研究成果

2000

Selective increase in cellular Aβ42 is related to apoptosis but not necrosis

Ohyagi, Y., Yamada, T., Nishioka, K., Clarke, N. J., Tomlinson, A. J., Naylor, S., Nakabeppu, Y., Kira, J. I. & Younkin, S. G., 1 17 2000, : : NeuroReport. 11, 1, p. 167-171 5 p.

研究成果: ジャーナルへの寄稿記事

64 引用 (Scopus)

Soft metal ions, Cd(II) and Hg(II), induce triple-stranded α-helical assembly and folding of a de novo designed peptide in their trigonal geometries

Li, X., Suzuki, K., Kanaori, K., Tajima, K., Kashiwada, A., Hiroaki, H., Kohda, D. & Tanaka, T., 1 1 2000, : : Protein Science. 9, 7, p. 1327-1333 7 p.

研究成果: ジャーナルへの寄稿記事

70 引用 (Scopus)

Structural basis for double-sieve discrimination of L-valine from L-isoleucine and L-threonine by the complex of tRNA(Val) and valyl-tRNA synthetase

Fukai, S., Nureki, O., Sekine, S. I., Shimada, A., Tao, J., Vassylyev, D. G. & Yokoyama, S., 11 22 2000, : : Cell. 103, 5, p. 793-803 11 p.

研究成果: ジャーナルへの寄稿記事

223 引用 (Scopus)

Structural basis of presequence recognition by the mitochondrial protein import receptor Tom20

Abe, Y., Shodai, T., Muto, T., Mihara, K., Torii, H., Nishikawa, S. I., Endo, T. & Kohda, D., 3 3 2000, : : Cell. 100, 5, p. 551-560 10 p.

研究成果: ジャーナルへの寄稿記事

358 引用 (Scopus)

Synergistic effect of interleukin-15 and interleukin-12 on antitumor activity in a murine malignant pleurisy model

Kimura, K., Nishimura, H., Matsuzaki, T., Yokokura, T., Nimura, Y. & Yoshikai, Y., 7 15 2000, : : Cancer Immunology Immunotherapy. 49, 2, p. 71-77 7 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Targeted disruption of Skp2 results in accumulation of cyclin E and p27 (Kip1), polyploidy and centrosome overduplication

Nakayama, K., Nagahama, H., Minamishima, Y. A., Matsumoto, M., Nakamichi, I., Kitagawa, K., Shirane, M., Tsunematsu, R., Tsukiyama, T., Ishida, N., Kitagawa, M., Nakayama, K. I. & Hatakeyama, S., 5 2 2000, : : EMBO Journal. 19, 9, p. 2069-2081 13 p.

研究成果: ジャーナルへの寄稿記事

594 引用 (Scopus)

The 2.0 Å crystal structure of Thermus thermophilus methionyl-tRNA synthetase reveals two RNA-binding modules

Sugiura, I., Nureki, O., Ugaji-Yoshikawa, Y., Kuwabara, S., Shimada, A., Tateno, M., Lorber, B., Giegé, R., Moras, D., Yokoyama, S. & Konno, M., 2 1 2000, : : Structure. 8, 2, p. 197-208 12 p.

研究成果: ジャーナルへの寄稿記事

77 引用 (Scopus)

The ortholog of human ataxin-2 is essential for early embryonic patterning in C. elegans

Kiehl, T. R., Shibata, H. & Pulst, S. M., 1 1 2000, : : Journal of Molecular Neuroscience. 15, 3, p. 231-241 11 p.

研究成果: ジャーナルへの寄稿記事

41 引用 (Scopus)

The paternal methylation imprint of the mouse H19 locus is acquired in the gonocyte stage during foetal testis development

Ueda, T., Abe, K., Miura, A., Yuzuriha, M., Zubair, M., Noguchi, M., Niwa, K., Kawase, Y., Kono, T., Matsuda, Y., Fujimoto, H., Shibata, H., Hayashizaki, Y. & Sasaki, H., 9 2 2000, : : Genes to Cells. 5, 8, p. 649-659 11 p.

研究成果: ジャーナルへの寄稿記事

175 引用 (Scopus)

The role of interleukin 15 in mounting an immune response against microbial infections

Yoshikai, Y. & Nishimura, H., 4 2000, : : Microbes and Infection. 2, 4, p. 381-389 9 p.

研究成果: ジャーナルへの寄稿評論記事

39 引用 (Scopus)

Tyk2 plays a restricted role in IFNα signaling, although it is required for IL-12-mediated T cell function

Shimoda, K., Kato, K., Aoki, K., Matsuda, T., Miyamoto, A., Shibamori, M., Yamashita, M., Numata, A., Takase, K., Kobayashi, S., Shibata, S., Asano, Y., Gondo, H., Sekiguchi, K., Nakayama, K., Nakayama, T., Okamura, T., Okamura, S., Niho, Y. & Nakayama, K. I., 1 1 2000, : : Immunity. 13, 4, p. 561-571 11 p.

研究成果: ジャーナルへの寄稿記事

238 引用 (Scopus)

Ubiquitin-dependent proteolysis by SCF complex

Nakayama, K. & Nakayama, K. I., 12 1 2000, : : Seikagaku. 72, 2, p. 113-117 5 p.

研究成果: ジャーナルへの寄稿記事

Vγl+ γδ T cells play protective roles at an early phase of murine cytomegalovirus infection through production of interferon-γ

Ninomiya, T., Takimoto, H., Matsuzaki, G., Hamano, S., Yoshida, H., Yoshikai, Y., Kimura, G. & Nomoto, K., 1 1 2000, : : Immunology. 99, 2, p. 187-194 8 p.

研究成果: ジャーナルへの寄稿記事

53 引用 (Scopus)

γδ T cells may dichotomously modulate infection with avirulent Salmonella choleraesuis via IFN-γ and IL-13 in mice

Naiki, Y., Nishimura, H., Itohara, S. & Yoshikai, Y., 5 25 2000, : : Cellular Immunology. 202, 1, p. 61-69 9 p.

研究成果: ジャーナルへの寄稿記事

11 引用 (Scopus)
2001

Accumulation of 8-oxo-2′-deoxyguanosine and increased expression of hMTH1 protein in brain tumors

Iida, T., Furuta, A., Kawashima, M., Nishida, J. I., Nakabeppu, Y. & Iwaki, T., 4 2001, : : Neuro-Oncology. 3, 2, p. 73-81 9 p.

研究成果: ジャーナルへの寄稿記事

65 引用 (Scopus)
27 引用 (Scopus)

Analysis of polyprenols by supercritical fluid chromatography

Bamba, T., Fukusaki, E. I., Nakazawa, Y., Sato, H., Ute, K., Kitayama, T. & Kobayashi, A., 12 1 2001, : : KOBUNSHI RONBUNSHU. 58, 12, p. 642-649 8 p.

研究成果: ジャーナルへの寄稿記事

2 引用 (Scopus)

A novel mitogen-activated protein kinase phosphatase is an important negative regulator of lipopolysaccharide-mediated c-Jun N-terminal kinase activation in mouse macrophage cell lines

Matsuguchi, T., Musikacharoen, T., Johnson, T. R., Kraft, A. S. & Yoshikai, Y., 10 10 2001, : : Molecular and cellular biology. 21, 20, p. 6999-7009 11 p.

研究成果: ジャーナルへの寄稿記事

64 引用 (Scopus)

Association analysis of polymorphisms in the upstream region of the human dopamine D4 receptor gene (DRD4) with schizophrenia and personality traits

Mitsuyasu, H., Hirata, N., Sakai, Y., Shibata, H., Takeda, Y., Ninomiya, H., Kawasaki, H., Tashiro, N. & Fukumaki, Y., 3 10 2001, : : Journal of Human Genetics. 46, 1, p. 26-31 6 p.

研究成果: ジャーナルへの寄稿記事

71 引用 (Scopus)

Association study of polymorphisms in the GluR5 kainate receptor gene (GRIK1) with schizophrenia

Shibata, H., Joo, A., Fujii, Y., Tani, A., Makino, C., Hirata, N., Kikuta, R., Ninomiya, H., Tashiro, N. & Fukumaki, Y., 10 30 2001, : : Psychiatric Genetics. 11, 3, p. 139-144 6 p.

研究成果: ジャーナルへの寄稿記事

30 引用 (Scopus)

Bilirubin impairs bactericidal activity of neutrophils through an antioxidant mechanism in vitro

Arai, T., Yoshikai, Y., Kamiya, J., Nagino, M., Uesaka, K., Yuasa, N., Oda, K., Sano, T. & Nimura, Y., 1 1 2001, : : Journal of Surgical Research. 96, 1, p. 107-113 7 p.

研究成果: ジャーナルへの寄稿記事

27 引用 (Scopus)

Ca2+-induced switching of troponin and tropomyosin on actin filaments as revealed by electron cryo-microscopy

Narita, A., Yasunaga, T., Ishikawa, T., Mayanagi, K. & Wakabayashi, T., 4 27 2001, : : Journal of Molecular Biology. 308, 2, p. 241-261 21 p.

研究成果: ジャーナルへの寄稿記事

96 引用 (Scopus)

Characterization of a mouse gene (Fbxw6) that encodes a homologue of Caenorhabditis elegans SEL-10

Maruyama, S. I., Hatakeyama, S., Nakayama, K., Ishida, N., Kawakami, K. & Nakayama, K. I., 9 15 2001, : : Genomics. 78, 3, p. 214-222 9 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Characterization of CD28-CD4+ T cells in living kidney transplant patients with long-term allograft acceptance

Kato, M., Matsuguchi, T., Ono, Y., Hattori, R., Ohshima, S. & Yoshikai, Y., 12 17 2001, : : Human Immunology. 62, 12, p. 1335-1345 11 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Cytokine-independent Jak3 Activation upon T Cell Receptor (TCR) Stimulation through Direct Association of Jak3 and the TCR Complex

Tomita, K., Saijo, K., Yamasaki, S., Iida, T., Nakatsu, F., Arase, H., Ohno, H., Shirasawa, T., Kuriyama, T., O'Shea, J. J. & Saito, T., 7 6 2001, : : Journal of Biological Chemistry. 276, 27, p. 25378-25385 8 p.

研究成果: ジャーナルへの寄稿記事

29 引用 (Scopus)

Deafness due to degeneration of cochlear neurons in caspase-3-deficient mice

Morishita, H., Makishima, T., Kaneko, C., Lee, Y. S., Segil, N., Takahashi, K., Kuraoka, A., Nakagawa, T., Nabekura, J., Nakayama, K. & Nakayama, K. I., 1 1 2001, : : Biochemical and Biophysical Research Communications. 284, 1, p. 142-149 8 p.

研究成果: ジャーナルへの寄稿記事

28 引用 (Scopus)

Degradation of p27Kip1 at the G0-G1 Transition Mediated by a Skp2-independent Ubiquitination Pathway

Hara, T., Kamura, T., Nakayama, K., Oshikawa, K., Hatakeyama, S. & Nakayama, K., 12 28 2001, : : Journal of Biological Chemistry. 276, 52, p. 48937-48943 7 p.

研究成果: ジャーナルへの寄稿記事

187 引用 (Scopus)

Dichotomous effect of a traditional Japanese medicine, Bu-zhong-yi-qi-tang on allergic asthma in mice

Ishimitsu, R., Nishimura, H., Kawauchi, H., Kawakita, T. & Yoshikai, Y., 4 21 2001, : : International Immunopharmacology. 1, 5, p. 857-865 9 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

Docking Protein Gab2 Is Phosphorylated by ZAP-70 and Negatively Regulates T Cell Receptor Signaling by Recruitment of Inhibitory Molecules

Yamasaki, S., Nishida, K., Hibi, M., Sakuma, M., Shiina, R., Takeuchi, A., Ohnishi, H., Hirano, T. & Saito, T., 11 30 2001, : : Journal of Biological Chemistry. 276, 48, p. 45175-45183 9 p.

研究成果: ジャーナルへの寄稿記事

67 引用 (Scopus)

Down-regulation of p27Kip1 expression is required for development and function of T cells

Tsukiyama, T., Ishida, N., Shirane, M., Minamishima, Y. A., Hatakeyama, S., Kitagawa, M., Nakayama, K. & Nakayama, K. I., 1 1 2001, : : Journal of Immunology. 166, 1, p. 304-312 9 p.

研究成果: ジャーナルへの寄稿記事

50 引用 (Scopus)

E2A and HEB activate the pre-TCRα promoter during immature T cell development

Takeuchi, A., Yamasaki, S., Takase, K., Nakatsu, F., Arase, H., Onodera, M. & Saito, T., 8 15 2001, : : Journal of Immunology. 167, 4, p. 2157-2163 7 p.

研究成果: ジャーナルへの寄稿記事

37 引用 (Scopus)

Enhancement of laminar FosB expression in frontal cortex of rats receiving long chronic clozapine administration

Rodríguez, J. J., Garcia, D. R., Nakabeppu, Y. & Pickel, V. M., 1 1 2001, : : Experimental Neurology. 168, 2, p. 392-401 10 p.

研究成果: ジャーナルへの寄稿記事

9 引用 (Scopus)

Enzymatic properties of the de novo-type mouse DNA (cytosine-5) methyltransferases

Aoki, A., Suetake, I., Miyagawa, J., Fujio, T., Chijiwa, T., Sasaki, H. & Tajima, S., 9 1 2001, : : Nucleic acids research. 29, 17, p. 3506-3512 7 p.

研究成果: ジャーナルへの寄稿記事

132 引用 (Scopus)

Erratum: Human Oggl, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide (Cancer Research (September 1, 2001) (6388-6393))

Jaiswal, M., LaRusso, N. F., Nishioka, K., Nakabeppu, Y. & Gores, G. J., 10 15 2001, : : Cancer Research. 61, 20, 1 p.

研究成果: ジャーナルへの寄稿コメント/討論

1 引用 (Scopus)

Essential role of the prosurvival bcl-2 homologue A1 in mast cell survival after allergic activation

Xiang, Z., Ahmed, A. A., Möller, C., Nakayama, K. I., Hatakeyama, S. & Nilsson, G., 12 3 2001, : : Journal of Experimental Medicine. 194, 11, p. 1561-1569 9 p.

研究成果: ジャーナルへの寄稿記事

91 引用 (Scopus)

Expression and prognostic significance of O6-methylguanine-DNA methyltransferase in hepatocellular, gastric, and breast cancers

Matsukura, S., Miyazaki, K., Yakushiji, H., Ogawa, A., Harimaya, K., Nakabeppu, Y. & Sekiguchi, M., 12 1 2001, : : Annals of Surgical Oncology. 8, 10, p. 807-816 10 p.

研究成果: ジャーナルへの寄稿記事

43 引用 (Scopus)

Expression of DNA methyltransferases DNMT1, 3A, and 3B in normal hematopoiesis and in acute and chronic myelogenous leukemia

Mizuno, S. I., Chijiwa, T., Okamura, T., Akashi, K., Fukumaki, Y., Niho, Y. & Sasaki, H., 3 1 2001, : : Blood. 97, 5, p. 1172-1179 8 p.

研究成果: ジャーナルへの寄稿記事

328 引用 (Scopus)

Expression of hMTHI in the hippocampi of control and Alzheimer's disease

Furuta, A., Iida, T., Nakabeppu, Y. & Iwaki, T., 9 17 2001, : : NeuroReport. 12, 13, p. 2895-2899 5 p.

研究成果: ジャーナルへの寄稿記事

38 引用 (Scopus)

FosB in rat striatum: Normal regional distribution and enhanced expression after 6-month haloperidol administration

Rodrguez, J. J., Garcia, D. R., Nakabeppu, Y. & Pickel, V. M., 2 8 2001, : : Synapse. 39, 2, p. 122-132 11 p.

研究成果: ジャーナルへの寄稿記事

21 引用 (Scopus)

Gene cloning, expression, crystallization and preliminary x-ray analysis of Thermus thermophilus arginyl-tRNA synthetase

Shimada, A., Nureki, O., Dohmae, N., Takio, K. & Yokoyama, S., 2 22 2001, : : Acta Crystallographica Section D: Biological Crystallography. 57, 2, p. 272-275 4 p.

研究成果: ジャーナルへの寄稿記事

5 引用 (Scopus)

Gene expression of osteoclast differentiation factor is induced by lipopolysaccharide in mouse osteoblasts via toll-like receptors

Kikuchi, T., Matsuguchi, T., Tsuboi, N., Mitani, A., Tanaka, S., Matsuoka, M., Yamamoto, G., Hishikawa, T., Noguchi, T. & Yoshikai, Y., 3 1 2001, : : Journal of Immunology. 166, 5, p. 3574-3579 6 p.

研究成果: ジャーナルへの寄稿記事

175 引用 (Scopus)

Haematopoietic cell-specific CDM family protein DOCK2 is essential for lymphocyte migration

Fukui, Y., Hashimoto, O., Sanui, T., Oono, T., Koga, H., Abe, M., Inayoshi, A., Noda, M., Oike, M., Shirai, T. & Sasazuki, T., 8 23 2001, : : Nature. 412, 6849, p. 826-831 6 p.

研究成果: ジャーナルへの寄稿記事

336 引用 (Scopus)

High-resolution analysis of polyprenols by supercritical fluid chromatography

Bamba, T., Fukusaki, E., Kajiyama, S., Ute, K., Kitayama, T. & Kobayashi, A., 3 9 2001, : : Journal of Chromatography A. 911, 1, p. 113-117 5 p.

研究成果: ジャーナルへの寄稿記事

25 引用 (Scopus)
115 引用 (Scopus)

Human MTH1 protein hydrolyzes the oxidized ribonucleotide, 2-hydroxy-ATP

Fujikawa, K., Kamiya, H., Yakushiji, H., Nakabeppu, Y. & Kasai, H., 1 15 2001, : : Nucleic acids research. 29, 2, p. 449-454 6 p.

研究成果: ジャーナルへの寄稿記事

90 引用 (Scopus)

Human Ogg1, a protein involved in the repair of 8-oxoguanine, is inhibited by nitric oxide

Jaiswal, M., LaRusso, N. F., Nishioka, N., Nakabeppu, Y. & Gores, G. J., 8 1 2001, : : Cancer Research. 61, 17, p. 6388-6393 6 p.

研究成果: ジャーナルへの寄稿記事

154 引用 (Scopus)

Hyperinsulinemia in PRIP-1 gene deleted mice

Doira, N., Kanematsu, T., Matsuda, M., Takeuchi, H., Nakano, H. O., Ito, Y., Nakayama, K., Nakayama, K. I. & Hirata, M., 1 1 2001, : : Biomedical Research. 22, 3, p. 157-165 9 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Impaired IL-15 production associated with susceptibility of murine AIDS to mycobacterial infection

Umemura, M., Hirose, K., Wajjwalku, W., Nishimura, H., Matsuguchi, T., Gotoh, Y., Takahashi, M., Makino, M. & Yoshikai, Y., 2 5 2001, : : Journal of Leukocyte Biology. 69, 1, p. 138-148 11 p.

研究成果: ジャーナルへの寄稿記事

13 引用 (Scopus)

Interleukin-15 Prevents Mouse Mast Cell Apoptosis through STAT6-mediated Bcl-xL Expression

Masuda, A., Matsuguchi, T., Yamaki, K., Hayakawa, T. & Yoshikai, Y., 7 13 2001, : : Journal of Biological Chemistry. 276, 28, p. 26107-26113 7 p.

研究成果: ジャーナルへの寄稿記事

64 引用 (Scopus)

Intracellular distribution of the antimutagenic enzyme MTH1 in the liver, kidney and testis of F344 rats and its modulation by cadmium

Kasprzak, K. S., Nakabeppu, Y., Kakuma, T., Sakai, Y., Tsuruya, K., Sekiguchi, M., Ward, J. M., Diwan, B. A., Nagashima, K. & Kasprzak, B. H., 1 1 2001, : : Experimental and Toxicologic Pathology. 53, 5, p. 325-335 11 p., 1.

研究成果: ジャーナルへの寄稿記事

10 引用 (Scopus)