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研究成果

年別の研究成果 2019 2022 2023

• 25 学術誌
• 2 コメント/討論

年別の研究成果

年別の研究成果

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• 2023

  Design and implementation of a hybrid cloud system for large-scale human genomic research

  Nagasaki, M., Sekiya, Y., Asakura, A., Teraoka, R., Otokozawa, R., Hashimoto, H., Kawaguchi, T., Fukazawa, K., Inadomi, Y., Murata, K. T., Ohkawa, Y., Yamaguchi, I., Mizuhara, T., Tokunaga, K., Sekiya, Y., Hanawa, T., Yamada, R. & Matsuda, F., 12月 2023, In: Human Genome Variation. 10, 1, 6.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Computational Capacity 100%

• Direct activation of microglia by β-glucosylceramide causes phagocytosis of neurons that exacerbates Gaucher disease

  Shimizu, T., Schutt, C. R., Izumi, Y., Tomiyasu, N., Omahdi, Z., Kano, K., Takamatsu, H., Aoki, J., Bamba, T., Kumanogoh, A., Takao, M. & Yamasaki, S., 2月 14 2023, In: Immunity. 56, 2, p. 307-319.e8

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  • Microglia 100%
  • Gaucher's Disease 100%
  • Gaucher Disease 100%
  • Phagocytosis 60%
  • Symptom 60%

• First proof-of-concept of UC/HILIC for extending the versatility of the current art of supercritical fluid separation

  Le, H. S., Izumi, Y. & Bamba, T., 2月 1 2023, In: Analytica Chimica Acta. 1240, 340741.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  • Chromatography 100%
  • Procedure 50%
  • Hydrophilic Interaction Chromatography 50%
  • Mobile Phase Composition 50%
  • Supercritical Fluid Chromatography 25%

• Mycobacterial mycolic acids trigger inhibitory receptor Clec12A to suppress host immune responses

  Nishimura, N., Tomiyasu, N., Torigoe, S., Mizuno, S., Fukano, H., Ishikawa, E., Katano, H., Hoshino, Y., Matsuo, K., Takahashi, M., Izumi, Y., Bamba, T., Akashi, K. & Yamasaki, S., 1月 2023, In: Tuberculosis. 138, 102294.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  • Mycobacteria 100%
  • Host Immune Response 100%
  • Mouse 50%
  • Host 50%
  • Contrast 25%
  1 被引用数 (Scopus)

• Senescence atlas reveals an aged-like inflamed niche that blunts muscle regeneration

  Moiseeva, V., Cisneros, A., Sica, V., Deryagin, O., Lai, Y., Jung, S., Andrés, E., An, J., Segalés, J., Ortet, L., Lukesova, V., Volpe, G., Benguria, A., Dopazo, A., Aznar-Benitah, S., Urano, Y., del Sol, A., Esteban, M. A., Ohkawa, Y., Serrano, A. L., & 2 othersPerdiguero, E. & Muñoz-Cánoves, P., 1月 5 2023, In: Nature. 613, 7942, p. 169-178 10 p.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Cells 100%
  • Stem Cell 46%
  • Muscle 30%
  • Regeneration 30%
  • Senescence 23%
  2 被引用数 (Scopus)

• Understanding the mechanism of CO₂-Assisted electrospray ionization for parameter optimization in supercritical fluid chromatography mass spectrometry

  Fujito, Y., Izumi, Y., Nakatani, K., Takahashi, M., Hayakawa, Y., Takayama, M. & Bamba, T., 3月 15 2023, In: Analytica Chimica Acta. 1246, 340863.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  • Supercritical Fluid Chromatography 100%
  • Mobile Phase Composition 100%
  • Anion 88%
  • Carbon Dioxide 88%
  • Multiple Sclerosis 88%
• 2022

  Attempts to Detect Lipid Metabolites from a Single Cell Using Proton-Transfer-Reaction Mass Spectrometry Coupled with Micro-Scale Supercritical Fluid Extraction: A Preliminary Study

  Hondo, T., Ota, C., Nakatani, K., Miyake, Y., Furutani, H., Bamba, T. & Toyoda, M., 2022, In: Mass Spectrometry. 11, 1, A0112.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Supercritical Fluid Extraction 100%
  • Anion 75%
  • Procedure 62%
  • Mass Spectrometry 50%
  • Proton 50%

• Change in fatty acid composition of plasma triglyceride caused by a 2 week comprehensive risk management for diabetes: A prospective observational study of type 2 diabetes patients with supercritical fluid chromatography/mass spectrometry-based semi-target lipidomic analysis

  Taya, N., Katakami, N., Omori, K., Hosoe, S., Watanabe, H., Takahara, M., Miyashita, K., Nishizawa, H., Konya, Y., Obara, S., Hidaka, A., Nakao, M., Takahashi, M., Izumi, Y., Shimomura, I. & Bamba, T., 2022, (印刷中) In: Journal of Diabetes Investigation.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Triglyceride 100%
  • Lipid Composition 71%
  • Fatty Acid 57%
  • Reduction (Chemistry) 42%
  • Triacylglycerol Blood Level 42%
  1 被引用数 (Scopus)

• Delivery of ceramide phosphoethanolamine lipids to the cleavage furrow through the endocytic pathway is essential for male meiotic cytokinesis

  Kunduri, G., Le, S. H., Baena, V., Vijaykrishna, N., Harned, A., Nagashima, K., Blankenberg, D., Yoshihiro, I., Narayan, K., Bamba, T., Acharya, U. & Acharya, J. K., 9月 1 2022, In: PLoS Biology. 20, 9, p. e3001599

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Ceramide 100%
  • Cleavage Furrow 50%
  • Membrane 25%
  • Light 25%
  • Cell Division 25%
  1 被引用数 (Scopus)

• Effects of targeting signal mutations in a mitochondrial presequence on the spatial distribution of the conformational ensemble in the binding site of Tom20

  Han, X., Maita, N., Shimada, A. & Kohda, D., 10月 2022, In: Protein Science. 31, 10, e4433.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  • Recognition 100%
  • Dynamics 75%
  • Mitochondrial Protein 75%
  • Binding Site 50%
  • Volume 25%

• In-Needle Pre-Column Derivatization for Amino Acid Quantification (iPDAQ) Using HPLC

  Soma, Y., Izumi, Y., Shimohira, T., Takahashi, M., Imado, Y., Tominaga, S., Tokito, K., Hata, K., Shinadama, S., Oshiro, M., Hayakawa, Y. & Bamba, T., 9月 2022, In: Metabolites. 12, 9, 807.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Derivatization 100%
  • Amino Acids 53%
  • Sample 26%
  • High-Performance Liquid Chromatography 20%
  • Time 6%

• nudt7 gene depletion causes transcriptomic change in early development of zebrafish

  Bhandari, S., Hong, K., Miyawaki-Kuwakado, A., Tomimatsu, K., Kim, Y-I., Nam, I-K., Sagerstrom, C. G., Nakamura, M. & Choe, S-K., 10月 21 2022, (印刷前の電子出版) In: Journal of biochemistry.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  • Transcription 100%
  • Zebra Fish 100%
  • Nested Gene 75%
  • Gene Activation 75%
  • Gene 75%

• nudt7 gene depletion causes transcriptomic change in early development of zebrafish

  Bhandari, S., Hong, K. H., Miyawaki-Kuwakado, A., Tomimatsu, K., Kim, Y. I., Nam, I. K., Sagerström, C. G., Nakamura, M. & Choe, S. K., 12月 27 2022, In: Journal of biochemistry. 173, 1, p. 53-63 11 p.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  • Transcription 100%
  • Zebra Fish 100%
  • Nested Gene 75%
  • Gene Activation 75%
  • Gene 75%

• PDZD8-deficient mice accumulate cholesteryl esters in the brain as a result of impaired lipophagy

  Morita, K., Wada, M., Nakatani, K., Matsumoto, Y., Hayashi, N., Yamahata, I., Mitsunari, K., Mukae, N., Takahashi, M., Izumi, Y., Bamba, T. & Shirane, M., 12月 22 2022, In: iScience. 25, 12, 105612.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Cholesterol Ester 100%
  • Cholesteryl Ester 100%
  • Brain 83%
  • Lipophagocytosis 50%
  • Mouse 50%
  1 被引用数 (Scopus)

• Prostaglandin E₂ receptor Ptger4b regulates female-specific peptidergic neurons and female sexual receptivity in medaka

  Fleming, T., Kikuchi, Y., Nakajo, M., Tachizawa, M., Inazumi, T., Tsuchiya, S., Sugimoto, Y., Saito, D., Suyama, M., Ohkawa, Y., Baba, T., Morohashi, K. I. & Okubo, K., 12月 2022, In: Communications Biology. 5, 1, 1215.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Neuron 100%
  • Peptidergic 71%
  • Oryzias 42%
  • Neuropeptide 42%
  • Estrogens 42%

• Remote solid cancers rewire hepatic nitrogen metabolism via host nicotinamide-N-methyltransferase

  Mizuno, R., Hojo, H., Takahashi, M., Kashio, S., Enya, S., Nakao, M., Konishi, R., Yoda, M., Harata, A., Hamanishi, J., Kawamoto, H., Mandai, M., Suzuki, Y., Miura, M., Bamba, T., Izumi, Y. & Kawaoka, S., 12月 2022, In: Nature communications. 13, 1, 3346.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Host 100%
  • Urea Cycle 60%
  • Mouse 40%
  • Biogenesis 40%
  • Solid 40%
  5 被引用数 (Scopus)

• Retrospective study for the universal applicability of the residue-based linear free energy relationship in the two-state exchange of protein molecules

  Fujinami, D., Hayashi, S. & Kohda, D., 12月 2022, In: Scientific reports. 12, 1, 16843.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Protein 100%
  • Peptide 50%
  • Energy 50%
  • Dynamics 25%
  • Experiment 25%

• STREAMING-tag system reveals spatiotemporal relationships between transcriptional regulatory factors and transcriptional activity

  Ohishi, H., Shimada, S., Uchino, S., Li, J., Sato, Y., Shintani, M., Owada, H., Ohkawa, Y., Pertsinidis, A., Yamamoto, T., Kimura, H. & Ochiai, H., 12月 2022, In: Nature communications. 13, 1, 7672.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Intein 100%
  • Reporter Gene 75%
  • Transcription Initiation Site 75%
  • Nested Gene 50%
  • Transcription 50%

• Symbiotic bacteria-dependent expansion of MR1-reactive T cells causes autoimmunity in the absence of Bcl11b

  Shibata, K., Motozono, C., Nagae, M., Shimizu, T., Ishikawa, E., Motooka, D., Okuzaki, D., Izumi, Y., Takahashi, M., Fujimori, N., Wing, J. B., Hayano, T., Asai, Y., Bamba, T., Ogawa, Y., Furutani-Seiki, M., Shirai, M. & Yamasaki, S., 12月 2022, In: Nature communications. 13, 1, 6948.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • T Cell 100%
  • Mouse 62%
  • Leukemia 25%
  • T Lymphocyte Receptor 25%
  • B-Cell Lymphoma 25%

• Tmsb10 triggers fetal Leydig differentiation by suppressing the RAS/ERK pathway

  Inoue, M., Baba, T., Takahashi, F., Terao, M., Yanai, S., Shima, Y., Saito, D., Sugihara, K., Miura, T., Takada, S., Suyama, M., Ohkawa, Y. & Morohashi, K. I., 12月 2022, In: Communications Biology. 5, 1, 974.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Leydig Cell 100%
  • Cells 50%
  • Cell Differentiation 50%
  • Cellular Differentiation 50%
  • Differentiation 33%

• Unified-Hydrophilic-Interaction/Anion-Exchange Liquid Chromatography Mass Spectrometry (Unified-HILIC/AEX/MS): A Single-Run Method for Comprehensive and Simultaneous Analysis of Polar Metabolome

  Nakatani, K., Izumi, Y., Takahashi, M. & Bamba, T., 12月 6 2022, In: Analytical Chemistry. 94, 48, p. 16877-16886 10 p.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Hydrophilic Interaction Chromatography 100%
  • Procedure 31%
  • Metabolic 31%
  • High Resolution Mass Spectrometry (HRMS) 18%
  • Separation 13%
• 2021

  Ddhd1 knockout mouse as a model of locomotive and physiological abnormality in familial spastic paraplegia

  Morikawa, T., Ohishi, H., Kosaka, K., Shimojo, T., Nagano, A., Taniguchi, I., Fujioka, R., Moriyama, K., Unoki, M., Takahashi, M., Nakao, M., Izumi, Y., Bamba, T., Sasaki, H., Miura, S. & Shibata, H., 2月 2021, In: Bioscience reports. 41, 2, BSR20204171.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Age 100%
  • Knockout Mouse 50%
  • Phospholipase A1 50%
  • Paraplegia 50%
  • Cerebrum 50%

• The structure of an archaeal oligosaccharyltransferase provides insight into the strict exclusion of proline from the N-glycosylation sequon

  Taguchi, Y., Yamasaki, T., Ishikawa, M., Kawasaki, Y., Yukimura, R., Mitani, M., Hirata, K. & Kohda, D., 12月 2021, In: Communications Biology. 4, 1, 941.

  研究成果: ジャーナルへの寄稿 › 学術誌 › 査読

  Open Access

  • Sequon 100%
  • Glycosylation 50%
  • Oligosaccharyltransferase 50%
  • Peptide 33%
  • Proline 33%
  4 被引用数 (Scopus)
• 2020

  Uncoupling the hydrolysis of lipid-linked oligosaccharide from the oligosaccharyl transfer reaction by point mutations in yeast oligosaccharyltransferase

  Yamasaki, T. & Kohda, D., 11月 2020, In: Journal of Biological Chemistry. 295, 47, p. 16072-16085 14 p.

  研究成果: ジャーナルへの寄稿 › 学術誌
• 2019

  A Radioisotope-free Oligosaccharyltransferase Assay Method

  Yamasaki, T. & Kohda, D., 3月 2019, In: Bio-protocol. 9, 5

  研究成果: ジャーナルへの寄稿 › 学術誌