別府病院

研究成果 2003 2018

2018
1 引用 (Scopus)

A variant of death-receptor 3 associated with rheumatoid arthritis interferes with apoptosis-induction of T cell

Hashiramoto, A., Konishi, Y., Murayama, K., Kawasaki, H., Yoshida, K., Tsumiyama, K., Tanaka, K., Mizuhara, M., Shiotsuki, T., Kitamura, H., Komai, K., Kimura, T., Yagita, H., Shiozawa, K. & Shiozawa, S., 1 1 2018, : : Journal of Biological Chemistry. 293, 6, p. 1933-1943 11 p.

研究成果: ジャーナルへの寄稿記事

Receptors, Tumor Necrosis Factor, Member 25
T-cells
Rheumatoid Arthritis
Apoptosis
T-Lymphocytes
2016

L'induction précoce de la surexpression de l'interféron-alpha 1 murin in vivo induit une expansion de lymphocytes T régulateurs hautement suppressifs qui protègent contre l'arthrite expérimentale

Matyja, K., Ribon, M., Hervé, R., Lemeiter, D., Tsumiyama, K., Shiozawa, S., Bessis, N., Boissier, M. C. & Decker, P., 11 1 2016, : : Revue du Rhumatisme (Edition Francaise). 83, p. A301-A302

研究成果: ジャーナルへの寄稿記事

Interferon-alpha
Lymphocytes
12 引用 (Scopus)

MMP-3 as a predictor for structural remission in RA patients treated with MTX monotherapy

Shiozawa, K., Yamane, T., Murata, M., Yoshihara, R., Tsumiyama, K., Imura, S. & Shiozawa, S., 2 27 2016, : : Arthritis Research and Therapy. 18, 1, 55.

研究成果: ジャーナルへの寄稿記事

Matrix Metalloproteinase 3
Methotrexate
Rheumatoid Arthritis
Antirheumatic Agents
Serum
2015
3 引用 (Scopus)

Refractory dermatomyositis complicated with myelodysplastic syndrome

Nakanishi, T., Horikoshi, H., Kusanagi, Y., Yamamura, T., Takahashi, R., Kimura, F. & Itoh, K., 10 1 2015, : : Internal Medicine. 54, 19, p. 2507-2511 5 p.

研究成果: ジャーナルへの寄稿記事

Dermatomyositis
Myelodysplastic Syndromes
Interstitial Lung Diseases
Skin Ulcer
Myositis
2014

Clinical utility of an array comparative genomic hybridization analysis for Williams syndrome

Yagihashi, T., Torii, C., Takahashi, R., Omori, M., Kosaki, R., Yoshihashi, H., Ihara, M., Minagawa-Kawai, Y., Yamamoto, J., Takahashi, T. & Kosaki, K., 11 1 2014, : : Congenital Anomalies. 54, 4, p. 225-227 3 p.

研究成果: ジャーナルへの寄稿記事

Williams Syndrome
Comparative Genomic Hybridization
Intellectual Disability
Fluorescence In Situ Hybridization
1 引用 (Scopus)

Induction of de novo autoimmune disease in normal mice upon repeated immunization with antigen

Tsumiyama, K. & Shiozawa, S., 1 1 2014, : : Methods in Molecular Biology. 1142, p. 85-90 6 p.

研究成果: ジャーナルへの寄稿記事

Autoimmunity
Autoimmune Diseases
Immunization
Antigens
Systemic Lupus Erythematosus
16 引用 (Scopus)

SOCS1 and regulation of regulatory T cells plasticity

Takahashi, R. & Yoshimura, A., 1 1 2014, : : Journal of Immunology Research. 2014, 943149.

研究成果: ジャーナルへの寄稿評論記事

Regulatory T-Lymphocytes
Cytokines
Helper-Inducer T-Lymphocytes
Autoimmunity
Autoimmune Diseases
2013
4 引用 (Scopus)

Expansion of PD-1-positive effector CD4 T cells in an experimental model of SLE: Contribution to the self-organized criticality theory

Miyazaki, Y., Tsumiyama, K., Yamane, T., Ito, M. & Shiozawa, S., 4 25 2013, : : Kobe Journal of Medical Sciences. 59, 2

研究成果: ジャーナルへの寄稿記事

Systemic Lupus Erythematosus
Theoretical Models
T-Lymphocytes
Autoantibodies
Antigens
4 引用 (Scopus)

IFN-γ-producing effector CD8 T lymphocytes cause immune glomerular injury by recognizing antigen presented as immune complex on target tissue

Tsumiyama, K., Hashiramoto, A., Takimoto, M., Tsuji-Kawahara, S., Miyazawa, M. & Shiozawa, S., 7 1 2013, : : Journal of Immunology. 191, 1, p. 91-96 6 p.

研究成果: ジャーナルへの寄稿記事

Antigen-Antibody Complex
T-Lymphocytes
Antigens
Wounds and Injuries
Immunization

Self-organized criticality theory and the expansion of PD-1-positive effector CD4 T cells: Search for autoantibody-inducing CD4 T cells

Miyazaki, Y., Tsumiyama, K., Yamane, T., Ito, M. & Shiozawa, S., 9 16 2013, : : Frontiers in Immunology. 4, APR, Article 87.

研究成果: ジャーナルへの寄稿記事

Autoantibodies
T-Lymphocytes
2011
44 引用 (Scopus)

Pathogenesis of joint destruction in rheumatoid arthritis

Shiozawa, S., Tsumiyama, K., Yoshida, K. & Hashiramoto, A., 4 1 2011, : : Archivum Immunologiae et Therapiae Experimentalis. 59, 2, p. 89-95 7 p.

研究成果: ジャーナルへの寄稿評論記事

Transcription Factor AP-1
Interleukin-1
Rheumatoid Arthritis
Joints
Matrix Metalloproteinases
105 引用 (Scopus)

SOCS1 is essential for regulatory T cell functions by preventing loss of Foxp3 expression as well as IFN-γ and IL-17A production

Takahashi, R., Nishimoto, S., Muto, G., Sekiya, T., Tamiya, T., Kimura, A., Morita, R., Asakawa, M., Chinen, T. & Yoshimura, A., 9 26 2011, : : Journal of Experimental Medicine. 208, 10, p. 2055-2067 13 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-17
Regulatory T-Lymphocytes
Cytokines
Antigen-Presenting Cells
Colitis
13 引用 (Scopus)

SOCS1 regulates type I/type II NKT cell balance by regulating IFNγ signaling

Hashimoto, M., Hiwatashi, K., Ichiyama, K., Morita, R., Sekiya, T., Kimura, A., Sugiyama, Y., Sibata, T., Kuroda, K., Takahashi, R. & Yoshimura, A., 3 18 2011, : : International Immunology. 23, 3, p. 165-176 12 p.

研究成果: ジャーナルへの寄稿記事

Natural Killer T-Cells
Cytokines
Knockout Mice
Interleukin-2
Sulfoglycosphingolipids
193 引用 (Scopus)

Suppressors of cytokine signaling (SOCS) proteins and JAK/STAT pathways: Regulation of T-cell inflammation by SOCS1 and SOCS3

Tamiya, T., Kashiwagi, I., Takahashi, R., Yasukawa, H. & Yoshimura, A., 5 1 2011, : : Arteriosclerosis, thrombosis, and vascular biology. 31, 5, p. 980-985 6 p.

研究成果: ジャーナルへの寄稿記事

Suppressor of Cytokine Signaling Proteins
Janus Kinases
Cytokines
Inflammation
T-Lymphocytes
83 引用 (Scopus)

Transcription Factor Smad-Independent T Helper 17 Cell Induction by Transforming-Growth Factor-β Is Mediated by Suppression of Eomesodermin

Ichiyama, K., Sekiya, T., Inoue, N., Tamiya, T., Kashiwagi, I., Kimura, A., Morita, R., Muto, G., Shichita, T., Takahashi, R. & Yoshimura, A., 5 27 2011, : : Immunity. 34, 5, p. 741-754 14 p.

研究成果: ジャーナルへの寄稿記事

Th17 Cells
Transforming Growth Factors
Transcription Factors
JNK Mitogen-Activated Protein Kinases
Cell Differentiation
2010
113 引用 (Scopus)

Mammalian clock gene Cryptochrome regulates arthritis via proinflammatory cytokine TNF-α

Hashiramoto, A., Yamane, T., Tsumiyama, K., Yoshida, K., Komai, K., Yamada, H., Yamazaki, F., Doi, M., Okamura, H. & Shiozawa, S., 2 1 2010, : : Journal of Immunology. 184, 3, p. 1560-1565 6 p.

研究成果: ジャーナルへの寄稿記事

Cryptochromes
Arthritis
Cytokines
Genes
Spleen
2009
46 引用 (Scopus)

Pathogenesis of rheumatoid arthritis and c-Fos/AP-1

Shiozawa, S. & Tsumiyama, K., 5 15 2009, : : Cell Cycle. 8, 10, p. 1539-1543 5 p.

研究成果: ジャーナルへの寄稿評論記事

Transcription Factor AP-1
Rheumatoid Arthritis
Arthritis
Matrix Metalloproteinases
Interleukin-1
5 引用 (Scopus)

Peripheral T cell lymphoma with a high titer of proteinase-3-antineutrophil cytoplasmic antibodies that resembled Wegener's granulomatosis

Shirai, T., Takahashi, R., Tajima, Y., Kohata, K., Yamamoto, J., Fujii, H., Takasawa, N., Ishizawa, K., Ichinohasama, R., Ishii, T. & Harigae, H., 12 1 2009, : : Internal Medicine. 48, 23, p. 2041-2045 5 p.

研究成果: ジャーナルへの寄稿記事

Myeloblastin
Peripheral T-Cell Lymphoma
Antineutrophil Cytoplasmic Antibodies
Granulomatosis with Polyangiitis
Biopsy
4 引用 (Scopus)

Prospective study of methotrexate treatment for rheumatoid arthritis treated legitimately according to the government recommended 8 mg/week dose

Hashiramoto, A., Shiozawa, K., Tanaka, Y., Yamane, T., Murata, M., Tanaka, C., Terashima, Y., Koyama, K., Nakagawa, N., Abe, S., Yoshihara, R., Saegusa, Y., Tsumiyama, K., Komai, K., Sakai, Y. & Shiozawa, S., 12 1 2009, : : Modern Rheumatology. 19, 6, p. 637-642 6 p.

研究成果: ジャーナルへの寄稿記事

Methotrexate
Rheumatoid Arthritis
Prospective Studies
Joints
Signs and Symptoms
30 引用 (Scopus)

Self-organized criticality theory of autoimmunity

Tsumiyama, K., Miyazaki, Y. & Shiozawa, S., 12 1 2009, : : PloS one. 4, 12, e8382.

研究成果: ジャーナルへの寄稿記事

autoimmunity
T-cells
Autoimmunity
T-lymphocytes
Autoantibodies
7 引用 (Scopus)

Sjögren's syndrome patients presenting with hypergammaglobulinemia are relatively unresponsive to cevimeline treatment 13474464

Komai, K., Shiozawa, K., Tanaka, Y., Yoshihara, R., Tanaka, C., Sakai, H., Yamane, T., Murata, M., Tsumiyama, K., Hashiramoto, A. & Shiozawa, S., 5 19 2009, : : Modern Rheumatology. 19, 4, p. 416-419 4 p.

研究成果: ジャーナルへの寄稿記事

Hypergammaglobulinemia
Saliva
Therapeutics
Mouth
cevimeline
2008
21 引用 (Scopus)

Easy and accurate diagnosis of rheumatoid arthritis using anti-cyclic citrullinated peptide 2 antibody, swollen joint count, and C-reactive protein/rheumatoid factor

Yamane, T., Hashiramoto, A., Tanaka, Y., Tsumiyama, K., Miura, Y., Shiozawa, K., Chihara, K. & Shiozawa, S., 3 1 2008, : : Journal of Rheumatology. 35, 3, p. 414-420 7 p.

研究成果: ジャーナルへの寄稿記事

Rheumatoid Factor
C-Reactive Protein
Rheumatoid Arthritis
Joints
Antibodies
23 引用 (Scopus)

Reversible bone marrow dysplasia in patients with systemic lupus erythematosus

Oka, Y., Kameoka, J., Hirabayashi, Y., Takahashi, R., Ishii, T., Sasaki, T. & Harigae, H., 7 11 2008, : : Internal Medicine. 47, 8, p. 737-742 6 p.

研究成果: ジャーナルへの寄稿記事

Developmental Bone Disease
Systemic Lupus Erythematosus
Bone Marrow
Erythroid Cells
Megakaryocytes
2007
7 引用 (Scopus)

A monoclonal antibody against human homocysteine-induced endoplasmic reticulum protein (Herp): A useful tool for evaluating endoplasmic reticulum stress

Oka, Y., Hirabayashi, Y., Ishii, T., Takahashi, R. & Sasaki, T., 7 27 2007, : : Tohoku Journal of Experimental Medicine. 212, 4, p. 431-437 7 p.

研究成果: ジャーナルへの寄稿記事

Endoplasmic Reticulum Stress
Staphylococcal Protein A
Homocysteine
Endoplasmic Reticulum
Monoclonal Antibodies
24 引用 (Scopus)

Angiopoietin 1 directly induces destruction of the rheumatoid joint by cooperative, but independent, signaling via ERK/MAPK and phosphatidylinositol 3-kinase/Akt

Hashiramoto, A., Sakai, C., Yoshida, K., Tsumiyama, K., Miura, Y., Shiozawa, K., Nose, M., Komai, K. & Shiozawa, S., 7 1 2007, : : Arthritis and rheumatism. 56, 7, p. 2170-2179 10 p.

研究成果: ジャーナルへの寄稿記事

Phosphatidylinositol 3-Kinase
Angiopoietin-1
Joints
Synovial Membrane
Western Blotting
4 引用 (Scopus)

A potential trigger of nephritogenic anti-DNA antibodies in lupus nephritis

Hirabayashi, Y., Oka, Y., Tada, M., Takahashi, R. & Ishii, T., 1 1 2007, Autoimmunity, Part D: Autoimmune Disease, Annus Mirabilis. Blackwell Publishing Inc., p. 92-95 4 p. (Annals of the New York Academy of Sciences; 巻数 1108).

研究成果: 著書/レポートタイプへの貢献会議での発言

Lupus Nephritis
Anti-Idiotypic Antibodies
Antibodies
Lymphocytes
Endoplasmic Reticulum Stress
2006
11 引用 (Scopus)

Two cases of systemic lupus erythematosus complicated with colonic ulcers

Miyahara, S., Ito, S., Soeda, A., Chino, Y., Hayashi, T., Takahashi, R., Goto, D., Matsumoto, I., Tsutsumi, A. & Sumida, T., 1 17 2006, : : Internal Medicine. 44, 12, p. 1298-1306 9 p.

研究成果: ジャーナルへの寄稿記事

Systemic Lupus Erythematosus
Ulcer
Steroids
Mesalamine
Therapeutics
2005

A case of pulmonary hypertension associated with systemic lupus erythematosus without anti-ribonucleoprotein antibodies

Suzuki, E., Hayashi, T., Ito, S., Miyazaki, K., Yamazaki, H., Machino, T., Takahashi, R., Chino, Y., Goto, D., Matsumoto, I., Tsutsumi, A., Sato, Y. & Sumida, T., 9 1 2005, : : Acta Medica et Biologica. 53, 3, p. 87-93 7 p.

研究成果: ジャーナルへの寄稿記事

Ribonucleoproteins
Pulmonary Hypertension
Systemic Lupus Erythematosus
Anti-Idiotypic Antibodies
Steroids
73 引用 (Scopus)

Association of mannose binding lectin (MBL) gene polymorphism and serum MBL concentration with characteristics and progression of systemic lupus erythematosus

Takahashi, R., Tsutsumi, A., Ohtani, K., Muraki, Y., Goto, D., Matsumoto, I., Wakamiya, N. & Sumida, T., 2 1 2005, : : Annals of the Rheumatic Diseases. 64, 2, p. 311-314 4 p.

研究成果: ジャーナルへの寄稿記事

Mannose-Binding Lectin
Polymorphism
Systemic Lupus Erythematosus
Genes
Serum
6 引用 (Scopus)

Clinical characteristics of anti-glucose-6-phosphate isomerase antibody-positive Japanese patients with rheumatoid arthritis

Hayashi, T., Matsumoto, I., Muraki, Y., Takahashi, R., Chino, Y., Goto, D., Ito, S., Tsutsumi, A. & Sumida, T., 8 1 2005, : : Modern Rheumatology. 15, 4, p. 258-263 6 p.

研究成果: ジャーナルへの寄稿記事

Glucose-6-Phosphate Isomerase
Rheumatoid Arthritis
Antibodies
Arthritis
Systemic Lupus Erythematosus
75 引用 (Scopus)

Mannose binding lectin: Genetics and autoimmune disease

Tsutsumi, A., Takahashi, R. & Sumida, T., 7 1 2005, : : Autoimmunity Reviews. 4, 6, p. 364-372 9 p.

研究成果: ジャーナルへの寄稿評論記事

Mannose-Binding Lectin
Inborn Genetic Diseases
Autoimmune Diseases
Serum
Autoantibodies
2004
29 引用 (Scopus)

Anti-mannose binding lectin antibodies in sera of Japanese patients with systemic lupus erythematosus

Takahashi, R., Tsutsumi, A., Ohtani, K., Goto, D., Matsumoto, I., Ito, S., Wakamiya, N. & Sumida, T., 6 1 2004, : : Clinical and Experimental Immunology. 136, 3, p. 585-590 6 p.

研究成果: ジャーナルへの寄稿記事

Mannose-Binding Lectin
Systemic Lupus Erythematosus
Antibodies
Serum
Complement C1q
36 引用 (Scopus)

Polymorphisms of IL-1β Gene in Japanese Patients with Sjögren's Syndrome and Systemic Lupus Erythematosus

Muraki, Y., Tsutsumi, A., Takahashi, R., Suzuki, E., Hayashi, T., Chino, Y., Goto, D., Matsumoto, I., Murata, H., Noguchi, E. & Sumida, T., 4 1 2004, : : Journal of Rheumatology. 31, 4, p. 720-725 6 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-1
Systemic Lupus Erythematosus
Genes
Genotype
Lacrimal Apparatus
8 引用 (Scopus)

Reiter's syndrome following intravesical bacille bilié de Calmette-Guérin treatment for superficial bladder carcinoma: Report of six cases

Murata, H., Adachi, Y., Ebitsuka, T., Chino, Y., Takahashi, R., Hayashi, T., Goto, D., Matsumoto, I., Tsutsumi, A., Akaza, H. & Sumida, T., 3 1 2004, : : Modern Rheumatology. 14, 1, p. 82-86 5 p.

研究成果: ジャーナルへの寄稿記事

Reactive Arthritis
Urinary Bladder
Arthritis
Carcinoma
Intravesical Administration
2003
7 引用 (Scopus)

Behçet's disease accompanied by myelodysplastic syndrome with trisomy 8: Two case reports and a review of 15 Japanese cases

Adachi, Y., Tsutsumi, A., Murata, H., Takemura, H., Chino, Y., Takahashi, R., Ebitsuka, T. & Sumida, T., 8 11 2003, : : Modern Rheumatology. 13, 1, p. 90-94 5 p.

研究成果: ジャーナルへの寄稿記事

Myelodysplastic Syndromes
Cecum
Chromosome Aberrations
Trisomy Chromosome 8
20 引用 (Scopus)

Mannose binding lectin gene polymorphism in patients with type I diabetes

Tsutsumi, A., Ikegami, H., Takahashi, R., Murata, H., Goto, D., Matsumoto, I., Fujisawa, T. & Sumida, T., 6 1 2003, : : Human Immunology. 64, 6, p. 621-624 4 p.

研究成果: ジャーナルへの寄稿記事

Mannose-Binding Lectin
Type 1 Diabetes Mellitus
Alleles
Genes
Gene Frequency