研究成果 1979 2020

1997
154 引用 (Scopus)

Serum levels of IL-10, IL-15 and soluble tumour necrosis factor-alpha (TNF-α) receptors in type C chronic liver disease

Kakumu, S., Okumura, A., Ishikawa, T., Yano, M., Enomoto, A., Nishimura, H., Yoshioka, K. & Yoshikai, Y., 1 1 1997, : : Clinical and Experimental Immunology. 109, 3, p. 458-463 6 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-15
Tumor Necrosis Factor Receptors
Interleukin-10
Liver Diseases
Chronic Disease
22 引用 (Scopus)

Significance of the conserved amino acid sequence for human MTH1 protein with antimutator activity

Cai, J. P., Kawate, H., Ihara, K., Yakushiji, H., Nakabeppu, Y., Tsuzuki, T. & Sekiguchi, M., 3 15 1997, : : Nucleic acids research. 25, 6, p. 1170-1176 7 p.

研究成果: ジャーナルへの寄稿記事

Amino Acid Sequence
Conserved Sequence
Codon
Lysine
Glutamic Acid
16 引用 (Scopus)

Structure and expression of the mouse L23mrp gene downstream of the imprinted H19 gene: Biallelic expression and lack of interaction with the H19 enhancers

Zubair, M., Hilton, K., Saam, J. R., Surani, M. A., Tilghman, S. M. & Sasaki, H., 1 1 1997, : : Genomics. 45, 2, p. 290-296 7 p.

研究成果: ジャーナルへの寄稿記事

Gene Expression
Alleles
Genes
CpG Islands
Chromosomes, Human, Pair 7
8 引用 (Scopus)

Substrate specificity of human O6-methylguanine-DNA methyltransferase for O6-benzylguanine derivatives in oligodeoxynucleotides

Terashima, I., Kawate, H., Kunihiko, S., Sekiguchi, M. & Kohda, K., 12 22 1997, : : Chemical Research in Toxicology. 10, 11, p. 1234-1239 6 p.

研究成果: ジャーナルへの寄稿記事

Oligodeoxyribonucleotides
Methyltransferases
Substrate Specificity
Derivatives
DNA
5 引用 (Scopus)

T cells bearing Vβ8 are preferentially infected with exogenous mouse mammary tumor virus

Upragarin, N., Nishimura, H., Wajjwalku, W., Ando, Y., Nagafuchi, S., Watanabe, T. & Yoshikai, Y., 12 1 1997, : : Journal of Immunology. 159, 5, p. 2189-2195 7 p.

研究成果: ジャーナルへの寄稿記事

Mouse mammary tumor virus
T-Lymphocytes
Lymph Nodes
Superantigens
Milk
Genes
Genomic Imprinting
Endoderm
Chromosomes, Human, Pair 7
Insulin-Like Growth Factor II
1998
177 引用 (Scopus)

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene

Hamasaki, A., Sendo, F., Nakayama, K., Ishida, N., Negishi, I., Nakayama, K. I. & Hatakeyama, S., 12 7 1998, : : Journal of Experimental Medicine. 188, 11, p. 1985-1992 8 p.

研究成果: ジャーナルへの寄稿記事

Neutrophils
Apoptosis
Genes
Transendothelial and Transepithelial Migration
Lipopolysaccharides
35 引用 (Scopus)

Activation of cyclin-dependent kinase 2 (Cdk2) in growth-stimulated rat astrocytes: Geranylgeranylated Rho small GTPase(s) are essential for the induction of cyclin E gene expression

Tanaka, T., Tatsuno, I., Noguchi, Y., Uchida, D., Oeda, T., Narumiya, S., Yasuda, T., Higashi, H., Kitagawa, M., Nakayama, K., Saito, Y. & Hirai, A., 10 9 1998, : : Journal of Biological Chemistry. 273, 41, p. 26772-26778 7 p.

研究成果: ジャーナルへの寄稿記事

Cyclin-Dependent Kinase 2
Cyclin E
rho GTP-Binding Proteins
Monomeric GTP-Binding Proteins
Gene expression
33 引用 (Scopus)

A methylation imprint mark in the mouse imprinted gene Grf1/Cdc25Mm locus shares a common feature with the U2afbp-rs gene: An association with a short tandem repeat and a hypermethylated region

Shibata, H., Yoda, Y., Kato, R., Ueda, T., Kamiya, M., Hiraiwa, N., Yoshiki, A., Plass, C., Pearsall, R. S., Held, W. A., Muramatsu, M., Sasaki, H., Kusakabe, M. & Hayashizaki, Y., 4 1 1998, : : Genomics. 49, 1, p. 30-37 8 p.

研究成果: ジャーナルへの寄稿記事

ras-GRF1
Microsatellite Repeats
Methylation
Germ Cells
Genes
15 引用 (Scopus)
Hybridomas
Spleen
Ligands
Peptides
Amino Acid Substitution
64 引用 (Scopus)

An isoleucine zipper peptide forms a native-like triple stranded coiled coil in solution

Suzuki, K., Hiroaki, H., Kohda, D. & Tanaka, T., 11 1 1998, : : Protein Engineering. 11, 11, p. 1051-1055 5 p.

研究成果: ジャーナルへの寄稿記事

Isoleucine
Fasteners
Peptides
Amides
Protons
120 引用 (Scopus)

Cell cycle regulation and differentiation in the human podocyte lineage

Nagata, M., Nakayama, K. I., Terada, Y., Hoshi, S. & Watanabe, T., 11 1998, : : American Journal of Pathology. 153, 5, p. 1511-1520 10 p.

研究成果: ジャーナルへの寄稿記事

Podocytes
Cell Differentiation
Cell Cycle
Cyclin-Dependent Kinases
Cyclin B1
170 引用 (Scopus)

Cip/Kip cyclin-dependent kinase inhibitors: Brakes of the cell cycle engine during development

Nakayama, K. & Nakayama, K., 1 1 1998, : : BioEssays. 20, 12, p. 1020-1029 10 p.

研究成果: ジャーナルへの寄稿評論記事

Cyclin-Dependent Kinases
Brakes
Cell Cycle
Cells
Engines
28 引用 (Scopus)

D1-receptor-related priming is attenuated by antisense-meditated 'knockdown' of fosB expression

Crocker, S. J., Morelli, M., Wigle, N., Nakabeppu, Y. & Robertson, G. S., 1 1 1998, : : Molecular Brain Research. 53, 1-2, p. 69-77 9 p.

研究成果: ジャーナルへの寄稿記事

Apomorphine
Immediate-Early Genes
Antisense Oligonucleotides
Dopamine Agonists
Oligonucleotides
5 引用 (Scopus)

Development of peptide vaccines inducing production of neutralizing antibodies against HIV-1 viruses in HLA-DQ6 mice

Takahashi, A., Ogasawara, K., Matsuki, N., Fujinaga, K., Nakaya, T., Ikuta, K., Auwanit, W., Honda, M., Fukui, Y., Sasazuki, T., Iwabuchi, K. & Onoé, K., 10 1 1998, : : Vaccine. 16, 16, p. 1537-1543 7 p.

研究成果: ジャーナルへの寄稿記事

Subunit Vaccines
subunit vaccines
Human immunodeficiency virus 1
Neutralizing Antibodies
neutralizing antibodies
26 引用 (Scopus)

Dibutyryl cyclic adenosine monophosphate protects mice against tumor necrosis factor-α-induced hepatocyte apoptosis accompanied by increased heat shock protein 70 expression

Takano, M., Arai, T., Mokuno, Y., Nishimura, H., Nimura, Y. & Yoshikai, Y., 6 1 1998, : : Cell Stress and Chaperones. 3, 2, p. 109-117 9 p.

研究成果: ジャーナルへの寄稿記事

Galactosamine
HSP70 Heat-Shock Proteins
Liver
Cyclic AMP
Hepatocytes
68 引用 (Scopus)

Disulfide bond structure of human epidermal growth factor receptor

Abe, Y., Odaka, M., Inagaki, F., Lax, I., Schlessinger, J. & Kohda, D., 5 1 1998, : : Journal of Biological Chemistry. 273, 18, p. 11150-11157 8 p.

研究成果: ジャーナルへの寄稿記事

Epidermal Growth Factor Receptor
Disulfides
Cysteine
Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
Laminin
6 引用 (Scopus)

Enhancer-dependent, locus-wide regulation of the imprinted mouse insulin-like growth factor II gene

Hatano, N., Eversole-Cire, P., Ferguson-Smith, A. C., Jones, P. A., Surani, M. A. & Sasaki, H., 5 1998, : : Journal of biochemistry. 123, 5, p. 984-991 8 p.

研究成果: ジャーナルへの寄稿記事

Insulin-Like Growth Factor II
Genes
Genomic Imprinting
Gene Transfer Techniques
Messenger RNA
1 引用 (Scopus)
Alkylating Agents
DNA Repair
Genes

Genomic imprinting and functional chromosome domain

Sasaki, H., 1 1 1998, : : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 43, 14, p. 2101-2108 8 p.

研究成果: ジャーナルへの寄稿評論記事

Angelman Syndrome
Genomic Imprinting
Prader-Willi Syndrome
Histone Deacetylases
Gene Expression Regulation

Genomic imprinting and mammalian development

Hatano, N. & Sasaki, H., 1 1 1998, : : Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme. 43, 4, p. 541-548 8 p.

研究成果: ジャーナルへの寄稿評論記事

Genomic Imprinting
Mammals
Alleles
23 引用 (Scopus)

Highly restricted T cell repertoire shaped by a single major histocompatibility complex-peptide ligand in the presence of a single rearranged T cell receptor β chain

Fukui, Y., Hashimoto, O., Inayoshi, A., Gyotoku, T., Sano, T., Koga, T., Gushima, T. & Sasazuki, T., 9 7 1998, : : Journal of Experimental Medicine. 188, 5, p. 897-907 11 p.

研究成果: ジャーナルへの寄稿記事

T-Cell Antigen Receptor
Major Histocompatibility Complex
Ligands
T-Lymphocytes
Peptides
17 引用 (Scopus)

Immediate-early gene expression in the brain of the thiamine-deficient rat

Hazell, A. S., McGahan, L., Tetzlaff, W., Bedard, A. M., Robertson, G. S., Nakabeppu, Y. & Hakim, A. M., 1 1 1998, : : Journal of Molecular Neuroscience. 10, 1, p. 1-15 15 p.

研究成果: ジャーナルへの寄稿記事

Immediate-Early Genes
Thiamine
Thalamus
Inferior Colliculi
Pyrithiamine
90 引用 (Scopus)

Interleukin 15 activity in the rectal mucosa of inflammatory bowel disease

Sakai, T., Kusugami, K., Nishimura, H., Ando, T., Yamaguchi, T., Ohsuga, M., Ina, K., Enomoto, A., Kimura, Y. & Yoshikai, Y., 1 1 1998, : : Gastroenterology. 114, 6, p. 1237-1243 7 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-15
Inflammatory Bowel Diseases
Mucous Membrane
Interleukin-2
Organ Culture Techniques
65 引用 (Scopus)

Interleukin-15 may be responsible for early activation of intestinal intraepithelial lymphocytes after oral infection with Listeria monocytogenes in rats

Hirose, K., Suzuki, H., Nishimura, H., Mitani, A., Washizu, J., Matsuguchi, T. & Yoshikai, Y., 12 1 1998, : : Infection and Immunity. 66, 12, p. 5677-5683 7 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-15
Listeria monocytogenes
Lymphocytes
Infection
Epithelial Cells
21 引用 (Scopus)

Ischemia-induced CA1 neuronal death is preceded by elevated FosB and Jun expression and reduced NCFI-A and JunB levels

McGahan, L., Hakim, A. M., Nakabeppu, Y. & Robertson, G. S., 5 1 1998, : : Molecular Brain Research. 56, 1-2, p. 146-161 16 p.

研究成果: ジャーナルへの寄稿記事

Ischemia
Neurons
Immediate-Early Genes
Prosencephalon
Hippocampus
84 引用 (Scopus)

Metal ion induced self-assembly of a designed peptide into a triple- stranded α-helical bundle: A novel metal binding site in the hydrophobic core

Suzuki, K., Hiroaki, H., Kohda, D., Nakamura, H. & Tanaka, T., 12 23 1998, : : Journal of the American Chemical Society. 120, 50, p. 13008-13015 8 p.

研究成果: ジャーナルへの寄稿記事

Binding sites
Self assembly
Peptides
Metal ions
Metals
43 引用 (Scopus)

Molecular analysis of suppression of interleukin-8 production by rebamipide in Helicobacter pylori-stimulated gastric cancer cell lines

Aihara, M., Azuma, A., Takizawa, H., Tsuchimoto, D., Funakoshi, Y., Shindo, Y., Ohmoto, Y., Imagawa, K., Kikuchi, M., Mukaida, N. & Matsushima, K., 10 3 1998, : : Digestive Diseases and Sciences. 43, 9 SUPPL., p. 174S-180S

研究成果: ジャーナルへの寄稿記事

Interleukin-8
Helicobacter pylori
Stomach Neoplasms
Cell Line
Helicobacter Infections
59 引用 (Scopus)

Molecular cloning of AtMMH, an Arabidopsis thaliana ortholog of the Escherichia coli mutM gene, and analysis of functional domains of its product

Ohtsubo, T., Matsuda, O., Iba, K., Terashima, I., Sekiguchi, M. & Nakabeppu, Y., 11 14 1998, : : Molecular and General Genetics. 259, 6, p. 577-590 14 p.

研究成果: ジャーナルへの寄稿記事

Molecular Cloning
Arabidopsis
Escherichia coli
Genes
Oligonucleotides
63 引用 (Scopus)

Multiple gene duplication and expression of mouse bcl-2-related genes, A1

Hatakeyama, S., Hamasaki, A., Negishi, I., Loh, D. Y., Sendo, F., Nakayama, K. & Nakayama, K. I., 5 26 1998, : : International Immunology. 10, 5, p. 631-637 7 p.

研究成果: ジャーナルへの寄稿記事

bcl-2 Genes
Gene Duplication
Gene Expression
Genes
Neutrophils
164 引用 (Scopus)

Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro

Ishikawa, K. I., Nagase, T., Suyama, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N. & Ohara, O., 1 1 1998, : : DNA Research. 5, 3, p. 169-176 8 p.

研究成果: ジャーナルへの寄稿記事

Complementary DNA
Clone Cells
Brain
Genes
Proteins
184 引用 (Scopus)

Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro

Nagase, T., Ishikawa, K. I., Suyama, M., Kikuno, R., Hirosawa, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N. & Ohara, O., 1 1 1998, : : DNA Research. 5, 6, p. 355-364 10 p.

研究成果: ジャーナルへの寄稿記事

Complementary DNA
Clone Cells
Brain
Genes
Proteins
45 引用 (Scopus)

Prostaglandin E2 protects against liver injury after Escherichia coli infection but hampers the resolution of the infection in mice

Takano, M., Nishimura, H., Kimura, Y., Washizu, J., Mokuno, Y., Nimura, Y. & Yoshikai, Y., 9 15 1998, : : Journal of Immunology. 161, 6, p. 3019-3025 7 p.

研究成果: ジャーナルへの寄稿記事

Escherichia coli Infections
Dinoprostone
Liver
Wounds and Injuries
Infection
65 引用 (Scopus)

Protective roles of T cells and interleukin-15 in Escherichia coli infection in mice

Takano, M., Nishimura, H., Kimura, Y., Mokuno, Y., Washizu, J., Itohara, S., Nimura, Y. & Yoshikai, Y., 7 1 1998, : : Infection and Immunity. 66, 7, p. 3270-3278 9 p.

研究成果: ジャーナルへの寄稿記事

Escherichia coli Infections
Interleukin-15
Inbred C3H Mouse
T-Lymphocytes
Lipopolysaccharides
42 引用 (Scopus)

Quantitative analysis of the T cell repertoire selected by a single peptide-major histocompatibility complex

Gapin, L., Fukui, Y., Kanellopoulos, J., Sano, T., Casrouge, A., Malier, V., Beaudoing, E., Gautheret, D., Claverie, J. M., Sasazuki, T. & Kourilsky, P., 6 1 1998, : : Journal of Experimental Medicine. 187, 11, p. 1871-1883 13 p.

研究成果: ジャーナルへの寄稿記事

Complementarity Determining Regions
Major Histocompatibility Complex
T-Lymphocytes
Peptides
T-Cell Antigen Receptor
2 引用 (Scopus)

Quick identification and localization of CpG islands in large genomic fragments by partial digestion with Hpa II and Hha I

Kato, R. & Sasaki, H., 1 1 1998, : : DNA Research. 5, 5, p. 287-295 9 p.

研究成果: ジャーナルへの寄稿記事

CpG Islands
Digestion
Cosmids
Islands
DNA
109 引用 (Scopus)

Separation of killing and tumorigenic effects of an alkylating agent in mice defective in two of the DNA repair genes

Kawate, H., Sakumi, K., Tsuzuki, T., Nakatsuru, Y., Ishikawa, T., Takahashi, S., Takano, H., Noda, T. & Sekiguchi, M., 4 28 1998, : : Proceedings of the National Academy of Sciences of the United States of America. 95, 9, p. 5116-5120 5 p.

研究成果: ジャーナルへの寄稿記事

Alkylating Agents
DNA Repair
Methylnitrosourea
DNA Mismatch Repair
Genes
13 引用 (Scopus)

Sequence of a 42-kb mouse region containing the imprinted H19 locus: Identification of a novel muscle-specific transcription unit showing biallelic expression

Ishihara, K., Kato, R., Furuumi, H., Zubair, M. & Sasaki, H., 9 15 1998, : : Mammalian Genome. 9, 9, p. 775-777 3 p.

研究成果: ジャーナルへの寄稿記事

Molecular Sequence Data
Genetic Transcription
Genomic Imprinting
Untranslated RNA
Muscle Proteins
64 引用 (Scopus)

The NF-κB binding site is essential for transcriptional activation of the IL-15 gene

Washizu, J., Nishimura, H., Nakamura, N., Nimura, Y. & Yoshikai, Y., 1 1 1998, : : Immunogenetics. 48, 1, p. 1-7 7 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-15
Transcriptional Activation
Lipopolysaccharides
Binding Sites
Macrophages
28 引用 (Scopus)

The regulatory role of heat shock protein 70-reactive CD4+ T cells during rat listeriosis

Kimura, Y., Yamada, K., Sakai, T., Mishima, K., Nishimura, H., Matsumoto, Y., Singh, M. & Yoshikai, Y., 3 9 1998, : : International Immunology. 10, 2, p. 117-130 14 p.

研究成果: ジャーナルへの寄稿記事

Listeriosis
HSP70 Heat-Shock Proteins
T-Lymphocytes
Listeria
Listeria monocytogenes
4 引用 (Scopus)

The roles of heat shock proteins in host defense against bacterial infection

Yoshikai, Y., 1 1 1998, : : Rinsho byori. The Japanese journal of clinical pathology. 46, 6, p. 564-573 10 p.

研究成果: ジャーナルへの寄稿評論記事

Cytoprotection
Heat-Shock Proteins
Bacterial Infections
Inflammation
Bacteria
66 引用 (Scopus)

Translational efficiency is up-regulated by alternative exon in murine IL-15 mRNA

Nishimura, H., Washizu, J., Nakamura, N., Enomoto, A. & Yoshikai, Y., 1 15 1998, : : Journal of Immunology. 160, 2, p. 936-942 7 p.

研究成果: ジャーナルへの寄稿記事

Interleukin-15
Exons
Messenger RNA
Protein Isoforms
Alternative Splicing

ミトコンドリア膜透過装置rat Tom20p cytoplasmic domainの溶液構造

阿部義人, 小代俊浩, 遠藤斗志也 & 神田大輔, 9 7 1998, : : Biophysics (Japan). 38, 2, p. S5

研究成果: ジャーナルへの寄稿記事

1999
71 引用 (Scopus)

Activation of T cells recognizing an epitope of heat-shock protein 70 can protect against rat adjuvant arthritis

Tanaka, S., Kimura, Y., Mitani, A., Yamamoto, G., Nishimura, H., Spallek, R., Singh, M., Noguchi, T. & Yoshikai, Y., 11 15 1999, : : Journal of Immunology. 163, 10, p. 5560-5565 6 p.

研究成果: ジャーナルへの寄稿記事

HSP70 Heat-Shock Proteins
T-Lymphocyte Epitopes
Experimental Arthritis
Mycobacterium tuberculosis
Interleukin-10
445 引用 (Scopus)

An F-box protein, FWD1, mediates ubiquitin-dependent proteolysis of β-catenin

Kitagawa, M., Hatakeyama, S., Shirane, M., Matsumoto, M., Ishida, N., Hattori, K., Nakamichi, I., Kikuchi, A., Nakayama, K. I. & Nakayama, K., 5 4 1999, : : EMBO Journal. 18, 9, p. 2401-2410 10 p.

研究成果: ジャーナルへの寄稿記事

F-Box Proteins
Proteolysis
Catenins
Ubiquitin
Ubiquitination
18 引用 (Scopus)

Bcl-xL is a negative regulator of caspase-3 activation in immature neurons during development

Urase, K., Momoi, T., Fujita, E., Isahara, K., Uchiyama, Y., Tokunaga, A., Nakayama, K. & Motoyama, N., 8 5 1999, : : Developmental Brain Research. 116, 1, p. 69-78 10 p.

研究成果: ジャーナルへの寄稿記事

Caspase 3
Neurons
Rhombencephalon
Caspases
Nervous System
16 引用 (Scopus)

Characterization of CD4+CD8αα+ and CD4-CD8αα+ intestinal intraepithelial lymphocytes in rats

Yamada, K., Kimura, Y., Nishimura, H., Namii, Y., Murase, M. & Yoshikai, Y., 1 25 1999, : : International Immunology. 11, 1, p. 21-28 8 p.

研究成果: ジャーナルへの寄稿記事

Lymphocytes
Interleukin-15
Interleukin-2
Transforming Growth Factors
Interleukin-4
61 引用 (Scopus)

Common pathway for the ubiquitination of IκBα, Iκbβ, and IκBε mediated by the F-box protein FWD1

Shirane, M., Hatakeyama, S., Hattori, K., Nakayama, K. & Nakayama, K., 10 1 1999, : : Journal of Biological Chemistry. 274, 40, p. 28169-28174 6 p.

研究成果: ジャーナルへの寄稿記事

F-Box Proteins
Ubiquitination
Proteins
SKP Cullin F-Box Protein Ligases
Proteolysis
210 引用 (Scopus)

Down-regulation of p27(Kip1) by two mechanisms, ubiquitin-mediated degradation and proteolytic processing

Shirane, M., Harumiya, Y., Ishida, N., Hirai, A., Miyamoto, C., Hatakeyama, S., Nakayama, K. I. & Kitagawa, M., 5 14 1999, : : Journal of Biological Chemistry. 274, 20, p. 13886-18893 5008 p.

研究成果: ジャーナルへの寄稿記事

Ubiquitin
Down-Regulation
Ubiquitination
Degradation
Processing
33 引用 (Scopus)

Effects of overexpression of PTP36, a putative protein tyrosine phosphatase, on cell adhesion, cell growth, and cytoskeletons in HeLa cells

Ogata, M., Takada, T., Mori, Y., Oh-Hora, M., Uchida, Y., Kosugi, A., Miyake, K. & Hamaoka, T., 4 30 1999, : : Journal of Biological Chemistry. 274, 18, p. 12905-12909 5 p.

研究成果: ジャーナルへの寄稿記事

Protein Tyrosine Phosphatases
Cell adhesion
Cell growth
Cytoskeleton
HeLa Cells