研究成果

1999

Sequence-ready 1-Mb YAC, BAC and cosmid contigs covering the distal imprinted region of mouse chromosome 7

Kato, R., Shirohzu, H., Yokomine, T., Mizuno, S. I., Mukai, T. & Sasaki, H., 1 1 1999, : : DNA Research. 6, 6, p. 401-405 5 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)

Spontaneous clustering of Thy-1 antigens on CD4+CD8+ thymocytes lacking TCR engagement by MHC/peptide complexes

Sano, T., Yamamoto, K., Fukui, Y. & Sasazuki, T., 2 19 1999, : : European Journal of Immunology. 29, 2, p. 403-412 10 p.

研究成果: ジャーナルへの寄稿記事

1 引用 (Scopus)

Structure and expression of the gene encoding mouse F-box protein, Fwd2

Miura, M., Hatakeyama, S., Hattori, K. & Nakayama, K. I., 11 15 1999, : : Genomics. 62, 1, p. 50-58 9 p.

研究成果: ジャーナルへの寄稿記事

16 引用 (Scopus)

The interaction of intestinal epithelial cells and intraepithelial lymphocytes in host defense

Yoshikai, Y., 1 1 1999, : : Immunologic Research. 20, 2, p. 219-235 17 p.

研究成果: ジャーナルへの寄稿評論記事

45 引用 (Scopus)

The oxidized forms of dATP are substrates for the human MutT homologue, the hMTH1 protein

Fujikawa, K., Kamiya, H., Yakushiji, H., Fujii, Y., Nakabeppu, Y. & Kasai, H., 6 25 1999, : : Journal of Biological Chemistry. 274, 26, p. 18201-18205 5 p.

研究成果: ジャーナルへの寄稿記事

177 引用 (Scopus)

The role of intrahepatic γδ-T cells for liver injury induced by Salmonella infection in mouse

Ishigami, M., Nishimura, H., Yoshioka, K., Kakumu, S. & Yoshikai, Y., 1 1 1999, : : MICROBIOLOGY and IMMUNOLOGY. 43, 5, p. 461-469 9 p.

研究成果: ジャーナルへの寄稿記事

8 引用 (Scopus)

The role of tumor necrosis factor (TNF)-α in the antitumor effect of intrapleural injection of Lactobacillus casei strain Shirota in mice

Yasutake, N., Matsuzaki, T., Kimura, K., Hashimoto, S., Yokokura, T. & Yoshikai, Y., 9 15 1999, : : Medical Microbiology and Immunology. 188, 1, p. 9-14 6 p.

研究成果: ジャーナルへの寄稿記事

32 引用 (Scopus)

The roles of intrahepatic Vα14+ NK1.1+ T cells for liver injury induced by Salmonella infection in mice

Ishigami, M., Nishimura, H., Naiki, Y., Yoshioka, K., Kawano, T., Tanaka, Y., Taniguchi, M., Kakumu, S. & Yoshikai, Y., 6 7 1999, : : Hepatology. 29, 6, p. 1799-1808 10 p.

研究成果: ジャーナルへの寄稿記事

69 引用 (Scopus)

The TAK1-NLK-MAPK-related pathway antagonizes signalling between β- catenin and transcription factor TCF

Ishitani, T., Ninomiya-Tsuji, J., Nagai, S. I., Nishita, M., Meneghini, M., Barker, N., Waterman, M., Bowerman, B., Clevers, H., Shibuya, H. & Matsumoto, K., 6 24 1999, : : Nature. 399, 6738, p. 798-802 5 p.

研究成果: ジャーナルへの寄稿記事

485 引用 (Scopus)

Ubiquitin-dependent degradation of IκBα is mediated by a ubiquitin ligase Skp1/Cul 1/F-box protein FWD1

Hatakeyama, S., Kitagawa, M., Nakayama, K., Shirane, M., Matsumoto, M., Hattori, K., Higashi, H., Nakano, H., Okumura, K., Onoé, K., Good, R. A. & Nakayama, K. I., 3 30 1999, : : Proceedings of the National Academy of Sciences of the United States of America. 96, 7, p. 3859-3863 5 p.

研究成果: ジャーナルへの寄稿記事

168 引用 (Scopus)
2000

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y. A., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M. & Nakayama, K., 6 15 2000, : : Genes and Development. 14, 12, p. 1439-1447 9 p.

研究成果: ジャーナルへの寄稿記事

411 引用 (Scopus)

Accumulation of adenine DNA glycosylase-sensitive sites in human mitochondrial DNA

Miyako, K., Takamatsu, C., Umeda, S., Tajiri, T., Furuichi, M., Nakabeppu, Y., Sekiguchi, M., Hamasaki, N., Takeshige, K. & Kang, D., 4 21 2000, : : Journal of Biological Chemistry. 275, 16, p. 12326-12330 5 p.

研究成果: ジャーナルへの寄稿記事

7 引用 (Scopus)

A defect in a single allele of the Mlh1 gene causes dissociation of the killing and tumorigenic actions of an alkylating carcinogen in methyltransferase-deficient mice

Kawate, H., Itoh, R., Sakumi, K., Nakabeppu, Y., Tsuzuki, T., Ide, F., Ishikawa, T., Noda, T., Nawata, H. & Sekiguchi, M., 2 28 2000, : : Carcinogenesis. 21, 2, p. 301-305 5 p.

研究成果: ジャーナルへの寄稿記事

36 引用 (Scopus)

A di-leucine signal in the ubiquitin moiety: Possible involvement in ubiqutination-mediated endocytosis

Nakatsu, F., Sakuma, M., Matsuo, Y., Arase, H., Yamasaki, S., Nakamura, N., Saito, T. & Ohno, H., 8 25 2000, : : Journal of Biological Chemistry. 275, 34, p. 26213-26219 7 p.

研究成果: ジャーナルへの寄稿記事

68 引用 (Scopus)

Aldehyde dehydrogenase (ALDH) 2 associates with oxidation of methoxyacetaldehyde; in vitro analysis with liver subcellular fraction derived from human and Aldh2 gene targeting mouse

Kitagawa, K., Kawamoto, T., Kunugita, N., Tsukiyama, T., Okamoto, K., Yoshida, A., Nakayama, K. & Nakayama, K. I., 7 7 2000, : : FEBS Letters. 476, 3, p. 306-311 6 p.

研究成果: ジャーナルへの寄稿記事

105 引用 (Scopus)

Antitumor effect of heat-killed Lactobacillus plantarum L-137 through restoration of impaired interleukin-12 production in tumor-bearing mice

Murosaki, S., Muroyama, K., Yamamoto, Y. & Yoshikai, Y., 1 1 2000, : : Cancer Immunology Immunotherapy. 49, 3, p. 157-164 8 p.

研究成果: ジャーナルへの寄稿記事

60 引用 (Scopus)

A protective role of interleukin-15 in a mouse model for systemic infection with herpes simplex virus

Tsunobuchi, H., Nishimura, H., Goshima, F., Daikoku, T., Suzuki, H., Nakashima, I., Nishiyama, Y. & Yoshikai, Y., 9 15 2000, : : Virology. 275, 1, p. 57-66 10 p.

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

Cbl suppresses B cell receptor-mediated phospholipase C (PLC)-γ2 activation by regulating B cell linker protein-PLC-γ2 binding

Yasuda, T., Maeda, A., Kurosaki, M., Tezuka, T., Hironaka, K., Yamamoto, T. & Kurosaki, T., 2 21 2000, : : Journal of Experimental Medicine. 191, 4, p. 641-650 10 p.

研究成果: ジャーナルへの寄稿記事

80 引用 (Scopus)

Cell cycle-dependent expression of mammalian E2-C regulated by the anaphase-promoting complex/cyclosome

Yamanaka, A., Hatakeyama, S., Kominami, K. I., Kitagawa, M., Matsumoto, M. & Nakayama, K. I., 1 1 2000, : : Molecular biology of the cell. 11, 8, p. 2821-2831 11 p.

研究成果: ジャーナルへの寄稿記事

43 引用 (Scopus)

Characterization of human polymorphic DNA repair methyltransferase

Inoue, R., Abe, M., Nakabeppu, Y., Sekiguchi, M., Mori, T. & Suzuki, T., 3 22 2000, : : Pharmacogenetics. 10, 1, p. 59-66 8 p.

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

Chlorella vulgaris culture supernatant (CVS) reduces psychological stress-induced apoptosis in thymocytes of mice

Hasegawa, T., Noda, K., Kumamoto, S., Ando, Y., Yamada, A. & Yoshikai, Y., 11 20 2000, : : International Journal of Immunopharmacology. 22, 11, p. 877-885 9 p.

研究成果: ジャーナルへの寄稿記事

44 引用 (Scopus)

Comparative genomic sequencing identifies novel tissue-specific enhancers and sequence elements for methylation-sensitive factors implicated in Igf2/H19 imprinting

Ishihara, K., Hatano, N., Furuumi, H., Kato, R., Iwaki, T., Miura, K., Jinno, Y. & Sasaki, H., 5 1 2000, : : Genome Research. 10, 5, p. 664-671 8 p.

研究成果: ジャーナルへの寄稿レター

70 引用 (Scopus)

Cutting edge: Naturally occurring soluble form of mouse toll-like receptor 4 inhibits lipopolysaccharide signaling

Iwami, K. I., Matsuguchi, T., Masuda, A., Kikuchi, T., Musikacharoen, T. & Yoshikai, Y., 12 15 2000, : : Journal of Immunology. 165, 12, p. 6682-6686 5 p.

研究成果: ジャーナルへの寄稿記事

197 引用 (Scopus)

Differences in interleukin-12 and -15 production by dendritic-cells at the early stage of Listeria monocytogenes infection between BALB/c and C57 BL/6 mice

Liu, T., Nishimura, H., Matsuguchi, T. & Yoshikai, Y., 5 25 2000, : : Cellular Immunology. 202, 1, p. 31-40 10 p.

研究成果: ジャーナルへの寄稿記事

39 引用 (Scopus)

Differential expression of cytokeratin after orthotopic implantation of newly established human tongue cancer cell lines of defined metastatic ability

Morifuji, M., Taniguchi, S., Sakai, H., Nakabeppu, Y. & Ohishi, M., 1 1 2000, : : American Journal of Pathology. 156, 4, p. 1317-1326 10 p.

研究成果: ジャーナルへの寄稿記事

42 引用 (Scopus)

Differential regulation of fos family genes in the ventrolateral and dorsomedial subdivisions of the rat suprachiasmatic nucleus

Schwartz, W. J., Carpino, A., De La Iglesia, H. O., Baler, R., Klein, D. C., Nakabeppu, Y. & Aronin, N., 6 1 2000, : : Neuroscience. 98, 3, p. 535-547 13 p.

研究成果: ジャーナルへの寄稿記事

81 引用 (Scopus)

Differential roles of interleukin 15 mRNA isoforms generated by alternative splicing in immune responses in vivo

Nishimura, H., Yajima, T., Naiki, Y., Tsunobuchi, H., Umemura, M., Itano, K., Matsuguchi, T., Suzuki, M., Ohashi, P. S. & Yoshikai, Y., 1 3 2000, : : Journal of Experimental Medicine. 191, 1, p. 157-169 13 p.

研究成果: ジャーナルへの寄稿記事

126 引用 (Scopus)

Erratum: A novel protein with RNA-binding motifs interacts with ataxin-2 (Human Molecular Genetics (2000) vol.9 (1303-1313))

Shibata, H., Huynh, D. P. & Pulst, S. M., 8 17 2000, : : Human Molecular Genetics. 9, 12, 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

Expression of mouse mammary tumor virus superantigen accelerates tumorigenicity of myeloma cells

Umemura, M., Wajjwalku, W., Upragarin, N., Liu, T., Nishimura, H., Matsuguchi, T., Nishiyama, Y., Wilson, G. M. & Yoshikai, Y., 9 13 2000, : : Journal of virology. 74, 18, p. 8226-8233 8 p.

研究成果: ジャーナルへの寄稿記事

4 引用 (Scopus)

Expression of toll-like receptor 2 on γδ T cells bearing invariant Vγ6/Vδ1 induced by Escherichia coli infection in mice

Mokuno, Y., Matsuguchi, T., Takano, M., Nishimura, H., Washizu, J., Ogawa, T., Takeuchi, O., Akira, S., Nimura, Y. & Yoshikai, Y., 7 15 2000, : : Journal of Immunology. 165, 2, p. 931-940 10 p.

研究成果: ジャーナルへの寄稿記事

123 引用 (Scopus)

Flow-cytometric separation and enrichment of hepatic progenitor cells in the developing mouse liver

Suzuki, A., Zheng, Y. W., Kondo, R., Kusakabe, M., Takada, Y., Fukao, K., Nakauchi, H. & Taniguchi, H., 1 1 2000, : : Hepatology. 32, 6, p. 1230-1239 10 p.

研究成果: ジャーナルへの寄稿記事

267 引用 (Scopus)

Functional significance of conserved residues in the phosphohydrolase module of Escherichia coli MutT protein

Shimokawa, H., Fujii, Y., Furuichi, M., Sekiguchi, M. & Nakabeppu, Y., 9 1 2000, : : Nucleic acids research. 28, 17, p. 3240-3249 10 p.

研究成果: ジャーナルへの寄稿記事

26 引用 (Scopus)

Gene expressions of Toll-like receptor 2, but not Toll-like receptor 4, is induced by LPS and inflammatory cytokines in mouse macrophages

Matsuguchi, T., Musikacharoen, T., Ogawa, T. & Yoshikai, Y., 11 15 2000, : : Journal of Immunology. 165, 10, p. 5767-5772 6 p.

研究成果: ジャーナルへの寄稿記事

239 引用 (Scopus)

Hematin polymerization assay as a high-throughput screen for identification of new antimalarial pharmacophores

Kurosawa, Y., Dorn, A., Kitsuji-Shirane, M., Shimada, H., Satoh, T., Matile, H., Hofheinz, W., Masciadri, R., Kansy, M. & Ridley, R. G., 1 1 2000, : : Antimicrobial Agents and Chemotherapy. 44, 10, p. 2638-2644 7 p.

研究成果: ジャーナルへの寄稿記事

71 引用 (Scopus)

HLA-DR2-restricted responses to proteolipid protein 95-116 peptide cause autoimmune encephalitis in transgenic mice

Kawamura, K., Yamamura, T., Yokoyama, K., Chui, D. H., Fukui, Y., Sasazuki, T., Inoko, H., David, C. S. & Tabira, T., 4 2000, : : Journal of Clinical Investigation. 105, 7, p. 977-984 8 p.

研究成果: ジャーナルへの寄稿記事

42 引用 (Scopus)

Identification of human MutY homolog (hMYH) as a repair enzyme for 2-hydroxyadenine in DNA and detection of multiple forms of hMYH located in nuclei and mitochondria

Ohtsubo, T., Nishioka, K., Imaiso, Y., Iwai, S., Shimokawa, H., Oda, H., Fujiwara, T. & Nakabeppu, Y., 3 15 2000, : : Nucleic acids research. 28, 6, p. 1355-1364 10 p.

研究成果: ジャーナルへの寄稿記事

254 引用 (Scopus)

Increased susceptibility to chemotherapeutic alkylating agents of mice deficient in DNA repair methyltransferase

Shiraishi, A., Kunihiko, S. & Sekiguchi, M., 2000, : : Carcinogenesis. 21, 10, p. 1879-1883 5 p.

研究成果: ジャーナルへの寄稿記事

62 引用 (Scopus)
54 引用 (Scopus)

Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells

Masuda, A., Matsuguchi, T., Yamaki, K., Hayakawa, T., Kubo, M., Larochelle, W. J. & Yoshikai, Y., 9 22 2000, : : Journal of Biological Chemistry. 275, 38, p. 29331-29337 7 p.

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

Isoforms of JSAP1 scaffold protein generated through alternative splicing

Ito, M., Akechi, M., Hirose, R., Ichimura, M., Takamatsu, N., Xu, P., Nakabeppu, Y., Tadayoshi, S., Yamamoto, K. I. & Yoshioka, K., 9 19 2000, : : Gene. 255, 2, p. 229-234 6 p.

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)

Memory-type CD8+ T cells protect IL-2 receptor α-deficient mice from systemic infection with herpes simplex virus type 2

Tsunobuchi, H., Nishimura, H., Goshima, F., Daikoku, T., Nishiyama, Y. & Yoshikai, Y., 10 15 2000, : : Journal of Immunology. 165, 8, p. 4552-4560 9 p.

研究成果: ジャーナルへの寄稿記事

24 引用 (Scopus)

Mice lacking a CDK inhibitor, p57(Kip2), exhibit skeletal abnormalities and growth retardation

Takahashi, K., Nakayama, K. I. & Nakayama, K., 1 1 2000, : : Journal of biochemistry. 127, 1, p. 73-83 11 p.

研究成果: ジャーナルへの寄稿記事

102 引用 (Scopus)

Molecular analysis of α-thalassemia in Nepal: Correlation with malaria endemicity

Sakai, Y., Kobayashi, S., Shibata, H., Furuumi, H., Endo, T., Fucharoen, S., Hamano, S., Acharya, G. P., Kawasaki, T. & Fukumaki, Y., 1 1 2000, : : Journal of Human Genetics. 45, 3, p. 127-132 6 p.

研究成果: ジャーナルへの寄稿記事

12 引用 (Scopus)

NAK is an IκB kinase-activating kinase

Tojima, Y., Fujimoto, A., Delhase, M., Chen, Y., Hatekeyama, S., Nakayama, K. I., Kaneko, Y., Nimura, Y., Motoyama, N., Ikeda, K., Karin, M. & Nakanishi, M., 4 13 2000, : : Nature. 404, 6779, p. 778-782 5 p.

研究成果: ジャーナルへの寄稿記事

278 引用 (Scopus)

Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability

Ishida, N., Kitagawa, M., Hatakeyama, S. & Nakayama, K., 8 18 2000, : : Journal of Biological Chemistry. 275, 33, p. 25146-25154 9 p.

研究成果: ジャーナルへの寄稿記事

173 引用 (Scopus)

Prediction of structural domains of TAP reveals details of its interaction with p15 and nucleoporins

Suyama, M., Doerks, T., Braun, I. C., Sattler, M., Izaurralde, E. & Bork, P., 1 1 2000, : : EMBO Reports. 1, 1, p. 53-58 6 p.

研究成果: ジャーナルへの寄稿記事

61 引用 (Scopus)

Re-annotating the Mycoplasma pneumoniae genome sequence: Adding value, function and reading frames

Dandekar, T., Huynen, M., Regula, J. T., Ueberle, B., Zimmermann, C. U., Andrade, M. A., Doerks, T., Sánchez-Pulido, L., Snel, B., Suyama, M., Yuan, Y. P., Herrmann, R. & Bork, P., 9 1 2000, : : Nucleic acids research. 28, 17, p. 3278-3288 11 p.

研究成果: ジャーナルへの寄稿記事

184 引用 (Scopus)

Selective increase in cellular Aβ42 is related to apoptosis but not necrosis

Ohyagi, Y., Yamada, T., Nishioka, K., Clarke, N. J., Tomlinson, A. J., Naylor, S., Nakabeppu, Y., Kira, J. I. & Younkin, S. G., 1 17 2000, : : NeuroReport. 11, 1, p. 167-171 5 p.

研究成果: ジャーナルへの寄稿記事

64 引用 (Scopus)

Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase

Fukai, S., Nureki, O., Sekine, S. I., Shimada, A., Tao, J., Vassylyev, D. G. & Yokoyama, S., 11 22 2000, : : Cell. 103, 5, p. 793-803 11 p.

研究成果: ジャーナルへの寄稿記事

223 引用 (Scopus)

Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20

Abe, Y., Shodai, T., Muto, T., Mihara, K., Torii, H., Nishikawa, S. I., Endo, T. & Kohda, D., 3 3 2000, : : Cell. 100, 5, p. 551-560 10 p.

研究成果: ジャーナルへの寄稿記事

358 引用 (Scopus)