研究成果 1979 2020

[Mitochondrial quality control and regulation of neuronal function].

Shirane, M., 2014, : : Seikagaku. The Journal of Japanese Biochemical Society. 86, 4, p. 479-482 4 p.

研究成果: ジャーナルへの寄稿評論記事

Tacrolimus Binding Proteins
Mitochondria
Molecular Chaperones
Neurons
Quality control

[Studies of T cells for better understanding of immunity and allergy].

Yoshikai, Y., 1 1 2011, : : Nihon Jibiinkoka Gakkai kaiho. 114, 6, p. 539-546 8 p.

研究成果: ジャーナルへの寄稿評論記事

Immunity
Hypersensitivity
T-Lymphocytes

2-Oxoadenosine induces cytotoxicity through intracellular accumulation of 2-oxo-ATP and depletion of ATP but not via the p38 MAPK pathway

Asada, S., Ohta, E., Akimoto, Y., Abolhassani, N., Tsuchimoto, D. & Nakabeppu, Y., 12 1 2017, : : Scientific Reports. 7, 1, 6528.

研究成果: ジャーナルへの寄稿記事

公開
Adenosine Kinase
p38 Mitogen-Activated Protein Kinases
Adenosine Triphosphate
Cell Death
Nucleoside-Triphosphatase
11 引用 (Scopus)

3-O-sulfo-β-d-galactose moiety of endogenous sulfoglycolipids is a potential ligand for immunoglobulin-like receptor LMIR5

Phongsisay, V., Iizasa, E., Hara, H. & Yamasaki, S., 2 1 2015, : : Molecular Immunology. 63, 2, p. 595-599 5 p.

研究成果: ジャーナルへの寄稿記事

Glycolipids
Galactose
C-Type Lectins
Immunoglobulins
Basophils
16 引用 (Scopus)

8-Chloro-dGTP, a hypochlorous acid-modified nucleotide, is hydrolyzed by hMTH1, the human MutT homolog

Fujikawa, K., Yakushiji, H., Nakabeppu, Y., Suzuki, T., Masuda, M., Ohshima, H. & Kasai, H., 2 13 2002, : : FEBS Letters. 512, 1-3, p. 149-151 3 p.

研究成果: ジャーナルへの寄稿記事

Hypochlorous Acid
Nucleotides
Pyrophosphatases
Purine Nucleotides
Adenosinetriphosphate
Islands of Calleja
Neurogenesis
Dentate Gyrus
Phenotype
Lateral Ventricles
26 引用 (Scopus)
Mitochondrial DNA
Neurons
Antioxidants
Neurodegenerative Diseases
Cytosine
66 引用 (Scopus)

8-Oxoguanine causes neurodegeneration during MUTYH-mediated DNA base excision repair

Sheng, Z., Oka, S., Tsuchimoto, D., Abolhassani, N., Nomaru, H., Sakumi, K., Yamada, H. & Nakabeppu, Y., 12 3 2012, : : Journal of Clinical Investigation. 122, 12, p. 4344-4361 18 p.

研究成果: ジャーナルへの寄稿記事

Microglia
DNA Repair
Carcinogenesis
Oxidative Stress
Apoptosis Inducing Factor
64 引用 (Scopus)

8-Oxoguanine causes spontaneous de novo germline mutations in mice

Ohno, M., Sakumi, K., Fukumura, R., Furuichi, M., Iwasaki, Y., Hokama, M., Ikemura, T., Tsuzuki, T., Gondo, Y. & Nakabeppu, Y., 4 1 2014, : : Scientific reports. 4, 4689.

研究成果: ジャーナルへの寄稿記事

Germ-Line Mutation
Mutation
Germ Cells
Exome
DNA
10 引用 (Scopus)

8-oxoguanine DNA glycosylase (OGG1) deficiency elicits coordinated changes in lipid and mitochondrial metabolism in muscle

Vartanian, V., Tumova, J., Dobrzyn, P., Dobrzyn, A., Nakabeppu, Y., Lloyd, R. S. & Sampath, H., 7 2017, : : PloS one. 12, 7, e0181687.

研究成果: ジャーナルへの寄稿記事

DNA Glycosylases
glycosylases
Lipid Metabolism
Metabolism
Muscle
58 引用 (Scopus)

8-Oxoguanine DNA Glycosylase (OGG1) Deficiency Increases Susceptibility to Obesity and Metabolic Dysfunction

Sampath, H., Vartanian, V., Rollins, M. R., Sakumi, K., Nakabeppu, Y. & Lloyd, R. S., 12 17 2012, : : PloS one. 7, 12, e51697.

研究成果: ジャーナルへの寄稿記事

DNA Glycosylases
glycosylases
obesity
Obesity
Fats
99 引用 (Scopus)

8-Oxoguanine formation induced by chronic UVB exposure makes Ogg1 knockout mice susceptible to skin carcinogenesis

Kunisada, M., Sakumi, K., Tominaga, Y., Budiyanto, A., Ueda, M., Ichihashi, M., Nakabeppu, Y. & Nishigori, C., 7 15 2005, : : Cancer Research. 65, 14, p. 6006-6010 5 p.

研究成果: ジャーナルへの寄稿記事

Knockout Mice
Carcinogenesis
Skin
Sarcoma
DNA Damage
1 引用 (Scopus)

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K., 8 1 2019, : : EBioMedicine. 46, p. 150-159 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Genes
Breast Neoplasms
Survival
RNA Sequence Analysis
Organized Financing
408 引用 (Scopus)

Aberrant cell cycle checkpoint function and early embryonic death in Chk1(-/-) mice

Takai, H., Tominaga, K., Motoyama, N., Minamishima, Y. A., Nagahama, H., Tsukiyama, T., Ikeda, K., Nakayama, K., Nakanishi, M. & Nakayama, K., 6 15 2000, : : Genes and Development. 14, 12, p. 1439-1447 9 p.

研究成果: ジャーナルへの寄稿記事

Cell Cycle Checkpoints
Mammals
Blastocyst
DNA Damage
Embryonic Structures
31 引用 (Scopus)

Ability of various alkylating agents to induce adaptive and SOS responses: A study with lacZ fusion

Otsuka, M., Nakabeppu, U. & Sekiguchi, M., 9 1985, : : Mutation Research DNA Repair Reports. 146, 2, p. 149-154 6 p.

研究成果: ジャーナルへの寄稿記事

Alkylating Agents
Galactosidases
Ethylnitrosourea
Methylnitronitrosoguanidine
Lac Operon
85 引用 (Scopus)

Ablation of Fbxw7 Eliminates Leukemia-Initiating Cells by Preventing Quiescence

Takeishi, S., Matsumoto, A., Onoyama, I., Naka, K., Hirao, A. & Nakayama, K., 3 18 2013, : : Cancer Cell. 23, 3, p. 347-361 15 p.

研究成果: ジャーナルへの寄稿記事

Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Hematopoietic Stem Cells
Stem Cells
Maintenance
6 引用 (Scopus)

Ablation of p27 enhance kainate-induced seizure and hippocampal degeneration

Ueyama, C., Akashiba, H., Nakayama, K., Nakayama, K., Nishiyama, N. & Matsuki, N., 11 2007, : : NeuroReport. 18, 17, p. 1781-1785 5 p.

研究成果: ジャーナルへの寄稿記事

Kainic Acid
Seizures
Cell Death
Retinoblastoma Protein
Cyclin-Dependent Kinases
14 引用 (Scopus)

Ablation of the microglial protein DOCK2 reduces amyloid burden in a mouse model of Alzheimer's disease

Cimino, P. J., Yang, Y., Li, X., Hemingway, J. F., Cherne, M. K., Khademi, S. B., Fukui, Y., Montine, K. S., Montine, T. J. & Keene, C. D., 4 1 2013, : : Experimental and Molecular Pathology. 94, 2, p. 366-371 6 p.

研究成果: ジャーナルへの寄稿記事

Cytokinesis
Ablation
Amyloid
Alzheimer Disease
Proteins
239 引用 (Scopus)

Abnormal angiogenesis in Foxo1 (Fkhr)-deficient mice

Furuyama, T., Kitayama, K., Shimoda, Y., Ogawa, M., Sone, K., Yoshida-Araki, K., Hisatsune, H., Nishikawa, S. I., Nakayama, K., Nakayama, K., Ikeda, K., Motoyama, N. & Mori, N., 8 13 2004, : : Journal of Biological Chemistry. 279, 33, p. 34741-34749 9 p.

研究成果: ジャーナルへの寄稿記事

Endothelial cells
Endothelial Cells
Vascular Endothelial Growth Factor A
Embryonic Stem Cells
Stem cells
13 引用 (Scopus)

Abnormality in Wnt signaling is causatively associated with oxidative stress-induced intestinal tumorigenesis in MUTYH-null mice

Isoda, T., Nakatsu, Y., Yamauchi, K., Piao, J., Yao, T., Honda, H., Nakabeppu, Y. & Tsuzuki, T., 8 23 2014, : : International journal of biological sciences. 10, 8, p. 940-947 8 p.

研究成果: ジャーナルへの寄稿記事

abnormality
tumor
carcinogenesis
Carcinogenesis
Oxidative Stress
1 引用 (Scopus)

Abnormal rearrangements of T-cell receptor genes occur in long-term cultured bone marrow cells of lpr/lpr mice

Ohga, S., Yoshikai, Y., Matsumoto, K., Kishihara, K., Matsuzaki, G. & Nomoto, K., 1989, : : Immunology. 67, 4, p. 543-546 4 p.

研究成果: ジャーナルへの寄稿記事

T-Cell Receptor Genes
Bone Marrow Cells
Cultured Cells
T-Lymphoid Precursor Cells
Wasting Syndrome
6 引用 (Scopus)

A BP-Based Algorithm for Performing Bayesian Inference in Large Perceptron-Type Networks

Kabashima, Y. & Uda, S., 2004, International Conference on Algorithmic Learning Theory. p. 479-493

研究成果: 著書/レポートタイプへの貢献会議での発言

14 引用 (Scopus)

Absence of LTB4/BLT1 axis facilitates generation of mouse GM-CSF-induced long-lasting antitumor immunologic memory by enhancing innate and adaptive immune systems

Yokota, Y., Inoue, H., Matsumura, Y., Nabeta, H., Narusawa, M., Watanabe, A., Sakamoto, C., Hijikata, Y., Iga-Murahashi, M., Takayama, K., Sasaki, F., Nakanishi, Y., Yokomizo, T. & Tani, K., 10 25 2012, : : Blood. 120, 17, p. 3444-3454 11 p.

研究成果: ジャーナルへの寄稿記事

Immunologic Memory
Leukotriene B4
Immune system
Granulocyte-Macrophage Colony-Stimulating Factor
Tumors
47 引用 (Scopus)

Absence of SKP2 expression attenuates BCR-ABL-induced myeloproliferative disease

Agarwal, A., Bumm, T. G. P., Corbin, A. S., O'Hare, T., Loriaux, M., Van Dyke, J., Willis, S. G., Deininger, J., Nakayama, K. I., Druker, B. J. & Deininger, M. W., 9 1 2008, : : Blood. 112, 5, p. 1960-1970 11 p.

研究成果: ジャーナルへの寄稿記事

S-Phase Kinase-Associated Proteins
Bone Marrow
Cells
F-Box Proteins
Transformed Cell Line

A case of amebiasis with negative serologic markers that caused intra-abdominal abscess

Tanaka, R., Furusyo, N., Takeda, R., Yamasaki, S., Kusaga, A., Ogawa, E., Masayuki, M., Nakanishi, R. & Maehara, Y., 11 1 2017, : : Journal of Infection and Chemotherapy. 23, 11, p. 778-781 4 p.

研究成果: ジャーナルへの寄稿記事

Abdominal Abscess
Amebiasis
Abscess
Serology
Tomography

A case of breakthrough hepatitis caused by HBV-DNA mutations after 4 years combination therapy of Lamivudine and Adefovir dipivoxil

Miyazaki, M., Higuchi, N., Tanaka, M., Ueda, A., Kato, M., Tsuji, Y., Kotoh, K. & Takyanagi, R., 10 14 2009, : : Acta Hepatologica Japonica. 50, 9, p. 514-519 6 p.

研究成果: ジャーナルへの寄稿記事

Lamivudine
Hepatitis
Mutation
DNA
Chronic Hepatitis B

A case of fatal intrahepatic cholestasis with primary AL amyloidosis: Is early diagnosis possible?

Takao, S., Tanaka, K., Miyazaki, M., Tanaka, M., Ohashi, T., Kato, M., Kotoh, K., Aishima, S. & Takayanagi, R., 10 1 2013, : : Clinical Journal of Gastroenterology. 6, 5, p. 386-389 4 p.

研究成果: ジャーナルへの寄稿記事

Amyloidosis
Early Diagnosis
Immunoglobulin Light Chains
Liver
Intrahepatic Cholestasis
7 引用 (Scopus)

Accelerated clinical course of prion disease in mice compromised in repair of oxidative DNA damage

Jalland, C. M. O., Benestad, S. L., Ersdal, C., Scheffler, K., Suganthan, R., Nakabeppu, Y., Eide, L., Bjørås, M. & Tranulis, M. A., 1 1 2014, : : Free Radical Biology and Medicine. 68, p. 1-7 7 p.

研究成果: ジャーナルへの寄稿記事

Prion Diseases
Prions
DNA Damage
Repair
DNA Repair
177 引用 (Scopus)

Accelerated neutrophil apoptosis in mice lacking A1-a, a subtype of the bcl-2-related A1 gene

Hamasaki, A., Sendo, F., Nakayama, K., Ishida, N., Negishi, I., Nakayama, K. I. & Hatakeyama, S., 12 7 1998, : : Journal of Experimental Medicine. 188, 11, p. 1985-1992 8 p.

研究成果: ジャーナルへの寄稿記事

Neutrophils
Apoptosis
Genes
Transendothelial and Transepithelial Migration
Lipopolysaccharides
5 引用 (Scopus)

Accelerated progression of a murine retrovirus-induced immunodeficiency syndrome in fas mutant C57BL/6 lpr/lpr mice

Hiromatsu, K., Usami, J., Aoki, Y., Makino, M. & Yoshikai, Y., 1 1 1997, : : MICROBIOLOGY and IMMUNOLOGY. 41, 3, p. 221-227 7 p.

研究成果: ジャーナルへの寄稿記事

Retroviridae
Murine Acquired Immunodeficiency Syndrome
Murine Leukemia Viruses
T-Lymphocytes
CD95 Antigens
30 引用 (Scopus)
Chlorella vulgaris
Leukocyte Count
Cyclophosphamide
Water
Escherichia coli Infections
55 引用 (Scopus)

Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development

Ichiyanagi, T., Ichiyanagi, K., Miyake, M. & Sasaki, H., 1 1 2013, : : Nucleic acids research. 41, 2, p. 738-745 8 p.

研究成果: ジャーナルへの寄稿記事

Germ Cells
Methylation
Cytosine
Retroelements
Spermatogonia
65 引用 (Scopus)

Accumulation of 8-oxo-2′-deoxyguanosine and increased expression of hMTH1 protein in brain tumors

Iida, T., Furuta, A., Kawashima, M., Nishida, J. I., Nakabeppu, Y. & Iwaki, T., 4 2001, : : Neuro-Oncology. 3, 2, p. 73-81 9 p.

研究成果: ジャーナルへの寄稿記事

Brain Neoplasms
Proteins
Oxidative Stress
Glioma
DNA Damage
22 引用 (Scopus)

Accumulation of 8-oxo-deoxyguanosine in cardiovascular tissues with the development of hypertension

Ohtsubo, T., Ohya, Y., Nakamura, Y., Kansui, Y., Furuichi, M., Matsumura, K., Fujii, K., Iida, M. & Nakabeppu, Y., 6 1 2007, : : DNA Repair. 6, 6, p. 760-769 10 p.

研究成果: ジャーナルへの寄稿記事

Deoxyguanosine
Tissue
Endothelial cells
Hypertension
Aorta
74 引用 (Scopus)

Accumulation of 8-oxoguanine in the cellular DNA and the alteration of the OGG1 expression during ischemia-reperfusion injury in the rat kidney

Tsuruya, K., Furuichi, M., Tominaga, Y., Shinozaki, M., Tokumoto, M., Yoshimitsu, T., Fukuda, K., Kanai, H., Hirakata, H., Iida, M. & Nakabeppu, Y., 2 3 2003, : : DNA Repair. 2, 2, p. 211-229 19 p.

研究成果: ジャーナルへの寄稿記事

Reperfusion Injury
Rats
Kidney
DNA
Reperfusion
8 引用 (Scopus)

Accumulation of adenine DNA glycosylase-sensitive sites in human mitochondrial DNA

Miyako, K., Takamatsu, C., Umeda, S., Tajiri, T., Furuichi, M., Nakabeppu, Y., Sekiguchi, M., Hamasaki, N., Takeshige, K. & Kang, D., 4 21 2000, : : Journal of Biological Chemistry. 275, 16, p. 12326-12330 5 p.

研究成果: ジャーナルへの寄稿記事

DNA Glycosylases
Adenine
Mitochondrial DNA
Electron Transport
Guanine
7 引用 (Scopus)

Accurate estimation of 5-methylcytosine in mammalian mitochondrial DNA

Matsuda, S., Yasukawa, T., Sakaguchi, Y., Ichiyanagi, K., Unoki, M., Gotou, K., Fukuda, K., Sasaki, H., Suzuki, T. & Kang, D., 2018, : : Scientific Reports. 8, 1

研究成果: ジャーナルへの寄稿記事

公開
116 引用 (Scopus)

A central role for DOCK2 during interstitial lymphocyte motility and sphingosine-1-phosphate-mediated egress

Nombela-Arrieta, C., Mempel, T. R., Soriano, S. F., Mazo, I., Wymann, M. P., Hirsch, E., Martínez-A., C., Fukui, Y., Von Andrian, U. H. & Stein, J. V., 3 19 2007, : : Journal of Experimental Medicine. 204, 3, p. 497-510 14 p.

研究成果: ジャーナルへの寄稿記事

1-Phosphatidylinositol 4-Kinase
Lymphocytes
T-Lymphocytes
Lymph Nodes
B-Lymphocytes

Acetaldehyde administrationinduces salsolinol formation in vivo in the dorsal striatum of Aldh2-knockout and C57BL/6N mice

Ito, A., Jamal, M., Ameno, K., Tanaka, N., Takakura, A., Kawamoto, T., Kitagawa, K., Nakayama, K., Matsumoto, A., Miki, T. & Kinoshita, H., 10 15 2018, : : Neuroscience Letters. 685, p. 50-54 5 p.

研究成果: ジャーナルへの寄稿記事

Acetaldehyde
Inbred C57BL Mouse
Knockout Mice
Dopamine
Serotonin
13 引用 (Scopus)

A chromatin integration labelling method enables epigenomic profiling with lower input

Harada, A., Maehara, K., Handa, T., Arimura, Y., Nogami, J., Hayashi-Takanaka, Y., Shirahige, K., Kurumizaka, H., Kimura, H. & Ohkawa, Y., 2 1 2019, : : Nature Cell Biology. 21, 2, p. 287-296 10 p.

研究成果: ジャーナルへの寄稿記事

Epigenomics
Chromatin
Chromatin Immunoprecipitation
Histone Code
Immunoprecipitation
90 引用 (Scopus)

A chromosome 14 inversion in a T-cell lymphoma is caused by site-specific recombination between immunoglobulin and T-cell receptor loci

Denny, C. T., Yoshikai, Y., Mak, T. W., Smith, S. D., Hollis, G. F. & Kirsch, I. R., 12 1 1986, : : Nature. 320, 6062, p. 549-551 3 p.

研究成果: ジャーナルへの寄稿記事

Chromosomes, Human, Pair 14
T-Cell Lymphoma
T-Cell Antigen Receptor
Genetic Recombination
Immunoglobulins
26 引用 (Scopus)

A cluster of noncoding RNAs activates the ESR1 locus during breast cancer adaptation

Tomita, S., Abdalla, M. O. A., Fujiwara, S., Matsumori, H., Maehara, K., Ohkawa, Y., Iwase, H., Saitoh, N. & Nakao, M., 4 29 2015, : : Nature communications. 6, 6966.

研究成果: ジャーナルへの寄稿記事

Untranslated RNA
loci
breast
estrogens
cancer
7 引用 (Scopus)

A co-localization model of paired ChIP-seq data using a large ENCODE data set enables comparison of multiple samples

Maehara, K., Odawara, J., Harada, A., Yoshimi, T., Nagao, K., Obuse, C., Akashi, K., Tachibana, T., Sakata, T. & Ohkawa, Y., 1 1 2013, : : Nucleic acids research. 41, 1, p. 54-62 9 p.

研究成果: ジャーナルへの寄稿記事

Encyclopedias
Chromatin Immunoprecipitation
RNA Polymerase III
RNA Polymerase II
DNA
22 引用 (Scopus)

A comparative immunohistochemistry of O6-methylguanine-DNA methyltransferase and p53 in diffusely infiltrating astrocytomas

Yuan, Q., Matsumoto, K., Nakabeppu, Y. & Iwaki, T., 9 1 2003, : : Neuropathology. 23, 3, p. 203-209 7 p.

研究成果: ジャーナルへの寄稿記事

Astrocytoma
Methyltransferases
Immunohistochemistry
DNA
Guanine
12 引用 (Scopus)

A comparative study of the enzymologieal features of α-amylase in the Drosophila melanogaster species subgroup

Shibata, H. & Yamazaki, T., 1 1 1994, : : Japanese Journal of Genetics. 69, 3, p. 251-258 8 p.

研究成果: ジャーナルへの寄稿記事

Amylases
Drosophila melanogaster
Temperature
Phylogeny
Enzymes
8 引用 (Scopus)

A comprehensive screening system for damaged nucleotide-binding proteins

Tsuchimoto, D., Iyama, T., Nonaka, M., Abolhassani, N., Ohta, E., Sakumi, K. & Nakabeppu, Y., 11 28 2010, : : Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 703, 1, p. 37-42 6 p.

研究成果: ジャーナルへの寄稿評論記事

Inosine Triphosphate
Carrier Proteins
Nucleotides
Inosine Monophosphate
Adenosine Triphosphate
2 引用 (Scopus)
公開
Hepatocytes
Fibroblasts
Fatty Liver
Lipids
Preclinical Drug Evaluations
82 引用 (Scopus)

A critical role for the innate immune signaling molecule IRAK-4 in T cell activation

Suzuki, N., Suzuki, S., Millar, D. G., Unno, M., Hara, H., Calzascia, T., Yamasaki, S., Yokosuka, T., Chen, N. J., Elford, A. R., Suzuki, J. I., Takeuchi, A., Mirtsos, C., Bouchard, D., Ohashi, P. S., Yeh, W. C. & Saito, T., 3 31 2006, : : Science. 311, 5769, p. 1927-1932 6 p.

研究成果: ジャーナルへの寄稿記事

Adaptive Immunity
T-Lymphocytes
Innate Immunity
T-Cell Antigen Receptor
Protein Kinases
41 引用 (Scopus)

A Critical Role of CD30 Ligand/CD30 in Controlling Inflammatory Bowel Diseases in Mice

Sun, X., Somada, S., Shibata, K., Muta, H., Yamada, H., Yoshihara, H., Honda, K., Nakamura, K., Takayanagi, R., Tani, K., Podack, E. R. & Yoshikai, Y., 1 1 2008, : : Gastroenterology. 134, 2

研究成果: ジャーナルへの寄稿記事

CD30 Ligand
Oxazolone
Trinitrobenzenes
Colitis
Sulfonic Acids
38 引用 (Scopus)

A Critical Role of the 3′ Terminus of Nascent DNA Chains in Recognition of Stalled Replication Forks

Mizukoshi, T., Tanaka, T., Arai, K. I., Kohda, D. & Masai, H., 10 24 2003, : : Journal of Biological Chemistry. 278, 43, p. 42234-42239 6 p.

研究成果: ジャーナルへの寄稿記事

DNA
Proteins
Double-Stranded DNA Breaks
Sensors
DNA Replication