研究成果 1979 2019

2019
Islands of Calleja
Neurogenesis
Dentate Gyrus
Phenotype
Lateral Ventricles
1 引用 (Scopus)

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K., 8 1 2019, : : EBioMedicine. 46, p. 150-159 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Genes
Breast Neoplasms
Survival
RNA Sequence Analysis
Organized Financing
7 引用 (Scopus)

A chromatin integration labelling method enables epigenomic profiling with lower input

Harada, A., Maehara, K., Handa, T., Arimura, Y., Nogami, J., Hayashi-Takanaka, Y., Shirahige, K., Kurumizaka, H., Kimura, H. & Ohkawa, Y., 2 1 2019, : : Nature Cell Biology. 21, 2, p. 287-296 10 p.

研究成果: ジャーナルへの寄稿記事

Epigenomics
Chromatin
Chromatin Immunoprecipitation
Histone Code
Immunoprecipitation

Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation

Kanatsu-Shinohara, M., Yamamoto, T., Toh, H., Kazuki, Y., Kazuki, K., Imoto, J., Ikeo, K., Oshima, M., Shirahige, K., Iwama, A., Nabeshima, Y., Sasaki, H. & Shinohara, T., 8 13 2019, : : Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16404-16409 6 p.

研究成果: ジャーナルへの寄稿記事

公開
Glycolysis
Stem Cells
JNK Mitogen-Activated Protein Kinases
Cell Aging
Telomere Shortening

A highly sensitive determination method for acrylamide in beverages, grains, and confectioneries by supercritical fluid chromatography tandem mass spectrometry

Yoshioka, T., Izumi, Y., Nagatomi, Y., Miyamoto, Y., Suzuki, K. & Bamba, T., 10 1 2019, : : Food Chemistry. 294, p. 486-492 7 p.

研究成果: ジャーナルへの寄稿記事

supercritical fluid chromatography
Supercritical Fluid Chromatography
Beverages
Acrylamide
acrylamides
1 引用 (Scopus)

Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours in Drosophila mxc mutants

Araki, M., Kurihara, M., Kinoshita, S., Awane, R., Sato, T., Ohkawa, Y. & Inoue, Y. H., 1 1 2019, : : DMM Disease Models and Mechanisms. 12, 6, dmm037721.

研究成果: ジャーナルへの寄稿記事

公開
Immune system
Drosophila
Tumors
Immune System
Peptides

Biochemical analysis of nucleosome targeting by Tn5 transposase

Sato, S., Arimura, Y., Kujirai, T., Harada, A., Maehara, K., Nogami, J., Ohkawa, Y. & Kurumizaka, H., 8 1 2019, : : Open Biology. 9, 8, 190116.

研究成果: ジャーナルへの寄稿記事

公開
Nucleosomes
DNA
Tn5 transposase
DNA sequences
Genomics
公開
Chromatin Assembly and Disassembly
Calcineurin
Skeletal Muscle
Gene Expression
Enzymes
3 引用 (Scopus)

CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome

Unoki, M., Funabiki, H., Velasco, G., Francastel, C. & Sasaki, H., 1 2 2019, : : Journal of Clinical Investigation. 129, 1, CI99751.

研究成果: ジャーナルへの寄稿記事

Chromosome Segregation
Mutation
HEK293 Cells
Chromatin
Apoptosis
1 引用 (Scopus)

Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires HeS1 to bind diverse DNA sites

Noguchi, Y. T., Nakamura, M., Hino, N., Nogami, J., Tsuji, S., Sato, T., Zhang, L., Tsujikawa, K., Tanaka, T., Izawa, K., Okada, Y., Doi, T., Kokubo, H., Harada, A., Uezumi, A., Gessler, M., Ohkawa, Y. & Fukada, S. I., 2 1 2019, : : Development (Cambridge). 146, 4, dev163618.

研究成果: ジャーナルへの寄稿記事

公開
Muscle Cells
Stem Cells
DNA
Myogenin
Chromatin

CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors

Miki, M., ono, T., Fujimori, N., Takaoka, T., Kawabe, K., Miyasaka, Y., Takao, O., Saito, D., Nakamura, M., Ohkawa, Y., Oda, Y., Suyama, M., Ito, T. & Ogawa, Y., 7 1 2019, : : Cancer Medicine. 8, 8, p. 3748-3760 13 p.

研究成果: ジャーナルへの寄稿記事

公開
Matrix Metalloproteinase 7
Neuroendocrine Tumors
Recurrence
Genes
Neoplasms
Heavy Ion Radiotherapy
Sarcoma
Spine
Spinal Cord Compression
Compression Fractures
公開
Supercritical Fluid Chromatography
supercritical fluids
liquid chromatography
High performance liquid chromatography
chromatography

Comparison of sequential derivatization with concurrent methods for GC/MS-based metabolomics

Miyagawa, H. & Bamba, T., 2 1 2019, : : Journal of Bioscience and Bioengineering. 127, 2, p. 160-168 9 p.

研究成果: ジャーナルへの寄稿記事

Metabolomics
Metabolites
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
2 引用 (Scopus)

Computational investigation of the conformational dynamics in Tom20-mitochondrial presequence tethered complexes

Srivastava, A., Tama, F., Kohda, D. & Miyashita, O., 1 1 2019, : : Proteins: Structure, Function and Bioinformatics. 87, 1, p. 81-90 10 p.

研究成果: ジャーナルへの寄稿記事

Disulfides
Molecular Dynamics Simulation
Membranes
Peptides
Molecular dynamics

Conformational ensemble of an intrinsically flexible loop in mitochondrial import protein Tim21 studied by modeling and molecular dynamics simulations

Srivastava, A., Bala, S., Motomura, H., Kohda, D., Tama, F. & Miyashita, O., 1 1 2019, (受理済み/印刷中) : : Biochimica et Biophysica Acta - General Subjects. 129417.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Proteins
Molecular Dynamics Simulation
Molecular dynamics
Crystals
Computer simulation

Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study

Bala, S., Shinya, S., Srivastava, A., Ishikawa, M., Shimada, A., Kobayashi, N., Kojima, C., Tama, F., Miyashita, O. & Kohda, D., 1 1 2019, (受理済み/印刷中) : : Biochimica et Biophysica Acta - General Subjects. 129418.

研究成果: ジャーナルへの寄稿記事

Conformations
Crystals
Proteins
Yeasts
Yeast
3 引用 (Scopus)

Development of a practical online supercritical fluid extraction–supercritical fluid chromatography/mass spectrometry system with an integrated split-flow method

Sakai, M., Hayakawa, Y., Funada, Y., Ando, T., Fukusaki, E. & Bamba, T., 5 10 2019, : : Journal of Chromatography A. 1592, p. 161-172 12 p.

研究成果: ジャーナルへの寄稿記事

Supercritical Fluid Chromatography
Supercritical fluids
Chromatography
Mass spectrometry
Mass Spectrometry

Diabetes Mellitus, A risk factor for Alzheimer's Disease

Nakabeppu, Y. (版) & Ninomiya, T. (版), 5 7 2019, Singapore: Springer. 248 p. (Advances in Experimental Medicine and Biology)

研究成果: 著書/レポートタイプ著書

Diabetes Mellitus
Alzheimer Disease
Insulin
Glucose
Vascular Dementia
1 引用 (Scopus)

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Muto, Y., Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y. & Nakayama, K., 4 1 2019, : : Journal of Experimental Medicine. 216, 4, p. 950-965 16 p.

研究成果: ジャーナルへの寄稿記事

公開
Carcinogenesis
Homeostasis
Iron
Iron Overload
Liver

Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes

Konno, D., Kishida, C., Maehara, K., Ohkawa, Y., Kiyonari, H., Okada, S. & Matsuzaki, F., 8 1 2019, : : Development (Cambridge). 146, 15, dev174243.

研究成果: ジャーナルへの寄稿記事

公開
Telencephalon
Homeobox Genes
Gene Dosage
Olfactory Bulb
Neurogenesis
3 引用 (Scopus)

Elucidating functions of DP1 and DP2 subunits from the Thermococcus kodakarensis family D DNA polymerase

Takashima, N., Ishino, S., Oki, K., Takafuji, M., Yamagami, T., Matsuo, R., Mayanagi, K. & Ishino, Y., 1 22 2019, : : Extremophiles. 23, 1, p. 161-172 12 p.

研究成果: ジャーナルへの寄稿記事

Thermococcus
Transcription Factor DP1
Archaea
DNA-Directed DNA Polymerase
DNA

Gas chromatography-mass spectrometry metabolomics-based prediction of potato tuber sprouting during long-term storage

Fukuda, T., Takamatsu, K., Bamba, T. & Fukusaki, E., 8 1 2019, : : Journal of Bioscience and Bioengineering. 128, 2, p. 249-254 6 p.

研究成果: ジャーナルへの寄稿記事

Metabolomics
Biomarkers
Solanum tuberosum
Gas chromatography
Gas Chromatography-Mass Spectrometry

Generation of human oogonia from induced pluripotent stem cells in vitro

Yamashiro, C., Sasaki, K., Yabuta, Y., Kojima, Y., Nakamura, T., Okamoto, I., Yokobayashi, S., Murase, Y., Ishikura, Y., Shirane, K., Sasaki, H., Yamamoto, T. & Saitou, M., 3 1 2019, : : Obstetrical and Gynecological Survey. 74, 3, p. 158-159 2 p.

研究成果: ジャーナルへの寄稿コメント/討論

Oogonia
Induced Pluripotent Stem Cells
In Vitro Techniques
6 引用 (Scopus)

Genomic Imprinting and Physiological Processes in Mammals

the Erice Imprinting Group, 2 21 2019, : : Cell. 176, 5, p. 952-965 14 p.

研究成果: ジャーナルへの寄稿評論記事

Physiological Phenomena
Genomic Imprinting
Mammals
Physiology
Genes

Germline mutation: De novo mutation in reproductive lineage cells

Kunihiko, S., 1 1 2019, : : Genes and Genetic Systems. 94, 1, p. 3-12 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Germ-Line Mutation
Mutation Rate
Genome
Mutation
Cell Division
1 引用 (Scopus)

Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection

Au Yeung, W. K., Brind'Amour, J., Hatano, Y., Yamagata, K., Feil, R., Lorincz, M. C., Tachibana, M., Shinkai, Y. & Sasaki, H., 4 2 2019, : : Cell Reports. 27, 1, p. 282-293.e4

研究成果: ジャーナルへの寄稿記事

公開
Methylation
Oocytes
Chromatin
Chromosome Segregation
Chromosomes

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., 2 1 2019, : : Anticancer research. 39, 2, p. 671-677 7 p.

研究成果: ジャーナルへの寄稿記事

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Exome
1 引用 (Scopus)

Identification of metabolites associated with onset of CAD in diabetic patients using ce-ms analysis: A pilot study

Omori, K., Katakami, N., Yamamoto, Y., Ninomiya, H., Takahara, M., Matsuoka, T. A., Bamba, T., Fukusaki, E. & Shimomura, I., 1 1 2019, : : Journal of atherosclerosis and thrombosis. 26, 3, p. 233-245 13 p.

研究成果: ジャーナルへの寄稿記事

公開
Metabolites
Coronary Artery Disease
Medical problems
Arteries
Galactosamine

Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia

Shiomi, M., Takeda, H., Irino, Y., Kimura, N., Yamada, S., Kuniyoshi, N., Kikumori, A., Koike, Y., Koike, T., Yoshida, M., Izumi, Y., Shinohara, M., Bamba, T. & Ishida, T., 5 1 2019, : : Atherosclerosis. 284, p. 18-23 6 p.

研究成果: ジャーナルへの寄稿記事

Hyperlipoproteinemia Type II
Coronary Artery Disease
Animal Models
Biomarkers
Rabbits

Improved quantitation of lipid classes using supercritical fluid chromatography with a charged aerosol detector

Takeda, H., Takahashi, M., Hara, T., Izumi, Y. & Bamba, T., 1 1 2019, : : Journal of Lipid Research. 60, 8, p. 1465-1474 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Supercritical Fluid Chromatography
Aerosols
Detectors
Lipids
Molecules
1 引用 (Scopus)

Intragenic antagonistic roles of protein and circRNA in tumorigenesis

Guarnerio, J., Zhang, Y., Cheloni, G., Panella, R., Mae Katon, J., Simpson, M., Matsumoto, A., Papa, A., Loretelli, C., Petri, A., Kauppinen, S., Garbutt, C., Petur Nielsen, G., Deshpande, V., Castillo-Martin, M., Cordon-Cardo, C., Dimitrios, S., Clohessy, J. G., Batish, M. & Pandolfi, P. P., 8 1 2019, : : Cell Research. 29, 8, p. 628-640 13 p.

研究成果: ジャーナルへの寄稿記事

Carcinogenesis
Neoplasms
Proteins
Angiogenesis Inducing Agents
Transcription Factors

Locomotor Training Increases Synaptic Structure With High NGL-2 Expression After Spinal Cord Hemisection

Kobayakawa, K., DePetro, K. A., Zhong, H., Pham, B., Hara, M., Harada, A., Nogami, J., Ohkawa, Y. & Edgerton, V. R., 1 1 2019, : : Neurorehabilitation and Neural Repair.

研究成果: ジャーナルへの寄稿記事

Spinal Cord
Synapses
RNA
Synaptophysin
Gene Ontology

Logical design of oral glucose ingestion pattern minimizing blood glucose in humans

Fujii, M., Murakami, Y., Karasawa, Y., Sumitomo, Y., Fujita, S., Koyama, M., Uda, S., Kubota, H., Inoue, H., Konishi, K., Oba, S., Ishii, S. & Kuroda, S., 12 1 2019, : : npj Systems Biology and Applications. 5, 1, 31.

研究成果: ジャーナルへの寄稿記事

公開
Glucose
Blood
Blood Glucose
Eating
Insulin

Long-term maintenance of functional primary human hepatocytes using small molecules

Katsuda, T., Kawamata, M., Inoue, A., Yamaguchi, T., Abe, M. & Ochiya, T., 1 1 2019, (受理済み/印刷中) : : FEBS Letters.

研究成果: ジャーナルへの寄稿記事

Epithelial-Mesenchymal Transition
Drug Discovery
Cytochrome P-450 Enzyme System
Cytochrome P-450 CYP3A
Hepatocytes

Macrophage centripetal migration drives spontaneous healing process after spinal cord injury

Kobayakawa, K., Ohkawa, Y., Yoshizaki, S., Tamaru, T., Saito, T., Kijima, K., Yokota, K., Hara, M., Kubota, K., Matsumoto, Y., Harimaya, K., Ozato, K., Masuda, T., Makoto, T., Tamura, T., Inoue, K., Reggie Edgerton, V., Iwamoto, Y., Nakashima, Y. & Okada, S., 5 15 2019, : : Science Advances. 5, 5, eaav5086.

研究成果: ジャーナルへの寄稿記事

公開
spinal cord injuries
macrophages
healing
interferon
lesions

miR-124 dosage regulates prefrontal cortex function by dopaminergic modulation

Kozuka, T., Omori, Y., Watanabe, S., Tarusawa, E., Yamamoto, H., Chaya, T., Furuhashi, M., Morita, M., Sato, T., Hirose, S., Ohkawa, Y., Yoshimura, Y., Hikida, T. & Furukawa, T., 12 1 2019, : : Scientific reports. 9, 1, 3445.

研究成果: ジャーナルへの寄稿記事

Prefrontal Cortex
MicroRNAs
Central Nervous System
Methamphetamine
Pyramidal Cells

Molecular pathophysiology of insulin depletion, mitochondrial dysfunction, and oxidative stress in Alzheimer’s disease brain

Nakabeppu, Y., 1 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 27-44 18 p. (Advances in Experimental Medicine and Biology; 巻数 1128).

研究成果: 著書/レポートタイプへの貢献

Oxidative stress
Brain
Alzheimer Disease
Oxidative Stress
Medical problems

Mouse polycomb group gene Cbx2 promotes osteoblastic but suppresses adipogenic differentiation in postnatal long bones

Katoh-Fukui, Y., Baba, T., Sato, T., Otake, H., Nagakui-Noguchi, Y., Shindo, M., Suyama, M., Ohkawa, Y., Tsumura, H., Morohashi, K-I. & Fukami, M., 3 1 2019, : : Bone. 120, p. 219-231 13 p.

研究成果: ジャーナルへの寄稿記事

Mesenchymal Stromal Cells
Bone and Bones
Cell Lineage
Genes
Polycomb-Group Proteins
1 引用 (Scopus)

Novel components of germline sex determination acting downstream of foxl3 in medaka

Kikuchi, M., Nishimura, T., Saito, D., Shigenobu, S., Takada, R., Gutierrez-Triana, J. A., Cerdán, J. L. M., Takada, S., Wittbrodt, J., Suyama, M. & Tanaka, M., 1 1 2019, : : Developmental Biology. 445, 1, p. 80-89 10 p.

研究成果: ジャーナルへの寄稿記事

Oryzias
Germ Cells
Sex Differentiation
Chromatids
Ubiquitin-Protein Ligases
1 引用 (Scopus)

Origins of brain insulin and its function

Nakabeppu, Y., 1 1 2019, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 1-11 11 p. (Advances in Experimental Medicine and Biology; 巻数 1128).

研究成果: 著書/レポートタイプへの貢献

Brain
Insulin
Neurology
Glucose
Central Nervous System

Oxidative stress induces different tissue dependent effects on Mutyh-deficient mice

Chen, J., Huang, Z., Wu, X., Kang, J., Ren, Y., Gao, W., Lu, X., Wang, J., Ding, W., Nakabeppu, Y., Fan, Y. & Wang, Y., 11 1 2019, : : Free Radical Biology and Medicine. 143, p. 482-493 12 p.

研究成果: ジャーナルへの寄稿記事

Oxidative stress
Galactose
Oxidative Stress
Tissue
Liver
1 引用 (Scopus)

Pathological changes of distal motor neurons after complete spinal cord injury

Yokota, K., Kubota, K., Kobayakawa, K., Saito, T., Hara, M., Kijima, K., Maeda, T., Katoh, H., Ohkawa, Y., Nakashima, Y. & Okada, S., 1 9 2019, : : Molecular Brain. 12, 1, 4.

研究成果: ジャーナルへの寄稿記事

Motor Neurons
Spinal Cord Injuries
Spinal Cord
Microdissection
Thoracic Injuries

Pillars Article: Restoration of T Cell Development in RAG-2-Deficient Mice by Functional TCR Transgenes. Science. 1993. 259: 822-825

Shinkai, Y., Koyasu, S., Nakayama, K., Murphy, K. M., Loh, D. Y., Reinherz, E. L. & Alt, F. W., 3 1 2019, : : Journal of immunology (Baltimore, Md. : 1950). 202, 5, p. 1317-1320 4 p.

研究成果: ジャーナルへの寄稿記事

Transgenes
T-Lymphocytes

Poorly controlled diabetes during pregnancy and lactation activates the Foxo1 pathway and causes glucose intolerance in adult offspring

Inoguchi, Y., Ichiyanagi, K., Ohishi, H., Maeda, Y., Sonoda, N., Ogawa, Y., Inoguchi, T. & Sasaki, H., 12 1 2019, : : Scientific reports. 9, 1, 10181.

研究成果: ジャーナルへの寄稿記事

公開
Glucose Intolerance
Streptozocin
Lactation
Pregnancy
Gluconeogenesis
Heavy Ion Radiotherapy
Spontaneous Fractures
Single-Photon Emission-Computed Tomography
Bone and Bones
Bone Remodeling

Potentials of C-C motif chemokine 2–C-C chemokine receptor type 2 blockers including propagermanium as anticancer agents

Yumimoto, K., Sugiyama, S., Mimori, K. & Nakayama, K., 7 1 2019, : : Cancer Science. 110, 7, p. 2090-2099 10 p.

研究成果: ジャーナルへの寄稿評論記事

公開
C Chemokines
CC Chemokines
Chemokine Receptors
Antineoplastic Agents
Inflammation

Preface to the special issue on novel measurement techniques for visualizing ‘live’ protein molecules at work

Nishida, N., Tsukazaki, T. & Kohda, D., 1 1 2019, (受理済み/印刷中) : : Biochimica et Biophysica Acta - General Subjects. 129421.

研究成果: ジャーナルへの寄稿編集

3 引用 (Scopus)

Prevention of cancer dormancy by Fbxw7 ablation eradicates disseminated tumor cells

Shimizu, H., Takeishi, S., Nakatsumi, H. & Nakayama, K., 2 21 2019, : : JCI insight. 4, 4

研究成果: ジャーナルへの寄稿記事

Neoplasms
Breast Neoplasms
Drug Therapy
Paclitaxel
Heterografts
Arm Injuries
Ossification of Posterior Longitudinal Ligament
Pectoralis Muscles
Prone Position
Brachial Plexus