生体分子情報学

研究成果 1992 2019

2014
23 引用 (Scopus)

Ischemic acute kidney injury perturbs homeostasis of serine enantiomers in the body fluid in mice: Early detection of renal dysfunction using the ratio of serine enantiomers

Sasabe, J., Suzuki, M., Miyoshi, Y., Tojo, Y., Okamura, C., Ito, S., Konno, R., Mita, M., Hamase, K. & Aiso, S., 1 29 2014, : : PloS one. 9, 1, e86504.

研究成果: ジャーナルへの寄稿記事

Enantiomers
body fluids
Body fluids
enantiomers
Body Fluids
11 引用 (Scopus)

Kidney fibrosis is independent of the amount of ascorbic acid in mice with unilateral ureteral obstruction

Nishida, H., Kurahashi, T., Saito, Y., Otsuki, N., Kwon, M., Ohtake, H., Yamakawa, M., Yamada, K-I., Miyata, S., Tomita, Y. & Fujii, J., 1 1 2014, : : Free Radical Research. 48, 9, p. 1115-1124 10 p.

研究成果: ジャーナルへの寄稿記事

Ureteral Obstruction
Ascorbic Acid
Fibrosis
Kidney
Collagen
18 引用 (Scopus)

Localization of Serine Racemase and Its Role in the Skin

Inoue, R., Yoshihisa, Y., Tojo, Y., Okamura, C., Yoshida, Y., Kishimoto, J., Luan, X., Watanabe, M., Mizuguchi, M., Nabeshima, Y., Hamase, K., Matsunaga, K., Shimizu, T. & Mori, H., 1 1 2014, : : Journal of Investigative Dermatology. 134, 6, p. 1618-1626 9 p.

研究成果: ジャーナルへの寄稿記事

Keratinocytes
Skin
Epidermis
Serine
N-Methyl-D-Aspartate Receptors
4 引用 (Scopus)

Novel styrylbenzene derivatives for detecting amyloid deposits

Nakazono, M., Obayashi, K., Sasamoto, K., Tomiyoshi, K., Suenaga, G. & Ando, Y., 9 25 2014, : : Clinica Chimica Acta. 436, p. 27-34 8 p.

研究成果: ジャーナルへの寄稿記事

Amyloid Plaques
Amyloid
Deposits
Derivatives
Amyloidosis
24 引用 (Scopus)

Peptide tag/probe pairs based on the coordination chemistry for protein labeling

Uchinomiya, S., Ojida, A. & Hamachi, I., 2 17 2014, : : Inorganic Chemistry. 53, 4, p. 1816-1823 8 p.

研究成果: ジャーナルへの寄稿評論記事

Labeling
marking
peptides
chemistry
proteins
7 引用 (Scopus)

Preparation of a monoclonal antibody against notoginsenoside R1, a distinctive saponin from panax notoginseng, and its application to indirect competitive elisa

Limsuwanchote, S., Wungsintaweekul, J., Yusakul, G., Han, J. Y., Tabata, K., Tanaka, H., Shoyama, Y. & Morimoto, S., 1 1 2014, : : Planta medica. 80, 4, p. 337-342 6 p.

研究成果: ジャーナルへの寄稿記事

Panax notoginseng
Saponins
Monoclonal Antibodies
Panax
Cell Fusion
12 引用 (Scopus)

Reductive detoxification of acrolein as a potential role for aldehyde reductase (AKR1A) in mammals

Kurahashi, T., Kwon, M., Homma, T., Saito, Y., Lee, J., Takahashi, M., Yamada, K-I., Miyata, S. & Fujii, J., 9 12 2014, : : Biochemical and Biophysical Research Communications. 452, 1, p. 136-141 6 p.

研究成果: ジャーナルへの寄稿記事

Acrolein
Aldehyde Reductase
Detoxification
Mammals
Fibroblasts
7 引用 (Scopus)

Tempol intake improves inflammatory status in aged mice

Yamato, M., Ishimatsu, A., Yamanaka, Y., Mine, T. & Yamada, K-I., 1 1 2014, : : Journal of Clinical Biochemistry and Nutrition. 55, 1, p. 11-14 4 p.

研究成果: ジャーナルへの寄稿記事

Oxidative stress
Antioxidants
Plasmas
Aging of materials
Body Temperature
4 引用 (Scopus)

Unsymmetric indolylmaleimides: Synthesis, photophysical properties and amyloid detection

Nakazono, M., Obayashi, K., Oshikawa, Y., Tani, K., Suenaga, G., Ando, Y., Nanbu, S. & Kuwano, R., 9 1 2014, : : Journal of Photochemistry and Photobiology A: Chemistry. 289, p. 39-46 8 p.

研究成果: ジャーナルへの寄稿記事

Amyloid
Pyrroles
Dione
pyrroles
synthesis
2013
22 引用 (Scopus)

A disruption mechanism of the molecular clock in a MPTP mouse model of parkinson's disease

Hayashi, A., Matsunaga, N., Okazaki, H., Kakimoto, K., Kimura, Y., Azuma, H., Ikeda, E., Shiba, T., Yamato, M., Yamada, K. I., Koyanagi, S. & Ohdo, S., 6 1 2013, : : NeuroMolecular Medicine. 15, 2, p. 238-251 14 p.

研究成果: ジャーナルへの寄稿記事

AMP-Activated Protein Kinases
Parkinson Disease
Circadian Clocks
Dopaminergic Neurons
Adenosine Triphosphate
2 引用 (Scopus)

Amino Acid and Bioamine Separations

Miyoshi, Y., Oyama, T., Koga, R. & Hamase, K., 1 1 2013, Liquid Chromatography: Applications. Elsevier Inc., p. 131-147 17 p.

研究成果: 著書/レポートタイプへの貢献

Amino Acids
Fluorescence
Liquids
13 引用 (Scopus)

Development of an enzyme immunoassay using a monoclonal antibody against the psychoactive diterpenoid salvinorin A

Paudel, M. K., Shirota, O., Tabata, K., Tanaka, H., Sekita, S. & Morimoto, S., 9 27 2013, : : Journal of Natural Products. 76, 9, p. 1654-1660 7 p.

研究成果: ジャーナルへの寄稿記事

salvinorin A
Diterpenes
Immunosorbents
Immunoenzyme Techniques
Assays
14 引用 (Scopus)

Development of an indirect competitive enzyme-linked immunosorbent assay (icELISA) using highly specific monoclonal antibody against paclitaxel

Chao, Z., Tan, M., Paudel, M. K., Sakamoto, S., Ma, L., Tabata, K., Tanaka, H., Shoyama, Y., Xuan, L. & Morimoto, S., 7 1 2013, : : Journal of Natural Medicines. 67, 3, p. 512-518 7 p.

研究成果: ジャーナルへの寄稿記事

Immunosorbents
Paclitaxel
Assays
Enzyme-Linked Immunosorbent Assay
Monoclonal Antibodies

Electron spin resonance spectroscopy studies on 15N-labeled and their deuterated nitroxyl spin probes used in molecular imaging

Jebaraj, D. D., Benial, A. M. F., Ichikawa, K., Yamada, K-I. & Utsumi, H., 7 18 2013, Proceeding of International Conference on Recent Trends in Applied Physics and Material Science, RAM 2013. p. 1171-1172 2 p. (AIP Conference Proceedings; 巻数 1536).

研究成果: 著書/レポートタイプへの貢献会議での発言

electron paramagnetic resonance
probes
spectroscopy
superhigh frequencies
convolution integrals
36 引用 (Scopus)

In-cell covalent labeling of reactive His-tag fused proteins

Uchinomiya, S., Nonaka, H., Wakayama, S., Ojida, A. & Hamachi, I., 6 4 2013, : : Chemical Communications. 49, 44, p. 5022-5024 3 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Proteins
Cells

Molecular dynamics dependence of overhauser-enhanced magnetic resonance imaging (OMRI): An ESR study

Meenakumari, V., Benial, A. M. F., Ichikawa, K., Yamada, K-I., Jawahar, A. & Utsumi, H., 3 15 2013, Solid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012. p. 952-953 2 p. (AIP Conference Proceedings; 巻数 1512).

研究成果: 著書/レポートタイプへの貢献会議での発言

magnetic resonance
electron paramagnetic resonance
molecular dynamics
augmentation
free radicals
18 引用 (Scopus)

Novel ascorbic acid-resistive nitroxide in a lipid emulsion: An efficient brain imaging contrast agent for MRI of small rodents

Emoto, M. C., Yamada, K-I., Yamato, M. & Fujii, H. G., 6 24 2013, : : Neuroscience Letters. 546, p. 11-15 5 p.

研究成果: ジャーナルへの寄稿記事

Emulsions
Neuroimaging
Contrast Media
Ascorbic Acid
Rodentia

Permeability studies of redox-sensitive nitroxyl radicals through bilayer lipid membranes

Dhas, M. K., Benial, A. M. F., Ichikawa, K., Yamada, K-I., Hyodo, F., Jawahar, A. & Utsumi, H., 3 15 2013, Solid State Physics - Proceedings of the 57th DAE Solid State Physics Symposium 2012. p. 132-133 2 p. (AIP Conference Proceedings; 巻数 1512).

研究成果: 著書/レポートタイプへの貢献会議での発言

lipids
permeability
membranes
electron paramagnetic resonance
probes
7 引用 (Scopus)

Permeability Studies of Redox-Sensitive Nitroxyl Spin Probes Through Lipid Membranes Using an L-Band ESR Spectrometer

Milton Franklin Benial, A., Kumara Dhas, M., Ichikawa, K., Yamada, K-I., Hyodo, F., Jawahar, A. & Utsumi, H., 1 1 2013, : : Applied Magnetic Resonance. 44, 4, p. 439-447 9 p.

研究成果: ジャーナルへの寄稿記事

ultrahigh frequencies
lipids
electron paramagnetic resonance
permeability
spectrometers
10 引用 (Scopus)

PET-dependent fluorescence sensing of enzyme reactions using the large and tunable pKa shift of aliphatic amines

Oshikawa, Y. & Ojida, A., 12 18 2013, : : Chemical Communications. 49, 97, p. 11373-11375 3 p.

研究成果: ジャーナルへの寄稿記事

Amines
Enzymes
Fluorescence
Fluorescent Dyes
186 引用 (Scopus)

Protein organic chemistry and applications for labeling and engineering in live-cell systems

Takaoka, Y., Ojida, A. & Hamachi, I., 4 8 2013, : : Angewandte Chemie - International Edition. 52, 15, p. 4088-4106 19 p.

研究成果: ジャーナルへの寄稿評論記事

Labeling
Proteins
Amino acids
Organic Chemistry
Amino Acids
5 引用 (Scopus)

Redox potential of nitroxides is an index to evaluate superoxide dismutase mimic activity

Yamasaki, T., Matsuoka, Y., Mito, F., Yamato, M. & Yamada, K-I., 1 1 2013, : : Asian Journal of Organic Chemistry. 2, 5, p. 388-391 4 p.

研究成果: ジャーナルへの寄稿記事

Superoxides
Superoxide Dismutase
Oxidation-Reduction
18 引用 (Scopus)
Mammals
Alanine
Oxidoreductases
Amino Acids
Liquids
2012
22 引用 (Scopus)

Alteration of intrinsic amounts of D-serine in the mice lacking serine racemase and D-amino acid oxidase

Miyoshi, Y., Konno, R., Sasabe, J., Ueno, K., Tojo, Y., Mita, M., Aiso, S. & Hamase, K., 11 1 2012, : : Amino Acids. 43, 5, p. 1919-1931 13 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
Serine
Brain
Tissue
Amino Acid Isomerases

Challenges for Futuristic Nanomedical Detection, Diagnosis and Treatment

Ojida, A. & Kato, M., 1 1 2012, : : Yakugaku Zasshi. 132, 2, 1 p.

研究成果: ジャーナルへの寄稿記事

105 引用 (Scopus)

D-Amino acid oxidase controls motoneuron degeneration through D-serine

Sasabe, J., Miyoshi, Y., Suzuki, M., Mita, M., Konno, R., Matsuoka, M., Hamase, K. & Aiso, S., 1 10 2012, : : Proceedings of the National Academy of Sciences of the United States of America. 109, 2, p. 627-632 6 p.

研究成果: ジャーナルへの寄稿記事

D-Amino-Acid Oxidase
Motor Neurons
Serine
Amyotrophic Lateral Sclerosis
Mitogen-Activated Protein Kinase Kinases
25 引用 (Scopus)

D-Amino acids in the brain and mutant rodents lacking D-amino-acid oxidase activity

Yamanaka, M., Miyoshi, Y., Ohide, H., Hamase, K. & Konno, R., 11 1 2012, : : Amino Acids. 43, 5, p. 1811-1821 11 p.

研究成果: ジャーナルへの寄稿評論記事

D-Amino-Acid Oxidase
Rodentia
Brain
Serine
Amino Acids
20 引用 (Scopus)

Design of a multinuclear Zn(ii) complex as a new molecular probe for fluorescence imaging of His-tag fused proteins

Fujishima, S. H., Nonaka, H., Uchinomiya, S., Kawase, Y. A., Ojida, A. & Hamachi, I., 1 14 2012, : : Chemical Communications. 48, 4, p. 594-596 3 p.

研究成果: ジャーナルへの寄稿記事

Molecular Probes
G-Protein-Coupled Receptors
Fluorescent Dyes
Histidine
Fluorescence

Development of a simultaneous two-dimensional micro-HPLC analysis system for the chiral amino acid metabolomics study in mammals

Miyoshi, Y., Tojo, Y., Han, H., Mita, M. & Hamase, K., 1 1 2012, : : bunseki kagaku. 61, 6, p. 489-499 11 p.

研究成果: ジャーナルへの寄稿記事

Mammals
Amino Acids
Enantiomers
Biomarkers
Animals
12 引用 (Scopus)

Enantioselective two-dimensional high-performance liquid chromatographic determination of N-methyl-d-aspartic acid and its analogues in mammals and bivalves

Koga, R., Miyoshi, Y., Negishi, E., Kaneko, T., Mita, M., Lindner, W. & Hamase, K., 12 21 2012, : : Journal of Chromatography A. 1269, p. 255-261 7 p.

研究成果: ジャーナルへの寄稿記事

Mammals
Bivalvia
Aspartic Acid
Enantiomers
Acids
9 引用 (Scopus)

High-fat diet-induced obesity and insulin resistance were ameliorated via enhanced fecal bile acid excretion in tumor necrosis factor-alpha receptor knockout mice

Yamato, M., Shiba, T., Ide, T., Seri, N., Kudo, W., Ando, M., Yamada, K-I., Kinugawa, S. & Tsutsui, H., 1 1 2012, : : Molecular and cellular biochemistry. 359, 1-2, p. 161-167 7 p.

研究成果: ジャーナルへの寄稿記事

Tumor Necrosis Factor Receptors
High Fat Diet
Nutrition
Bile Acids and Salts
Knockout Mice
60 引用 (Scopus)

HPLC analysis of naturally occurring free d-amino acids in mammals

Miyoshi, Y., Koga, R., Oyama, T., Han, H., Ueno, K., Masuyama, K., Itoh, Y. & Hamase, K., 10 1 2012, : : Journal of Pharmaceutical and Biomedical Analysis. 69, p. 42-49 8 p.

研究成果: ジャーナルへの寄稿評論記事

Mammals
High Pressure Liquid Chromatography
Amino Acids
Metabolomics
Enantiomers
3 引用 (Scopus)

Intracellular logistics of BST-2/Tetherin

Fujita, H., Fujimoto, K., Tokunaga, K. & Tanaka, Y., 6 2012, : : Current HIV Research. 10, 4, p. 321-326 6 p.

研究成果: ジャーナルへの寄稿評論記事

Bone Marrow
Antigens
Glycosylphosphatidylinositols
Membrane Lipids
Endocytosis
3 引用 (Scopus)

Label-free fluorescent detection of loop-mediated isothermal amplification of nucleic acid using pyrophosphate-selective xanthene-based Zn(II)-coordination chemosensor

Kittiloespaisan, E., Ojida, A., Hamachi, I., Seetang-Nun, Y., Kiatpathomchai, W. & Wongkongkatep, J., 2012, : : Chemistry Letters. 41, 12, p. 1666-1668 3 p.

研究成果: ジャーナルへの寄稿記事

Xanthenes
Nucleic Acids
Amplification
Labels
Viruses
77 引用 (Scopus)

Ligand-directed acyl imidazole chemistry for labeling of membrane-bound proteins on live cells

Fujishima, S. H., Yasui, R., Miki, T., Ojida, A. & Hamachi, I., 3 7 2012, : : Journal of the American Chemical Society. 134, 9, p. 3961-3964 4 p.

研究成果: ジャーナルへの寄稿記事

Labeling
Membrane Proteins
Ligands
Proteins
Membranes
87 引用 (Scopus)

Organelle-localizable fluorescent chemosensors for site-specific multicolor imaging of nucleoside polyphosphate dynamics in living cells

Kurishita, Y., Kohira, T., Ojida, A. & Hamachi, I., 11 14 2012, : : Journal of the American Chemical Society. 134, 45, p. 18779-18789 11 p.

研究成果: ジャーナルへの寄稿記事

Polyphosphates
Nucleosides
Organelles
Cells
Imaging techniques

Permeability studies of nitroxyl spin probes through lipid membranes using L-band ESR spectrometer

Franklin Benial, A. M., Dhas, M. K., Ichikawa, K., Yamada, K-I., Hyodo, F., Jawahar, A. & Utsumi, H., 12 1 2012, Solid State Physics - Proceedings of the 56th DAE Solid State Physics Symposium 2011. 1 版 p. 185-186 2 p. (AIP Conference Proceedings; 巻数 1447, 番号 1).

研究成果: 著書/レポートタイプへの貢献会議での発言

ultrahigh frequencies
lipids
permeability
spectrometers
membranes
9 引用 (Scopus)

Photochemical dynamics of indolylmaleimide derivatives

Murakami, T., Nakazono, M., Kondorskiy, A., Ishida, T. & Nanbu, S., 8 28 2012, : : Physical Chemistry Chemical Physics. 14, 32, p. 11546-11555 10 p.

研究成果: ジャーナルへの寄稿記事

Anions
Derivatives
Molecular dynamics
indoles
anions
25 引用 (Scopus)

Preliminary organic compound analysis of microparticles returned from Asteroid 25143 Itokawa by the Hayabusa mission

Naraoka, H., Mita, H., Hamase, K., Mita, M., Yabuta, H., Saito, K., Fukushima, K., Kitajima, F., Sandford, S. A., Nakamura, T., Noguchi, T., Okazaki, R., Nagao, K., Ebihara, M., Yurimoto, H., Tsuchiyama, A., Abe, M., Shirai, K., Ueno, M., Yada, T. および6人, Ishibashi, Y., Okada, T., Fujimura, A., Mukai, T., Yoshikawa, M. & Kawaguchi, J., 12 1 2012, : : GEOCHEMICAL JOURNAL. 46, 1, p. 61-72 12 p.

研究成果: ジャーナルへの寄稿記事

Asteroids
microparticles
asteroids
organic compounds
Organic compounds
6 引用 (Scopus)

Preparation of a single-chain variable fragment and a recombinant antigen-binding fragment against the anti-malarial drugs, artemisinin and artesunate, and their application in an ELISA

Paudel, M. K., Takei, A., Sakoda, J., Juengwatanatrakul, T., Tabata, K., Putalun, W., Shoyama, Y., Tanaka, H. & Morimoto, S., 2 21 2012, : : Analytical Chemistry. 84, 4, p. 2002-2008 7 p.

研究成果: ジャーナルへの寄稿記事

Single-Chain Antibodies
Immunosorbents
Antimalarials
Assays
Antigens
45 引用 (Scopus)

Rapid and convenient detection of ascorbic acid using a fluorescent nitroxide switch

Matsuoka, Y., Yamato, M., Yamasaki, T., Mito, F. & Yamada, K-I., 12 1 2012, : : Free Radical Biology and Medicine. 53, 11, p. 2112-2118 7 p.

研究成果: ジャーナルへの寄稿記事

Ascorbic Acid
Switches
Fluorophores
Reducing Agents
Fluorescence

Synthesis and Utilization of α-Substituted Nitroxides

Yamasaki, T., Mito, F., Matsuoka, Y., Yamato, M. & Yamada, K-I., 9 12 2012, : : InTech. p. 247 262 p., 8.

研究成果: ジャーナルへの寄稿記事

35 引用 (Scopus)

The detrimental eff ect of nitric oxide on tissue is associated with infl ammatory events in the vascular endothelium and neutrophils in mice with dextran sodium sulfate-induced colitis

Yasukawa, K., Tokuda, H., Tun, X., Utsumi, H. & Yamada, K-I., 12 1 2012, : : Free Radical Research. 46, 12, p. 1427-1436 10 p.

研究成果: ジャーナルへの寄稿記事

Dextran Sulfate
Vascular Endothelium
Colitis
Nitric Oxide
Neutrophils
6 引用 (Scopus)

Theoretical study of photo-physical properties of indolylmaleimide derivatives

Zheng, Z., Zhao, Y., Nakazono, M. & Nanbu, S., 2 28 2012, : : Physical Chemistry Chemical Physics. 14, 9, p. 3017-3024 8 p.

研究成果: ジャーナルへの寄稿記事

indoles
Physical properties
physical properties
Derivatives
succinimides
9 引用 (Scopus)

Type 1 diabetes mellitus in mice increases hippocampal d-serine in the acute phase after streptozotocin injection

Suzuki, M., Sasabe, J., Furuya, S., Mita, M., Hamase, K. & Aiso, S., 7 23 2012, : : Brain Research. 1466, p. 167-176 10 p.

研究成果: ジャーナルへの寄稿記事

Streptozocin
Type 1 Diabetes Mellitus
Serine
Diabetes Mellitus
Injections
22 引用 (Scopus)

Whole-body kinetic image of a redox probe in mice using Overhauser-enhanced MRI

Kosem, N., Naganuma, T., Ichikawa, K., Phumala Morales, N., Yasukawa, K., Hyodo, F., Yamada, K-I. & Utsumi, H., 7 15 2012, : : Free Radical Biology and Medicine. 53, 2, p. 328-336 9 p.

研究成果: ジャーナルへの寄稿記事

Body Image
Magnetic resonance imaging
Oxidation-Reduction
Kinetics
Pharmacokinetics
2011
11 引用 (Scopus)

17,20-Lyase inhibitors. Part 4: Design, synthesis and structure-activity relationships of naphthylmethylimidazole derivatives as novel 17,20-lyase inhibitors

Kaku, T., Matsunaga, N., Ojida, A., Tanaka, T., Hara, T., Yamaoka, M., Kusaka, M. & Tasaka, A., 3 1 2011, : : Bioorganic and Medicinal Chemistry. 19, 5, p. 1751-1770 20 p.

研究成果: ジャーナルへの寄稿記事

Steroid 17-alpha-Hydroxylase
Structure-Activity Relationship
Derivatives
Cytochrome P-450 CYP3A
Human Activities
8 引用 (Scopus)

A fluorescent single domain antibody against plumbagin expressed in silkworm larvae for fluorescence-linked immunosorbent assay (FLISA)

Sakamoto, S., Pongkitwitoon, B., Tabata, K., Putalun, W., Maenaka, K., Tanaka, H. & Morimoto, S., 5 21 2011, : : The Analyst. 136, 10, p. 2056-2063 8 p.

研究成果: ジャーナルへの寄稿記事

Single-Domain Antibodies
Immunosorbents
Bombyx
chimera
Antibodies
5 引用 (Scopus)
Stereoisomerism
Chromatography
Amino Acids
18 引用 (Scopus)

A novel ascorbic acid-resistant nitroxide in fat emulsion is an efficient brain imaging probe for in vivo EPR imaging of mouse

Emoto, M., Mito, F., Yamasaki, T., Yamada, K. I., Sato-Akaba, H., Hirata, H. & Fujii, H., 11 1 2011, : : Free Radical Research. 45, 11-12, p. 1325-1332 8 p.

研究成果: ジャーナルへの寄稿記事

Emulsions
Neuroimaging
Ascorbic Acid
Paramagnetic resonance
Brain