研究成果 1979 2020

フィルター
記事
2020

Characterization of genetic-origin-dependent monoallelic expression in mouse embryonic stem cells

Ohishi, H., Au Yeung, W. K., Unoki, M., Ichiyanagi, K., Fukuda, K., Maenohara, S., Shirane, K., Chiba, H., Sado, T. & Sasaki, H., 1 1 2020, : : Genes to Cells. 25, 1, p. 54-64 11 p.

研究成果: ジャーナルへの寄稿記事

Genes
Retroelements
Embryonic Stem Cells
Epigenomics
Single Nucleotide Polymorphism

Conformational ensemble of an intrinsically flexible loop in mitochondrial import protein Tim21 studied by modeling and molecular dynamics simulations

Srivastava, A., Bala, S., Motomura, H., Kohda, D., Tama, F. & Miyashita, O., 2 2020, : : Biochimica et Biophysica Acta - General Subjects. 1864, 2, 129417.

研究成果: ジャーナルへの寄稿記事

Mitochondrial Proteins
Molecular Dynamics Simulation
Molecular dynamics
Crystals
Computer simulation

Crystal contact-free conformation of an intrinsically flexible loop in protein crystal: Tim21 as the case study

Bala, S., Shinya, S., Srivastava, A., Ishikawa, M., Shimada, A., Kobayashi, N., Kojima, C., Tama, F., Miyashita, O. & Kohda, D., 2 2020, : : Biochimica et Biophysica Acta - General Subjects. 1864, 2, 129418.

研究成果: ジャーナルへの寄稿記事

Conformations
Crystals
Proteins
Yeasts
Yeast

DOCK family proteins: key players in immune surveillance mechanisms

Kunimura, K., Uruno, T. & Fukui, Y., 1 9 2020, : : International immunology. 32, 1, p. 5-15 11 p.

研究成果: ジャーナルへの寄稿記事

公開
Guanine Nucleotide Exchange Factors
Cytokinesis
Proteins
Immune Evasion
Severe Combined Immunodeficiency
Pyruvate Dehydrogenase Complex
Synechococcus
Acetyl Coenzyme A
Fluxes
Pyruvic Acid

Impaired upregulation of Stat2 gene restrictive to pancreatic β-cells is responsible for virus-induced diabetes in DBA/2 mice

Mine, K., Nagafuchi, S., Hatano, S., Tanaka, K., Mori, H., Takahashi, H., Anzai, K. & Yoshikai, Y., 1 22 2020, : : Biochemical and Biophysical Research Communications. 521, 4, p. 853-860 8 p.

研究成果: ジャーナルへの寄稿記事

公開
STAT2 Transcription Factor
Inbred DBA Mouse
Medical problems
Viruses
Up-Regulation

Imprinted Cdkn1c genomic locus cell-autonomously promotes cell survival in cerebral cortex development

Laukoter, S., Beattie, R., Pauler, F. M., Amberg, N., Nakayama, K. I. & Hippenmeyer, S., 12 1 2020, : : Nature communications. 11, 1, 195.

研究成果: ジャーナルへの寄稿記事

公開
cerebral cortex
loci
Cerebral Cortex
Cell Survival
Cells

Long-term maintenance of functional primary human hepatocytes using small molecules

Katsuda, T., Kawamata, M., Inoue, A., Yamaguchi, T., Abe, M. & Ochiya, T., 1 1 2020, : : FEBS Letters. 594, 1, p. 114-125 12 p.

研究成果: ジャーナルへの寄稿記事

Cytochrome P-450 CYP3A
Hepatocytes
Drug Discovery
Molecules
Cytochrome P-450 CYP1A2

Metabolic effects of RUBCN/Rubicon deficiency in kidney proximal tubular epithelial cells

Matsuda, J., Takahashi, A., Takabatake, Y., Sakai, S., Minami, S., Yamamoto, T., Fujimura, R., Namba-Hamano, T., Yonishi, H., Nakamura, J., Kimura, T., Kaimori, J. Y., Matsui, I., Takahashi, M., Nakao, M., Izumi, Y., Bamba, T., Matsusaka, T., Niimura, F., Yanagita, M. および2人, Yoshimori, T. & Isaka, Y., 1 1 2020, (受理済み/印刷中) : : Autophagy.

研究成果: ジャーナルへの寄稿記事

OGG1 deficiency alters the intestinal microbiome and increases intestinal inflammation in a mouse model

Simon, H., Vartanian, V., Wong, M. H., Nakabeppu, Y., Sharma, P., Stephen Lloyd, R. & Sampath, H., 1 1 2020, : : PloS one. 15, 1, e0227501.

研究成果: ジャーナルへの寄稿記事

公開
Nutrition
inflammation
animal models
Inflammation
mice

Production of BBF2H7-derived small peptide fragments via endoplasmic reticulum stress-dependent regulated intramembrane proteolysis

Matsuhisa, K., Saito, A., Cai, L., Kaneko, M., Okamoto, T., Sakaue, F., Asada, R., Urano, F., Yanagida, K., Okochi, M., Kudo, Y., Matsumoto, M., Nakayama, K. I. & Imaizumi, K., 1 1 2020, : : FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 34, 1, p. 865-880 16 p.

研究成果: ジャーナルへの寄稿記事

公開
Proteolysis
Peptide Fragments
Endoplasmic Reticulum Stress
Peptide Hydrolases
Basic-Leucine Zipper Transcription Factors

The role of galanin in the differentiation of mucosal mast cells in mice

Yamaguchi, T., Ikeda, Y., Tashiro, K., Ohkawa, Y. & Kawabata, K., 1 1 2020, : : European Journal of Immunology. 50, 1, p. 110-118 9 p.

研究成果: ジャーナルへの寄稿記事

Galanin
Mast Cells
Connective Tissue Cells
Receptor, Galanin, Type 3
Dextran Sulfate
2019
Islands of Calleja
Neurogenesis
Dentate Gyrus
Phenotype
Lateral Ventricles
1 引用 (Scopus)

A 23 gene–based molecular prognostic score precisely predicts overall survival of breast cancer patients

Shimizu, H. & Nakayama, K. I., 8 2019, : : EBioMedicine. 46, p. 150-159 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Genes
Breast Neoplasms
Survival
RNA Sequence Analysis
Organized Financing
13 引用 (Scopus)

A chromatin integration labelling method enables epigenomic profiling with lower input

Harada, A., Maehara, K., Handa, T., Arimura, Y., Nogami, J., Hayashi-Takanaka, Y., Shirahige, K., Kurumizaka, H., Kimura, H. & Ohkawa, Y., 2 1 2019, : : Nature Cell Biology. 21, 2, p. 287-296 10 p.

研究成果: ジャーナルへの寄稿記事

Epigenomics
Chromatin
Chromatin Immunoprecipitation
Histone Code
Immunoprecipitation

A fail-safe system to prevent oncogenesis by senescence is targeted by SV40 small T antigen

Oshikawa, K., Matsumoto, M., Kodama, M., Shimizu, H. & Nakayama, K. I., 1 1 2019, (受理済み/印刷中) : : Oncogene.

研究成果: ジャーナルへの寄稿記事

Simian virus 40
Viral Tumor Antigens
Carcinogenesis
Oncogenes
Heterochromatin

Aging of spermatogonial stem cells by Jnk-mediated glycolysis activation

Kanatsu-Shinohara, M., Yamamoto, T., Toh, H., Kazuki, Y., Kazuki, K., Imoto, J., Ikeo, K., Oshima, M., Shirahige, K., Iwama, A., Nabeshima, Y., Sasaki, H. & Shinohara, T., 8 13 2019, : : Proceedings of the National Academy of Sciences of the United States of America. 116, 33, p. 16404-16409 6 p.

研究成果: ジャーナルへの寄稿記事

公開
Glycolysis
Stem Cells
JNK Mitogen-Activated Protein Kinases
Cell Aging
Telomere Shortening

A highly sensitive determination method for acrylamide in beverages, grains, and confectioneries by supercritical fluid chromatography tandem mass spectrometry

Yoshioka, T., Izumi, Y., Nagatomi, Y., Miyamoto, Y., Suzuki, K. & Bamba, T., 10 1 2019, : : Food Chemistry. 294, p. 486-492 7 p.

研究成果: ジャーナルへの寄稿記事

supercritical fluid chromatography
Supercritical Fluid Chromatography
Beverages
Acrylamide
acrylamides

Alternative mRNA splicing in three venom families underlying a possible production of divergent venom proteins of the habu snake, protobothrops flavoviridis

Ogawa, T., Oda-Ueda, N., Hisata, K., Nakamura, H., Chijiwa, T., Hattori, S., Isomoto, A., Yugeta, H., Yamasaki, S., Fukumaki, Y., Ohno, M., Satoh, N. & Shibata, H., 10 9 2019, : : Toxins. 11, 10, 581.

研究成果: ジャーナルへの寄稿記事

公開
Trimeresurus
Snakes
Venoms
Alternative Splicing
Genes
2 引用 (Scopus)

Anti-tumour effects of antimicrobial peptides, components of the innate immune system, against haematopoietic tumours in Drosophila mxc mutants

Araki, M., Kurihara, M., Kinoshita, S., Awane, R., Sato, T., Ohkawa, Y. & Inoue, Y. H., 1 1 2019, : : DMM Disease Models and Mechanisms. 12, 6, dmm037721.

研究成果: ジャーナルへの寄稿記事

公開
Immune system
Drosophila
Tumors
Immune System
Peptides

Biochemical analysis of nucleosome targeting by Tn5 transposase

Sato, S., Arimura, Y., Kujirai, T., Harada, A., Maehara, K., Nogami, J., Ohkawa, Y. & Kurumizaka, H., 8 1 2019, : : Open Biology. 9, 8, 190116.

研究成果: ジャーナルへの寄稿記事

公開
Nucleosomes
DNA
Tn5 transposase
DNA sequences
Genomics
1 引用 (Scopus)

Broad Heterochromatic Domains Open in Gonocyte Development Prior to De Novo DNA Methylation

Yamanaka, S., Nishihara, H., Toh, H., Eijy Nagai, L. A., Hashimoto, K., Park, S. J., Shibuya, A., Suzuki, A. M., Tanaka, Y., Nakai, K., Carninci, P., Sasaki, H. & Siomi, H., 10 7 2019, : : Developmental Cell. 51, 1, p. 21-34.e5

研究成果: ジャーナルへの寄稿記事

DNA Methylation
Genes
Genome
Methyltransferases
Chromatin

Calcineurin broadly regulates the initiation of skeletal muscle-specific gene expression by binding target promoters and facilitating the interaction of the SWI/SNF chromatin remodeling enzyme

Witwicka, H., Nogami, J., Syed, S. A., Maehara, K., Padilla-Benavides, T., Ohkawa, Y. & Imbalzano, A. N., 10 1 2019, : : Molecular and cellular biology. 39, 19, e00063-19.

研究成果: ジャーナルへの寄稿記事

公開
Chromatin Assembly and Disassembly
Calcineurin
Skeletal Muscle
Gene Expression
Enzymes
7 引用 (Scopus)

CDCA7 and HELLS mutations undermine nonhomologous end joining in centromeric instability syndrome

Unoki, M., Funabiki, H., Velasco, G., Francastel, C. & Sasaki, H., 1 2 2019, : : Journal of Clinical Investigation. 129, 1, CI99751.

研究成果: ジャーナルへの寄稿記事

Chromosome Segregation
Mutation
HEK293 Cells
Chromatin
Apoptosis
3 引用 (Scopus)

Cell-autonomous and redundant roles of Hey1 and HeyL in muscle stem cells: HeyL requires HeS1 to bind diverse DNA sites

Noguchi, Y. T., Nakamura, M., Hino, N., Nogami, J., Tsuji, S., Sato, T., Zhang, L., Tsujikawa, K., Tanaka, T., Izawa, K., Okada, Y., Doi, T., Kokubo, H., Harada, A., Uezumi, A., Gessler, M., Ohkawa, Y. & Fukada, S. I., 2 2019, : : Development (Cambridge). 146, 4, dev163618.

研究成果: ジャーナルへの寄稿記事

公開
Muscle Cells
Stem Cells
DNA
Myogenin
Chromatin

Cell competition corrects noisy Wnt morphogen gradients to achieve robust patterning in the zebrafish embryo

Akieda, Y., Ogamino, S., Furuie, H., Ishitani, S., Akiyoshi, R., Nogami, J., Masuda, T., Shimizu, N., Ohkawa, Y. & Ishitani, T., 12 1 2019, : : Nature communications. 10, 1, 4710.

研究成果: ジャーナルへの寄稿記事

公開
embryos
Zebrafish
Embryonic Structures
Catenins
gradients

Chromatin-bound CRM1 recruits SET-Nup214 and NPM1c onto HOX clusters causing aberrant HOX expression in leukemia cells

Oka, M., Mura, S., Otani, M., Miyamoto, Y., Nogami, J., Maehara, K., Harada, A., Tachibana, T., Yoneda, Y. & Ohkawa, Y., 11 22 2019, : : eLife. 8

研究成果: ジャーナルへの寄稿記事

公開
Nuclear Pore Complex Proteins
Chromatin
Leukemia
Nuclear Export Signals
Proteins
2 引用 (Scopus)

CLEC3A, MMP7, and LCN2 as novel markers for predicting recurrence in resected G1 and G2 pancreatic neuroendocrine tumors

Miki, M., Oono, T., Fujimori, N., Takaoka, T., Kawabe, K., Miyasaka, Y., Ohtsuka, T., Saito, D., Nakamura, M., Ohkawa, Y., Oda, Y., Suyama, M., Ito, T. & Ogawa, Y., 7 2019, : : Cancer Medicine. 8, 8, p. 3748-3760 13 p.

研究成果: ジャーナルへの寄稿記事

公開
Matrix Metalloproteinase 7
Neuroendocrine Tumors
Recurrence
Genes
Neoplasms

Clinical Features of Liver Injury Induced by Immune Checkpoint Inhibitors in Japanese Patients

Imoto, K., Kohjima, M., Hioki, T., Kurashige, T., Kurokawa, M., Tashiro, S., Suzuki, H., Kuwano, A., Tanaka, M., Okada, S., Kato, M. & Ogawa, Y., 1 1 2019, : : Canadian Journal of Gastroenterology and Hepatology. 2019, 6391712.

研究成果: ジャーナルへの寄稿記事

公開
Liver
Wounds and Injuries
Immunosuppressive Agents
Prednisolone
Chemical and Drug Induced Liver Injury
Heavy Ion Radiotherapy
Sarcoma
Spine
Spinal Cord Compression
Compression Fractures
公開
Supercritical Fluid Chromatography
supercritical fluids
liquid chromatography
High performance liquid chromatography
chromatography

Comparison of sequential derivatization with concurrent methods for GC/MS-based metabolomics

Miyagawa, H. & Bamba, T., 2 2019, : : Journal of Bioscience and Bioengineering. 127, 2, p. 160-168 9 p.

研究成果: ジャーナルへの寄稿記事

Metabolomics
Metabolites
Gas chromatography
Gas Chromatography-Mass Spectrometry
Mass spectrometry
3 引用 (Scopus)

Computational investigation of the conformational dynamics in Tom20-mitochondrial presequence tethered complexes

Srivastava, A., Tama, F., Kohda, D. & Miyashita, O., 1 2019, : : Proteins: Structure, Function and Bioinformatics. 87, 1, p. 81-90 10 p.

研究成果: ジャーナルへの寄稿記事

Disulfides
Molecular Dynamics Simulation
Membranes
Peptides
Molecular dynamics

Development of a new monoclonal antibody specific to mouse Vγ6 chain

Hatano, S., Tun, X., Noguchi, N., Yue, D., Yamada, H., Sun, X., Matsumoto, M. & Yoshikai, Y., 1 1 2019, : : Life Science Alliance. 2, 3, e201900363.

研究成果: ジャーナルへの寄稿記事

公開
T-cells
antibody
monoclonal antibodies
T-lymphocytes
Monoclonal Antibodies
3 引用 (Scopus)

Development of a practical online supercritical fluid extraction–supercritical fluid chromatography/mass spectrometry system with an integrated split-flow method

Sakai, M., Hayakawa, Y., Funada, Y., Ando, T., Fukusaki, E. & Bamba, T., 5 10 2019, : : Journal of Chromatography A. 1592, p. 161-172 12 p.

研究成果: ジャーナルへの寄稿記事

Supercritical Fluid Chromatography
Supercritical fluids
Chromatography
Mass spectrometry
Mass Spectrometry
2 引用 (Scopus)

Disruption of FBXL5-mediated cellular iron homeostasis promotes liver carcinogenesis

Muto, Y., Moroishi, T., Ichihara, K., Nishiyama, M., Shimizu, H., Eguchi, H., Moriya, K., Koike, K., Mimori, K., Mori, M., Katayama, Y. & Nakayama, K. I., 4 1 2019, : : Journal of Experimental Medicine. 216, 4, p. 950-965 16 p.

研究成果: ジャーナルへの寄稿記事

公開
Carcinogenesis
Homeostasis
Iron
Iron Overload
Liver

Dmrt factors determine the positional information of cerebral cortical progenitors via differential suppression of homeobox genes

Konno, D., Kishida, C., Maehara, K., Ohkawa, Y., Kiyonari, H., Okada, S. & Matsuzaki, F., 8 2019, : : Development (Cambridge). 146, 15, dev174243.

研究成果: ジャーナルへの寄稿記事

公開
Telencephalon
Homeobox Genes
Gene Dosage
Olfactory Bulb
Neurogenesis
3 引用 (Scopus)

Elucidating functions of DP1 and DP2 subunits from the Thermococcus kodakarensis family D DNA polymerase

Takashima, N., Ishino, S., Oki, K., Takafuji, M., Yamagami, T., Matsuo, R., Mayanagi, K. & Ishino, Y., 1 22 2019, : : Extremophiles. 23, 1, p. 161-172 12 p.

研究成果: ジャーナルへの寄稿記事

Thermococcus
Transcription Factor DP1
Archaea
DNA-Directed DNA Polymerase
DNA

Frequent Detection of Pituitary-Derived PrPres in Human Prion Diseases

Honda, H., Matsumoto, M., Shijo, M., Hamasaki, H., Sadashima, S., Suzuki, S. O., Aishima, S., Kai, K., Nakayama, K. I., Sasagasako, N. & Iwaki, T., 10 1 2019, : : Journal of neuropathology and experimental neurology. 78, 10, p. 922-929 8 p.

研究成果: ジャーナルへの寄稿記事

Prion Diseases
Human Growth Hormone
Pituitary Gland
Molecular Weight
Dura Mater

Gas chromatography-mass spectrometry metabolomics-based prediction of potato tuber sprouting during long-term storage

Fukuda, T., Takamatsu, K., Bamba, T. & Fukusaki, E., 8 1 2019, : : Journal of Bioscience and Bioengineering. 128, 2, p. 249-254 6 p.

研究成果: ジャーナルへの寄稿記事

Metabolomics
Biomarkers
Solanum tuberosum
Gas chromatography
Gas Chromatography-Mass Spectrometry

Generation of Nanog reporter mice that distinguish pluripotent stem cells from unipotent primordial germ cells

Terada, M., Kawamata, M., Kimura, R., Sekiya, S., Nagamatsu, G., Hayashi, K., Horisawa, K. & Suzuki, A., 11 1 2019, : : Genesis. 57, 11-12, e23334.

研究成果: ジャーナルへの寄稿記事

Pluripotent Stem Cells
Germ Cells
Embryonic Stem Cells
Genetic Promoter Regions
Transgenic Mice

Germline mutation: De novo mutation in reproductive lineage cells

Sakumi, K., 1 1 2019, : : Genes and Genetic Systems. 94, 1, p. 3-12 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Germ-Line Mutation
Mutation Rate
Genome
Mutation
Cell Division

GPR40 activation initiates store-operated Ca2+ entry and potentiates insulin secretion via the IP3R1/STIM1/Orai1 pathway in pancreatic β-cells

Usui, R., Yabe, D., Fauzi, M., Goto, H., Botagarova, A., Tokumoto, S., Tatsuoka, H., Tahara, Y., Kobayashi, S., Manabe, T., Baba, Y., Kurosaki, T., Herrera, P. L., Ogura, M., Nagashima, K. & Inagaki, N., 12 1 2019, : : Scientific reports. 9, 1, 15562.

研究成果: ジャーナルへの寄稿記事

公開
Inositol 1,4,5-Trisphosphate Receptors
Insulin
Glucose
Endoplasmic Reticulum
Inositol 1,4,5-Trisphosphate
2 引用 (Scopus)

Histone H3K9 Methyltransferase G9a in Oocytes Is Essential for Preimplantation Development but Dispensable for CG Methylation Protection

Au Yeung, W. K., Brind'Amour, J., Hatano, Y., Yamagata, K., Feil, R., Lorincz, M. C., Tachibana, M., Shinkai, Y. & Sasaki, H., 4 2 2019, : : Cell Reports. 27, 1, p. 282-293.e4

研究成果: ジャーナルへの寄稿記事

公開
Methylation
Oocytes
Chromatin
Chromosome Segregation
Chromosomes

Identification of genomic alterations acquired during treatment with EGFR-TKIs in non-small cell lung cancer

Kubo, N., Harada, T., Shiraishi, Y., Nosaki, K., Nakagaki, N., Takeshita, M., Ouchi, H., Iwama, E., Tanaka, K., Okamoto, I., Sasaki, H. & Nakanishi, Y., 2 2019, : : Anticancer research. 39, 2, p. 671-677 7 p.

研究成果: ジャーナルへの寄稿記事

Epidermal Growth Factor Receptor
Non-Small Cell Lung Carcinoma
Protein-Tyrosine Kinases
Therapeutics
Exome
2 引用 (Scopus)

Identification of metabolites associated with onset of CAD in diabetic patients using ce-ms analysis: A pilot study

Omori, K., Katakami, N., Yamamoto, Y., Ninomiya, H., Takahara, M., Matsuoka, T. A., Bamba, T., Fukusaki, E. & Shimomura, I., 1 1 2019, : : Journal of atherosclerosis and thrombosis. 26, 3, p. 233-245 13 p.

研究成果: ジャーナルへの寄稿記事

公開
Metabolites
Coronary Artery Disease
Medical problems
Arteries
Galactosamine

Identification of novel serum markers for the progression of coronary atherosclerosis in WHHLMI rabbits, an animal model of familial hypercholesterolemia

Shiomi, M., Takeda, H., Irino, Y., Kimura, N., Yamada, S., Kuniyoshi, N., Kikumori, A., Koike, Y., Koike, T., Yoshida, M., Izumi, Y., Shinohara, M., Bamba, T. & Ishida, T., 5 1 2019, : : Atherosclerosis. 284, p. 18-23 6 p.

研究成果: ジャーナルへの寄稿記事

Hyperlipoproteinemia Type II
Coronary Artery Disease
Animal Models
Biomarkers
Rabbits

Identification of ZBTB24 protein domains and motifs for heterochromatin localization and transcriptional activation

Aktar, S., Sasaki, H. & Unoki, M., 11 1 2019, : : Genes to Cells. 24, 11, p. 746-755 10 p.

研究成果: ジャーナルへの寄稿記事

Amino Acid Motifs
Heterochromatin
Zinc Fingers
AT-Hook Motifs
Transcriptional Activation

Improved quantitation of lipid classes using supercritical fluid chromatography with a charged aerosol detector

Takeda, H., Takahashi, M., Hara, T., Izumi, Y. & Bamba, T., 1 1 2019, : : Journal of Lipid Research. 60, 8, p. 1465-1474 10 p.

研究成果: ジャーナルへの寄稿記事

公開
Supercritical Fluid Chromatography
Aerosols
Detectors
Lipids
Molecules

Inter-laboratory comparison of metabolite measurements for metabolomics data integration

Izumi, Y., Matsuda, F., Hirayama, A., Ikeda, K., Kita, Y., Horie, K., Saigusa, D., Saito, K., Sawada, Y., Nakanishi, H., Okahashi, N., Takahashi, M., Nakao, M., Hata, K., Hoshi, Y., Morihara, M., Tanabe, K., Bamba, T. & Oda, Y., 11 2019, : : Metabolites. 9, 11, 257.

研究成果: ジャーナルへの寄稿記事

公開
Metabolomics
Data integration
Metabolites
Solvent extraction
Assays