記事

triterpenoid saponins
Astragalus
Saponins
saponins
skeleton
2 引用 (Scopus)

Demethylation of methylmercury and the enhanced production of formaldehyde in mouse liver

Uchikawa, T., Kanno, T., Maruyama, I., Mori, N., Yasutake, A., Ishii, Y. & Yamada, H., 1 1 2016, : : Journal of Toxicological Sciences. 41, 4, p. 479-487 9 p.

研究成果: ジャーナルへの寄稿記事

Liver
Formaldehyde
Superoxides
Sarcosine
Tissue
6 引用 (Scopus)

Detection of Ganoderic Acid A in Ganoderma lingzhi by an Indirect Competitive Enzyme-Linked Immunosorbent Assay

Sakamoto, S., Kohno, T., Shimizu, K., Tanaka, H. & Morimoto, S., 5 1 2016, : : Planta medica. 82, 8, p. 747-751 5 p.

研究成果: ジャーナルへの寄稿記事

Ganoderma
Reishi
Immunosorbents
Assays
Enzyme-Linked Immunosorbent Assay

Determination of D-amino acids and their distribution in mammals

Miyoshi, Y., Koga, R. & Hamase, K., 1 1 2016, D-Amino Acids: Physiology, Metabolism, and Application. Springer Japan, p. 3-17 15 p.

研究成果: 著書/レポートタイプへの貢献

Mammals
Amino Acids
Enantiomers
Animals
Technology