研究成果 1976 2019

2016

Development of a functional contrast agent for targeting lipid-derived radicals

Yamada, K. I., 1 1 2016, : : Yakugaku Zasshi. 136, 8, p. 1093-1100 8 p.

研究成果: ジャーナルへの寄稿評論記事

Contrast Media
Lipids
Electrons
Oxidative Stress
Fluorescence

Development of fluorescence sensing mechanism for cell functional analysis

Ojida, A. & Takashima, I., 1 1 2016, : : Yakugaku Zasshi. 136, 1, p. 3-7 5 p.

研究成果: ジャーナルへの寄稿評論記事

Fluorescent Dyes
Fluorescence
Metals
Ions
Biological Phenomena
10 引用 (Scopus)

Development of pH-Responsive BODIPY Probes for Staining Late Endosome in Live Cells

Miao, F., Uchinomiya, S., Ni, Y., Chang, Y. T. & Wu, J., 11 1 2016, : : ChemPlusChem. 81, 11, p. 1209-1215 7 p.

研究成果: ジャーナルへの寄稿記事

Coloring Agents
Fluorescent Dyes
Fusion reactions
Cells
Infrared radiation
12 引用 (Scopus)
Zinc
Esters
Transesterification
Amines
Catalyst activity
7 引用 (Scopus)

Diacylglycerol kinase ζ generates dipalmitoyl-phosphatidic acid species during neuroblastoma cell differentiation

Mizuno, S., Kado, S., Goto, K., Takahashi, D. & Sakane, F., 12 2016, : : Biochemistry and Biophysics Reports. 8, p. 352-359 8 p.

研究成果: ジャーナルへの寄稿記事

Diacylglycerol Kinase
Phosphatidic Acids
Neuroblastoma
Cell Differentiation
Tretinoin
8 引用 (Scopus)

Diethylenetriamine-Mediated Direct Cleavage of Unactivated Carbamates and Ureas

Noshita, M., Shimizu, Y., Morimoto, H. & Ohshima, T., 12 2 2016, : : Organic Letters. 18, 23, p. 6062-6065 4 p.

研究成果: ジャーナルへの寄稿記事

Carbamates
ureas
Urea
cleavage
Amides
11 引用 (Scopus)

Differential Effect of Membrane Composition on the Pore-Forming Ability of Four Different Sea Anemone Actinoporins

García-Linares, S., Rivera-De-Torre, E., Morante, K., Tsumoto, K., Caaveiro, J. M. M., Gavilanes, J. G., Slotte, J. P. & Martínez-Del-Pozo, Á., 12 6 2016, : : Biochemistry. 55, 48, p. 6630-6641 12 p.

研究成果: ジャーナルへの寄稿記事

Sea Anemones
Aptitude
Sphingomyelins
Membranes
Chemical analysis
9 引用 (Scopus)

Different roles of negative and positive components of the circadian clock in oncogene-induced neoplastic transformation

Katamune, C., Koyanagi, S., Shiromizu, S., Matsunaga, N., Shimba, S., Shibata, S. & Ohdo, S., 5 13 2016, : : Journal of Biological Chemistry. 291, 20, p. 10541-10550 10 p.

研究成果: ジャーナルへの寄稿記事

Circadian Clocks
Oncogenes
Clocks
Cell Aging
Fibroblasts
36 引用 (Scopus)
Amination
Amino acids
Derivatives
Catalysis
Amino Acids
8 引用 (Scopus)

DNA cleavage at the AP site via β-elimination mediated by the AP site-binding ligands

Abe, Y. S. & Sasaki, S., 2 15 2016, : : Bioorganic and Medicinal Chemistry. 24, 4, p. 910-914 5 p.

研究成果: ジャーナルへの寄稿記事

DNA Cleavage
Binding Sites
Ligands
DNA
Alkylating Agents
49 引用 (Scopus)

Dorsal horn neurons release extracellular ATP in a VNUT-dependent manner that underlies neuropathic pain

Masuda, T., Ozono, Y., Mikuriya, S., Kohro, Y., Tozaki-Saitoh, H., Iwatsuki, K., Uneyama, H., Ichikawa, R., Salter, M. W., Tsuda, M. & Inoue, K., 8 12 2016, : : Nature communications. 7, 12529.

研究成果: ジャーナルへの寄稿記事

Posterior Horn Cells
transporter
pain
adenosine triphosphate
nucleotides
19 引用 (Scopus)

Duloxetine inhibits microglial P2X4 receptor function and alleviates neuropathic pain after peripheral nerve injury

Yamashita, T., Yamamoto, S., Zhang, J., Kometani, M., Tomiyama, D., Kohno, K., Tozaki-Saitoh, H., Inoue, K. & Tsuda, M., 10 2016, : : PloS one. 11, 10, e0165189.

研究成果: ジャーナルへの寄稿記事

Purinergic P2X4 Receptors
Peripheral Nerve Injuries
peripheral nerves
Neuralgia
pain

Dysfunction of Glial Cells in Neurological and Psychological Disorders: From Bench to Bedside

Katafuchi, T. & Noda, M., 1 1 2016, : : Advances in Neuroimmune Biology. 6, 2, p. 59-60 2 p.

研究成果: ジャーナルへの寄稿編集

Nervous System Diseases
Neuroglia
Psychology
9 引用 (Scopus)

Dysfunction of glutamate receptors in microglia may cause neurodegeneration

Noda, M., 4 1 2016, : : Current Alzheimer Research. 13, 4, p. 381-386 6 p.

研究成果: ジャーナルへの寄稿記事

Glutamate Receptors
Microglia
Isoxazoles
Propionates
Ionotropic Glutamate Receptors
6 引用 (Scopus)

Effect of linker length between variable domains of single chain variable fragment antibody against daidzin on its reactivity

Yusakul, G., Sakamoto, S., Pongkitwitoon, B., Tanaka, H. & Morimoto, S., 1 1 2016, : : Bioscience, Biotechnology and Biochemistry. 80, 7, p. 1306-1312 7 p.

研究成果: ジャーナルへの寄稿記事

Single-Chain Antibodies
Bombyx
Nucleopolyhedrovirus
Immunosorbents
Peptides

Effect of patient education for diabetic outpatients by a hospital pharmacist: A retrospective study

Ichiki, Y., Kobayashi, D., Kubota, T., Ozono, S., Murakami, A., Yamakawa, Y., Zeki, K. & Shimazoe, T., 1 1 2016, : : Yakugaku Zasshi. 136, 12, p. 1667-1674 8 p.

研究成果: ジャーナルへの寄稿コメント/討論

Patient Education
Pharmacists
Outpatients
Retrospective Studies
Education
3 引用 (Scopus)

Effect on catalysis by replacement of catalytic residue from hen egg white lysozyme to Venerupis philippinarum lysozyme*

Abe, Y., Kubota, M., Takazaki, S., Ito, Y., Yamamoto, H., Kang, D., Ueda, T. & Imoto, T., 9 1 2016, : : Protein Science. p. 1637-1647 11 p.

研究成果: ジャーナルへの寄稿記事

Egg White
Muramidase
Catalysis
Acetylglucosamine
Decomposition
4 引用 (Scopus)
Epidemiologic Effect Modifiers
Cell proliferation
DNA-Directed DNA Polymerase
Cell Proliferation
Halogens
3 引用 (Scopus)

Effects on deaf patients of medication education by pharmacists

Hyoguchi, N., Kobayashi, D., Kubota, T. & Shimazoe, T., 10 1 2016, : : Journal of Deaf Studies and Deaf Education. 21, 4, p. 416-421 6 p.

研究成果: ジャーナルへの寄稿記事

pharmacist
Patient Education
Pharmacists
Hearing
medication
5 引用 (Scopus)
Nucleopolyhedrovirus
Single-Chain Antibodies
Bombyx
Paclitaxel
docetaxel
2 引用 (Scopus)
Deoxyribose
Thioguanine
Crosslinking
Thymidine
Nucleic Acids

Emission characteristics of paliperidone from invega™ tablets in one-dose packages and the evaluation of patients

Kito, H., Ishida, Y., Kunimi, M., Morooka, Y., Hirowatari, T., Akamine, T., Hashimoto, H., Koyanagi, S., Ohdo, S. & Kamimura, H., 1 1 2016, : : Japanese Pharmacology and Therapeutics. 44, 1, p. 65-69 5 p.

研究成果: ジャーナルへの寄稿記事

Tablets
Delayed-Action Preparations
Medication Adherence
Paliperidone Palmitate
Osmotic Pressure
14 引用 (Scopus)

Enantioselective determination of citrulline and ornithine in the urine of D-amino acid oxidase deficient mice using a two-dimensional high-performance liquid chromatographic system

Koga, R., Miyoshi, Y., Sato, Y., Mita, M., Konno, R., Lindner, W. & Hamase, K., 10 7 2016, : : Journal of Chromatography A. 1467, p. 312-317 6 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
Citrulline
Ornithine
Enantiomers
Urine

Enzyme Immunoassay for Salvinorin A (a Main Component in Salvia divinorum)

Tanaka, H., Paudel, M. K., Shirota, O., Tabata, K., Sekita, S. & Morimoto, S., 4 15 2016, Stimulants, Club and Dissociative Drugs, Hallucinogens, Steroids, Inhalants and International Aspects. Elsevier Inc., 巻 2. p. 749-756 8 p.

研究成果: 著書/レポートタイプへの貢献

salvinorin A
Salvia
Mentha
Lamiaceae
Plant Extracts
3 引用 (Scopus)

Ephedrae herba stimulates hepatocyte growth factor-induced MET endocytosis and downregulation via early/late endocytic pathways in gefitinib-resistant human lung cancer cells

Nishimura, Y., Hyuga, S., Takiguchi, S., Hyuga, M., Itoh, K. & Hanawa, T., 5 2016, : : International journal of oncology. 48, 5, p. 1895-1906 12 p.

研究成果: ジャーナルへの寄稿記事

Hepatocyte Growth Factor
Endocytosis
Lung Neoplasms
Down-Regulation
Endosomes
10 引用 (Scopus)

Fluorescence probe for the convenient and sensitive detection of ascorbic acid

Matsuoka, Y., Yamato, M. & Yamada, K. I., 1 2016, : : Journal of Clinical Biochemistry and Nutrition. 58, 1, p. 16-22 7 p.

研究成果: ジャーナルへの寄稿評論記事

Ascorbic Acid
Fluorescence
Fluorescent Dyes
Oxidation-Reduction
Electrons
15 引用 (Scopus)

Fluorescence probes to detect lipid-derived radicals

Yamada, K. I., Mito, F., Matsuoka, Y., Ide, S., Shikimachi, K., Fujiki, A., Kusakabe, D., Ishida, Y., Enoki, M., Tada, A., Ariyoshi, M., Yamasaki, T. & Yamato, M., 8 1 2016, : : Nature Chemical Biology. 12, 8, p. 608-613 6 p.

研究成果: ジャーナルへの寄稿記事

Fluorescence
Lipids
Diethylnitrosamine
Apoptosis
Inflammation
31 引用 (Scopus)

Glucocorticoid regulation of ATP release from spinal astrocytes underlies diurnal exacerbation of neuropathic mechanical allodynia

Koyanagi, S., Kusunose, N., Taniguchi, M., Akamine, T., Kanado, Y., Ozono, Y., Masuda, T., Kohro, Y., Matsunaga, N., Tsuda, M., Salter, M. W., Inoue, K. & Ohdo, S., 10 14 2016, : : Nature communications. 7, 13102.

研究成果: ジャーナルへの寄稿記事

glucocorticoids
pain
adenosine triphosphate
Hyperalgesia
Astrocytes
13 引用 (Scopus)

Identification of a membrane-bound prepore species clarifies the lytic mechanism of actinoporins

Morante, K., Bellomio, A., Gil-Cartón, D., Redondo-Morata, L., Sot, J., Scheuring, S., Valle, M., González-Mañas, J. M., Tsumoto, K. & Caaveiro, J. M. M., 9 9 2016, : : Journal of Biological Chemistry. 291, 37, p. 19210-19219 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Sea Anemones
Cryoelectron Microscopy
Atomic Force Microscopy
Military operations
Cell membranes
13 引用 (Scopus)

Identification of a Potent and Selective GPR4 Antagonist as a Drug Lead for the Treatment of Myocardial Infarction

Fukuda, H., Ito, S., Watari, K., Mogi, C., Arisawa, M., Okajima, F., Kurose, H. & Shuto, S., 5 12 2016, : : ACS Medicinal Chemistry Letters. 7, 5, p. 493-497 5 p.

研究成果: ジャーナルへの寄稿記事

Lead compounds
Endothelial cells
G-Protein-Coupled Receptors
Myocardial Infarction
Tissue
3 引用 (Scopus)

Identification of immunoglobulin gene sequences from a small read number of mRNA-seq using hybridomas

Kuniyoshi, Y., Maehara, K., Iwasaki, T., Hayashi, M., Semba, Y., Fujita, M., Sato, Y., Kimura, H., Harada, A. & Ohkawa, Y., 10 2016, : : PloS one. 11, 10, e0165473.

研究成果: ジャーナルへの寄稿記事

immunoglobulin genes
Immunoglobulin Genes
hybridomas
Hybridomas
Immunoglobulins
2 引用 (Scopus)

Identification of novel secreted fatty acids that regulate nitrogen catabolite repression in fission yeast

Sun, X., Hirai, G., Ueki, M., Hirota, H., Wang, Q., Hongo, Y., Nakamura, T., Hitora, Y., Takahashi, H., Sodeoka, M., Osada, H., Hamamoto, M., Yoshida, M. & Yashiroda, Y., 2 19 2016, : : Scientific reports. 6, 20856.

研究成果: ジャーナルへの寄稿記事

Catabolite Repression
Schizosaccharomyces
Nitrogen
Fatty Acids
Amino Acids
7 引用 (Scopus)

Immunochromatographic strip assay for detection of bioactive Ganoderma triterpenoid, ganoderic acid A in Ganoderma lingzhi

Sakamoto, S., Kikkawa, N., Kohno, T., Shimizu, K., Tanaka, H. & Morimoto, S., 10 1 2016, : : Fitoterapia. 114, p. 51-55 5 p.

研究成果: ジャーナルへの寄稿記事

Ganoderma
Immunochromatography
Reishi
Agaricales
Gold Colloid
6 引用 (Scopus)

Impaired differentiation of macrophage lineage cells attenuates bone remodeling and inflammatory angiogenesis in Ndrg1 deficient mice

Watari, K., Shibata, T., Nabeshima, H., Shinoda, A., Fukunaga, Y., Kawahara, A., Karasuyama, K., Fukushi, J. I., Iwamoto, Y., Kuwano, M. & Ono, M., 1 18 2016, : : Scientific reports. 6, 19470.

研究成果: ジャーナルへの寄稿記事

Bone Remodeling
Macrophages
Knockout Mice
Genes
Osteoclasts
5 引用 (Scopus)

Improved quality of life in patients with no-option critical limb ischemia undergoing gene therapy with DVC1-0101

Matsumoto, T., Tanaka, M., Yoshiya, K., Yoshiga, R., Matsubara, Y., Horiuchi-Yoshida, K., Yonemitsu, Y. & Maehara, Y., 7 15 2016, : : Scientific reports. 6, 30035.

研究成果: ジャーナルへの寄稿記事

Genetic Therapy
Ischemia
Extremities
Quality of Life
Sendai virus
1 引用 (Scopus)

In-Cell Enzymology to Probe His-Heme Ligation in Heme Oxygenase Catalysis

Sigala, P. A., Morante, K., Tsumoto, K., Caaveiro, J. M. M. & Goldberg, D. E., 8 30 2016, : : Biochemistry. 55, 34, p. 4836-4849 14 p.

研究成果: ジャーナルへの寄稿記事

Heme Oxygenase (Decyclizing)
Catalysis
Heme
Ligation
Biliverdine
4 引用 (Scopus)

Inhibition of G0/G1 Switch 2 Ameliorates Renal Inflammation in Chronic Kidney Disease

Naoya, M., Ikeda, E., Kakimoto, K., Watanabe, M., Shindo, N., Tsuruta, A., Ikeyama, H., Hamamura, K., Higashi, K., Yamashita, T., Kondo, H., Yoshida, Y., Matsuda, M., Ogino, T., Tokushige, K., Itcho, K., Furuichi, Y., Nakao, T., Yasuda, K., Doi, A. および7人, Amamoto, T., Aramaki, H., Makoto, T., Inoue, K., Ojida, A., Satoru, K. & Ohdo, S., 11 1 2016, : : EBioMedicine. 13, p. 262-273 12 p.

研究成果: ジャーナルへの寄稿記事

Chronic Renal Insufficiency
Switches
Inflammation
Kidney
Gene encoding
4 引用 (Scopus)
Derivatives
Antineoplastic Agents
Cell Survival
Cells
Substrates
30 引用 (Scopus)

Interplay between microbial d-amino acids and host d-amino acid oxidase modifies murine mucosal defence and gut microbiota

Sasabe, J., Miyoshi, Y., Rakoff-Nahoum, S., Zhang, T., Mita, M., Davis, B. M., Hamase, K. & Waldor, M. K., 7 25 2016, : : Nature Microbiology. 1, 16125.

研究成果: ジャーナルへの寄稿記事

Oxidoreductases
Amino Acids
Microbiota
Small Intestine
Gastrointestinal Microbiome
8 引用 (Scopus)

Intracellular delivery of chemical probes using a glutathione-responsive traceless tag

Aoyama, E., Fuchida, H., Oshikawa, Y., Uchinomiya, S. & Ojida, A., 1 1 2016, : : Chemical Communications. 52, 49, p. 7715-7718 4 p.

研究成果: ジャーナルへの寄稿記事

Glutathione
Molecules
2 引用 (Scopus)

Introduction of an N-glycosylation site into UDP-glucuronosyltransferase 2B3 alters its sensitivity to cytochrome P450 3A1-dependent modulation

Nakamura, T., Yamaguchi, N., Miyauchi, Y., Takeda, T., Yamazoe, Y., Nagata, K., Mackenzie, P. I., Yamada, H. & Ishii, Y., 11 14 2016, : : Frontiers in Pharmacology. 7, NOV, 427.

研究成果: ジャーナルへの寄稿記事

Glucuronosyltransferase
Glycosylation
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP3A
Hymecromone
5 引用 (Scopus)

Isomeric iodinated analogs of nimesulide: Synthesis, physicochemical characterization, cyclooxygenase-2 inhibitory activity, and transport across Caco-2 cells

Yamamoto, Y., Arai, J., Hisa, T., Saito, Y., Mukai, T., Ohshima, T., Maeda, M. & Yamamoto, F., 1 1 2016, : : Bioorganic and Medicinal Chemistry. 24, 16, p. 3727-3733 7 p.

研究成果: ジャーナルへの寄稿記事

nimesulide
Caco-2 Cells
Cyclooxygenase 2
Brain
Celecoxib
6 引用 (Scopus)

Long inverted repeat transiently stalls DNA replication by forming hairpin structures on both leading and lagging strands

Lai, P. J., Lim, C. T., Le, H. P., Katayama, T., Leach, D. R. F., Furukohri, A. & Maki, H., 2 1 2016, : : Genes to Cells. 21, 2, p. 136-145 10 p.

研究成果: ジャーナルへの寄稿記事

DNA Replication
Cruciform DNA
Plasmids
DNA
Exonucleases
4 引用 (Scopus)

Lung adenocarcinoma may be a more susceptive subtype to a dendritic cell-based cancer vaccine than other subtypes of non-small cell lung cancers: a multicenter retrospective analysis

Takahashi, H., Shimodaira, S., Ogasawara, M., Ota, S., Kobayashi, M., Abe, H., Morita, Y., Nagai, K., Tsujitani, S., Okamoto, M., Suzuki, Y., Nakanishi, Y., Yonemitsu, Y. & for the DC Vaccine Study Group at the Japanese Society of Immunotherapy, T. DC. V. S. G. A. T. J. S. O. I., 9 1 2016, : : Cancer Immunology, Immunotherapy. 65, 9, p. 1099-1111 13 p.

研究成果: ジャーナルへの寄稿記事

Cancer Vaccines
Non-Small Cell Lung Carcinoma
Dendritic Cells
Vaccines
Erythema
NADPH Oxidase
Nicotinic Receptors
Microglia
Nicotine
Protons
30 引用 (Scopus)
Rhodium
Substrates
Alkynes
Acetic acid
Acetic Acid

Memorial address for Dr. Hideyuki Yamada, distinguished professor

Ishii, Y., 10 1 2016, : : Drug Metabolism Reviews. 48, 4, p. 471-472 2 p.

研究成果: ジャーナルへの寄稿評論記事

19 引用 (Scopus)

Methylmercury, an environmental electrophile capable of activation and disruption of the Akt/CREB/Bcl-2 signal transduction pathway in SH-SY5Y cells

Unoki, T., Abiko, Y., Toyama, T., Uehara, T., Tsuboi, K., Nishida, M., Kaji, T. & Kumagai, Y., 6 30 2016, : : Scientific reports. 6, 28944.

研究成果: ジャーナルへの寄稿記事

Signal Transduction
Cell Survival
Apoptosis Regulatory Proteins
Neuroblastoma
Phosphatidylinositol 3-Kinases
50 引用 (Scopus)

Microglia in the spinal cord and neuropathic pain

Tsuda, M., 1 1 2016, : : Journal of Diabetes Investigation. 7, 1, p. 17-26 10 p.

研究成果: ジャーナルへの寄稿記事

Microglia
Neuralgia
Spinal Cord
Purinergic P2X4 Receptors
Pain
2 引用 (Scopus)

Micro-scale and rapid expression screening of highly expressed and/or stable membrane protein variants in Saccharomyces cerevisiae

Shiroishi, M., Moriya, M. & Ueda, T., 10 1 2016, : : Protein Science. p. 1863-1872 10 p.

研究成果: ジャーナルへの寄稿記事

Yeast
Saccharomyces cerevisiae
Screening
Membrane Proteins
Gel Chromatography